LASTING EFFECTS OF MATERNAL IMMUNE ACTIVATION ON THE OFFSPRING’S HYPOTHALAMUS AND RESPONSE TO STRESSORS

USDA NIFA Award No. 2018-67015-27413 Project No. ILLU-538-636

PIs: Sandra Rodriguez Zas and Rodney Johnson

Collaborators: Laurie Rund, Marissa Keever, Haley Rymut, Olivia Perez, Courtney Bolt, Adrienne Antonson, Megan Caputo, Alexandra Houser, Jalisa Zimmerman, Bruce Southey, Maria Villamil, Alvaro Hernandez

Undergraduate students: Alejandro Hernandez, Amaan Chalisa, Erica Lemay, Erica Chang Fanny Yang, Jordan Holm, Rebecca Lii, Riccai-Jenine Hunter, Tori Palmer, Caroline Pocher, Sarah Graham, Britten Gordon, Kelsie Weisenberger, Nicole Southey, Cole Maxye, Paulina Topor, Abrar Motawea, Brittany Anglin, Klara Dvorak, and Rachel Anthos

Outcomes

2020

Keever, M.R., Zhang, P., Bolt, C.R., Antonson, A.M., Rymut, H.E., Caputo, M.P., Houser, A.K., Hernandez, A.G., Southey, B.R., Rund, L.A. and Johnson, R.W., 2020. Lasting and sex-dependent impact of maternal immune activation on molecular pathways of the Amygdala. Frontiers in Neuroscience, 14, p.774. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431923/

Rymut, H.E., Bolt, C.R., Caputo, M.P., Houser, A.K., Antonson, A.M., Zimmerman, J.D., Villamil, M.B., Southey, B.R., Rund, L.A., Johnson, R.W. and Rodriguez-Zas, S.L., 2020. Long-lasting impact of maternal immune activation and interaction with a second immune challenge on pig behavior. Frontiers in Veterinary Science, 7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732429/

Keever M.R., Zhang, P., Bolt C.R., Rymut H.E., Antonson A. M., Corbett M. P., Houser A. K., Southey B.R., Rund L.A., Johnson R.W., Rodriguez-Zas S.L. 2020. Detection of sex-by-maternal immune activation effects on the molecular pathways of the pig amygdala. American Society of Animal Science (ASAS) Annual Meeting and Trade Show, Madison, WI, July 2020. PSV-6 https://academic.oup.com/jas/issue/98/Supplement_4.

Rymut, H.E., Bolt, C.R., Corbett, M.P., Rund, L.A., Johnson, R.W. and Rodriguez-Zas, S.L., 2020. PSV-18 Program Chair Poster Pick: Poly (I: C) dose response and its effects on piglet sickness behaviors. Journal of Animal Science, 98(Supplement_4), pp.218-218. https://academic.oup.com/jas/issue/98/Supplement_4.

Keever, M.R., Zhang, P., Bolt, C.R., Rymut, H.E., Antonson, A.M., Corbett, M.P., Houser, A.K., Southey, B.R., Rund, L.A., Johnson, R.W. and Rodriguez-Zas, S.L., 2020. PSVIII-1 A transcriptomic study of the effect of PRRSV infection during gestation on the piglet amygdala. Journal of Animal Science, 98(Supplement_4),. pp.255-256. https://academic.oup.com/jas/issue/98/Supplement_4.

Rymut H.E., Bolt C.R., Caputo M.P., Rund L.A., Johnson R.W., Rodriguez-Zas S.L. 2020. PRRSV infection during gestation eliciting changes in piglet sickness behaviors following an immune challenge. American Society of Animal Science (ASAS) Annual Meeting and Trade Show, Madison, WI, July 2020. PSVIII-19. https://academic.oup.com/jas/issue/98/Supplement_4.

Keever M.R., Rymut H.E., Rund L.A., Johnson R.W., Rodriguez-Zas S.L. 2020. Effect of gestational viral infection on offspring immune signaling pathways in the amygdala. In Proceedings of the Conference of Research Workers in Animal Diseases (CRWAD). December 2020. 376, 277p. https://crwad.org/presentations/

Rymut H.E., Bolt C.R., Keever M.R., Rund L.A., Johnson R.W., Rodriguez-Zas S.L. 2020. Combined effects of stressors across ages on blood chemokine profiles in the pig. In Proceedings of the Conference of Research Workers in Animal Diseases (CRWAD). December 2020. 375, 276p. https://crwad.org/presentations/

2019

Rymut HE, Houser AK, Sizemore CR, Rund LA, Johnson RW, Rodriguez-Zas SL. Effect of PRRSV infection during gestation on sickness behaviors in the piglets after immune challenge. 2019 American Society of Animal Science annual meeting. Abstract 662280. https://www.asas.org/meetings/annual-2019/abstract-and-program-information.

Rymut HE, Sizemore CR, Rund LA, Houser AK, Johnson RW, Rodriguez-Zas SL. Impact of PRRSV infection during gestation on the protein levels in the blood of piglets. 2019 American Society of Animal Science annual meeting. Abstract 662309. https://www.asas.org/meetings/annual-2019/abstract-and-program-information.

Sizemore CR, Rymut HE, Houser AK, Rund LA, Houser AK, Johnson RW, Rodriguez-Zas SL. Maternal immune activation alters inflammatory cytokine profiles in response to weaning. 2019 American Society of Animal Science annual meeting. Abstract 661480. https://www.asas.org/meetings/annual-2019/abstract-and-program-information.

Sizemore CR, Rymut HE, Houser AK, Rund LA, Houser AK, Johnson RW, Rodriguez-Zas SL. Effect of maternal immune activation during gestation on piglets’ cortisol response to stress. 2019 American Society of Animal Science annual meeting. Abstract 661404. https://www.asas.org/meetings/annual-2019/abstract-and-program-information.

Sizemore CR, Rymut HE, Rund LA, Johnson RW, Rodriguez-Zas, SL. 2019. Study of inflammatory and stress indicators in offspring from PRRSV-infected gilts. Conference of Research Workers in Animal Diseases (CRWAD) November 2-5, 2019, 1:083. https://crwad.org/crwad-2019/#1591359243457-c12d9294-5fb4.

Rymut HE, Sizemore CR, Rund LA, Johnson RW, Rodriguez-Zas, SL. 2019. Long-lasting changes in pig disease and metabolic markers following maternal infection. Conference of Research Workers in Animal Diseases (CRWAD) November 2-5, 2019, https://crwad.org/crwad-2019/#1591359243457-c12d9294-5fb4. 2:161.

2018

Sizemore CR, Rund L, Antonson AM, Corbett MP, Zimmerman J, Southey BR, Johnson RW, Rodriguez Zas, SL. Profile of maternal and offspring changes im response to PRRSV infection during pregnancy. 2018 Conference of Research Workers in Animal Diseases. Chicago, Illinois, December 2018, P071. https://crwad.org/crwad-2018/#1591774674095-772831d6-3c82.

Rund L, Sizemore CR, Antonson AM, Corbett MP, Zimmerman J, Southey BR, Johnson RW, Rodriguez Zas, SL. 2018. Impact of PRRSV infection during pregnancy on metabolic indicators. Chicago, Illinois, December 2018, 223. https://crwad.org/crwad-2018/#1591774674095-772831d6-3c82