This multi-institutional and multidisciplinary Partnerships for International Research and Education (PIRE) project is developing a use-inspired integrated coupled infrastructure framework across multiple cities in India with high potential to scale our design framework for South Asian and global cities facing similar air quality issues and considering a path to investments in clean transportation. Here we are developing a Transportation-Air Quality Coupled Infrastructure System (TAQCIS) – a roadmap to facilitate informed accelerated decision-making as cities plan to adopt clean transportation options. The project aims to integrate (i) physical sciences via high-resolution fully coupled urban-chemistry-weather-climate model outputs for air quality and clean transportation scenarios; (ii) transportation and human systems using behavioral reactions to travel demand management (TDM) strategies impacting congestion, air pollution, safety, and effectiveness of clean (electric) transportation; (iii) social sciences to assess robustness and resilience of clean transportation interventions; and (iv) education to inform public, train the trainers, and teach students and scholars in the U.S., India, and globally.