Dissertations

2021 

Dr. Martin Garcia Chavez – “Development of Novel Compounds to Improve the Resistance Profile and Spectrum of Activity of Fusidic Acid.”


2020

Dr. Sarah Perlmutter — “The Influence of Positively Charged Nitrogen Species on Compound Accumulation and Activity in Gram-Negative Bacteria”

​Dr. Riley L. Svec — “Development of Imidazotetrazines for the Treatment of Glioblastoma and as Synthetic Precursors to Diazo Species”


2019

Dr. Alfredo Garcia — “Ring Distortion of the Alkaloid Sinomenine and Novel Prodrug Approaches to Broad-Spectrum Antibiotics” 


​2018

Dr. Evi Llablani — “Discovery and Biological Evaluation of Ferroptocide”

Dr. Bryon Drown — “Chemical Approaches to Understanding Small-Molecule Accumulation in Bacteria and Poly(ADP-Ribosyl)ation”


2017

Dr. Jessie Peh — “Procaspase-3 Activation as a Strategy to Overcome Resistance to Targeted Anticancer Therapies”

Dr. Michelle F. Richter — “Development of Predictive Guidelines for Compound Accumulation in Gram-Negative Bacteria”


2016

Dr. Michael J. Lambrecht — “The Chemical and Enzymatic Synthesis of Poly(ADP-Ribose)”

​Dr. Rachel C. Botham — “Development of PAC-1 as a Privileged Agent for Combination Chemotherapy”


2015

Dr. Robert W. Hicklin — “Chemical Diversification of the Natural Products Quinine, Abietic Acid, and Pleuromutilin by Ring Distortion”

Dr. Elizabeth I. Parkinson — “Deoxynyboquinoes as NQO1-Targeted Anticancer Compounds and Deoxynybomycins as Potent and Selective Antibiotics”

Dr. Howard S. Roth — “Improving the Process Syntheis, Potency, and Pharmacokinetics of the Anticancer Compound PAC-1”


2014

Dr. Claire E. Knezevic — “Development of Poly(ADP-Ribose) Glycohydrolase Inhibitors and Tetracyclic Indoles as Anticancer Compounds”

Dr. Emilia C. Calvaresi — “Small Molecule Inhibitors of Lactate Dehydrogenase A as an Anticancer Strategy”


2013

Dr. Julia J. Williams — “Suitability of RelBE and MazEF Toxin-Antitoxin Systems as Antibacterial Targets”

Dr. Karen Morrison — “Chemical Diversification and Anticancer Activity of Natural Products”


2012

Dr. Timothy Alan Flood, Jr. — “Advances in High-Throughput Screening: Better Compounds, Novel Targets, Enhanced Sensors”


2011

Dr. Joseph Bair — “The Development of Deoxynyboquinone as a Personalized Anticancer Compound”

Dr. Quinn Peterson — “Small Molecule Activators of Procaspase-3 as an Anticancer Strategy”

Dr. Rahul Palchaudhuri — “Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics”

Dr. Diana West — “The Discovery and Characterization of Anticancer Procaspase-Activating Compounds”

Dr. Kristin Finch — “The Discovery of Small Molecule Inhibitors of Poly(ADP-Ribose) Mediated Cell Death”

Dr. Nora Wang — “The Identification and Characterization of Novel Antibacterial Compounds via Target-Based and Whole Cell Screening Approaches”


2010

Dr. Elizabeth Moritz Halvorsen — “The Prevalence of Toxin-Antitoxin Systems and Their Tractability as Novel Antimicrobial Targets”

Dr. Mirth T. Hoyt — “The Anticancer Mode of Action of the Quinone Natural Product Cribostatin 6”

Dr. James T. Heeres — “High-Throughput Detection of Protein—Protein and Protein—DNA Interactions Via Photonic Crystal Biosensors: Applications to Apoptosis Inducing Factor”


2009

Dr. Todd Meyer — “Selective Targeting of RNA with Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops”

Dr. Benjamin Leslie — “Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds that Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action”


2008

Dr. Christina Thompson — “The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs”

Dr. Robin S. Dothager — “Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds that Induce G1 Cell Cycle Arrest”

Dr. Amanda C. Nottbohm — “Chemical Tools to Monitor and Inhibit Poly (ADP-Ribosyl) ation”


2007

Dr. David Goode — “Small Molecule Modulation of Caspase Enzymatic Activity”

Dr. Jason R. Thomas — “Toward the Therapies of Tomorrow: Selective RNA-Binding Small Molecules and Cytoprotective Strategies for ROS-Mediated Disease States”


2006

Dr. Dinty J. Musk — “Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation inPseudomonas aeruginosa”

Dr. Karson S. Putt — “The Modulation of Life and Death: Small Molecule Activators and Inhibitors of Necrotic and Apoptotic Pathways”

Dr. Vitaliy Nesterenko — “Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules”