Amy Weckle

aweckle

Education
Michigan State University

B.S. Microbiology, 2001

Research Interest

I provide support to all aspects of the lab from training new lab members in our standard operating procedures, to troubleshooting experimental difficulties, to the preparation of manuscripts. I maintain lab organization in the form of a sample database as well as ensuring all the proper supplies are on hand. Some of the projects I have been involved in include in vitro functional assays of estrogen receptor β, transcriptome analysis of an elephant placenta, expression and sequencing of galectins in various primates, age dependent gene expression changes in the human brain, and the origin of growth hormone genes in the placenta. In addition to assisting in the day-to-day operations of the lab, I am also the Editorial Assistant for Molecular Phylogenetics and Evolution for which Dr. Wildman is the Editor-in-Chief.

Publications

Weckle A, Aiello AE, Uddin M, Galea S, Coulborn RM, Soliven R, Meier H, Wildman DE. Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting.  J Vis Exp. 2015 Nov 30;(105). doi: 10.3791/52227.

Lipovich L, Hou ZC, Jia H, Sinkler C, McGowen M, Sterner KN, Weckle A, Sugalski AB, Pipes L, Gatti DL, Mason CE, Sherwood CC, Hof PR, Kuzawa CW, Grossman LI, Goodman M, Wildman DE. High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans. J Comp Neurol. 2016 Feb 1;524(2):288-308. doi: 10.1002/cne.23843. Epub 2015 Aug 20.

Sterner KN, McGowen MR, Chugani HT, Tarca AL, Sherwood CC, Hof PR, Kuzawa CW, Boddy AM, Raaum RL, Weckle A, Lipovich L, Grossman LI, Uddin M, Goodman M, Wildman DE. Characterization of human cortical gene expression in relation to glucose utilization.Am J Hum Biol. 2013 May-Jun;25(3):418-30. doi: 10.1002/ajhb.22394. Epub 2013 Apr 4.

Sterner KN, Weckle A, Chugani HT, Tarca AL, Sherwood CC, Hof PR, Kuzawa CW, Boddy AM, Abbas A, Raaum RL, Grégoire L, Lipovich L, Grossman LI, Uddin M, Goodman M, Wildman DE. Dynamic gene expression in the human cerebral cortex distinguishes children from adults.  PLoS One. 2012;7(5):e37714. doi: 10.1371/journal.pone.0037714. Epub 2012 May 30.

Hou ZC, Sterner KN, Romero R, Than NG, Gonzalez JM, Weckle A, Xing J, Benirschke K, Goodman M, Wildman DE.  Elephant transcriptome provides insights into the evolution of eutherian placentation.  Genome Biol Evol. 2012;4(5):713-25. doi: 10.1093/gbe/evs045. Epub 2012 Apr 30.

Jameson NM, Hou ZC, Sterner KN, Weckle A, Goodman M, Steiper ME, Wildman DE.  Genomic data reject the hypothesis of a prosimian primate clade.  J Hum Evol. 2011 Sep;61(3):295-305. doi: 10.1016/j.jhevol.2011.04.004. Epub 2011 May 26.

Papper Z, Jameson NM, Romero R, Weckle AL, Mittal P, Benirschke K, Santolaya-Forgas J, Uddin M, Haig D, Goodman M, Wildman DE. Ancient origin of placental expression in the growth hormone genes of anthropoid primates. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17083-8.
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Than NG, Romero R, Goodman M, Weckle A, Xing J, Dong Z, Xu Y, Tarquini F, Szilagyi A, Gal P, Hou Z, Tarca AL, Kim CJ, Kim JS, Haidarian S, Uddin M, Bohn H, Benirschke K, Santolaya-Forgas J, Grossman LI, Erez O, Hassan SS, Zavodszky P, Papp Z, Wildman DE. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9731-6.
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Than NG, Romero R, Erez O, Weckle A, Tarca AL, Hotra J, Abbas A, Han YM, Kim SS, Kusanovic JP, Gotsch F, Hou Z, Santolaya-Forgas J, Benirschke K, Papp Z, Grossman LI, Goodman M, Wildman DE. Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15819-24.
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Fang, H.L., Abdolalipour, M., Duanmu, Z., Smigelski, J.R., Weckle, A., Kocarek, T.A., Runge-Morris, M. Regulation of glucocorticoid-inducible hydroxysteroid sulfotransferase (SULT2A-40/41) gene transcription in primary cultured rat hepatocytes: role of CCAAT/enhancer-binding protein liver-enriched transcription factors. Drug Metabolism and Disposition. 2005, 33: 147-156.
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Thomas, R.D., Green, M.R., Wilson, C., Weckle, A., Duanmu, Z., Kocarek, T.A., Runge-Morris, M. Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells. Chemico-Biological Interactions. 2006, 15: 204-216.
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Duanmu, Z., Weckle, A., Koukourataki, S.B., Hines, R.N., Falany, J.L., Falany, C.N., Kocarek, T.A., Runge-Morris, M. Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre and postnatal human liver. Journal of Pharmacology and Experimental Therapeutics. 2006, 316: 1310-1317.
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Contact

aweckle@illinois.edu

A publish.illinois.edu site