This work by Dr. Louie builds on previous works by our group and others showing that non-neurotropic viral infection can alter oligodendrocyte homeostasis. Using spatial transcriptomics, tissue clearing and immunostaining as well as Single-Cell Energetic Metabolism by Profiling Translation Inhibition (SCENITH). Louie et al., characterize the spatial transcriptomic changes that occur during cuprizone induced demyelination and remyelination as well as the effect of IAV infection during remyelination. The work further shows that myelination during development and remyelination after cuprizone intoxication is associated with increased mitochondrial dependency in oligodendrocytes. In contrast, infection increased glycolytic capacity of oligodendrocytes and microglia and impaired remyelination. The paper is found here: https://www.cell.com/iscience/fulltext/S2589-0042(24)01689-4