Myung Ryul received his Ph.D. in chemical biology from the laboratory of professor Injae Shin at Yonsei University in Korea. He also worked in the laboratories of Prof. Sam Gellman and Prof. Sean Palecek at University of Wisconsin at Madison. He joined the Hergenrother lab in May 2018. His work is focused on the design and synthesis of novel broad-spectrum antibacterials by conversion of Gram-positive only antibiotics.
Publications:
Incorporation of b-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2
Lee, M.-R.; Raman, N.; Gellman, S. H.; Lynn, D. M.; Palecek, S. P.
ACS Chem. Biol. 2017,12, 2975-2780.
Antifungal activity of a β-peptide in synthetic urine media: Toward materials-based approaches to reducing catheter-associated urinary tract fungal infections
Raman, N.; Lee, M.-R.; Rodriguez Lopez, A. d. L.; Palecek, S. P.; Lynn, D. M.
Acta Biomater. 2016, 43, 240-250.
Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2
Lee, M.-R.; Raman, N.; Gellman, S. H.; Lynn, D. M.; Palecek, S. P.
ACS Chem. Biol. 2017,12(12), 2975-2980.
Antifungal activity of a β-peptide in synthetic urine media: Toward materials-based approaches to reducing catheter-associated urinary tract fungal infections
Raman, N.; Lee, M.-R.; Rodriguez Lopez, A. d. L.; Palecek, S. P.; Lynn, D. M.
Acta Biomater. 2016, 43, 240-250.
Hydrophobicity of antifungal β-peptides is associated with their cytotoxic effect on in vitro human colon Caco-2 and liver HepG2 cells
Mora-Navarro, C.; Mendez-Vega, J.; Caraballo-Leon, J.; Lee, M.-R.; Palecek, S.; Torres-Lugo, M.; Ortiz-Bermudez, P.
PLoS One 2016,11(3), e0149271/0149271-e0149271/0149218.
Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection
Raman, N.; Marchillo, K.; Lee, M.-R.; Rodriguez Lopez, A. d. L.; Andes, D. R.; Palecek, S. P.; Lynn, D. M.
ACS Biomater.Sci. Eng. 2016, 2(1), 112-121.
Antifungal activity of 14-helical β-peptides against planktonic cells and biofilms of Candida Species
Raman, N.; Lee, M.-R.; Lynn, D. M.; Palecek, S. P.
Pharmaceuticals 2015, 8(3), 483-503.
Polymer multilayers loaded with antifungal β-peptides kill planktonic Candida albicans and reduce formation of fungal biofilms on the surfaces of flexible catheter tubes
Raman, N.; Lee, M.-R.; Palecek, S. P.; Lynn, D. M.
J. Controlled Release 2014,191, 54-62.
Hydrophobicity and helicity regulate the antifungal activity of 14-helical β-peptides
Lee, M.-R.; Raman, N.; Gellman, S. H.; Lynn, D. M.; Palecek, S. P.
ACS Chem. Biol. 2014,9(7), 1613-1621.
Sheet-Like Assemblies of Charged Amphiphilic α/β-Peptides at the Air-Water Interface
Segman-Magidovich, S.; Lee, M.-R.; Vaiser, V.; Struth, B.; Gellman, S. H.; Rapaport, H.
Chem. – Eur. J. 2011,17(52), 14857-14866, S14857/14851-S14857/14856.
Highly Stable Pleated-Sheet Secondary Structure in Assemblies of Amphiphilic α/β-Peptides at the Air-Water Interface
Segman, S.; Lee, M.-R.; Vaiser, V.; Gellman, S. H.; Rapaport, H.
Angew. Chem., Int. Ed. 2010, 49(4), 716-719, S716/711-S716/713.
Nylon-3 Copolymers that Generate Cell-Adhesive Surfaces Identified by Library Screening
Lee, M.-R.; Stahl, S. S.; Gellman, S. H.; Masters, K. S.
J. Am. Chem. Soc. 2009,131(46), 16779-16789.
Construction of Carbohydrate Microarrays by Using One-Step, Direct Immobilizations of Diverse Unmodified Glycans on Solid Surfaces
Park, S.; Lee, M.-R.; Shin, I.
Bioconjugate Chem. 2009, 20(1), 155-162.
Synthesis of β-Lactams Bearing Functionalized Side Chains from a Readily Available Precursor
Lee, M.-R.; Stahl, S. S.; Gellman, S. H.
Org. Lett. 2008,10(22), 5317-5319.
Carbohydrate microarrays as powerful tools in studies of carbohydrate-mediated biological processes
Park, S.; Lee, M.-R.; Shin, I.
Chem. Commun. (Cambridge, U. K.) 2008,(37),4389-4399.
An apoptosis-inducing small molecule that binds to heat shock protein 70
Williams, D. R.; Ko, S.-K.; Park, S.; Lee, M.-R.; Shin, I.
Angew. Chem., Int. Ed. 2008, 47(39),7466-7469.
Chemical tools for functional studies of glycans
Park, S.; Lee, M.-R.; Shin, I.
Chem. Soc. Rev. 2008,37(8), 1579-1591.
Fluorescent high-throughput screening of chemical inducers of neuronal differentiation in skeletal muscle cells
Williams, D. R.; Kim, G.-H.; Lee, M.-R.; Shin, I.
Nat. Protoc. 2008, 3(5), 835-839.
Fabrication of carbohydrate chips and their use to probe protein-carbohydrate interactions
Park, S.; Lee, M.-R.; Shin, I.
Nat. Protoc. 2007, 2(11), 2747-2758.
Synthetic Small Molecules that Induce Neurogenesis in Skeletal Muscle
Williams, D. R.; Lee, M.-R.; Song, Y.-A.; Ko, S.-K.; Kim, G.-H.; Shin, I.
J. Am. Chem. Soc. 2007,129(30),9258-9259.
Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides
Lee, M.-R.; Raguse, T. L.; Schinnerl, M.; Pomerantz, W. C.; Wang, X.; Wipf, P.; Gellman, S. H.
Org. Lett. 2007, 9(9),1801-1804.
Protein microarrays to study carbohydrate-recognition events
Lee, M.-R.; Park, S.; Shin, I.
Bioorg. Med. Chem. Lett. 2006,16(19), 5132-5135.
Efficient Solid-Phase Synthesis of Trifunctional Probes and Their Application to the Detection of Carbohydrate-Binding Proteins
Lee, M.-R.; Jung, D.-W.; Williams, D.; Shin, I.
Org. Lett. 2005,7(24), 5477-5480.
Facile Preparation of Carbohydrate Microarrays by Site-Specific, Covalent Immobilization of Unmodified Carbohydrates on Hydrazide-Coated Glass Slides
Lee, M.-R.; Shin, I.
Org. Lett. 2005,7(19), 4269-4272.
Fabrication of chemical microarrays by efficient immobilization of hydrazide-linked substances on epoxide-coated glass surfaces
Lee, M.-R.; Shin, I.
Angew. Chem., Int. Ed. 2005,44(19), 2881-2884.
Carbohydrate microarrays: An advanced technology for functional studies of glycans
Shin, I.; Park, S.; Lee, M.-R.
Chem. – Eur. J. 2005,11(10), 2894-2901.
Carbohydrate chips for studying high-throughput carbohydrate-protein interactions
Park, S.; Lee, M.-R.; Pyo, S.-J.; Shin, I.
J. Am. Chem. Soc. 2004,126(15), 4812-4819.
Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs
Lee, M.-R.; Baek, K.-H.; Jin, H. J.; Jung, Y.-G.; Shin, I.
Angew. Chem., Int. Ed. 2004,43(13),1675-1678.
NMR studies on turn mimetic analogs derived from melanocyte-stimulating hormones
Cho, M.-K.; Kim, S.-S.; Lee, M.-R.; Shin, J.; Lee, J.; Lim, S.-K.; Baik, J.-H.; Yoon, C.-J.; Shin, I.; Lee, W.
J. Biochem. Mol. Biol. 2003,36(6), 552-557.
Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties
Kim, K.-M.; Kim, K.-H.; Kang, T.-C.; Kim, W.-Y.; Lee, M.-R.; Jung, H.-J.; Hwang, I. K.; Ko, S.-B.; Koh, J.-Y.; Won, M. H.; Oh, E.-G.; Shin, I.
Bioorg. Med. Chem. Lett. 2003,13(14),2273-2275.
Di-oxanipecotic acids as more stable turn motifs than di-nipecotic acids
Baek, B.-H.; Lee, M.-R.; Kim, K.-Y.; Cho, U.-I.; Boo, D. W.; Shin, I.
Tetrahedron Lett. 2003, 44(17), 3447-3450.
De novo design of non-hydrogen-bonded helical pseudopeptides composed of oxanipecotic acid oligomers
Lee, M.-R.; Kim, K.-Y.; Cho, U.-I.; Boo, D. W.; Shin, I.
Chem. Commun.(Cambridge, U. K.) 2003,(8), 968-969.
Novel consecutive beta- and gamma-turn mimetics composed of alpha-aminooxy tripeptides
Baek, B.-H.; Lee, M.-R.; Kim, K.-Y.; Cho, U.-I.; Boo, D. W.; Shin, I.
Org Lett 2003, 5(7), 971-974.
The first solid-phase synthesis of oligomeric α-aminooxy peptides
Lee, M.-R.; Lee, J.; Baek, B.-H.; Shin, I.
Synlett 2003,(3),325-328.
Synthesis of novel glycopeptidomimetics containing O- and N-glycosylated α-aminooxy acids by fragment coupling on solid support
Lee, M.-R.; Lee, J.; Shin, I.
Synlett 2002,(9),1463-1466.
Chemoselective ligation of maleimidosugars to peptides/protein for the preparation of neoglycopeptides/neoglycoprotein
Shin, I.; Jung, H. J.; Lee, M.-R.
Tetrahedron Lett. 2001,42(7), 1325-1328.
Synthesis of optically active phthaloyl D-aminooxy acids from L-amino acids or L-hydroxy acids as building blocks for the preparation of aminooxy peptides
Shin, I.; Lee, M.-R.; Lee, J.; Jung, M.; Lee, W.; Yoon, J.
J. Org. Chem. 2000, 65(22), 7667-7675.