2024
Deepak K Singh*, Zhengmin Cong*, You Jin Song*, Minxue Liu, Ritu Chaudhary, Dazhen Liu, Rishabh Prasanth, Rajendra K., Simon Lizarazo, Anurupa Moitra, Lisa M. Jenkins, Rohit Bhargava, Kevin Van Bortle, Supriya G. Prasanth and Kannanganattu V. Prasanth (2024) MANCR lncRNA modulates cell-cycle progression and metastasis in breast cancer cells by regulating the isoform-specific expression of nuclear Rho-GEF in cis. Molecular and cellular biology Aug 12:1-19. doi: 10.1080/10985549.2024.2383773
Fredy Kurniawan+, Arindam Chakraborty+, Humayra Oishi, Minxue Liu, Mariam K. Arif, David Chen, Rishabh Prasanth, Yo-Chuen Lin, Godwin Olalaye, Dazhen Li, Kannanganattu V. Prasanth, and Supriya G. Prasanth (2024) Phosphorylation of Orc6 during mitosis suppresses DNA replication and is essential for ribosome biogenesis. Molecular and cellular biology 44(7):289-301. doi: 10.1080/10985549.2024.2356880
Hina Ahmad, Neha Chetlangia, and Supriya G. Prasanth. Chromatin’s influence on pre-RC assembly and function. Biology 2024 13(3), 152; https://doi.org/10.3390/biology13030152 (special issue: The replication licensing system)
Hao Q, Liu M, Daulatabad SV, Gaffari S, Song YJ, Srivastava R, Bhaskar S, Moitra A, Mangan H, Tseng E, Gilmore RB, Frier SM, Chen X, Wang C, Huang S, Chamberlain S, Jin H, Korlach J, McStay B, Sinha S, Janga SC, Prasanth SG, Prasanth KV. Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression. Elife. 2024 Jan 19; 13:e80684. Doi:10.7554/eLife.80684.
2023
Abid Khan and Supriya G. Prasanth. BENDing with polycomb in pluripotency and cancer Bioessays, Volume 45, Issue 8, August 2023:e2300046. Doi:10.1002/bies.20230046. Epub 2023 May 17
Lin Y-C+, Liu D+, Chakraborty A, Macias V, Brister E, Sonalkar J, Shen Y, Ha, TJ, Kajdacsy-Balla A, Prasanth KV and Prasanth SG (2023) DNA damage-induced, S-phase specific phosphorylation of Orc6 is critical for the maintenance of genome stability. Molecular & Cellular Biology 10.1080/10985549.2023.2196204; 43(4):143-156. Epub 2023 Apr 25.
Liu D, Sonalkar J, Prasanth SG (2023). ORChestra coordinates the replication and repair music. Bioessays Apr;45(4):e2200229. doi: 10.1002/bies.202200229. Epub 2023 Feb 22.
2022
Yo Chuen Lin, Dazhen Liu, Arindam Chakraborty, Lyudmila Y Kadyrova, You Jin Song, Qinyu Hao, Jaba Mitr, Rosaline Y.C. Hsu, Mariam K. Arif, Sneha Adusumilli, Ting-Wei Liao, Taekjip Ha, Farid A Kadyrov, Kannanganattu V. Prasanth, and Supriya G. Prasanth (2022) Orc6 is a component of the replication fork and enables efficient mismatch repair. Proc Natl Acad Sci USA May 31;119(22):e2121406119. doi: 10.1073/pnas.2121406119 PMC9295755
Kurniawan F and Prasanth SG (2022) A BEN-domain protein and polycomb complex work coordinately to regulate transcription. Transcription Feb-Jun;13(1-3):82-87. doi: 10.1080/21541264.2022.2105128. Epub 2022 Jul 29.
Fredy Kurniawan1+, Neha Chetlangia1+, Mohammad Kamran1+, Christophe E. Redon2$, Lorinc Pongor2$, Qinyu Sun1, Yo-Chuen Lin1, Vijay Mohan1, Oways Shaqildi1, Darya Asoudegi1, Qinyu Hao1, Abid Khan1, Mirit Aladjem2, Kannanganattu V. Prasanth1# and Supriya G. Prasanth (2022) BEND3 safeguards pluripotency by repressing differentiation-associated genes. Proc Natl Acad Sci USA March 1, 2022 119 (9) e2107406119; https://doi.org/10.1073/pnas.2107406119
Luqian Zheng, JIngjing Liu, Lijie Niu, Mohammad Kamran, Ally WH Yang, Arttu Jolma, Qi
Dai, Timothy R Hughes, Dinshaw J Patel, Long Zhang, Supriya G Prasanth, Yang Yu,
Aiming Ren, and Eric C Lai (2022) Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins. Genes Dev. 2022 Feb 1;36(3-4):225-240. doi: 10.1101/gad.348993.121. Epub 2022 Feb 10. PMID: 35144965
2021
Yo-Chuen Lin and Supriya G. Prasanth (2021): Replication initiation: implications in genome integrity. DNA repair Jul;103:103131. doi: 10.1016/j.dnarep.2021.103131.
Q, Zong Z, Sun Q, Lin YC, Song YJ, Hashemikhabir S, Hsu R, Kamran M, Chaudhary R, Tripathi D, Singh D, Chakraborty A, Li X, Kim Y, Orjalo A, Polycarpou-Schwarz M, Moriarity B, Jenkins L, Johansson H, Zhu Y, Diederichs S, Bagchi A, Kim T, Janga SC, Lal A, Prasanth SG and Prasanth KV (2020) The S phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. eLife Oct 27;9:e55102. doi: 10.7554/eLife.55102.
2020
Rosaline Hsu, Sumanprava Giri, Yating Wang, Yo-Chuen Lin, Dazhen Liu, Susan Wopat, Arindam Chakraborty, Kannanganattu V. Prasanth, and Supriya G. Prasanth. The E3 ligase RFWD3 associates with ORC and stabilizes ORC in a p53-dependent manner. 2020 Cell cycle Oct, 2020 10.1080/15384101.2020.1829823
Hao Q, Zong Z, Sun Q, Lin YC, Song YJ, Hashemikhabir S, Hsu R, Kamran M, Chaudhary R, Tripathi D, Singh D, Chakraborty A, Li X, Kim Y, Orjalo A, Polycarpou-Schwarz M, Moriarity B, Jenkins L, Johansson H, Zhu Y, Diederichs S, Bagchi A, Kim T, Janga SC, Lal A, Prasanth SG and Prasanth KV (2020) The S phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. eLife Oct 27;9:e55102. doi: 10.7554/eLife.55102.
Rosaline Y.C. Hsu, Yo-Chuen Lin, Christophe Redon, Qinyu Sun, Deepak K. Singh, Yating Wang, Vasudha Aggarwal, Jaba Mitra, Abhijith Matur, Branden Moriarity, Taekjip Ha, Mirit I Aladjem, Kannanganattu V. Prasanth and Supriya G. Prasanth (2020) ORCA/LRWD1 regulates homologous recombination at ALT-telomeres by modulating heterochromatin organization. iScience, April 17: https://doi.org/10.1016/j.isci.2020.101038
2019
Tariq A, Hao Q, Sun Q, Singh DK, Jadaliha M, Zhang Y, Chetlangia N, Ma J, Holton S, Bhargava R, Lal A, Prasanth SG, Prasanth KV: LncRNA-mediated regulation of SOX9 expression in basal sub-type breast cancer cells. RNA. 2019 Nov 5. pii: rna.073254.119. doi: 10.1261/rna.073254.119. [Epub ahead of print]
2018
Yo-Chuen Lin+, Yating Wang+, Rosaline Hsu, Sumanprava Giri, Susan Wopat, Mariam K. 
Arif, Arindam Chakraborty, Kannanganattu V. Prasanth, and Supriya G. Prasanth*: PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication. PNAS (USA) 2018 Dec 10. pii: 201814521. doi: 10.1073/pnas.1814521115. [Epub ahead of print]
Mahdieh Jadaliha1, Omid Gholamalamdari1, Wei Tang2, Yang Zhang3, Ana Petracovici1, Qinyu Hao1, Aamira Tariq1, Tae Gyoon Kim1, Sarah E. Holton3, Deepak K. Singh1, Xiao Ling Li4, Susan M. Freier5, Stefan Ambs2, Rohit Bhargava3, Ashish Lal4, Supriya G. Prasanth1, Jian Ma3&6 and Kannanganattu V. Prasanth1# A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability. Plos Genetics 2018 Nov 29;14(11):e1007802. doi: 10.1371/journal.pgen.1007802. eCollection 2018 Nov
Sun Q, Tripathi V, Yoon, JH, Singh D, Hao, Q, Min K, Davila S, Zealy R, Li Z, Polycarpou-Schwarz M, Lehrmann E, Zhang Y, Becker K, Freier S, Zhu Y, Diedrichs S, Prasanth SG, Lal A, Gorospe M and Prasanth KV (2018) MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs. Nucleic Acids Res. 2018 Nov 2;46(19):10405-10416. doi: 10.1093/nar/gky696.
2017
Anantharaman A, Gholamalamdari O, Khan A, Yoon JH, Jantsch MF, Hartner JC, Gorospe M, Prasanth SG, Prasanth KV (2017). RNA editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn-RNA. Febs Letters Aug 18. doi: 10.1002/1873-3468.12795. [Epub ahead of print]
Singh DK, Gholamalamdari O, Jadaliha M, Ling Li X, Lin YC, Zhang Y, Guang S, Hashemikhabir S, Towari S, Zhu YJ, Khan A, Chakraborty A, Macias V, Balla AK, Bhargava R, Janga SC, Ma J, Prasanth SG, Lal A and Prasanth KV (2017). PSIP/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes. Carcinogenesis. Jun 17. Doi: 10.1093/carcino/bgx062 [Epub ahead of print]
Anantharaman A, Tripathi V, Khan A, Yoon JH, Singh DK, Gholamalamdari O, Guang S, Ohlson J, Wahlstedt H, Öhman M, Jantsch MF, Conrad NK, Ma J, Gorospe M, Prasanth SG, Prasanth KV. (2017). ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins. Nucleic Acids Res. pii: gkw1304. doi: 10.1093/nar/gkw1304. PMCID: PMC53971
Wang Y, Khan A, Marks AB, Smith OK, Giri S, Lin YC, Creager R, MacAlpine DM, Prasan
th KV, Aladjem MI, Prasanth SG. (2017). Tempral association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization. Nucleic Acids Res. pii: gkw1211. PMCID: PMC5389698
2016
Prasanth SG, Prasanth KV. (2016). Easy stress relief by EZH2. Cell 167(7): 1678-1680.
Jadaliha M, Zong X, Malakar P, Ray T, Singh DK, Freier SM, Jensen T, Prasanth SG, Karni R, Ray PS, Prasanth KV. (2016). Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer. Oncotarget. 7(26): 40418-40436. PMCID: 5130017.
Anantharaman A, Jadaliha M, Tripathi V, Nakagawa S, Hirose T, Jantsch MF, Prasanth SG, Prasanth KV. (2016). Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA. Sci Rep. 6:34043. PMCID: 5036046.
Zong X, Nakagawa S, Freier SM, Fei J, Ha T, Prasanth SG, Prasanth KV. (2016) Natural antisense RNA promoters 3’ end processing and maturation of MALAT1 lncRNA. Nucleic Acids Research 44(6): 2898-908 doi: 10.1093/nar/gkw047. PMCID PMC4824109
Giri S, Prasanth SG. (2016) Association of ORCA/LRWD1 with repressive histone methyl transferases mediates heterochromatin organization. Nucleus Nov2; 6(6): 435-41. doi: 10.1080/19491034.2015.1102814.
Ma L, Rajsekhar G, Wang R, Bhaduri B, Sridharan S, Mir M, Chakraborty A, Iyer R, Prasanth S, Millet S, Gilletter MU and Popescu G (2016). Phase correlation imaging of unlabeled cell dynamics. Sci. Rep. 6:32702. PMCID 5018886
Giri S, Chakraborty A, Sathyan 
KM, Prasanth KV, Prasanth SG. (2016) Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner. Journal of Cell Science Jan 15; 129(2): 417-29. doi: 10.1242/jcs.178889. PMC4732289
2015
Khan A, Prasanth SG. (2015) BEND3 mediates transcriptional repression and heterochromatins organization. Transcription Oct 20; 6(5): 102-5. doi: 10.1080/21541264.2015.1100228
Abid Khan, Sumanprava Giri, Yating Wang, Arindam Chakraborty, Archit K. Gh
osh, Aparna Anantharaman, Vasudha Aggarwal, Kizhakke M. Sathyan, Taekjip Ha, Kannanganattu V Prasanth and Supriya G Prasanth (2015) BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. PNAS (USA) Jul 7; 112(27): 8338-43. doi: 10.1073/pnas.1424705112. PMC4500215
Sumanprava Giri, Vasudha Aggarwal, Julien Pontis, Zhen Shen, Arindam Chakraborty, 
Abid Khan, Craig Mizzen, Kannanganattu V. Prasanth, Slimane Ait-Si-Ali, Taekjip Ha and Supriya G. Prasanth (2015) ORCA/LRWD1 organizes heterochromatin by assembling histone H3lysine 9 methyltransferases on chromatin. eLIFE Apr 29;4. doi: 10.7554/eLife.06496.
Nihan Kara, Manzar Hossain, Supriya G. Prasanth and Bruce Stillman (2015) Orc1 binding to mitotic chromosomes precedes spatial patterning during G1 phase and assembly of the Origin Recognition Complex in human cells. J. Biol. Chem. pii.jbc.M114.625012 PMID: 25784553.
2014
Arindam Chakraborty and Supriya G. Prasanth (2014) Phosphorylation-dephosphorylation cycle of HP1a governs accurate mitotic progression. Cell cycle Jun 1; 13(11):1663-70 PMC4111712
Yan Sun, Dong Li, Sumanprava Giri, Supriya G. Prasanth and Dongwan Yoo (2014) Differential host cell gene expression and regulation of cell cycle progression by nonstructural protein 11 of porcine reproductive and respiratory syndrome virus. Biomed research international. 2014:430508. Doi: 10.1155/2014/430508. PMCID: PMC3955671
Arindam Chakraborty, Kannanganattu V. Prasanth and Supriya G. Prasanth. (2014) Dynamic phosphorylation of HP1a regulates mitotic progression in human cells. Nature Communications Mar 12; 5:3445. Doi: 10.1038/ncomms4445. PMCID: PMC3982596
2013-2012
Vidisha Tripathi, Zhen Shen, Arindam Chakraborty, Sumanprava Giri, Sue M. Freier, Xiaolin Wu, Yongqing Zhang, Myriam Gorospe, Supriya G. Prasanth, Ashish Lal and Kannanganattu V. Prasanth (2013) Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B- PLoS Genet. Mar;9(3):e1003368. doi: 10.1371/journal.pgen.1003368. (PMCID: PMC3605280)
Zhen Shen and Supriya G. Prasanth (2012) Emerging players in the initiation of eukaryotic DNA Cell Division 7(1): 22 (PMCID: PMC3520825).
Zhen Shen & Supriya G. Prasanth (2012) Orc2 protects ORCA from ubiquitin-mediated degradation. Cell Cycle 11(19): October 1: 3578-3589 (also featured News and Views).
Zhen Shen, Arindam Chakraborty, Ankur Jain, Sumanprava Giri, Taekjip Ha, 
Kannanganattu V. Prasanth and Supriya G. Prasanth (2012) Dynamic association of ORCA with preRC components regulates DNA replication initiation. Mol Cell Biol. 32(15): 3107-3120, (Cover Page).
Sumanprava Giri and Supriya G. Prasanth (2012) Replicating and transcribing on twisted roads of chromatin. Brief Funct Genomics 11(3): 188-204.
2011-2010
Zhuo Wang , Daniel L. Marks, Scott P. Carney, Larry J Millet, Martha U Gillette, Agustin Mihi, Paul V Braun, Zhen Shen, Supriya G. Prasanth, Gabriel Popescu. (2011) Spatial light interference tomography (SLIT). Opt Express 19(21): 19907-18.
Kizhakke M. Sathyan, Zhen Shen, Vidisha Tripathy, Kannanganattu V. Prasanth and Supriya G. Prasanth (2011) A BEN domain containing protein, associates with heterochromatin and represses transcription. J Cell Sci. 124(18): 3149-63. Issue highlight, Cover page
Mustafa Mir, Zhou Wang, Zhen Shen, Michael Bednarz, Rashid Bashir, Ido Golding, Supriya G. Prasanth, Gabriel Popescu. (2011) Optical measurement of cycle-dependent cell growth. PNAS (USA) 108(32): 13124-9.
Arindam Chakraborty, Zhen Shen and Supriya G. Prasanth (2011) “ORCanization” on heterochromatin: linking DNA replication initiation to chromatin organization. Epigenetics 6(6): 665-670 (invited point of view).
Ruiping Zheng, Zhen Shen, Vidisha Tripathi, Zhenyu Xuan, Susan M. Freier, C. Frank Bennett, Supriya G. Prasanth and Kannanganattu V. Prasanth (2010) Poly-purine repeat-containing RNAs: A novel class of long non-coding RNAs in mammalian cells. Journal of Cell Science 123(21): 3734-44. Issue highlight.
Zhen Shen, Kizhakke M. Sathyan, Yijie Geng, Ruiping Zheng, Arindam Chakraborty, Bri
an Freeman, Fei Wang, Kannanganattu V. Prasanth and Supriya G. Prasanth (2010) A novel WD-repeat protein stabilizes ORC binding to chromatin. Molecular Cell 40(1): 99-111. (Top 20 downloaded paper in Molecular Cell, October 2010).
Vidisha Tripathi, Jonathan D. Ellis, Zhen Shen, David Y. Song, Qun Pa, Andrew T. Watt, Susan M. Freier, C. Frank Bennett, Alok Sharma, P. A. Bubulya, Benjamin J. Blencowe, Supriya G. Prasanth and K.V Prasanth (2010) The Nuclear-retained Non-coding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation. Molecular Cell 39(6): 925-938. Preview: (2010) Long noncoding RNAs add another layer to pre-mRNA splicing regulation. Mol. Cell 39(6): 833-4. Faculty of 1000
Supriya G. Prasanth*, Zhen Shen, Kannanganattu V. Prasanth and Bruce Stillman* (2010). Human ORCs are essential for HP1 binding to chromatin and heterochromatin organization. PNAS (USA). 107 (34): 15093-98. (*Co-corresponding author)
Prior to 2009 (Select Publications)
Adriana Hemerly, Supriya G. Prasanth, Khalid Siddiqui and Bruce Stillman (2009). Orc1 Controls Centriole and Centrosome Copy Number in Human Cells. Science 323: 789-793. Editor’s choice: Cell Biology Counting Centrosomes, Sci. Signal, 2009, Vol. 2, Issue 57, p. ec52. Research Highlights: This Week in Science Volume 323, Number 5915, 2009. Faculty of 1000
Kannanganattu V. Prasanth, Supriya G. Prasanth, Zhenyu Xuan, Stephen Hearn, Susan M. Freier, Frank C. Bennett, Micheal Q. Zhang and David L. Spector (2005). Regulating gene expression through RNA nuclear retention. Cell 123(2): 249-63. Preview: (2005). A Nuclear RNA is Cut Out for Translation. Cell, 123(2): 181-183. Research Highlights and News & Views: Quick-release RNA. Science, 2005, Vol 310: 408; RNA in reserve. Nature 2005, Vol. 437: 1211; Unleash the messenger. Nature Cell Biology, 2005, Vol. 7: 1054-1055; Something for a stressful day. Nature reviews Mol. Cell Biology, 2005, Vol. 6: 900 and Nature reviews Genetics, 2005, Vol. 6: 876. Faculty of 1000
Supriya G. Prasanth, Kannanganattu V. Prasanth, Khalid Siddiqui, David L. Spector and Bruce Stillman (2004) Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J. 23(13): 2651-6.
Supriya G. Prasanth, Juan Méndez, Kannanganattu V. Prasanth and Bruce Stillman (2004) Dynamics of pre-replication complex proteins during the cell division cycle. Phil Trans. Biol. Sci. 359, 7-19 (Discussion meeting issue ‘Replicating and reshaping DNA: celebration of the jubilee of the double helix).
Kannanganattu V. Prasanth, Paula A. Sacco-Bubulya, Supriya G. Prasanth and David L. Spector (2003) Sequential entry of components of the gene expression machinery into daughter nuclei. Mol. Biol. Cell 14(3): 1043-1057.
Supriya G. Prasanth, Kannanganattu V. Prasanth and Bruce Stillman (2002) Orc6 involved in DNA replication, chromosome segregation and cytokinesis. Science 297(5583): 1026-1031. Issue Highlights: Jack of all Cell division. Science 297(5583): 893. Faculty of 1000