Publications

  • Son, Kook, et al. “Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.” The Journal of clinical investigation129.5 (2019).Link to PubMed
  • Kim, D., Reyes-Ordoñez, A., & Chen, J. (2019). Lentivirus-Mediated RNAi in Skeletal Myogenesis. In Myogenesis (pp. 95-110). Humana Press, New York, NY. Link to PubMed
  • D. Dutta, K.-Y. Lai, A. Reyes-Ordoñez, J. Chen*, and W. A. van der Donk*, (2018) Lanthionine synthetase C-like protein 2 (LanCL2) isimportant for adipogenic differentiation. J. Lipid. Res. 59, 1433-45. Link to PubMed
  • Y. Fang, C. M. Hill, J. Darcy, A. Reyes-Ordoñez, E. Arauz, S. McFadden, C. Zhang, J. Osland, J. Gao, T. Zhang, S. J. Frank, M. A. Javors, R. Yuan, J. J. Kopchick, L. Y. Sun, J. Chen, and A. Bartke, (2018) Effects of rapamycin on growth hormone receptor knockout mice. Proc Natl Acad Sci USA. 2018 Jan 29. pii: 201717065. doi: 10.1073/pnas.1717065115. Link to PubMed
  • C. L. Rosenberger and J. Chen (2018) To grow or not to grow: TOR and SnRK2 coordinate growth and stress response in Arabidopsis. Molecular Cell 69, 3-4. Link to PubMed
  • Z. S. Mahmassani, K. Son, Y. Pincu, M. Munroe, J. Drnevich, J. Chen, M. D. Boppart, (2017) α 7β 1 Integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise, Am. J. Physiol. Cell Physiol., 312, C638-C650.Link to PubMed
  • A. Arif, F. Terenzi, A. A. Potdar, J. Jia, J. Sacks, A. China, D. Halawani, K. Vasu, X. Li, J. M. Brown, J. Chen, S. C. Kozma, G. Thomas. and P. L. Fox, (2017) EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice, Nature, 542, 357-361.Link to PubMed
  • R. J. Waldemer-Streyer, A. Reyes-Ordonez, D. Kim, R. Zhang, N. Singh and J. Chen, (2017) Cxcl14 depletion accelerates skeletal myogenesis by promoting cell cycle withdrawal, npj Regenerative Medicine, 2, 16017.Link to PubMed
  • C. He, M. Zeng, D. Dutta, T. H. Koh, J. Chen*, and W. A. van der Donk*, (2017) LanCL proteins are not Involved in Lanthionine Synthesis in Mammals, Sci. Rep., 7, 40980.Link to PubMed
  • M.-S. Yoon*, K. Son, E. Arauz, J. Han, S. Kim, and J. Chen*, (2016) Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling, Cell Rep., 16, 1510-1517.Link to PubMed
  • E. Arauz, V. Aggarwal, A. Jain, T. Ha*, and J. Chen*, (2016) Single-Molecule Analysis of Lipid-Protein Interactions in Crude Cell Lysates, Anal. Chem., 88, 4269-76.Link to PubMed
  • R. J. Waldemer-Streyer and J. Chen, (2015) Myocyte-derived Tnfsf14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration, Cell Death & Disease, 6, e2026.Link to PubMed
  • M.-S. Yoon, C.L. Rosenberger, C. Wu, N. Truong, J.V. Sweedler, and J. Chen, (2015) Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid, Mol. Cell, 58, 549-556.Link to PubMed
  • A. Jain, E. Arauz, V. Aggarwal, N. Ikon, J. Chen*, and T. Ha*, (2014) Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown, Proc. Natl. Acad. Sci. USA, 111, 17833-38.Link to PubMed
  • M. Zeng, W. A. van der Donk*, J. Chen*, (2014) Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt, Mol. Biol. Cell 25, 3954-61.Link to PubMed
  • M.-S. Yoon and J. Chen, (2013) Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis, Mol. Biol. Cell 24, 3754-63.Link to PubMed
  • N. Khanna, Y. Fang, M.-S. Yoon, and J. Chen, (2013) XPLN is an endogenous inhibitor of mTORC2, Proc. Natl. Acad. Sci. USA 110, 15979-84.Link to PubMed
  • M.-S. Yoon, C. Zhang, Y. Sun, C. J. Schoenherr, and J. Chen, (2013) Mechanistic target of rapamycin controls homeostasis of adipogenesis, J. Lipid Res. 54, 2166-73.Link to PubMed
  • Y. Ge, R. J. Waldemer, R. Nalluri, P. D. Nuzzi, and J. Chen, (2013) RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation, PLoS One 8, e68068.Link to PubMed
  • Y. Ge, R. J. Waldemer, R. Nalluri, P. D. Nuzzi, and J. Chen, (2013) Flt3L is a novel regulator of skeletal myogenesis, J. Cell Sci. 126, 3370-9.Link to PubMed
  • Y. Ge and J. Chen, (2012) mTOR signaling network in skeletal myogenesis, J. Biol. Chem. 287, 43928-45.Link to PubMed
  • C. Zhang, A. A. Wendel, M. R. Keogh, T. E. Harris, J. Chen, and R. A. Coleman, (2012) Glycerolipid signals alter mTORC2 to diminish insulin signaling, Proc. Natl. Acad. Sci. USA 109, 1667-72.Link to PubMed
  • M.-S. Yoon, G. Du, J. M. Backer, M. A. Frohman, & J. Chen, (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway, J. Cell Biol. 195, 435-47.Link to PubMed
  • Y. Ge, M.-S. Yoon, & J. Chen, (2011) Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1), J. Biol. Chem., 286, 35675-82.Link to PubMed
  • M.-S. Yoon, Y. Sun, E. Arauz, Y. Jiang, & J. Chen, (2011) Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect, J. Biol. Chem. 286, 29568-74.Link to PubMed
  • Y. Ge, Y. Sun and J. Chen, (2011) IGF-II is regulated by microRNA125b in skeletal myogenesis, J. Cell Biol. 192, 69-81.Link to PubMed
  • Y. Ge and J. Chen, (2011) MicroRNAs in skeletal myogenesis, Cell Cycle 10, 441.Link to PubMed
  • A. Jain, R. Liu, B. Ramani, E. Arauz, Y. Ishitsuka, K. Raguathan, J. Park, J. Chen, Y. Xiang and T. Ha, (2011) Probing cellular protein complexes using single-molecule pull-down, Nature 473, 484-88.Link to PubMed
  • Y. Sun, Y. Ge, J. Drnevich, Y. Zhao, M. Band and J. Chen, (2010) Mammalian Target of Rapamycin controls microRNA-1 and follistatin in skeletal myogenesis, J. Cell Biol. 189, 1157-69.Link to PubMed
  • J.-H. Kim, M.-S. Yoon and J. Chen, (2009) signal transducer and activator of transcription 3 (STAT3) mediates amino acids-induced insulin resistance through Ser727 phosphorylation, J. Biol. Chem., 284, 35425.Link to PubMed
  • Y. Ge, A.-L. Wu, C. Warnes, J. Liu, C. Zhang, H. Kawasome, N. Terada, M. Boppart, C. J. Schoenherr and J. Chen, (2009) mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms, Am. J. Physiol. Cell. Physiol., 297, 1434.Link to PubMed
  • C. Zhang, M.-S. Yoon, & J. Chen, (2009) Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes, Am. J. Physiol. Endo. & Metab., 296, 862.Link to PubMed
  • Y. Sun & J. Chen, (2008) mTOR signaling: PLD takes center stage, Cell Cycle, 7, 20.Link to PubMed
  • Y. Sun, Y. Fang, M.-S. Yoon, C. Zhang, M. Roccio, F. J. Zwartkrause, M. Armstrong, H. A. Brown, & J. Chen, (2008) Phospholipase D1 is an effector of Rheb in the mTOR pathway, Proc. Natl. Acad. Sci. USA, 105, 8286.Link to PubMed
  • M.-S. Yoon & J. Chen, (2008) PLD regulates myoblast differentiation through the mTOR�IGF-II pathway, J. Cell Sci., 121, 282.Link to PubMed
  • J.-H. Kim, J. E. Kim, H.-Y. Liu, W. Cao, & J. Chen, (2008) Regulation of IL-6 induced hepatic insulin resistance by mTOR through the STAT3-SOCS3 pathway, J. Biol. Chem., 283, 708.Link to PubMed
  • A.-L. Wu, J.-H. Kim, C. Zhang, T. G. Unterman, & J. Chen, (2008) FoxO1 negatively regulates skeletal myocyte differentiation through degradation of mTOR pathway components, Endocrinology, 149, 1407.Link to PubMed
  • R. A. Bachmann, J.-H. Kim, A.-L. Wu, I.-H. Park, and J. Chen, (2006) A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1, J. Biol. Chem. 281, 7357.Link to PubMed
  • I.-H. Park and J. Chen, (2005) Mammalian Target of Rapamycin (mTOR) Signaling Is Required for a Late-stage Fusion Process during Skeletal Myotube Maturation, J. Biol. Chem. 280, 32009.Link to PubMed
  • I.-H. Park, E. Erbay, P. Nuzzi, and J. Chen, (2005) Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1, Exp. Cell Res. 309, 211.Link to PubMed
  • J. E. Kim and J. Chen, (2004) Regulation of PPARγ activity by mTOR and amino acids in adipogenesis, Diabetes 53, 2748.Link to PubMed
  • Y. Fang, I.-H. Park, A. Wu, G. Du, P. Huang, M.A. Frohman, S.J. Walker, H.A. Brown, & J. Chen, (2003) PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1, Current Biology 13, 2037.Link to PubMed
  • E. Erbay, I.-H. Park, P. Nuzzi, C.J. Schoenherr, and J. Chen, (2003) IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients, J. Cell Biol. 163, 931.Link to PubMed
  • Y. Fang, M. Viella-Bach, R. Bachmann, A. Flanigan, and J. Chen, (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling, Science 294, 1942.Link to PubMed
  • E. Erbay and J. Chen, (2001) The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism, J. Biol. Chem. 276, 36079 (Accelerated Publication).Link to PubMed
  • I.-H. Park, R. Bachmann, H. Shirazi and J. Chen, (2002) Regulation of S6 kinase 2 by the mammalian target of rapamycin, J. Biol. Chem. 277, 31423.Link to PubMed
  • J. E. Kim and J. Chen, (2000) Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation, Proc. Natl. Acad. Sci. USA 97, 14340Link to PubMed
  • M. Vilella-Bach, P. Nuzzi, Y. Fang & J. Chen, (1999) The FKBP12-Rapamycin-binding Domain Is Required for FKBP12-Rapamycin-associated Protein Kinase Activity and G1 Progression, J. Biol. Chem. 274, 4266Link to PubMed