GLIM Imaging for Thick Embryos

Gradient Light Interference Microscopy (GLIM) was judged one of the ten best microscopy innovations in the 2018 Microscopy Today Innovation Award competition. Dr. Marcello Rubessa and Dr. Matthew B. Wheeler and their Beckmann Institute collaborators, Dr. Gabriel Popescu, Dr. Tan Nguyen and Ph.D. student Mikhail Kandel will receive this prestigious award at the Microscopy & Microanalysis 2018 meeting in Baltimore, Maryland, on August 5, 2018.

GLIM extracts extract three-dimensional information from both thin and thick unlabeled specimens. GLIM can potentially become a valuable tool for in vitro fertilization, where contrast agents and fluorophores may impact the viability of the embryo. Since GLIM is implemented as an add-on module to an existing inverted microscope, we anticipate that it will be adopted rapidly by the biological community.

Matthew B. Wheeler