Publications

  1.  Rationalizing generation of broad spectrum antibiotics with the addition of a positive charge
    Haloi, N.; Vasan, A.K.; Geddes, E.; Prasanna, A.; Wen, P.-C.; Metcalf, W.W.; Hergenrother, P.J.; Tajkhorshid, E.
    Chem. Sci. 2021, in press published on web October 14, 2021

  1. A LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli
    Geddes, E.J; Li, Z.; Hergenrother, P.J.
    Nature Protocols 202116, 4833-4854

  1. A small molecule activator of the unfolded protein response eradicates human breast tumors in mice
    Boudreau, MW; Duraki, D; Wang, L.; Mao, C.; Kim, J.E.; Tang, B.; Fanning, S.W.; Kiefer, J.; Tarasow, T.M.; Bruckheimer, E.M.; Moreno, R.; Mousses, S.; Greene, G.L.; Roy, E.J.; Park, B.H.; Fan, T.M.; Nelson, E.R.; Hergenrother, P.J.; Shapiro, D.J.
    Science Transl. Med. 2021, 13, eabf1383

  1. Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
    Tonnus, W; Meyer, C; Steinebach, C; Belavgeni, A; von Mässenhausen, A; Zamora Gonzalez, N; Maremonti, F; Gembardt, F; Himmerkus, N; Latk, M; Locke, S; Marschner, J; Li, W; Short, S; Doll, S; Ingold, I; Proneth, B; Daniel, C; Kabgani, N; Kramann, R; Hergenrother, PJ; Bornstein, S; Hugo, C; Becker, J; Amann, K; Anders, H-J; Kreisel, D; Pratt, D; Gütschow, M; Conrad, M; Motika, S; Linkermann A.
    Nature Comm. 2021, 12, 4402

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  1. Evaluation of a procaspase-3 activator with hydroxyureas or temozolomide against high-grade meningioma in cell culture and canine cancer patients
    Tonogai, E.; Huang, S.; Botham, R.; Berry, M.; Joslyn, S.; Daniel, G.; Chen, Z.; Rao, J.; Zhang, X.; Basuli, F.; Rossmisl, J.; Riggins, G.; LeBlanc, A.; Fan, T.; Hergenrother, P.J.
    Neuro-Oncology 2021, 23, 1723-1735

  1. Utilizing feline oral squamous cell carcinoma patients to develop a targeted therapy with potential for human head-and-neck cancer
    Lundberg, A.P.; Boudreau, M.W.; Selting, K.A.; Chatkewitz, L.E.; Samuelson, J.; Francis, J.M.; Parkinson, E.I.; Barger, A.M.; Hergenrother, P.J.; Fan, T.F.
    Neoplasia 20218, 811-822.

  1. Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity
    Furiassi, L; Tonogai, E.J.; Hergenrother, P.J.
    Angew. Chem. Int. Ed. 202160, 16119-16128

  1. Facilitating compound entry as a means to discover antibiotics for Gram-negative bacteria
    Munoz, K.A. and Hergenrother, P.J.
    Acc. Chem. Res. 202154, 1322-1333

  1. A phosphonate natural product made by Pantoea ananatis is necessary and sufficient for the hallmark lesion of onion center rot
    Polidore, A.L.A.; Furiassi, L.; Hergenrother, P.J.; Metcalf, W.M. 
    mBio202112, e3402-3420.

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  1. Synthesis of fusidic acid derivatives yields a potent antibiotic with an improved resistance profile
    Garcia Chavez, M.; Garcia, A.; Lee, H.Y.; Lau, G.W.; Parker, E.N.; Komnick, K.E.; Hergenrother, P.J.
    ACS Infect. Dis. 20217, 493-505

  1. Synthetic studies on selective, proapoptotic isomalabaricane triterpenoids aided by computational techniques
    Boyko, Y.D.; Huck, C.J.; Ning, S.; Shved, A.S.; Yang, C.; Chu, F.; Tonogai, E.J.; Hergenrother, P.J.; Sarlah, D.
    J. Am. Chem. Soc. 2021, 143, 2138-2155

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  1. Compound uptake into E. coli can be facilitated by N-alkyl guanidiniums and pyridinium
    Perlmutter, S.J.; Geddes, E.J.; Drown, B.S.; Motika, S.E.; Lee, M.R.; Hergenrother, P.J.  
    ACS Infect. Dis., 20217, 162-173

  1. Re-engineering natural products to engage new biological targets
    Motika, S. E. and Hergenrother, P. J.
    Nat. Prod. Rep. 2020, 37, 1395-1403.

  1. Saliva-based molecular testing for SARS-CoV-2 that bypasses RNA extraction
    Ranoa, D.R.E.; Holland, R.L.; Alnaji, F.G.; Green, K.J.; Wang, L.; Brooke, C.B.; Burke, M.D.; Fan, T.M.; Hergenrother, P. J.
    BioRxiv. June 18, 2020, doi.org/10.1101/2020.06.18.159434

  1. A gram-negative antibiotic active through inhibition of an essential riboswitch
    Motika, S. E.; Ulrich, R. J.; Geddes, E. J.; Lee, H. Y.; Lau, G. W.; Hergenrother, P. J.
    J. Am. Chem. Soc. 2020142, 10856-10862

  1.  Imidazotetrazines as weighable diazomethane surrogates for esterifications and cyclopropanations
    Svec, R.L. and Hergenrother, P.J. 
    Angew. Chem. Int. Ed. 2020, 59, 1857-1862

  1. Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens
    Parker, E. N.; Drown, B. S.; Geddes, E. J.; Lee, H.-Y.; Ismail, N.; Lau, G. W. and Hergenrother, P. J.
    Nature Microbiology 2020, 5, 67-75

  1. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
    Janin M.; Ortiz-Barahona V.; Boudreau M.W.; Hergenrother P.J.; Esteller M. and others
    Acta Neuropathol. 2019, 138, 1053-1074

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  1. Procaspase-3 overexpression in cancer: A paradoxical observation with therapeutic potential
    Boudreau, M. W.; Peh, J.; Hergenrother, P. J.
    ACS Chem. Biol201914, 2335-2348

  1. Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis
    Llabani, E.; Hicklin, R. W.; Lee, H.-Y.; Motika, S. E.; Crawford, L. A.; Weerapana, E., Hergenrother, P. J.
    Nature Chem. 201911, 521

  1. Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins
    Thirawatananond, P.; McPherson, R. L.; Malhi, J.; Nathan, S.; Lambrecht, M.J.; Brichacek, M.; Hergenrother, P.J.; Leung, A.K.L.; Gabelli, S.B.
    Sci. Reports20199, 5940

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  1. Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers
    Schlein, L. J.; Fadl-Alla, B.; Pondenis, H. C.; Lezmi, S.; Eberhart, C. G.; LeBlanc, A. K.; Dickinson, P. J.; Hergenrother, P. J.; Fan, T. M.
    Front. Oncol. 20199, 96

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  1. Enantioselective synthesis of isocarbostyril alkaloids and analogs using catalytic dearomative functionalization of benzene
    Bingham, T. W.; Hernandez, L. W.; Olson, D. G.; Svec, R. L.; Hergenrother, P. J.; Sarlah, D
    J. Am. Chem. Soc. 2019141, 657-670

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  1. The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics
    Richter, M. F. and Hergenrother, P. J.
    Ann NY Acad Sci. 2019, 1435, 18-38.

  1. (ADP-ribosyl) hydrolases: Structural basis for differential substrate recognition and inhibition
    Rack, J.G.M.; Ariza, A.; Drown, B. S.; Henfrey, C.; Shirai, T.; Hergenrother, P. J.; Ahel, I.
    Cell Chem. Biol. 201825, 1533-1546

  1. Oxygen starvation unmasks a killer
    Svec, R. L. and Hergenrother, P. J.
    Cell Chem. Biol. 2018, 25, 1313-1314.

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  1. Monitoring poly(ADP-ribosyl)glycohydrolase activity with a continuous fluorescent substrate
    Drown, B. S.; Shirai, T.; Rack, J.G.M.; Ahel, I.; Hergenrother, P. J.
    Cell Chem. Biol. 201825, 1562-1570

  1. Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma
    Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. M.; Riggins, G. J.; Hergenrother, P. J.
    ACS Chem. Biol. 2018,13, 3206-3216.

  1. Preparation of structurally diverse compounds from the natural product lycorine
    Tasker, S. Z.; Cowfer, A. E.; Hergenrother P. J.
    Org. Lett. 2018, 20, 5894-5898.

  1. Overcoming resistance to targeted anticancer therapies through small-molecule mediated MEK degradation
    Peh, J.; Boudreau, M. W.; Smith, H. M.; and Hergenrother, P. J.
    Cell Chem. Biol. 201825, 996-1005.

  1. Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death
    Livezey, M.; Huang, R.;Hergenrother, P. J.; Shapiro, D.S.
    Cell Death Differ. 201825, 1796-1807.

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  1. Going on offense against the Gram-negative defense
    Drown, B.S. and Hergenrother, P. J.
    Proc Natl. Acad. Sci. 2018115, 6530-6532.

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  1. How many human proteoforms are there?
    Aebersold, R; Agar, J.N.; Amster, I.J.; Baker, M.S.; Bertozzi, C.R.; Boja, E.S.; Costello, C.E.; Cravatt, B.F.; Fenselau, C., Garcia, B.A.; Ge, Y.; Gunawardena, J.; Hendrickson, R.C.; Hergenrother, P.J.; Huber, C.G.; Ivanov, A.R.; Jensen, O.N.; Jewett, M.C.; Kelleher, N.L.; Kiessling, L.L.; Krogan, N.J.; Larsen, M.R.; Loo, J.A.; Ogorzalek Loo, R.R.; Lundberg, E.; MacCoss, M.J.; Mallick, P.; Mootha, V.K.; Mrksich, M.; Muir, T.W.; Patrie, S.M.; Pesavento, J.J.; Pitteri, S.J.; Rodriguez, H.; Saghatelian, A.; Sandoval, W.; Schlüter, H.; Sechi, S.; Slavoff, S.A.; Smith, L.M.; Snyder, M.P.; Thomas, P.M.; Uhlén, M.; Van Eyk, J.E.; Vidal, M.; Walt, D.R.; White, F.M.; Williams, E.R.; Wohlschlager, T.; Wysocki, V.H.; Yates, N.A.; Young, N.L.; Zhang, B.  
    Nature Chem. Biol. 201814, 206-214.

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  1. Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNBI expression   
    Doganay, S.; Lee, M. Y.; Baum, A.; Peh, J.; Hwang, S. Y.; Yoo, J. Y.; Hergenrother, P. J.; Garcia-Sastre, A.; Myong, S.; Ha, T.  
    Integr. Biol. 20179, 857-867.

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  1. Broad-Spectrum Antibiotics, a Call for Chemists
    Richter, M. F.; Hergenrother, P. J.
    Chem 20173, 10-13 (essay).

  1. Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
    Joshi, A. D.; Botham, R. C.; Schlein, L. J.; Roth, H. S.; Mangraviti, A.; Borodovsky, A.; Tyler, B.; Joslyn, S.; Looper, J. S.; Podell, M.; Fan, T. F.; Hergenrother, P. J.; Riggins, G. J.
    Oncotarget 2017, 8, 80124-80138.

  1. Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer
    Granchi, C.; Fortunato, S.; Meni, S.; Rizzolio, F.; Caligiuri, I.; Tuccinardi, T.; Lee, H.-Y.; Hergenrother, P. J.; Minutolo, F.
    J. Agric. Food Chem. 2017, 65, 5639-5649.

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  1. Predictive Compound Accumulation Rules Yield a Broad-Spectrum Antibiotic
    Richter, M. F.; Drown, B. S.; Riley, A. P.; Garcia, A.; Shirai, T.; Svec, R. L.; Hergenrother, P. J. 
    Nature 2017, 545, 299-304.

  1. Taming Reactive Benzynes
    Tasker, S. Z.; Hergenrother, P. J.
    Nature Chem. 2017, 9, 504-506 (News & Views).

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  1. Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death
    Lee, H.-Y.; Parkinson, E. I.; Granchi, C.; Paterni, I.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P. J.
    ACS Chem. Biol. 2017, 12, 1416-1424.

  1. Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for the Novel Anti-Cancer Agent Isobutyl-Deoxynyboquinone (IB-DNQ), a NQO1 Bioactivatable Molecule, in the Domestic Felid Species
    Lundberg, A. P.; Francis, J. M.; Pajak, M.; Parkinson, E. I.; Wycislo, K. L.; Rosol, T. J.; Brown, M. E.; London, C. A.; Dirikolu, L.; Hergenrother, P. J.; Fan. T. M.
    Invest New Drugs 201735, 134-144.

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  1. Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine
    Garcia, A.; Drown, B. S.; Hergenrother, P. J.
    Org. Lett. 2016, 18, 4852-4855.

  1. Porous Photonic Crystal External Cavity Laser Biosensor
    Huang, Q.; Peh, J.; Hergenrother, P. J.; Cunningham, B. T.
    Appl. Phys. Lett. 2016, 109, 071103.

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  1. Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics
    Botham, R. C.; Roth, H. S.; Book, A. P.; Roady, P. J.; Fan, T. M.; Hergenrother, P. J.
    ACS Central Science 2016, 2, 545-559.

  1. Targeting Multidrug-resistant Ovarian Cancer Through Estrogen Receptor α Dependent ATP Depletion Caused by Hyperactivation of the Unfolded Protein Response
    Zheng, Z.; Andruska, N. D.; Lambrecht, M. L.; Sisi, H.; Hergenrother, P. J.; Nelson, E.; Shapiro, D. J. 
    Oncotarget 2016, 9, 14741-14753.

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  1. The Combination of Vemurafenib and Procaspase-3 Activation is Synergistic in Mutant BRAF Melanomas
    Peh, J.; Fan, T. M.; Wycislo, K. L.; Roth, H. S.; Hergenrother, P. J.
    Mol. Cancer Ther. 2016, 15, 1859-1869.

  1. A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy
    Luu, L. M.; Nguyen, L.; Peng, S.; Lee, J.; Lee, H. Y.; Wong, C. H.; Hergenrother, P. J.; Chan, H. Y.; Zimmerman, S. C.
    ChemMedChem 2016, 11, 1428-1435.

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  1. Derivatives of Procaspase-Activating Compound 1 (PAC-1) and Their Anticancer Activities
    Roth, H. S.; Hergenrother, P. J.
    Curr. Med. Chem. 2016, 23, 201-241 (review).

  1. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
    Palchaudhuri, R.; Lambrecht, M. J.; Botham, R. C.; Partlow, K. C.; Van Ham, T. J.; Putt, K. S.; Nguyen, L. T.; Kim, S.-H.; Peterson, R. T.; Fan, T. M.; Hergenrother, P. J.
    Cell Reports 201513, 2027-2036.

  1. Deoxynyboquinones as NQO1-Activated Cancer Therapeutics
    Parkinson, E. I.; Hergenrother, P. J.
    Acc. Chem. Res. 201548, 2715-2733.

  1. Salicylketoximes that Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells
    Granchi, C.; Qian, Y.; Lee, H. Y.; Paterni, I.; Pasero, C.; Iegre, J.; Carlson, K. E.; Tuccinardi, T.; Chen, X.; Katzenellenbogen, J. A.; Hergenrother, P. J.; Minutolo, F.
    ChemMedChem 201510, 1892-1900.

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  1. Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria
    Parkinson, E. I.; Bair, J. S.; Nakamura, B.; Lee, H. Y.; Kuttab, H. I.; Southgate, E. H.; Lezmi, S.; Lau, G. W.; Hergenrother, P. J.  
    Nat. Commun. 20156, 6947.

  1. Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics
    Roth, H. S.; Botham, R. C.; Schmid, S. C.; Fan, T. M.; Dirikolu, L.; Hergenrother, P. J.  
    J. Med. Chem. 201558, 4046-4065.

  1. Synthesis and Biological Evaluation of Non-Glucose Glycoconjugated N-Hydroyxindole Class LDH Inhibitors as Anticancer Agents
    DiBussolo, V.; Calvaresi, E. C.; Granchi, C.; DelBino, L.; Frau, I.; Lang, M.; Tuccinardi, T.; Macchia, M.; Matinelli, A.; Hergenrother, P. J.; Minutolo, F.  
    RSC Adv. 20155, 19944-19954.

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  1. Synthesis of Dimeric ADP-Ribose and Its Structure with Human Poly(ADP-Ribose) Glycohydrolase
    Lambrecht, M. J.; Brichacek, M.; Barkauskaite, E.; Ariza, A.; Ahel, I.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2015137, 3558-3564.

  1. Synthesis of Bridged Oxafenestranes from Pleuromutilin
    Hicklin, R. W.; López Silva, T. L.; Hergenrother, P. J.  
    Angew. Chem. Int. Ed. 201453, 9880-9883.

  1. Detection of Protein-Small Molecule Binding Using a Self-Referencing External Cavity Laser Biosensor
    Zhang, M.; Peh, J.; Hergenrother, P. J.; Cunningham, B. T.  
    J. Am. Chem. Soc. 2014136, 5840-5843.

  1. Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor
    Wong, C.-H.; Nguyen, L.; Peh, J.; Luu, L. M.; Sanchez, J. S.; Richardson, S. L.; Tuccinardi, T.; Tsoi, H.; Chan, W. Y.; Chan, H. Y. E.; Baranger, A. M.; Hergenrother, P. J.; Zimmerman, S. C.
    J. Am. Chem. Soc. 2014136, 6355-6361.

  1. Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity.
    Botham, R. C.; Fan, T. M.; Im, I.; Borst, L. B.; Dirikolu, L.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2014136, 1312-1319.

  1. Light Activation of Staphylococcus aureus Toxin YoeBSa1 Reveals Guanosine-Specific Endoribonuclease Activity
    Larson, A. S.; Hergenrother, P. J.  
    Biochemistry 201453, 188-201.

  1. Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid
    Rafferty, R. J.; Hicklin, R. W.; Maloof, K. A.; Hergenrother, P. J.  
    Angew. Chem. Int. Ed. 201453, 220-224.

  1. Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines
    Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. 
    J. Org. Chem. 201479, 473-486.

  1. Natural Products as Starting Points for the Synthesis of Complex and Diverse Compounds
    Morrison, K. C.; Hergenrother, P. J.  
    Nat. Prod. Rep. 201431, 6-14.

  1. Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor
    Calvaresi, E. C.; Granchi, C.; Tuccinardi, T.; DiBussolo, V.; Huigens, R. W.; Lee, H.-Y.; Palchaudhuri, R.; Macchia, M.; Martinelli, A.; Minutolo, F.; Hergenrother, P. J.
    ChemBioChem 201314, 2263-2267.

  1. Synthesis and Anticancer Activity of All Known (–)-Agelastatin Alkaloids 
    Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.  
    J. Org. Chem. 201378, 11970-11984.

  1. Detection of Endogenous MazF Enzymatic Activity in Staphylococcus aureus
    van Rensburg, J. J.; Hergenrother, P. J.
    Anal. Biochem. 2013443, 81-87.

  1. Synthesis of (+/-)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis
    Granger, B. A.; Jewett, I. T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E. I.; Hergenrother, P. J.; Martin, S. F.
    J. Am. Chem. Soc. 2013135,12984-12986.

  1. Efficient NQO1 Substrates are Potent and Selective Anticancer Agents
    Parkinson, E. I.; Bair, J. S.; Cismesia, M.; Hergenrother, P. J. 
    ACS Chem. Biol. 20138, 2173-2183.

  1. Assessing the Differential Action on Cancer Cells of LDH-A Inhibitors based on the N-Hydroxyindole-2-Carboxylate (NHI) and Malonic (Mal) Scaffolds
    Granchi, C.; Calvaresi, E. C.; Tuccinardi, T.; Paterni, I.; Macchia, M.; Martinelli, A.; Hergenrother, P. J.; Minutolo, F. 
    Org. Biomol. Chem. 201311, 6588-6596.

  1. Glucose conjugation for the specific targeting and treatment of cancer
    Calvaresi, E. C.; Hergenrother, P. J.  
    Chem. Sci. 20134, 2319-2333.

  1. External Cavity Laser Biosensor
    Ge, C.; Lu, M.; George, S.; Flood, T. A.; Wagner, C.; Zheng, J.; Pokhriyal, A.; Eden, J. G.; Hergenrother, P. J.; Cunningham, B. T.  
    Lab Chip 201313, 1247-1256.

  1. Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids
    Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M. 
    Chem. Sci. 20134, 1646-1657.

  1. A Ring Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products
    Huigens, R. W.; Morrison, K. C.; Hicklin, R. W.; Flood, T. A.; Richter, M. F.; Hergenrother, P. J.
    Nature Chem. 20135, 195-202.

  1. Structure and Mechanism of a Canonical Poly(ADP-Ribose) Glycohydrolase
    Dunstan, M. S.; Barkauskaite, E.; Lafite, P.; Knezevic, C. E.; Brassington, A.; Ahel, M.; Hergenrother, P. J.; Leys, D.; Ahel, I.  
    Nat. Commun. 20123, 878.

  1. An NQO1 Substrate with Potent Anti-Tumor Activity that Selectively Kills by PARP-1-Induced Programmed Necrosis
    Huang, X.; Dong, Y.; Bey, E. A.; Kilgore, J. A.; Bair, J. S.; Li, L.-S.; Patel, M.; Parkinson, E. I.; Wang, Y.; Williams, N. S.; Gao, J.; Hergenrother, P. J.; Boothman, D. A. 
    Cancer Res. 201272, 3038-3047.

  1. Differential effects of procaspase-3 activating compounds in the induction of cancer cell death
    West, D. C.; Qin, Y.; Peterson, Q. P.; Thomas, D. L.; Palchaudhuri, R. P.; Morrison, K. C.; Lucas, P. W.; Palmer, A. E.; Fan, T. M; Hergenrother, P. J.
    Mol. Pharmaceutics 20129, 1425-1434.

  1. Artificial Activation of Toxin-Antitoxin Systems as an Antibacterial Strategy
    Williams, J. J.; Hergenrother, P. J.
    Trends Microbiol. 201220, 291-298.

  1. Identification of a Novel Protein Synthesis Inhibitor Active Against Gram-Positive Bacteria
    Eibergen, N. R.; Im, I.; Patel, N. Y.; Hergenrother, P. J.  
    ChemBioChem 201213, 574-583. 

  1. Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)
    Finch, K. E.; Knezevic, C. E.; Nottbohm, A. C.; Partlow, K. C.; Hergenrother, P. J.
    ACS Chem. Biol. 20127, 563-570. 

  1. Whole Cell Microtubule Analysis by Flow Cytometry
    Morrison, K.C.; Hergenrother, P. J.  
    Anal. Biochem. 2012420, 26-32. 

  1. Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)
    Hsu, D. C.; Roth, H. S.; West, D. C.; Botham, R. C.; Novotny, C. J.; Schmid, S. C.; Hergenrother, P. J. 
    ACS Comb. Sci. 201214, 44-50. 

  1. Runaway ROS as a Selective Anticancer Strategy
    Parkinson, E. I.; Hergenrother, P. J.  
    ChemMedChem 20116, 1957-1959. 

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  1. Toxin-Antitoxin (TA) Systems are Prevalent and Transcribed in Clinical Isolates of Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus
    Williams, J. J.; Halvorsen, E. M.; Dwyer, E. M.; DiFazio, R. M.; Hergenrother, P. J.  
    FEMS Microbiol. Lett. 2011322, 41-50. 

  1. Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins
    Risberg, K.; Guldvik, I. J.; Palchaudhuri, R.; Xi, Y.; Ju, J.; Fodstad, O.; Hergenrother, P. J.; Andersson, Y. 
    J. Immunother. 201134, 438-447. 

  1. Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents Against Cancer Cells
    Granchi, C.; Roy, S.; Giacomelli, C.; Macchia, M.; Tuccinardi, T.; Martinelli, A.; Lanza, M.; Betti, L.; Giannaccini, G.; Lucacchini, A.; Funel, N.; Leon, L. G.; Giovannetti, E.; Peters, G. J.; Palchaudhuri, R.; Calvaresi, E. C.; Hergenrother, P. J.; Minutolo, F.
    J. Med. Chem. 201154, 1599-1612. 

  1. Txe, an Endoribonuclease of the Enterococcal Axe-Txe Toxin-Antitoxin System, cleaves mRNA and inhibits protein synthesis
    Halvorsen, E. M.; Williams, J. J.; Bhimani, A. J.; Billings, E. A.; Hergenrother, P. J. 
    Microbiology 2011157, 387-397.

  1. Transcript Profiling and RNA Interference as Tools to Identify Small Molecule Mechanisms and Therapeutic Potential
    Palchaudhuri, R.; Hergenrother, P. J.  
    ACS Chem. Biol. 20116, 21-33. 

  1. Cribostatin 6 Induces Death in Cancer Cells Through a Reactive Oxygen Species (ROS)-Mediated Mechanism
    Hoyt, M.T.; Palchaudhuri, R.; Hergenrother, P. J.
    Invest. New Drugs 201129, 562-573. 

  1. High-Throughput Screening for Modulators of Protein-Protein Interactions: Use of Photonic Crystal Biosensors and Complementary Technologies
    Heeres, J. T.; Hergenrother, P. J. 
    Chem. Soc. Rev. 201140, 4398-4410. 

  1. Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for PAC-1, a Preferential Small Molecule Activator of Procaspase-3, in Healthy Dogs
    Lucas, P. W.; Schmit, J. M.; Peterson, Q. P.; West, D. C.; Hsu, D. C.; Novotny, C. J.; Dirikoul, L.; Deorge, D. R.; Garrett, L. D.; Hergenrother, P. J.; Fan, T. M. 
    Invest. New Drugs 201129, 901-911. 

  1. A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth that Enhances Proteasome-dependent Degradation of Estrogen Receptor α
    Cherian, M. T.; Mao, C.; Aninye, I. O.; Reynolds, P. D.; Schiff, R.; Hergenrother, P. J.; Nordeen, S. K.; Wilson, E. M.; Shapiro, D. J. 
    J. Biol. Chem. 2010285, 41863-41873. 

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  1. Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound
    Peterson, Q. P.; Hsu, D. C.; Novotny, C. J.; West, D. C.; Kim, D.; Schmit, J. M.; Dirikolu, L.; Hergenrother, P. J.; Fan, T. M.  
    Cancer Res. 201070, 7232-7241.

  1. Identification of Novel Synthetic Toll-Like Receptor 2 Agonists by High-Throughput Screening
    Guan, Y.; Omueti-Ayoade, K.; Mutha, S. K.; Hergenrother, P. J.; Tapping, R. I. 
    J. Biol. Chem. 2010285, 23755-23763.

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  1. Phenylcinnamides as Novel Antimitotic Agents
    Leslie, B. J.; Holaday, C. R.; Nguyen, T.; Hergenrother, P. J.  
    J. Med. Chem. 201053, 3964-3972. 

  1. N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines
    Stefely, J. A.; Palchaudhuri, R.; Miller, P. A.; Peterson, R. J.; Moraski, G. C.; Hergenrother, P. J.; Miller, M. J. 
    J. Med. Chem. 201053, 3389-3395.

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  1. Chemistry and Biology of Deoxynyboquinone, a Potent Inducer of Cancer Cell Death
    Bair, J. S.; Palchaudhuri, R.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2010132, 5469-5478.

  1. Preparation of the Caspase-3/7 Substrate Ac-DEVD-pNA by Solution-Phase Peptide Synthesis
    Peterson, Q. P.; Goode, D. R.; West, D. C.; Botham, R. C.; Hergenrother, P. J. 
    Nature Protocols 20105, 294-302.

  1. Identifying Modulators of Protein-Protein Interactions Using Photonic Crystal Biosensors
    Heeres, J. T.; Kim, S.-H.; Leslie, B. J.; Lidstone, E. A.; Cunningham, B. T.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2009131, 18202-18203.

  1. A Method for Identifying Small Molecule Aggregators Using Photonic Crystal Biosensor Microplates 
    Chan, L. L; Lidstone, E. A.; Finch, K. E.; Heeres, J. T.; Hergenrother, P. J.; Cunningham, B. T. 
    J. Lab. Autom. 200914, 348-359.

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  1. Procaspase-3 Activation as an Anti-Cancer Strategy: Structure-Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3
    Peterson, Q. P.; Hsu, D. C.; Goode, D. R.; Novotny, C. J.; Totten, R. K.;  Hergenrother, P. J. 
    J. Med. Chem. 200952, 5721-5731.

  1. Small Molecule Ligands for Bulged RNA Secondary Structures 
    Meyer, S. T.; Hergenrother, P. J.
    Org. Lett. 200911, 4052-4055.

  1. PAC-1 Activates Procaspase-3 in vitro Through Relief of Zinc-Mediated Inhibition 
    Peterson, Q. P.; Goode, D. R.; West, D. C.; Ramsey, K. N.; Lee, J. J.; Hergenrother, P. J. 
    J. Mol. Biol. 2009388, 144-158.

  1. Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Having Also Selective and Powerful Anticancer Activity 
    Rosenthal, A. S.; Chen, X.; Liu, J.; West, D. C.; Hergenrother, P. J.; Shapiro, T. A; Posner, G. H. 
    J. Med. Chem. 200952, 1198-1203.

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  1. The Total Synthesis and Cytoprotective Properties of Dykellic Acid 
    Thompson, C. M.; Quinn, C. A.;  Hergenrother, P. J. 
    J. Med. Chem. 200952, 117-125.

  1. Phosphate Mimics: Cyclic Compounds
    Nottbohm, A. C.; Hergenrother, P. J. 
    Wiley Encyclopedia of Chemical Biology 2008, 1-15.

  1. Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells 
    Palchaudhuri, R.; Hergenrother, P. J. 
    Bioorg. Med. Chem. Lett. 200818, 5888-5891.

  1. Exposing Plasmids as the Achilles’ Heel of Drug-Resistant Bacteria
    Williams, J. J.; Hergenrother, P. J. 
    Curr. Opin. Chem. Biol. 200812, 389-399.

  1. The Complex Role of the Triphenylmethyl Motif in Anticancer Compounds 
    Palchaudhuri, R.; Nesterenko, V.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2008130, 10274-10274.

  1. A General Method for Discovering Inhibitors of Protein-DNA Interactions Using Photonic Crystal Biosensors 
    Chan, L. C.; Pineda, M.; Heeres, J. T.; Hergenrother, P. J.; Cunningham, B. T. 
    ACS Chem. Biol. 20083, 437-448.

  1. Identification of the Cellular Targets of Bioactive Small Organic Molecules Using Affinity Reagents 
    Leslie, B. J.; Hergenrother, P. J. 
    Chem. Soc. Rev. 200837, 1347-1360.

  1. Identification of Promiscuous Small Molecule Activators in High-Throughput Enzyme Activation Screens 
    Goode, D. R.; Totten, R. K.; Heeres, J. T.; Hergenrother, P. J. 
    J. Med. Chem. 200851, 2346-2349.

  1. A Small Molecule, Identified as an Inhibitor of the Binding of Estrogen Receptor a to Estrogen Response Elements Blocks the Estrogen-dependent Growth of Cancer Cells
    Mao, C.; Patterson, N.; Cherian, M.; Aninye, I.; Zhang, C.; Patterson, N.; Cheng, J.; Putt, K. S.; Hergenrother, P. J.; Wilson, E.; Nordeen, S. K.; Shapiro, D. J.
    J. Biol. Chem. 2008283, 12819-12830.

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  1. Targeting RNA with Small Molecules 
    Thomas, J. R.; Hergenrother, P. J. 
    Chem. Rev. 2008108, 1171-1224.

  1. Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung
    Musk, D. J.; Hergenrother, P. J.
    J. Appl. Microbiol. 2008105, 380-388.

  1. DNA as a Target for Anti-Cancer Compounds: Methods to Determine the Mode of Binding and the Mechanism of Action 
    Palchaudhuri, R.; Hergenrother, P. J. 
    Curr. Opin. Biotechnol. 200718, 497-503.

  1. Poly(ADP-Ribose) Makes a Date with Death 
    Heeres, J. T.; Hergenrother, P. J. 
    Curr. Opin. Chem. Biol. 200711, 644-653.

  1. A Continuous Fluorometric Assay for the Assessment of MazF Ribonuclease Activity 
    Wang, N. R.; Hergenrother, P. J. 
    Anal. Biochem. 2007371, 173-183.

  1. Increased Poly(ADP-ribose) Polymerase Activity During Porcine Hemorrhagic Shock is Transient and Predictive of Mortality 
    Skarda, D. E.; Putt, K. S.; Hergenrother, P. J.; Mulier, K. E.; Beilman, G. J. 
    Resuscitation 200775, 135-144.

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  1. Multiplex Targeting, Tracking and Imaging of Apoptosis by Fluorescent Surface Enhanced Raman Spectroscopic Dots 
    Yu, K. N.; Lee, S.-M.; Han, J. Y.; Park, H.; Woo, M.-A.; Noh, M. S.; Hwang, S.-K.; Kwon, J.-T.; Jin, H.; Kim, Y.-K.; Hergenrother, P. J.; Jeong, D. H.; Lee, Y.-S.; Cho, M.-H. 
    Bioconjugate Chem. 200718, 1155-1162.

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  1. A Novel Colorimetric Substrate for Poly(ADP-Ribose) Polymerase-1 (PARP-1), VPARP, and Tankyrase-1
    Nottbohm, A. C.; Dothager, R. S.; Putt, K. S.; Hoyt, M. T.; Hergenrother, P. J.  
    Angew. Chem. Int. Ed. 200746, 2066-2069.

  1. The Promises and Pitfalls of Small-Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)
    Nottbohm, A. C.; Hergenrother, P. J. 
    Drug Discovery Research: New Frontiers in the Post-Genomic Era 2007, 163-185.

  1. A Novel Synthetic Analogue of a Constituent of Isodon excisus Inhibits Transcription of CYP1A1, -1A2, and -1B1 by Preventing Activation of the Aryl Hydrocarbon Receptor
    Sienkiewicz, P.; Ciolino, H.; Leslie, B. J.; Hergenrother, P. J.; Singletary, K.; Yeh, G. C.
    Carcinogenesis 200728, 1052-1057.

  1. Toxin-Antitoxin System are Ubiquitous and Plasmid-Encoded in Vancomycin Resistant Enterococci (VRE) 
    Moritz, E. M.; Hergenrother, P. J. 
    Proc. Natl. Acad. Sci. 2007104, 311-316.

  1. The Prevalence of Plasmids and Other Mobile Genetic Elements in Clinically Important Drug-Resistant Bacteria 
    Moritz, E. M.; Hergenrother, P. J. 
    Antimicrobial Resistance in Bacteria 2007, 25-53.

  1. Small-Molecule Activation of Procaspase-3 to Caspase-3 as a Personalized Anticancer Strategy
    Putt, K. S.; Chen, G. W.; Pearson, J. M.; Sandhorst, J. S.; Hoagland, M. S.; Kwon, J.-T.; Hwang, S.-K.; Jin, H.; Churchwell, M. I.; Cho, M.-H.; Doerge, D. R.; Helferich, W. G.; Hergenrother, P. J.  
    Nat. Chem. Biol. 20062, 543-50.

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BBC News Highlight – #1 Most emailed story on website worldwide on Monday, August 28, 3:20 pm
Scientific American Highlight
Guardian Highlight
Nature Podcast – September 7, 2006; description of our work starts ~19 minutes in 
Nature Chemical Biology News Highlight
Nature Reviews Research Highlight
Chemical & Engineering News Highlight


  1. The Compound 13-D Selectively Induces Apoptosis in White Blood Cancers Versus Other Cancer Cell Types
    Putt, K. S.; Nesterenko, V.; Dothager, R. S.; Hergenrother, P. J.  
    ChemBioChem 20067, 1916-1922.

  1. Biochemical and Thermodynamic Characterization of Compounds that Bind to RNA Hairpin Loops: Toward an Understanding of Selectivity 
    Thomas, J. R.; Liu, X.; Hergenrother, P. J. 
    Biochemistry 200645, 10928-10938. 

  1. Chemical Countermeasures for the Control of Bacterial Biofilms: Effective Compounds and Promising Targets 
    Musk, D. J.; Hergenrother, P. J. 
    Curr. Med. Chem. 200613, 2163-2177 (review).

  1. Obtaining and screening compound collections: A user’s guide and a call to chemists
    Hergenrother, P. J.  
    Curr. Opin. Chem. Biol. 200610, 213-218.

  1. Tools for Molecular Diversification and Their Applications to Chemical Biology
    Silverman, S. K.; Hergenrother, P. J. 
    Curr. Opin. Chem. Biol. 200610, 185-187.

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  1. DNA Binders and Related Subjects. Topics in Current Chemistry 253 (Book Review) 
    Hergenrother, P. J. 
    J. Am. Chem. Soc. 2006128, 3469-3470.

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  1. Size-Specific Ligands for RNA Hairpin Loops
    Thomas, J. R.; Liu, X.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2005127, 12434-12435. 

  1. Using Peptidic Inhibitors to Systematically Probe the S1′ Site of Caspase-3 and Caspase-7
    Goode, D. R.; Sharma, A. K.; Hergenrother, P. J. 
    Org. Lett. 20057, 3529-3532.

  1. Iron Salts Perturb Biofilm Formation and Disrupt Existing Biofilms of Pseudomonas aeruginosa
    Musk, D. J.; Banko, D. A.; Hergenrother, P. J.
    Chem. Biol. 200512, 789-796.

  1. Synthesis and Identification of Small Molecules that Potently Induce Apoptosis in Melanoma Cell Through G1 Cell Cycle Arrest
    Dothager, R. S.; Putt, K. S.; Allen, B. J.; Leslie, B. J.; Nesterenko, V.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2005127, 8686-8696. 

  1. The Relationship Between Aminoglycosides’ RNA Binding Proclivity and Their Antiplasmid Effect on an IncB Plasmid
    Thomas, J. R.; DeNap, J. C. B.; Wong, M.; Hergenrother, P. J. 
    Biochemistry 200544, 6800-6808. 

  1. Structure-based Design and In-Silico Virtual Screening of Combinatorial Libraries. A Combined Chemical/Computational Laboratory Assignment 
    Baudry, J.; Hergenrother, P. J. 
    J. Chem. Educ. 200582, 890-894.

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  1. Bacterial Death comes Full Circle: Targeting Plasmid Replication in Drug-Resistant Bacteria 
    DeNap, J. C. B.; Hergenrother, P. J. 
    Org. Biomol. Chem. 20053, 959-966.

  1. Direct Quantitation of Poly(ADP-Ribose) Polymerase (PARP) Activity as a Method to Distinguish Necrotic and Apoptotic Death in Cell and Tissue Samples
    Putt, K. S.; Beilman, G. J.; Hergenrother, P. J.
    ChemBioChem 20056, 53-55. 

  1. Combating Drug-Resistant Bacteria: Small Molecule Mimics of Plasmid Incompatibility as Antiplasmid Compounds
    DeNap, J. B.; Thomas, J. R.; Musk, D. J.; Hergenrother, P. J. 
    J. Am. Chem. Soc. 2004126, 15402-15404. 

  1. Deoxystreptamine Dimers bind to RNA Hairpin Loops
    Liu, X.; Thomas, J. R.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2004126, 9196-9197.

  1. Medicinal Chemistry – An Introduction 
    Hergenrother, P. J. 
    Synthesis 200413, 2248.

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  1. A non-radiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation
    Putt, K. S.; Hergenrother, P. J. 
    Anal. Biochem. 2004333, 256-264.

  1. An Enzymatic Assay for Poly(ADP-Ribose) Polymerase (PARP-1) via the Chemical Quantitation of NAD+: Application to the High-Throughput Screening of Small Molecules as Potential Inhibitors
    Putt, K. S.; Hergenrother, P. J. 
    Anal. Biochem. 2004326, 78-86. 

  1. Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells
    Nesterenko, V.; Putt, K. S.; Hergenrother, P. J.  
    J. Am. Chem. Soc. 2003125, 14672-14673. 

  1. Efficient Synthesis of Enantiopure β-Amino-γ-Keto Acids from ʟ-Homoserine
    Sharma, A. K.; Hergenrother, P. J. 
    Org. Lett. 20035, 2107-2109.

  1. The Use of pH to Influence Regio- and Chemoselectivity in the Asymmetric Aminohydroxylation of Styrenes 
    Nesterenko, V.; Byers, J. T.; Hergenrother, P. J. 
    Org. Lett. 20035, 281-284.

FROM HARVARD

  1. Dissecting Glucose Signaling with Diversity-Oriented Synthesis and Small Molecule Microarrays 
    Kuruvilla, F. G.; Shamji, A. F.; Sternson, S. M.; Hergenrother, P. J.; Schreiber, S. L. 
    Nature 2002416, 653-657.

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  1. Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol Containing Small Molecules on Glass Slides
    Hergenrother, P. J.; Depew, K. M.; Schreiber, S. L.  
    J. Am. Chem. Soc. 2000122, 7849-7850.

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FROM TEXAS

  1. Total Synthesis of Erythromycin B 
    Breton, P.; Hergenrother, P. J.; Hida, T.; Hodgson, A.; Judd, A. S.; Kraynack, E.; Kym, P. R.; Lee, W.-C.; Loft, M. S.; Yamashita, M.; Martin, S. F. 
    Tetrahedron 200763, 5709-5729.

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  1. An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B
    Hergenrother, P. J.; Hodgson, A.; Judd, A. S.; Lee, W.-C.; Martin, S. F.  
    Angew. Chem. Int. Ed. 200342, 3278-3281.

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  1. Altering Substrate Specificity of Phosphatidylcholine-Preferring Phospholipase C of Bacillus cereus by Random Mutagenesis of the Headgroup Binding Site 
    Antikainen, N. M.; Hergenrother, P. J.; Harris, M. M.; Corbett, B.; Martin, S. F.
    Biochemistry 200342, 1603-1610.

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  1. Characterization of Erythromycin Analogs by Collisional Activated Dissociation and Infrared Multiphoton Dissociation in a Quadrupole Ion Trap 
    Crowe, M. C.; Brodbelt, J. S.; Goolsby, B. J.; Hergenrother, P. J. 
    J. Am. Soc. Mass. Spectrom. 200213, 630-649.

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  1. Phosphatidylcholine-Preferring Phospholipase C from B. cereus. Function, Structure, and Mechanism.
    Hergenrother, P. J.; Martin, S. F.  
    Top. Curr. Chem. 2000211, 131-167.

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  1. A Novel Class of Zinc Binding Inhibitors for the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus
    Martin, S. F.; Follows, B. C.; Hergenrother, P. J.; Franklin, C. L.  
    J. Org. Chem. 200065, 4509-4514.

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  1. The Choline Binding site of Phospholipase C (Bacillus cereus): Insights into Substrate Specificity 
    Martin, S. F.; Follows, B. C.; Hergenrother, P. J.; Trotter, B. K. 
    Biochemistry 200039, 3410-3415.

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  1. Determination of the Substrate Specificity of the Phospholipase D from Streptomyces chromofuscus via an Inorganic Phosphate Quantitation Assay 
    Martin, S. F.; DeBlanc, R. L.; Hergenrother, P. J. 
    Anal. Biochem. 2000278, 106-110.

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  1. Catalytic Cycle of the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus. Solvent Viscosity, Deuterium Isotope Effects, and Proton Inventory Studies
    Martin, S. F., Hergenrother, P. J. 
    Biochemistry 199938, 4403-4408.

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  1. General Base Catalysis by the Phosphatidylchloine-Preferring Phospholipase C from Bacillus cereus: the Role of Glu4 and Asp55
    Martin, S. F.; Hergenrother, P. J. 
    Biochemistry 199837, 5755-5760.

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  1. Enzymatic Synthesis of a Modified Phospholipid and its Evaluation as a Substrate for B. cereus Phospholipase C 
    Martin, S. F.; Hergenrother, P. J. 
    Bioorg. Med. Chem. Lett. 19988, 593-596.

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  1. Determination of the Kinetic Parameters for Phospholipase C (Bacillus cereus) on Different Phospholipid Substrates Using a Chromogenic Assay Based on the Quantitation of Inorganic Phosphate
    Hergenrother, P. J.; Martin, S. F. 
    Anal. Biochem. 1997251, 45-49.

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  1. Chromogenic Assay for Phospholipase D from Streptomyces chromofuscus: Application to the Evaluation of Substrate Analogues
    Hergenrother, P. J.; Martin, S. F.; Haas, M. K.  
    Lipids 199732, 783-788.

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  1. Expression and Site-Directed Mutagenesis of the Phosphatidylcholine-Preferring Phospholipase C from Bacillus cereus: Probing the Role of Active Site Glu146
    Martin, S. F.; Spaller, M. R.; Hergenrother, P. J. 
    Biochemistry 199635, 12970-12977.

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  1. Chromogenic Assay for Phospholipase C from Bacillus cereus 
    Hergenrother, P. J.; Spaller, M. R.; Haas, M. K.; Martin, S. F. 
    Anal. Biochem. 1995229, 313-316.

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