Dissertations

2024

Dr. Sidney A. McKee – “Overcoming toxicity and Resistance Limitations of the Anticancer Drug Temozolomide”

Dr. Rebecca J. Ulrich – “Physicochemical Trends of Compound Efflux in Gram-Negative Bacteria and Characterization of Novel Antibacterials”


2023

Dr. Kristen A. Muñoz – “Development of LolCDE Inhibitors as Microbiome-Sparing Gram-Negative-Selective Antibiotics”


2022 

Dr. Emily J. Tonogai – “Identifying the Basis for Anticancer Synergy with PAC-1, with Applications to Meningioma”

Dr. Aya M. Kelly – “Unbiased Assessment of P-gp Efflux Towards Designing Blood-Brain Barrier Penetrant Compounds”

Dr. Lindsay E. Chatkewitz – “Identification and Validation of Novel Sult2B1b Inhibitors”

Dr. Emily J. Geddes – “Characterization of Small-Molecule Accumulation Trends and Novel Antibiotics in Gram-Negative Bacteria”

Dr. Matthew W. Boudreau – “The Development of 3-(4-hydroxyphenyl)indoline-2-ones and Other Strategies for the Treatment of Cancer”


2021 

Dr. Martin Garcia Chavez – “Development of Novel Compounds to Improve the Resistance Profile and Spectrum of Activity of Fusidic Acid”


2020

Dr. Sarah Perlmutter – “The Influence of Positively Charged Nitrogen Species on Compound Accumulation and Activity in Gram-Negative Bacteria”

​Dr. Riley L. Svec – “Development of Imidazotetrazines for the Treatment of Glioblastoma and as Synthetic Precursors to Diazo Species”


2019

Dr. Alfredo Garcia – “Ring Distortion of the Alkaloid Sinomenine and Novel Prodrug Approaches to Broad-Spectrum Antibiotics” 


​2018

Dr. Evi Llablani – “Discovery and Biological Evaluation of Ferroptocide”

Dr. Bryon Drown – “Chemical Approaches to Understanding Small-Molecule Accumulation in Bacteria and Poly(ADP-Ribosyl)ation”


2017

Dr. Jessie Peh – “Procaspase-3 Activation as a Strategy to Overcome Resistance to Targeted Anticancer Therapies”

Dr. Michelle F. Richter – “Development of Predictive Guidelines for Compound Accumulation in Gram-Negative Bacteria”


2016

Dr. Michael J. Lambrecht – “The Chemical and Enzymatic Synthesis of Poly(ADP-Ribose)”

​Dr. Rachel C. Botham – “Development of PAC-1 as a Privileged Agent for Combination Chemotherapy”


2015

Dr. Robert W. Hicklin – “Chemical Diversification of the Natural Products Quinine, Abietic Acid, and Pleuromutilin by Ring Distortion”

Dr. Elizabeth I. Parkinson – “Deoxynyboquinoes as NQO1-Targeted Anticancer Compounds and Deoxynybomycins as Potent and Selective Antibiotics”

Dr. Howard S. Roth – “Improving the Process Syntheis, Potency, and Pharmacokinetics of the Anticancer Compound PAC-1”


2014

Dr. Claire E. Knezevic – “Development of Poly(ADP-Ribose) Glycohydrolase Inhibitors and Tetracyclic Indoles as Anticancer Compounds”

Dr. Emilia C. Calvaresi – “Small Molecule Inhibitors of Lactate Dehydrogenase A as an Anticancer Strategy”


2013

Dr. Julia J. Williams – “Suitability of RelBE and MazEF Toxin-Antitoxin Systems as Antibacterial Targets”

Dr. Karen Morrison – “Chemical Diversification and Anticancer Activity of Natural Products”


2012

Dr. Timothy Alan Flood, Jr. – “Advances in High-Throughput Screening: Better Compounds, Novel Targets, Enhanced Sensors”


2011

Dr. Joseph Bair – “The Development of Deoxynyboquinone as a Personalized Anticancer Compound”

Dr. Quinn Peterson – “Small Molecule Activators of Procaspase-3 as an Anticancer Strategy”

Dr. Rahul Palchaudhuri – “Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics”

Dr. Diana West – “The Discovery and Characterization of Anticancer Procaspase-Activating Compounds”

Dr. Kristin Finch – “The Discovery of Small Molecule Inhibitors of Poly(ADP-Ribose) Mediated Cell Death”

Dr. Nora Wang – “The Identification and Characterization of Novel Antibacterial Compounds via Target-Based and Whole Cell Screening Approaches”


2010

Dr. Elizabeth Moritz Halvorsen – “The Prevalence of Toxin-Antitoxin Systems and Their Tractability as Novel Antimicrobial Targets”

Dr. Mirth T. Hoyt – “The Anticancer Mode of Action of the Quinone Natural Product Cribostatin 6”

Dr. James T. Heeres – “High-Throughput Detection of Protein—Protein and Protein—DNA Interactions Via Photonic Crystal Biosensors: Applications to Apoptosis Inducing Factor”


2009

Dr. Todd Meyer – “Selective Targeting of RNA with Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops”

Dr. Benjamin Leslie – “Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds that Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action”


2008

Dr. Christina Thompson – “The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs”

Dr. Robin S. Dothager – “Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds that Induce G1 Cell Cycle Arrest”

Dr. Amanda C. Nottbohm – “Chemical Tools to Monitor and Inhibit Poly (ADP-Ribosyl) ation”


2007

Dr. David Goode – “Small Molecule Modulation of Caspase Enzymatic Activity”

Dr. Jason R. Thomas – “Toward the Therapies of Tomorrow: Selective RNA-Binding Small Molecules and Cytoprotective Strategies for ROS-Mediated Disease States”


2006

Dr. Dinty J. Musk – “Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation inPseudomonas aeruginosa”

Dr. Karson S. Putt – “The Modulation of Life and Death: Small Molecule Activators and Inhibitors of Necrotic and Apoptotic Pathways”

Dr. Vitaliy Nesterenko – “Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules”