This work by Dr. Louie builds on previous works by our group and others showing that non-neurotropic viral infection can alter oligodendrocyte homeostasis. Using spatial transcriptomics, tissue clearing and immunostaining as well as Single-Cell Energetic Metabolism by Profiling Translation Inhibition (SCENITH). Louie et al., characterize the spatial transcriptomic changes that occur during cuprizone induced demyelination and remyelination as well as the effect of IAV infection during remyelination. The work further shows that myelination during development and remyelination after cuprizone intoxication is associated with increased mitochondrial dependency in oligodendrocytes. In contrast, infection increased glycolytic capacity of oligodendrocytes and microglia and impaired remyelination. The paper is found here: https://www.cell.com/iscience/fulltext/S2589-0042(24)01689-4

Allison’s paper describing the effects of feeding a hydrolyzed lipid blend diet on myelination in piglets is now published! You can find it here: doi: 10.1002/jnr.25243

Allison and Justin’s paper on how respiratory infection with Influenza A virus can alter oligodendrocyte homeostasis in adult mice is now published! You can find it here: doi: 10.1186/s12974-023-02862-2.

Dr. Justin Kim’s paper on the ability for omega-3 endocannabinoids to suppress disease in a relapsing model of multiple sclerosis is now published. You can find the article here: https://www.jbc.org/article/S0021-9258(23)00018-2/fulltext or the press release here: Harnessing good fats to relieve MS symptoms (asbmb.org).

Good luck as you start your new job, we are all going to miss you!

Allison has successfully defended her thesis entitled “Effects of a high cholesterol diet on the pathogenesis of influenza A virus infection in mature mice”. Congratulations Allison! We are fortunate that she will continue as a Ph.D. student in the Neuroscience Program!

Lisa Wetzel, undergraduate student worker extraordinaire, has graduated and will be attending veterinary school at Ohio State in just a few weeks! Further, her first author paper on how the enzymes Ido1 and Ido2 affect the pathogenesis of EAE is now published in Brain, Behavior and Immunity Health (https://www.sciencedirect.com/science/article/pii/S2666354620300818)!  Big congrats and good luck to you!!