Our laboratory is interested in understanding signal transduction mechanisms that underlie fundamental cellular and developmental processes in mammals. We employ a combination of experimental approaches including molecular biology, cell biology, biochemistry, biophysics, bioinformatics, and mouse models. Over the years we have unraveled novel signaling mechanisms, mostly of the mammalian target of rapamycin (mTOR) network, in the regulation of a wide range of biology, including cell growth, autophagy, metabolism, and skeletal muscle differentiation/regeneration. Currently, the lab is focusing on autophagy, cytokine signaling, and intercell communication in the contexts of skeletal muscle regeneration and muscular dystrophy.

CONTACT US:

Jie Chen, PI
C526 Chemical & Life Sciences Laboratory
Department of Cell & Developmental Biology
601 S. Goodwin Ave.
Urbana, IL 61801
Email: jiechen@illinois.edu

Adriana Reyes-Ordoñez, lab manager
C511 Chemical & Life Sciences Laboratory
Department of Cell & Developmental Biology
601 S. Goodwin Ave.
Urbana, IL 61801
Email: ariyis@illinois.edu