C.V.

Xuefeng Wang
Institute of Genomic BIology & Department of Physics
University of Illinois at Urbana-Champaign
Email: xfw@illinois.edu
Permanent Resident of U.S.A.

PROFESSIONAL POSITION

Assistant Professor, Physics & Astronomy department at Iowa State University                 Aug. 2015 – Present
Postdoctoral Research Associate (Mentor: Prof. Taekjip Ha, HHMI Investigator)
University of Illinois at Urbana-Champaign                        May. 2010 – May 2015

EDUCATION
Ph.D.                 Physics, Purdue University, West Lafayette, IN        Dec. 2009
B.S. and M.S.    Physics, Tsinghua University, Beijing, China            Aug. 2004

RESEARCH EXPERIENCE
Postdoctoral period
• Developed Tension Gauge Tether for molecular cellular force measurement and explore molecular tension required by integrin and Notch activation (Science 340, 2013).
• Discovered two distinct regimes of integrin forces: ~40 pN integrin force generated by cell membrane governs cell adhesion, spreading and FAK activation; >54 pN integrin force generated by cytoskeleton governs cell polarization and migration. (In preparation)
• Extended single-molecule pull-down (SiMPull) to single cell level (submitted).
PhD period
• Developed three optical biosensors and their associated scanning systems for protein microarray detection. Won 3 US patents which were commercialized by Perfinity Biosciences, Inc. and attracted a $2.5 million investment from Clarian Health Ventures. (Appl. Opt. 46, 2007; Appl. Opt. 47, 2008; Biosens. Bioelectron. 24, 2008; Anal. Bioanal. Chem. 393, 2009; Biosens. Bioelectron. 26, 2011).
• Invented Picometrology for optical analysis of ultra-thin films and characterized optical properties of graphene, gold and water nanofilm (Opt. Express 16, 2008; Appl. Phys. Lett. 95, 2009; Opt. Express 18, 2010; Appl. Phys. Lett. 97, 2010).

PATENTS (AS THE PRIMARY INVENTOR)

• System with extended range of molecular sensing through integrated multi-modal data acquisition. Issued Patent Number: US 7659968 (Licensed to and Commercialized by Perfinity Biosciences, Inc.)
• Method and apparatus for conjugate quadrature interferometric detection of an immunoassay. Issued Patent Number: US 7787126 (Licensed to and Commercialized by Perfinity Biosciences, Inc.)
• Balanced-quadrature interferometric protein microarray. WIPO Patent Publication number: WO/2010/039147

AWARDS AND HONORS

CPLC Postdoctoral Fellowship sponsored by NSF                                   2010-2014
US Immigrant with extraordinary abilities (EB1-A)                                             2012
The Bilsland Dissertation Fellowship                                                                 2009
Kirk Endowment Exploratory Research Recharge Grants                                 2009
H. Y. Fan Award for outstanding research in condensed matter physics           2009

PUBLICATIONS

1. X. F. Wang, J. Sun, Q. Xu, F. Chowdury, M. Rokhai, Y. Wang and T. Ha, “Two distinct regimes of integrin molecular forces”, (Submitted), 2014
2. X. F. Wang, Z. Rahil and T. Ha, “Constructing protein G based force sensor to study cadherin molecular forces”, (In finalization), 2014
3. X. F. Wang, S. Park, L. Zeng, A. Jain and T. Ha, “In-situ single molecule pull-down for single cell analysis”, (In finalization), 2014
4. X. F. Wang and T. Ha, “Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling”, Science, 340, 991-994 (2013).
Selected in Methods to Watch, “Tiny tools to measure force”, Nature Methods, 11, 29 (2014).
Selected in Research Highlights, “The Pull of a Cell”, Nature Methods, 10, 696-687 (2013).
5. X. F. Wang, M. Zhao, and D. D. Nolte, “Molecular layer detection on a diffractive optical balance”, Optics Letters, 37, 4098-4100 (2012).
6. X. F. Wang, M. Zhao, D. D. Nolte, and T. L. Ratliff, “Prostate specific antigen detection in patient sera by fluorescence-free BioCD protein array”, Biosensors & Bioelectronics, 26, 1871-1875 (2011).
7. X. F. Wang, M. Zhao, and D. D. Nolte, “Refractive index and dielectric constant transition of ultra-thin gold from cluster to Film”, Optics Express, 18, 24859-24867 (2010).
8. M. Zhao, X. F. Wang, and D. D. Nolte, “Mass-transport limitations in spot-based microarrays”, Biomedical Optics Express, 1, 983-997 (2010).
9. X. F. Wang, M. Zhao, and D. D. Nolte, “Ambient Molecular Water Accumulation on Silica Surfaces Detected by a Reflectance Interference Optical Balance”, Applied Physics Letters, 97, (2010).
10. X. F. Wang, M. Zhao, and D. D. Nolte, “Optical contrast and clarity of graphene on an arbitrary substrate”, Applied Physics Letters, 95, 081102 (2009). This paper has been also selected for Virtual Journal of Nanoscale Science & Technology.
11. X. F. Wang, M. Zhao, and D. D. Nolte, “Prostate-specific antigen immunoassays on the BioCD,” Analytical and Bioanalytical Chemistry, 393, 1151-1156 (2009).
12. X. F. Wang, Y. P. Chen, and D. D. Nolte, “Strong anomalous optical dispersion of graphene: complex refractive index measured by Picometrology,” Optics Express, 16, 22105-22112 (2008).
13. X. F. Wang, M. Zhao, and D. D. Nolte, “Land-contrast self-referencing interferometric protein microarray,” Applied Physics Letters, 93, (2008).
Selected in Research Highlights, “Protein Interference”, Nature Physics, 5, 9 (2009)
14. X. F. Wang, M. Zhao, and D. D. Nolte, “Area-scaling of interferometric and fluorescent detection of protein on antibody microarrays,” Biosensors & Bioelectronics, 24, 981-987 (2008).
15. X. F. Wang, M. Zhao, and D. D. Nolte, “Combined fluorescent and interferometric detection of protein on a BioCD,” Applied Optics, 47, 2779-2789 (2008).
16. M. Zhao, X. F. Wang, and D. D. Nolte, “Molecular interferometric imaging,” Optics Express, 16, 7102-7118 (2008).
17. X. F. Wang, M. Zhao, and D. D. Nolte, “Common-path interferometric detection of protein monolayer on the BioCD,” Applied Optics, 46, 7836-7849 (2007).
18. X. F. Wang, Y. Wang, Y. Jiang, and H. Ma, “Two-photon fluorescence anisotropy imaging,” Progress in Biochemistry and Biophysics, 32, 161-167 (2005).
19. Y. Jiang, Y. Wang, Y. Hao, X. F. Wang, Q. Y. Qiu, Q. F. Wang and H. Ma, “Effect of berberine on the proliferation of human pulmonary carcinoma cells,” Chinese Journal of Pathophysiology 21, 2170-2173 (2005).

CONFERENCE PUBLICATIONS

1. X. F. Wang, M. Zhao, and D. D. Nolte, “A novel concept for protein microarray: land-contrast BioCD,” Proceedings of SPIE 7170, 717003 (2009)
2. M. Zhao, X. F. Wang, and D. Nolte, “Probing mass-transport and binding inhomogeneity in macromolecular interactions by molecular interferometric imaging,” Proceedings of SPIE 7188, 71880O (2009)
3. X. F. Wang, and D. D. Nolte, “Picometrology of Ultra-thin Gold Film by Spinning-Disc Interferometry,” Conference on Lasers and Electro-Optics & Quantum Electronics and Laser Science Conference, Vols 1-9, 454-455 (2008)
4. M. Zhao, X. F. Wang, and D. Nolte, “Molecular Interferometric Imaging Biosensor to Study Molecular Interactions,” 2008 Conference on Lasers and Electro-Optics & Quantum Electronics and Laser Science Conference, Vols 1-9, 1899-1900 (2008)
5. X. F. Wang, M. Zhao, and D. D. Nolte, “Multiplexed BioCD for prostate specific antigen detection,” Proceedings of SPIE 6848, 68480S (2008)
6. M. Zhao, X. F. Wang, and D. Nolte, “The in-line-quadrature BioCD,” Proceedings of SPIE 6447, 64470B (2007)
7. X. F. Wang, M. Zhao, and D. D. Nolte, “Four-channel optical detection on protein-patterned BioCD,” Proceedings of SPIE 6447, 64470L (2007)

PRESENTATIONS

1. X. F. Wang, “Cellular forces measured and perturbed at the molecular level”, Northwestern University, Department of physics, Evanston, IL (Invited talk, 2014)
2. X. F. Wang, “Cellular forces measured and perturbed at the molecular level”, University of Washington, Department of physiology and biophysics, Seattle, WA (Invited talk, 2014)
3. X. F. Wang, “Cellular forces measured and perturbed at the molecular level”, Georgia Tech, Department of Biomedical Engineering, Atlanta, GA (Invited talk, 2014)
4. X. F. Wang and T. Ha, “Measure the molecular tension required for integrin and Notch activation using Tension Gauge Tether”, Exciting Biologies – Forces in biology, Dublin, Ireland (Invited talk, 2012)
5. X. F. Wang and T. Ha, “In Situ SiMPull for Single Cell Analysis”, American Society for Cell Biology Annual Meeting, San Francisco, CA (Invited talk, 2012)
6. X. F. Wang, M. Zhao, and D. D. Nolte, “Molecular water accumulation on silica measured with picometer height resolution,” Conference on Lasers and Electro-Optics, Baltimore, MA (Oral talk, 2010).
7. X. F. Wang, and D. D. Nolte, “Protein detection on an optical balance diffraction grating,” APS March meeting, Portland, Oregon (Oral talk, 2010)
8. X. F. Wang, M. Zhao, and D. D. Nolte, “Insulator-to-metal Transition of Gold Films Observed by Interferometric Picometrology,” Conference on Lasers and Electro-Optics, Baltimore, MA (Oral talk, 2009).
9. X. F. Wang and D. D. Nolte, “Complex refractive index of graphene measured by picometrology,” APS March meeting, Pittsburgh, PA (Oral talk, 2009)
10. X. F. Wang, M. Zhao, and D. D. Nolte, ” A novel concept for protein microarray: Land-contrast BioCD,” Photonics West, San Jose, CA (Oral talk, 2009)
11. X. F. Wang, and D. D. Nolte, “Picometrology of Ultra-thin Gold Film by Spinning-Disc Interferometry,” Conference on Lasers and Electro-Optics, San Jose, CA (Oral talk, 2008).
12. X. F. Wang, M. Zhao, and D. D. Nolte, “Multiplexed BioCD for prostate specific antigen detection” Photonics West, San Jose, CA (Oral talk, 2008)
13. X. F. Wang, and D. D. Nolte, “The Bragg Side-Band BioCD,” Conference on Lasers and Electro-Optics, Baltimore, MA (Poster, 2007).
14. X. F. Wang, M. Zhao, and D. D. Nolte, “Four-channel optical detection on protein-patterned BioCD ” Photonics West, San Jose, CA (Oral talk, 2007).

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