1. Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
    Gonzalez-Lopez A, Larsson DSD, Koripella RK, Cain BN, Sanyal S, Chavez MG, Hergenrother PJ, Sanyal S, Selmer M  
    Sci. Rep. 2024, 14, 14253
  1. A Gram-negative-selective antibiotic that spares the gut microbiome
    Muñoz KA, Ulrich RJ, Vasan AK, Sinclair M, Wen P-C, Holmes JR, Lee HY, Hung C-C, Fields CJ, Tajkhorshid E, Lau GW, Hergenrother PJ
    Nature 2024, 630, 429-436

  1. Precise readout of MEK1 proteoforms upon MAPK pathway modulation by individual ion mass spectrometry
    Drown BS, Gupta R, McGee JP, Hollas MAR, Hergenrother PJ, Kafader JO, Kelleher NL
    Anal. Chem. 2024, 96, 4455−4462

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  1. Using permeation guidelines to design new antibiotics – a PASsagE into Pseudomonas aeruginosa
    Cain BN and Hergenrother PJ
    Clin. Transl. Med. 2024, 4, e1600

  1. A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds
    Huang Y, Li X, Mai BK, Tonogai EJ, Smith AJ, Hergenrother PJ, Liu P, Hoveyda, AH
    Nature Chem. 2024, 16, 1003-1014

  1. New antibiotic targets a drug-resistant bacterium
    Gugger MK and Hergenrother PJ
    Nature 2024, 625, 451-452 (News & Views)

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  1. Discovery of KRB-456, a KRAS G12D switch-I/II allosteric pocket binder that inhibits the growth of pancreatic cancer patient-derived tumors
    Kazi A, Ranjan A, Kumar MVV, Agianian B, Chavez MG, Vudatha V, Wang, R, Vangipurapu R, Chen L, Kennedy P, Subramanian K, Quirke JCK, Beato F, Underwood P, Fleming JB, Trevino J, Hergenrother PJ, Gavathiotis E, Sebti S
    Cancer Res. Comm. 2023, 3, 2623-2639

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  1. Augmented concentration of isopentyl-deoxynyboquinone in tumors selectively kills NAD(P)H quinone oxidoreductase 1-positive cancer cells through programmed necrotic and apoptotic mechanisms
    Wang J, Su X, Jiang L, Boudreau MW, Chatkewitz LE, Kilgore JA, Zahid KR, Williams NS, Chen Y, Liu S, Hergenrother PJ, Huang X
    Cancers 2023, 15, 5844

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  1. Porin-independent accumulation in Pseudomonas enables antibiotic discovery
    Geddes EJ, Gugger MK, Garcia A, Chavez MG, Lee MR, Perlmutter SJ, Bieniossek C, Guasch L, Hergenrother PJ
    Nature 2023, 624, 145-153

  1. IP-DNQ induces mitochondrial dysfunction and G2/M phase cell cycle arrest to selectively kill NQO1-positive pancreatic cancer cells
    Jiang L, Liu Y, Tumbath S, Boudreau MW, Chatkewitz LE, Wang J, Su X, Rafiq,Zahid K, Li K, Chen Y, Yang K, Hergenrother PJ, Huang X
    Antioxid. Redox Signal. 2023, in press published on web November 11, 2023

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  1. The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma
    Boudreau MW, Tonogai EJ, Schane CP, Xi MX, Fischer JH, Vijayakumar J, Ji Y, Tarasow TM, Fan TM, Hergenrother PJ, Dudek AZ
    Melanoma Res. 2023, 33, 514-524

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  1. Phase 1 dose escalation study of procaspase activating compound-1 (PAC-1) in combination with temozolomide in patients with recurrent high-grade astrocytomas
    Holdhoff M, Nicholas KM, Peterson RA, Maraka S, Liu LC, Fischer JH, Wefel JS, Fan TM, Vannorsdall T, Russell M, Iacoboni M, Tarasow TM, Hergenrother PJ, Dudek AZ, Danciu OC
    Neuro-Oncol. Adv. 2023, 5, vdad087

  1. Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis
    Ghosh S, Yang R, Duraki D, Zhu J, Kim JE, Jabeen M, Mao C, Dai X, Livezey MR, Boudreau MW, Park BH, Nelson ER, Hergenrother PJ, Shapiro DJ
    Cancer Res. 2023, 83, 3115-3130

  1. A single CAR T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model
    Ranoa DRE, Sharma P, Shane CP, Lewis AN, Valdez E, Marada VVVR, Hager MV, Montgomery W, Wolf SP, Schreiber K, Schreiber H, Bailey K, Fan TM, Hergenrother PJ, Roy EJ, Kranz DM
    J. Immunother. Cancer 2023, 11, e006509

  1. A fluorescence polarization assay for macrodomains facilitates the identification of potent inhibitors of SARS-CoV-2 macrodomain
    Anmangandla A, Jana S, Peng K, Wallace SD, Bagde SR, Drown BS, Hergenrother PJ, Fromme JC, Lin H
    ACS Chem. Biol. 2023, 18, 1200-1207

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  1. Phase 1 study of procaspase activating compound-1 (PAC-1) in the treatment of advanced malignancies
    Danciu OC, Holdhoff M, Peterson RA, Fisher JH, Liu LC, Wang H, Venepalli NK, Chowdhery R, Nicholas MK, Russell MJ, Fan TM, Hergenrother PJ, Tarasow TM, Dudek AZ
    Brit. J. Cancer  2023, 128, 783

  1. Computational discovery of dynobactin antibiotics
    Munoz KA and Hergenrother PJ
    Nature Microbiology 2022, 7, 1512-1513 (News and Views).

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  1. An iterative approach guides discovery of the FabI inhibitor fabimycin, a late-stage antibiotic candidate with in vivo efficacy against drug-resistant gram-negative infections
    Parker EN, Cain BN, Hajian B, Ulrich RJ, Geddes EJ, Barkho S, Lee HY, Williams JD, Rynor M, Caridha D, Zaino A, Rodhe JM, Zak M, Shekhar M, Muñoz KA, Rzasa KM,  Temple ER, Hunt D, Jin X, Vuong C, Pannone K, Kelly AM, Mulligan MP, Lee KK, Lau GW, Hung DT, Hergenrother PJ
    ACS Cent. Sci. 2022, 8, 1145-1158

  1. Target-agnostic P-glycoprotein assessment yields strategies to evade efflux, leading to a BRAF inhibitor with intracranial efficacy
    Kelly, A.M.; Berry, M.R.; Tasker, S.Z.; McKee, S.A.; Fan, T.M.; Hergenrother, P.J.
     J. Am. Chem. Soc. 2022, 144, 12367-12380

  1. Mitigation of SARS-CoV-2 transmission at a large public university
    Ranoa, D.R.E.; Holland, R.L.; Alnaji, F.G.; Green, K.J.; . . . Sullivan, W.C.; Smith, R.L.; Goldenfeld, N.D.; Fan, T.M.; Hergenrother, P.J, Burke, M.D.
    Nature Comm. 2022, 13, 3207

  1. Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity
    Boudreau, M.W. and Hergenrother, P.J.
    RSC Med. Chem. 2022, 13, 711-725

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  1. Role of internal loop dynamics in antibiotic permeability of outer membrane porins
    Vasan, A.K.; Haloi, N.; Ulrich, R.J.; Metcalf, M.E.; Wen, P.C.; Metcalf, W.W.; Hergenrother, P.J.; Shukla, D.; Tajkhorshid, E.
    Proc. Natl. Acad. Sci. 2022, 119, e2117009119

  1. Novel imidazotetrazine evades known resistance mechanisms and is effective against temozolomide-resistant brain cancer in cell culture
    Svec, R.L; McKee, S.A.; Berry, M.R.; Kelly, A.M.; Fan, T.M.; Hergenrother, P.J.
    ACS Chem. Biol. 2022, 17, 299-313

  1. Activators of the anticipatory unfolded protein response with enhanced selectivity for estrogen receptor positive breast cancer
    Boudreau, M.W.; Mulligan, M.P.; Shapiro, D.J.; Fan, T.M.; Hergenrother, P.J.
    J. Med. Chem. 2022, 65, 3894-3912

  1. Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in overcoming targeted therapy dosage challenges
    Song, K.; Minami J.K.; Huang, A.; Dehkordi, S.R.; Lomeli, S.H.; Luebeck, J.; Goodman, M.H.; Moriceau, G.; Krijgsman, O.; Dharanipragada, P.; Ridgley, T.; Crosson, W.P.; Salazar, J.; Pazol, E.; Karin, G.; Jayaraman, R.; Balanis, N.G.; Alhani, S.; Sheu, K.; Ten Hoeve, J.; Palermo, A.; Motika, S.E.; Senaratne, T.N.; Paraiso, K.H.; Hergenrother, P.J.; Rao, P.N.; Multani, A.S.; Peeper, D.S.; Bafna, V.; Lo, R.S.; Graeber, T.G.
    Cancer Discov. 2022, 12, 1046-1069

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  1. Rationalizing generation of broad spectrum antibiotics with the addition of a positive charge
    Haloi, N.; Vasan, A.K.; Geddes, E.; Prasanna, A.; Wen, P.-C.; Metcalf, W.W.; Hergenrother, P.J.; Tajkhorshid, E.
    Chem. Sci. 2021, 12, 15028

  1. A LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli
    Geddes, E.J; Li, Z.; Hergenrother, P.J.
    Nature Protocols 202116, 4833-4854.

  1. A small molecule activator of the unfolded protein response eradicates human breast tumors in mice
    Boudreau, MW; Duraki, D; Wang, L.; Mao, C.; Kim, J.E.; Tang, B.; Fanning, S.W.; Kiefer, J.; Tarasow, T.M.; Bruckheimer, E.M.; Moreno, R.; Mousses, S.; Greene, G.L.; Roy, E.J.; Park, B.H.; Fan, T.M.; Nelson, E.R.; Hergenrother, P.J.; Shapiro, D.J.
    Science Transl. Med. 2021, 13, eabf1383

  1. Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
    Tonnus, W; Meyer, C; Steinebach, C; Belavgeni, A; von Mässenhausen, A; Zamora Gonzalez, N; Maremonti, F; Gembardt, F; Himmerkus, N; Latk, M; Locke, S; Marschner, J; Li, W; Short, S; Doll, S; Ingold, I; Proneth, B; Daniel, C; Kabgani, N; Kramann, R; Hergenrother, PJ; Bornstein, S; Hugo, C; Becker, J; Amann, K; Anders, H-J; Kreisel, D; Pratt, D; Gütschow, M; Conrad, M; Motika, S; Linkermann A.
    Nature Comm. 2021, 12, 4402

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  1. Evaluation of a procaspase-3 activator with hydroxyureas or temozolomide against high-grade meningioma in cell culture and canine cancer patients
    Tonogai, E.; Huang, S.; Botham, R.; Berry, M.; Joslyn, S.; Daniel, G.; Chen, Z.; Rao, J.; Zhang, X.; Basuli, F.; Rossmisl, J.; Riggins, G.; LeBlanc, A.; Fan, T.; Hergenrother, P.J.
    Neuro-Oncology 2021, 23, 1723-1735.

  1. Utilizing feline oral squamous cell carcinoma patients to develop a targeted therapy with potential for human head-and-neck cancer
    Lundberg, A.P.; Boudreau, M.W.; Selting, K.A.; Chatkewitz, L.E.; Samuelson, J.; Francis, J.M.; Parkinson, E.I.; Barger, A.M.; Hergenrother, P.J.; Fan, T.F.
    Neoplasia 20218, 811-822.

  1. Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity
    Furiassi, L; Tonogai, E.J.; Hergenrother, P.J.
    Angew. Chem. Int. Ed. 202160, 16119-16128.

  1. Facilitating compound entry as a means to discover antibiotics for Gram-negative bacteria
    Munoz, K.A. and Hergenrother, P.J.
    Acc. Chem. Res. 202154, 1322-1333.

  1. A phosphonate natural product made by Pantoea ananatis is necessary and sufficient for the hallmark lesion of onion center rot
    Polidore, A.L.A.; Furiassi, L.; Hergenrother, P.J.; Metcalf, W.M. 
    mBio202112, e3402-3420.

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  1. Synthesis of fusidic acid derivatives yields a potent antibiotic with an improved resistance profile
    Garcia Chavez, M.; Garcia, A.; Lee, H.Y.; Lau, G.W.; Parker, E.N.; Komnick, K.E.; Hergenrother, P.J.
    ACS Infect. Dis. 20217, 493-505.

  1. Synthetic studies on selective, proapoptotic isomalabaricane triterpenoids aided by computational techniques
    Boyko, Y.D.; Huck, C.J.; Ning, S.; Shved, A.S.; Yang, C.; Chu, F.; Tonogai, E.J.; Hergenrother, P.J.; Sarlah, D.
    J. Am. Chem. Soc. 2021, 143, 2138-2155.

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  1. Compound uptake into E. coli can be facilitated by N-alkyl guanidiniums and pyridinium
    Perlmutter, S.J.; Geddes, E.J.; Drown, B.S.; Motika, S.E.; Lee, M.R.; Hergenrother, P.J.  
    ACS Infect. Dis., 20217, 162-173.

  1. Re-engineering natural products to engage new biological targets
    Motika, S. E. and Hergenrother, P. J.
    Nat. Prod. Rep. 2020, 37, 1395-1403.

  1. Saliva-based molecular testing for SARS-CoV-2 that bypasses RNA extraction
    Ranoa, D.R.E.; Holland, R.L.; Alnaji, F.G.; Green, K.J.; Wang, L.; Brooke, C.B.; Burke, M.D.; Fan, T.M.; Hergenrother, P. J.
    BioRxiv. June 18, 2020,

  1. A gram-negative antibiotic active through inhibition of an essential riboswitch
    Motika, S. E.; Ulrich, R. J.; Geddes, E. J.; Lee, H. Y.; Lau, G. W.; Hergenrother, P. J.
    J. Am. Chem. Soc. 2020142, 10856-10862.

  1.  Imidazotetrazines as weighable diazomethane surrogates for esterifications and cyclopropanations
    Svec, R.L. and Hergenrother, P.J. 
    Angew. Chem. Int. Ed. 2020, 59, 1857-1862.

  1. Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens
    Parker, E. N.; Drown, B. S.; Geddes, E. J.; Lee, H.-Y.; Ismail, N.; Lau, G. W. and Hergenrother, P. J.
    Nature Microbiology 2020, 5, 67-75.

  1. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
    Janin M.; Ortiz-Barahona V.; Boudreau M.W.; Hergenrother P.J.; Esteller M. and others
    Acta Neuropathol. 2019, 138, 1053-1074.

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  1. Procaspase-3 overexpression in cancer: A paradoxical observation with therapeutic potential
    Boudreau, M. W.; Peh, J.; Hergenrother, P. J.
    ACS Chem. Biol201914, 2335-2348.

  1. Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis
    Llabani, E.; Hicklin, R. W.; Lee, H.-Y.; Motika, S. E.; Crawford, L. A.; Weerapana, E., Hergenrother, P. J.
    Nature Chem. 201911, 521

  1. Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins
    Thirawatananond, P.; McPherson, R. L.; Malhi, J.; Nathan, S.; Lambrecht, M.J.; Brichacek, M.; Hergenrother, P.J.; Leung, A.K.L.; Gabelli, S.B.
    Sci. Reports20199, 5940

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  1. Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers
    Schlein, L. J.; Fadl-Alla, B.; Pondenis, H. C.; Lezmi, S.; Eberhart, C. G.; LeBlanc, A. K.; Dickinson, P. J.; Hergenrother, P. J.; Fan, T. M.
    Front. Oncol. 20199, 96

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  1. Enantioselective synthesis of isocarbostyril alkaloids and analogs using catalytic dearomative functionalization of benzene
    Bingham, T. W.; Hernandez, L. W.; Olson, D. G.; Svec, R. L.; Hergenrother, P. J.; Sarlah, D
    J. Am. Chem. Soc. 2019141, 657-670.

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  1. The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics
    Richter, M. F. and Hergenrother, P. J.
    Ann NY Acad Sci. 2019, 1435, 18-38.

  1. (ADP-ribosyl) hydrolases: Structural basis for differential substrate recognition and inhibition
    Rack, J.G.M.; Ariza, A.; Drown, B. S.; Henfrey, C.; Shirai, T.; Hergenrother, P. J.; Ahel, I.
    Cell Chem. Biol. 201825, 1533-1546.

  1. Oxygen starvation unmasks a killer
    Svec, R. L. and Hergenrother, P. J.
    Cell Chem. Biol. 2018, 25, 1313-1314.

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  1. Monitoring poly(ADP-ribosyl)glycohydrolase activity with a continuous fluorescent substrate
    Drown, B. S.; Shirai, T.; Rack, J.G.M.; Ahel, I.; Hergenrother, P. J.
    Cell Chem. Biol. 201825, 1562-1570.

  1. Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma
    Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. M.; Riggins, G. J.; Hergenrother, P. J.
    ACS Chem. Biol. 2018,13, 3206-3216.

  1. Preparation of structurally diverse compounds from the natural product lycorine
    Tasker, S. Z.; Cowfer, A. E.; Hergenrother P. J.
    Org. Lett. 2018, 20, 5894-5898.

  1. Overcoming resistance to targeted anticancer therapies through small-molecule mediated MEK degradation
    Peh, J.; Boudreau, M. W.; Smith, H. M.; and Hergenrother, P. J.
    Cell Chem. Biol. 201825, 996-1005.

  1. Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death
    Livezey, M.; Huang, R.;Hergenrother, P. J.; Shapiro, D.S.
    Cell Death Differ. 201825, 1796-1807.

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  1. Going on offense against the Gram-negative defense
    Drown, B.S. and Hergenrother, P. J.
    Proc Natl. Acad. Sci. 2018115, 6530-6532.

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  1. How many human proteoforms are there?
    Aebersold, R; Agar, J.N.; Amster, I.J.; Baker, M.S.; Bertozzi, C.R.; Boja, E.S.; Costello, C.E.; Cravatt, B.F.; Fenselau, C., Garcia, B.A.; Ge, Y.; Gunawardena, J.; Hendrickson, R.C.; Hergenrother, P.J.; Huber, C.G.; Ivanov, A.R.; Jensen, O.N.; Jewett, M.C.; Kelleher, N.L.; Kiessling, L.L.; Krogan, N.J.; Larsen, M.R.; Loo, J.A.; Ogorzalek Loo, R.R.; Lundberg, E.; MacCoss, M.J.; Mallick, P.; Mootha, V.K.; Mrksich, M.; Muir, T.W.; Patrie, S.M.; Pesavento, J.J.; Pitteri, S.J.; Rodriguez, H.; Saghatelian, A.; Sandoval, W.; Schlüter, H.; Sechi, S.; Slavoff, S.A.; Smith, L.M.; Snyder, M.P.; Thomas, P.M.; Uhlén, M.; Van Eyk, J.E.; Vidal, M.; Walt, D.R.; White, F.M.; Williams, E.R.; Wohlschlager, T.; Wysocki, V.H.; Yates, N.A.; Young, N.L.; Zhang, B.  
    Nature Chem. Biol. 201814, 206-214.

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  1. Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNBI expression   
    Doganay, S.; Lee, M. Y.; Baum, A.; Peh, J.; Hwang, S. Y.; Yoo, J. Y.; Hergenrother, P. J.; Garcia-Sastre, A.; Myong, S.; Ha, T.  
    Integr. Biol. 20179, 857-867.

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  1. Broad-Spectrum Antibiotics, a Call for Chemists
    Richter, M. F.; Hergenrother, P. J.
    Chem 20173, 10-13 (essay).

  1. Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
    Joshi, A. D.; Botham, R. C.; Schlein, L. J.; Roth, H. S.; Mangraviti, A.; Borodovsky, A.; Tyler, B.; Joslyn, S.; Looper, J. S.; Podell, M.; Fan, T. F.; Hergenrother, P. J.; Riggins, G. J.
    Oncotarget 2017, 8, 80124-80138.

  1. Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer
    Granchi, C.; Fortunato, S.; Meni, S.; Rizzolio, F.; Caligiuri, I.; Tuccinardi, T.; Lee, H.-Y.; Hergenrother, P. J.; Minutolo, F.
    J. Agric. Food Chem. 2017, 65, 5639-5649.

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  1. Predictive Compound Accumulation Rules Yield a Broad-Spectrum Antibiotic
    Richter, M. F.; Drown, B. S.; Riley, A. P.; Garcia, A.; Shirai, T.; Svec, R. L.; Hergenrother, P. J. 
    Nature 2017, 545, 299-304.

  1. Taming Reactive Benzynes
    Tasker, S. Z.; Hergenrother, P. J.
    Nature Chem. 2017, 9, 504-506 (News & Views).

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  1. Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death
    Lee, H.-Y.; Parkinson, E. I.; Granchi, C.; Paterni, I.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P. J.
    ACS Chem. Biol. 2017, 12, 1416-1424.

  1. Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for the Novel Anti-Cancer Agent Isobutyl-Deoxynyboquinone (IB-DNQ), a NQO1 Bioactivatable Molecule, in the Domestic Felid Species
    Lundberg, A. P.; Francis, J. M.; Pajak, M.; Parkinson, E. I.; Wycislo, K. L.; Rosol, T. J.; Brown, M. E.; London, C. A.; Dirikolu, L.; Hergenrother, P. J.; Fan. T. M.
    Invest New Drugs 201735, 134-144.

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  1. Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine
    Garcia, A.; Drown, B. S.; Hergenrother, P. J.
    Org. Lett. 2016, 18, 4852-4855.

  1. Porous Photonic Crystal External Cavity Laser Biosensor
    Huang, Q.; Peh, J.; Hergenrother, P. J.; Cunningham, B. T.
    Appl. Phys. Lett. 2016, 109, 071103.

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  1. Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics
    Botham, R. C.; Roth, H. S.; Book, A. P.; Roady, P. J.; Fan, T. M.; Hergenrother, P. J.
    ACS Central Science 2016, 2, 545-559.

  1. Targeting Multidrug-resistant Ovarian Cancer Through Estrogen Receptor α Dependent ATP Depletion Caused by Hyperactivation of the Unfolded Protein Response
    Zheng, Z.; Andruska, N. D.; Lambrecht, M. L.; Sisi, H.; Hergenrother, P. J.; Nelson, E.; Shapiro, D. J. 
    Oncotarget 2016, 9, 14741-14753.

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  1. The Combination of Vemurafenib and Procaspase-3 Activation is Synergistic in Mutant BRAF Melanomas
    Peh, J.; Fan, T. M.; Wycislo, K. L.; Roth, H. S.; Hergenrother, P. J.
    Mol. Cancer Ther. 2016, 15, 1859-1869.

  1. A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy
    Luu, L. M.; Nguyen, L.; Peng, S.; Lee, J.; Lee, H. Y.; Wong, C. H.; Hergenrother, P. J.; Chan, H. Y.; Zimmerman, S. C.
    ChemMedChem 2016, 11, 1428-1435.

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  1. Derivatives of Procaspase-Activating Compound 1 (PAC-1) and Their Anticancer Activities
    Roth, H. S.; Hergenrother, P. J.
    Curr. Med. Chem. 2016, 23, 201-241 (review).

  1. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
    Palchaudhuri, R.; Lambrecht, M. J.; Botham, R. C.; Partlow, K. C.; Van Ham, T. J.; Putt, K. S.; Nguyen, L. T.; Kim, S.-H.; Peterson, R. T.; Fan, T. M.; Hergenrother, P. J.
    Cell Reports 201513, 2027-2036.

  1. Deoxynyboquinones as NQO1-Activated Cancer Therapeutics
    Parkinson, E. I.; Hergenrother, P. J.
    Acc. Chem. Res. 201548, 2715-2733.

  1. Salicylketoximes that Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells
    Granchi, C.; Qian, Y.; Lee, H. Y.; Paterni, I.; Pasero, C.; Iegre, J.; Carlson, K. E.; Tuccinardi, T.; Chen, X.; Katzenellenbogen, J. A.; Hergenrother, P. J.; Minutolo, F.
    ChemMedChem 201510, 1892-1900.

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  1. Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria
    Parkinson, E. I.; Bair, J. S.; Nakamura, B.; Lee, H. Y.; Kuttab, H. I.; Southgate, E. H.; Lezmi, S.; Lau, G. W.; Hergenrother, P. J.  
    Nat. Commun. 20156, 6947

  1. Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics
    Roth, H. S.; Botham, R. C.; Schmid, S. C.; Fan, T. M.; Dirikolu, L.; Hergenrother, P. J.  
    J. Med. Chem. 201558, 4046-4065.

  1. Synthesis and Biological Evaluation of Non-Glucose Glycoconjugated N-Hydroyxindole Class LDH Inhibitors as Anticancer Agents
    DiBussolo, V.; Calvaresi, E. C.; Granchi, C.; DelBino, L.; Frau, I.; Lang, M.; Tuccinardi, T.; Macchia, M.; Matinelli, A.; Hergenrother, P. J.; Minutolo, F.  
    RSC Adv. 20155, 19944-19954.

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  1. Synthesis of Dimeric ADP-Ribose and Its Structure with Human Poly(ADP-Ribose) Glycohydrolase
    Lambrecht, M. J.; Brichacek, M.; Barkauskaite, E.; Ariza, A.; Ahel, I.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2015137, 3558-3564.

  1. Synthesis of Bridged Oxafenestranes from Pleuromutilin
    Hicklin, R. W.; López Silva, T. L.; Hergenrother, P. J.  
    Angew. Chem. Int. Ed. 201453, 9880-9883.

  1. Detection of Protein-Small Molecule Binding Using a Self-Referencing External Cavity Laser Biosensor
    Zhang, M.; Peh, J.; Hergenrother, P. J.; Cunningham, B. T.  
    J. Am. Chem. Soc. 2014136, 5840-5843.

  1. Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor
    Wong, C.-H.; Nguyen, L.; Peh, J.; Luu, L. M.; Sanchez, J. S.; Richardson, S. L.; Tuccinardi, T.; Tsoi, H.; Chan, W. Y.; Chan, H. Y. E.; Baranger, A. M.; Hergenrother, P. J.; Zimmerman, S. C.
    J. Am. Chem. Soc. 2014136, 6355-6361.

  1. Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity.
    Botham, R. C.; Fan, T. M.; Im, I.; Borst, L. B.; Dirikolu, L.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2014136, 1312-1319.

  1. Light Activation of Staphylococcus aureus Toxin YoeBSa1 Reveals Guanosine-Specific Endoribonuclease Activity
    Larson, A. S.; Hergenrother, P. J.  
    Biochemistry 201453, 188-201.

  1. Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid
    Rafferty, R. J.; Hicklin, R. W.; Maloof, K. A.; Hergenrother, P. J.  
    Angew. Chem. Int. Ed. 201453, 220-224.

  1. Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines
    Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. 
    J. Org. Chem. 201479, 473-486.

  1. Natural Products as Starting Points for the Synthesis of Complex and Diverse Compounds
    Morrison, K. C.; Hergenrother, P. J.  
    Nat. Prod. Rep. 201431, 6-14.

  1. Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor
    Calvaresi, E. C.; Granchi, C.; Tuccinardi, T.; DiBussolo, V.; Huigens, R. W.; Lee, H.-Y.; Palchaudhuri, R.; Macchia, M.; Martinelli, A.; Minutolo, F.; Hergenrother, P. J.
    ChemBioChem 201314, 2263-2267.

  1. Synthesis and Anticancer Activity of All Known (–)-Agelastatin Alkaloids 
    Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.  
    J. Org. Chem. 201378, 11970-11984.

  1. Detection of Endogenous MazF Enzymatic Activity in Staphylococcus aureus
    van Rensburg, J. J.; Hergenrother, P. J.
    Anal. Biochem. 2013443, 81-87.

  1. Synthesis of (+/-)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis
    Granger, B. A.; Jewett, I. T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E. I.; Hergenrother, P. J.; Martin, S. F.
    J. Am. Chem. Soc. 2013135,12984-12986.

  1. Efficient NQO1 Substrates are Potent and Selective Anticancer Agents
    Parkinson, E. I.; Bair, J. S.; Cismesia, M.; Hergenrother, P. J. 
    ACS Chem. Biol. 20138, 2173-2183.

  1. Assessing the Differential Action on Cancer Cells of LDH-A Inhibitors based on the N-Hydroxyindole-2-Carboxylate (NHI) and Malonic (Mal) Scaffolds
    Granchi, C.; Calvaresi, E. C.; Tuccinardi, T.; Paterni, I.; Macchia, M.; Martinelli, A.; Hergenrother, P. J.; Minutolo, F. 
    Org. Biomol. Chem. 201311, 6588-6596.

  1. Glucose conjugation for the specific targeting and treatment of cancer
    Calvaresi, E. C.; Hergenrother, P. J.  
    Chem. Sci. 20134, 2319-2333.

  1. External Cavity Laser Biosensor
    Ge, C.; Lu, M.; George, S.; Flood, T. A.; Wagner, C.; Zheng, J.; Pokhriyal, A.; Eden, J. G.; Hergenrother, P. J.; Cunningham, B. T.  
    Lab Chip 201313, 1247-1256.

  1. Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids
    Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M. 
    Chem. Sci. 20134, 1646-1657.

  1. A Ring Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products
    Huigens, R. W.; Morrison, K. C.; Hicklin, R. W.; Flood, T. A.; Richter, M. F.; Hergenrother, P. J.
    Nature Chem. 20135, 195-202.

  1. Structure and Mechanism of a Canonical Poly(ADP-Ribose) Glycohydrolase
    Dunstan, M. S.; Barkauskaite, E.; Lafite, P.; Knezevic, C. E.; Brassington, A.; Ahel, M.; Hergenrother, P. J.; Leys, D.; Ahel, I.  
    Nat. Commun. 20123, 878.

  1. An NQO1 Substrate with Potent Anti-Tumor Activity that Selectively Kills by PARP-1-Induced Programmed Necrosis
    Huang, X.; Dong, Y.; Bey, E. A.; Kilgore, J. A.; Bair, J. S.; Li, L.-S.; Patel, M.; Parkinson, E. I.; Wang, Y.; Williams, N. S.; Gao, J.; Hergenrother, P. J.; Boothman, D. A. 
    Cancer Res. 201272, 3038-3047.

  1. Differential effects of procaspase-3 activating compounds in the induction of cancer cell death
    West, D. C.; Qin, Y.; Peterson, Q. P.; Thomas, D. L.; Palchaudhuri, R. P.; Morrison, K. C.; Lucas, P. W.; Palmer, A. E.; Fan, T. M; Hergenrother, P. J.
    Mol. Pharmaceutics 20129, 1425-1434.

  1. Artificial Activation of Toxin-Antitoxin Systems as an Antibacterial Strategy
    Williams, J. J.; Hergenrother, P. J.
    Trends Microbiol. 201220, 291-298.

  1. Identification of a Novel Protein Synthesis Inhibitor Active Against Gram-Positive Bacteria
    Eibergen, N. R.; Im, I.; Patel, N. Y.; Hergenrother, P. J.  
    ChemBioChem 201213, 574-583. 

  1. Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)
    Finch, K. E.; Knezevic, C. E.; Nottbohm, A. C.; Partlow, K. C.; Hergenrother, P. J.
    ACS Chem. Biol. 20127, 563-570. 

  1. Whole Cell Microtubule Analysis by Flow Cytometry
    Morrison, K.C.; Hergenrother, P. J.  
    Anal. Biochem. 2012420, 26-32. 

  1. Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)
    Hsu, D. C.; Roth, H. S.; West, D. C.; Botham, R. C.; Novotny, C. J.; Schmid, S. C.; Hergenrother, P. J. 
    ACS Comb. Sci. 201214, 44-50. 

  1. Runaway ROS as a Selective Anticancer Strategy
    Parkinson, E. I.; Hergenrother, P. J.  
    ChemMedChem 20116, 1957-1959. 

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  1. Toxin-Antitoxin (TA) Systems are Prevalent and Transcribed in Clinical Isolates of Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus
    Williams, J. J.; Halvorsen, E. M.; Dwyer, E. M.; DiFazio, R. M.; Hergenrother, P. J.  
    FEMS Microbiol. Lett. 2011322, 41-50. 

  1. Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins
    Risberg, K.; Guldvik, I. J.; Palchaudhuri, R.; Xi, Y.; Ju, J.; Fodstad, O.; Hergenrother, P. J.; Andersson, Y. 
    J. Immunother. 201134, 438-447. 

  1. Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents Against Cancer Cells
    Granchi, C.; Roy, S.; Giacomelli, C.; Macchia, M.; Tuccinardi, T.; Martinelli, A.; Lanza, M.; Betti, L.; Giannaccini, G.; Lucacchini, A.; Funel, N.; Leon, L. G.; Giovannetti, E.; Peters, G. J.; Palchaudhuri, R.; Calvaresi, E. C.; Hergenrother, P. J.; Minutolo, F.
    J. Med. Chem. 201154, 1599-1612. 

  1. Txe, an Endoribonuclease of the Enterococcal Axe-Txe Toxin-Antitoxin System, cleaves mRNA and inhibits protein synthesis
    Halvorsen, E. M.; Williams, J. J.; Bhimani, A. J.; Billings, E. A.; Hergenrother, P. J. 
    Microbiology 2011157, 387-397.

  1. Transcript Profiling and RNA Interference as Tools to Identify Small Molecule Mechanisms and Therapeutic Potential
    Palchaudhuri, R.; Hergenrother, P. J.  
    ACS Chem. Biol. 20116, 21-33. 

  1. Cribostatin 6 Induces Death in Cancer Cells Through a Reactive Oxygen Species (ROS)-Mediated Mechanism
    Hoyt, M.T.; Palchaudhuri, R.; Hergenrother, P. J.
    Invest. New Drugs 201129, 562-573. 

  1. High-Throughput Screening for Modulators of Protein-Protein Interactions: Use of Photonic Crystal Biosensors and Complementary Technologies
    Heeres, J. T.; Hergenrother, P. J. 
    Chem. Soc. Rev. 201140, 4398-4410. 

  1. Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for PAC-1, a Preferential Small Molecule Activator of Procaspase-3, in Healthy Dogs
    Lucas, P. W.; Schmit, J. M.; Peterson, Q. P.; West, D. C.; Hsu, D. C.; Novotny, C. J.; Dirikoul, L.; Deorge, D. R.; Garrett, L. D.; Hergenrother, P. J.; Fan, T. M. 
    Invest. New Drugs 201129, 901-911. 

  1. A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth that Enhances Proteasome-dependent Degradation of Estrogen Receptor α
    Cherian, M. T.; Mao, C.; Aninye, I. O.; Reynolds, P. D.; Schiff, R.; Hergenrother, P. J.; Nordeen, S. K.; Wilson, E. M.; Shapiro, D. J. 
    J. Biol. Chem. 2010285, 41863-41873. 

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  1. Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound
    Peterson, Q. P.; Hsu, D. C.; Novotny, C. J.; West, D. C.; Kim, D.; Schmit, J. M.; Dirikolu, L.; Hergenrother, P. J.; Fan, T. M.  
    Cancer Res. 201070, 7232-7241.

  1. Identification of Novel Synthetic Toll-Like Receptor 2 Agonists by High-Throughput Screening
    Guan, Y.; Omueti-Ayoade, K.; Mutha, S. K.; Hergenrother, P. J.; Tapping, R. I. 
    J. Biol. Chem. 2010285, 23755-23763.

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  1. Phenylcinnamides as Novel Antimitotic Agents
    Leslie, B. J.; Holaday, C. R.; Nguyen, T.; Hergenrother, P. J.  
    J. Med. Chem. 201053, 3964-3972. 

  1. N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines
    Stefely, J. A.; Palchaudhuri, R.; Miller, P. A.; Peterson, R. J.; Moraski, G. C.; Hergenrother, P. J.; Miller, M. J. 
    J. Med. Chem. 201053, 3389-3395.

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  1. Chemistry and Biology of Deoxynyboquinone, a Potent Inducer of Cancer Cell Death
    Bair, J. S.; Palchaudhuri, R.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2010132, 5469-5478.

  1. Preparation of the Caspase-3/7 Substrate Ac-DEVD-pNA by Solution-Phase Peptide Synthesis
    Peterson, Q. P.; Goode, D. R.; West, D. C.; Botham, R. C.; Hergenrother, P. J. 
    Nature Protocols 20105, 294-302.

  1. Identifying Modulators of Protein-Protein Interactions Using Photonic Crystal Biosensors
    Heeres, J. T.; Kim, S.-H.; Leslie, B. J.; Lidstone, E. A.; Cunningham, B. T.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2009131, 18202-18203.

  1. A Method for Identifying Small Molecule Aggregators Using Photonic Crystal Biosensor Microplates 
    Chan, L. L; Lidstone, E. A.; Finch, K. E.; Heeres, J. T.; Hergenrother, P. J.; Cunningham, B. T. 
    J. Lab. Autom. 200914, 348-359.

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  1. Procaspase-3 Activation as an Anti-Cancer Strategy: Structure-Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3
    Peterson, Q. P.; Hsu, D. C.; Goode, D. R.; Novotny, C. J.; Totten, R. K.;  Hergenrother, P. J. 
    J. Med. Chem. 200952, 5721-5731.

  1. Small Molecule Ligands for Bulged RNA Secondary Structures 
    Meyer, S. T.; Hergenrother, P. J.
    Org. Lett. 200911, 4052-4055.

  1. PAC-1 Activates Procaspase-3 in vitro Through Relief of Zinc-Mediated Inhibition 
    Peterson, Q. P.; Goode, D. R.; West, D. C.; Ramsey, K. N.; Lee, J. J.; Hergenrother, P. J. 
    J. Mol. Biol. 2009388, 144-158.

  1. Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Having Also Selective and Powerful Anticancer Activity 
    Rosenthal, A. S.; Chen, X.; Liu, J.; West, D. C.; Hergenrother, P. J.; Shapiro, T. A; Posner, G. H. 
    J. Med. Chem. 200952, 1198-1203.

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  1. The Total Synthesis and Cytoprotective Properties of Dykellic Acid 
    Thompson, C. M.; Quinn, C. A.;  Hergenrother, P. J. 
    J. Med. Chem. 200952, 117-125.

  1. Phosphate Mimics: Cyclic Compounds
    Nottbohm, A. C.; Hergenrother, P. J. 
    Wiley Encyclopedia of Chemical Biology 2008, 1-15.

  1. Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells 
    Palchaudhuri, R.; Hergenrother, P. J. 
    Bioorg. Med. Chem. Lett. 200818, 5888-5891.

  1. Exposing Plasmids as the Achilles’ Heel of Drug-Resistant Bacteria
    Williams, J. J.; Hergenrother, P. J. 
    Curr. Opin. Chem. Biol. 200812, 389-399.

  1. The Complex Role of the Triphenylmethyl Motif in Anticancer Compounds 
    Palchaudhuri, R.; Nesterenko, V.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2008130, 10274-10274.

  1. A General Method for Discovering Inhibitors of Protein-DNA Interactions Using Photonic Crystal Biosensors 
    Chan, L. C.; Pineda, M.; Heeres, J. T.; Hergenrother, P. J.; Cunningham, B. T. 
    ACS Chem. Biol. 20083, 437-448.

  1. Identification of the Cellular Targets of Bioactive Small Organic Molecules Using Affinity Reagents 
    Leslie, B. J.; Hergenrother, P. J. 
    Chem. Soc. Rev. 200837, 1347-1360.

  1. Identification of Promiscuous Small Molecule Activators in High-Throughput Enzyme Activation Screens 
    Goode, D. R.; Totten, R. K.; Heeres, J. T.; Hergenrother, P. J. 
    J. Med. Chem. 200851, 2346-2349.

  1. A Small Molecule, Identified as an Inhibitor of the Binding of Estrogen Receptor a to Estrogen Response Elements Blocks the Estrogen-dependent Growth of Cancer Cells
    Mao, C.; Patterson, N.; Cherian, M.; Aninye, I.; Zhang, C.; Patterson, N.; Cheng, J.; Putt, K. S.; Hergenrother, P. J.; Wilson, E.; Nordeen, S. K.; Shapiro, D. J.
    J. Biol. Chem. 2008283, 12819-12830.

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  1. Targeting RNA with Small Molecules 
    Thomas, J. R.; Hergenrother, P. J. 
    Chem. Rev. 2008108, 1171-1224.

  1. Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung
    Musk, D. J.; Hergenrother, P. J.
    J. Appl. Microbiol. 2008105, 380-388.

  1. DNA as a Target for Anti-Cancer Compounds: Methods to Determine the Mode of Binding and the Mechanism of Action 
    Palchaudhuri, R.; Hergenrother, P. J. 
    Curr. Opin. Biotechnol. 200718, 497-503.

  1. Poly(ADP-Ribose) Makes a Date with Death 
    Heeres, J. T.; Hergenrother, P. J. 
    Curr. Opin. Chem. Biol. 200711, 644-653.

  1. A Continuous Fluorometric Assay for the Assessment of MazF Ribonuclease Activity 
    Wang, N. R.; Hergenrother, P. J. 
    Anal. Biochem. 2007371, 173-183.

  1. Increased Poly(ADP-ribose) Polymerase Activity During Porcine Hemorrhagic Shock is Transient and Predictive of Mortality 
    Skarda, D. E.; Putt, K. S.; Hergenrother, P. J.; Mulier, K. E.; Beilman, G. J. 
    Resuscitation 200775, 135-144.

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  1. Multiplex Targeting, Tracking and Imaging of Apoptosis by Fluorescent Surface Enhanced Raman Spectroscopic Dots 
    Yu, K. N.; Lee, S.-M.; Han, J. Y.; Park, H.; Woo, M.-A.; Noh, M. S.; Hwang, S.-K.; Kwon, J.-T.; Jin, H.; Kim, Y.-K.; Hergenrother, P. J.; Jeong, D. H.; Lee, Y.-S.; Cho, M.-H. 
    Bioconjugate Chem. 200718, 1155-1162.

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  1. A Novel Colorimetric Substrate for Poly(ADP-Ribose) Polymerase-1 (PARP-1), VPARP, and Tankyrase-1
    Nottbohm, A. C.; Dothager, R. S.; Putt, K. S.; Hoyt, M. T.; Hergenrother, P. J.  
    Angew. Chem. Int. Ed. 200746, 2066-2069.

  1. The Promises and Pitfalls of Small-Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)
    Nottbohm, A. C.; Hergenrother, P. J. 
    Drug Discovery Research: New Frontiers in the Post-Genomic Era 2007, 163-185.

  1. A Novel Synthetic Analogue of a Constituent of Isodon excisus Inhibits Transcription of CYP1A1, -1A2, and -1B1 by Preventing Activation of the Aryl Hydrocarbon Receptor
    Sienkiewicz, P.; Ciolino, H.; Leslie, B. J.; Hergenrother, P. J.; Singletary, K.; Yeh, G. C.
    Carcinogenesis 200728, 1052-1057.

  1. Toxin-Antitoxin System are Ubiquitous and Plasmid-Encoded in Vancomycin Resistant Enterococci (VRE) 
    Moritz, E. M.; Hergenrother, P. J. 
    Proc. Natl. Acad. Sci. 2007104, 311-316.

  1. The Prevalence of Plasmids and Other Mobile Genetic Elements in Clinically Important Drug-Resistant Bacteria 
    Moritz, E. M.; Hergenrother, P. J. 
    Antimicrobial Resistance in Bacteria 2007, 25-53.

  1. Small-Molecule Activation of Procaspase-3 to Caspase-3 as a Personalized Anticancer Strategy
    Putt, K. S.; Chen, G. W.; Pearson, J. M.; Sandhorst, J. S.; Hoagland, M. S.; Kwon, J.-T.; Hwang, S.-K.; Jin, H.; Churchwell, M. I.; Cho, M.-H.; Doerge, D. R.; Helferich, W. G.; Hergenrother, P. J.  
    Nat. Chem. Biol. 20062, 543-50.

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BBC News Highlight – #1 Most emailed story on website worldwide on Monday, August 28, 3:20 pm
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Nature Chemical Biology News Highlight
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  1. The Compound 13-D Selectively Induces Apoptosis in White Blood Cancers Versus Other Cancer Cell Types
    Putt, K. S.; Nesterenko, V.; Dothager, R. S.; Hergenrother, P. J.  
    ChemBioChem 20067, 1916-1922.

  1. Biochemical and Thermodynamic Characterization of Compounds that Bind to RNA Hairpin Loops: Toward an Understanding of Selectivity 
    Thomas, J. R.; Liu, X.; Hergenrother, P. J. 
    Biochemistry 200645, 10928-10938. 

  1. Chemical Countermeasures for the Control of Bacterial Biofilms: Effective Compounds and Promising Targets 
    Musk, D. J.; Hergenrother, P. J. 
    Curr. Med. Chem. 200613, 2163-2177 (review).

  1. Obtaining and screening compound collections: A user’s guide and a call to chemists
    Hergenrother, P. J.  
    Curr. Opin. Chem. Biol. 200610, 213-218.

  1. Tools for Molecular Diversification and Their Applications to Chemical Biology
    Silverman, S. K.; Hergenrother, P. J. 
    Curr. Opin. Chem. Biol. 200610, 185-187.

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  1. DNA Binders and Related Subjects. Topics in Current Chemistry 253 (Book Review) 
    Hergenrother, P. J. 
    J. Am. Chem. Soc. 2006128, 3469-3470.

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  1. Size-Specific Ligands for RNA Hairpin Loops
    Thomas, J. R.; Liu, X.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2005127, 12434-12435. 

  1. Using Peptidic Inhibitors to Systematically Probe the S1′ Site of Caspase-3 and Caspase-7
    Goode, D. R.; Sharma, A. K.; Hergenrother, P. J. 
    Org. Lett. 20057, 3529-3532.

  1. Iron Salts Perturb Biofilm Formation and Disrupt Existing Biofilms of Pseudomonas aeruginosa
    Musk, D. J.; Banko, D. A.; Hergenrother, P. J.
    Chem. Biol. 200512, 789-796.

  1. Synthesis and Identification of Small Molecules that Potently Induce Apoptosis in Melanoma Cell Through G1 Cell Cycle Arrest
    Dothager, R. S.; Putt, K. S.; Allen, B. J.; Leslie, B. J.; Nesterenko, V.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2005127, 8686-8696. 

  1. The Relationship Between Aminoglycosides’ RNA Binding Proclivity and Their Antiplasmid Effect on an IncB Plasmid
    Thomas, J. R.; DeNap, J. C. B.; Wong, M.; Hergenrother, P. J. 
    Biochemistry 200544, 6800-6808. 

  1. Structure-based Design and In-Silico Virtual Screening of Combinatorial Libraries. A Combined Chemical/Computational Laboratory Assignment 
    Baudry, J.; Hergenrother, P. J. 
    J. Chem. Educ. 200582, 890-894.

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  1. Bacterial Death comes Full Circle: Targeting Plasmid Replication in Drug-Resistant Bacteria 
    DeNap, J. C. B.; Hergenrother, P. J. 
    Org. Biomol. Chem. 20053, 959-966.

  1. Direct Quantitation of Poly(ADP-Ribose) Polymerase (PARP) Activity as a Method to Distinguish Necrotic and Apoptotic Death in Cell and Tissue Samples
    Putt, K. S.; Beilman, G. J.; Hergenrother, P. J.
    ChemBioChem 20056, 53-55. 

  1. Combating Drug-Resistant Bacteria: Small Molecule Mimics of Plasmid Incompatibility as Antiplasmid Compounds
    DeNap, J. B.; Thomas, J. R.; Musk, D. J.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2004126, 15402-15404. 

  1. Deoxystreptamine Dimers bind to RNA Hairpin Loops
    Liu, X.; Thomas, J. R.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2004126, 9196-9197.

  1. Medicinal Chemistry – An Introduction 
    Hergenrother, P. J. 
    Synthesis 200413, 2248.

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  1. A non-radiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation
    Putt, K. S.; Hergenrother, P. J. 
    Anal. Biochem. 2004333, 256-264.

  1. An Enzymatic Assay for Poly(ADP-Ribose) Polymerase (PARP-1) via the Chemical Quantitation of NAD+: Application to the High-Throughput Screening of Small Molecules as Potential Inhibitors
    Putt, K. S.; Hergenrother, P. J. 
    Anal. Biochem. 2004326, 78-86. 

  1. Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells
    Nesterenko, V.; Putt, K. S.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2003125, 14672-14673. 

  1. Efficient Synthesis of Enantiopure β-Amino-γ-Keto Acids from ʟ-Homoserine
    Sharma, A. K.; Hergenrother, P. J. 
    Org. Lett. 20035, 2107-2109.

  1. The Use of pH to Influence Regio- and Chemoselectivity in the Asymmetric Aminohydroxylation of Styrenes 
    Nesterenko, V.; Byers, J. T.; Hergenrother, P. J. 
    Org. Lett. 20035, 281-284.


  1. Dissecting Glucose Signaling with Diversity-Oriented Synthesis and Small Molecule Microarrays 
    Kuruvilla, F. G.; Shamji, A. F.; Sternson, S. M.; Hergenrother, P. J.; Schreiber, S. L. 
    Nature 2002416, 653-657.

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  1. Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol Containing Small Molecules on Glass Slides
    Hergenrother, P. J.; Depew, K. M.; Schreiber, S. L.  
    J. Am. Chem. Soc. 2000122, 7849-7850.

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  1. Total Synthesis of Erythromycin B 
    Breton, P.; Hergenrother, P. J.; Hida, T.; Hodgson, A.; Judd, A. S.; Kraynack, E.; Kym, P. R.; Lee, W.-C.; Loft, M. S.; Yamashita, M.; Martin, S. F. 
    Tetrahedron 200763, 5709-5729.

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  1. An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B
    Hergenrother, P. J.; Hodgson, A.; Judd, A. S.; Lee, W.-C.; Martin, S. F.  
    Angew. Chem. Int. Ed. 200342, 3278-3281.

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  1. Altering Substrate Specificity of Phosphatidylcholine-Preferring Phospholipase C of Bacillus cereus by Random Mutagenesis of the Headgroup Binding Site 
    Antikainen, N. M.; Hergenrother, P. J.; Harris, M. M.; Corbett, B.; Martin, S. F.
    Biochemistry 200342, 1603-1610.

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  1. Characterization of Erythromycin Analogs by Collisional Activated Dissociation and Infrared Multiphoton Dissociation in a Quadrupole Ion Trap 
    Crowe, M. C.; Brodbelt, J. S.; Goolsby, B. J.; Hergenrother, P. J. 
    J. Am. Soc. Mass. Spectrom. 200213, 630-649.

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  1. Phosphatidylcholine-Preferring Phospholipase C from B. cereus. Function, Structure, and Mechanism.
    Hergenrother, P. J.; Martin, S. F.  
    Top. Curr. Chem. 2000211, 131-167.

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  1. A Novel Class of Zinc Binding Inhibitors for the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus
    Martin, S. F.; Follows, B. C.; Hergenrother, P. J.; Franklin, C. L.  
    J. Org. Chem. 200065, 4509-4514.

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  1. The Choline Binding site of Phospholipase C (Bacillus cereus): Insights into Substrate Specificity 
    Martin, S. F.; Follows, B. C.; Hergenrother, P. J.; Trotter, B. K. 
    Biochemistry 200039, 3410-3415.

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  1. Determination of the Substrate Specificity of the Phospholipase D from Streptomyces chromofuscus via an Inorganic Phosphate Quantitation Assay 
    Martin, S. F.; DeBlanc, R. L.; Hergenrother, P. J. 
    Anal. Biochem. 2000278, 106-110.

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  1. Catalytic Cycle of the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus. Solvent Viscosity, Deuterium Isotope Effects, and Proton Inventory Studies
    Martin, S. F., Hergenrother, P. J. 
    Biochemistry 199938, 4403-4408.

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  1. General Base Catalysis by the Phosphatidylchloine-Preferring Phospholipase C from Bacillus cereus: the Role of Glu4 and Asp55
    Martin, S. F.; Hergenrother, P. J. 
    Biochemistry 199837, 5755-5760.

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  1. Enzymatic Synthesis of a Modified Phospholipid and its Evaluation as a Substrate for B. cereus Phospholipase C 
    Martin, S. F.; Hergenrother, P. J. 
    Bioorg. Med. Chem. Lett. 19988, 593-596.

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  1. Determination of the Kinetic Parameters for Phospholipase C (Bacillus cereus) on Different Phospholipid Substrates Using a Chromogenic Assay Based on the Quantitation of Inorganic Phosphate
    Hergenrother, P. J.; Martin, S. F. 
    Anal. Biochem. 1997251, 45-49.

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  1. Chromogenic Assay for Phospholipase D from Streptomyces chromofuscus: Application to the Evaluation of Substrate Analogues
    Hergenrother, P. J.; Martin, S. F.; Haas, M. K.  
    Lipids 199732, 783-788.

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  1. Expression and Site-Directed Mutagenesis of the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus: Probing the Role of Active Site Glu146
    Martin, S. F.; Spaller, M. R.; Hergenrother, P. J. 
    Biochemistry 199635, 12970-12977.

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  1. Chromogenic Assay for Phospholipase C from Bacillus cereus 
    Hergenrother, P. J.; Spaller, M. R.; Haas, M. K.; Martin, S. F. 
    Anal. Biochem. 1995229, 313-316.

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