Hydrogen Peroxide

  1. Mancini, S. & Imlay, J. A. The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress. Mol. Microbiol. n/a–n/a (2015). doi:10.1111/mmi.12967
  2. Mishra, S. & Imlay, J. A. An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide. Mol. Microbiol. 90, 1356–1371 (2013).
  3. Kumar, S. R. & Imlay, J. A. How Escherichia coli tolerates profuse hydrogen peroxide formation by a catabolic pathway. J. Bacteriol. 195, 4569–4579 (2013).
  4. Anjem, A. & Imlay, J. A. Mononuclear iron enzymes are primary targets of hydrogen peroxide stress. J. Biol. Chem. 287, 15544–15556 (2012).
  5. Mishra, S. & Imlay, J. A. Why do bacteria use so many enzymes to scavenge hydrogen peroxide? Arch. Biochem. Biophys. 525, 145–60 (2012).
  6. Liu, Y., Bauer, S. C. & Imlay, J. A. The YaaA protein of the Escherichia coli OxyR regulon lessens hydrogen peroxide toxicity by diminishing the amount of intracellular unincorporated iron. J. Bacteriol. 193, 2186–2196 (2011).
  7. Jang, S. & Imlay, J. A. Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate. Mol. Microbiol. 78, 1448–1467 (2010).
  8. Imlay, J. A. Cellular defenses against superoxide and hydrogen peroxide. Annu. Rev. Biochem. 77,755–776 (2008).
  9. Jang, S. & Imlay, J. A. Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes. J. Biol. Chem. 282, 929–37 (2007).
  10. Park, S., You, X. & Imlay, J. A. Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 102, 9317–22 (2005).
  11. Pericone, C. D., Park, S., Imlay, J. A. & Weiser, J. N. Factors contributing to hydrogen peroxide resistance in Streptococcus pneumoniae include pyruvate oxidase (SpxB) and avoidance of the toxic effects of the Fenton reaction. J. Bacteriol. 185, 6815–6825 (2003).
  12. Seaver, L. C. & Imlay, J. a. Hydrogen peroxide fluxes and compartmentalization inside growing Escherichia coli. J. Bacteriol. 183, 7182–7189 (2001).
  13. Seaver, L. C. & Imlay, J. A. Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli. J. Bacteriol. 183, (2001).
  14. Imlay, J. A., Chin, S. M. & Linn, S. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 240, 640–2 (1988).
  15. Linn, S. & Imlay, J. A. Toxicity, mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide. J. Cell Sci. Suppl. 6, 289–301 (1987).
  16. Imlay, J. A. & Linn, S. Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide. J. Bacteriol. 166, 519–527 (1986).