1. Agarwal, V., Borisova, S. A., Metcalf, W. W., van der Donk, W. A.*, and Nair, S. K.* (2011) “Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase.” Chem. Biol., 18, 1230-40 (*Corresponding author)
  1. Nair, S. K.(*), and Severinov, K. (*) (2011) “Microcin C7: Mechanism of Action and Bacterial Resistance.” Future Microbiology. 7, 281-9 (*Corresponding author)
  1. Agarwal, V. and Nair, S.K. (2011) Antibiotics and Emerging Pathogens. Spring Encyclopedia of Sustainability Science and Technology.
  1. Cobb, R., Bae, B., Zhao, H., and Nair, S. K. (2011) “A New Acetyltransferase Fold in the Structure and Mechanism of the Phosphonate Biosynthetic Enzyme FrbF.” J. Biol. Chem. 286, 36132-41
  1. Peck, S. C., Cooke, H. A. , Cicchillo, R.M., Malova, P. Hammerschmidt, F., Nair, S. K., and van der Donk, W. A. (2011) “Mechanism and Substrate Recognition of 2-Hydroxyethylphosphonate Dioxygenase.” Biochemistry, 50, 6598-605.
  1. McIntosh, J., Donia, M., Nair, S. K., and Schmidt, E. (2011) “Enzymatic Basis of Ribosomal Peptide Prenylation in Cyanobacteria.” J. Am. Chem. Soc. 133, 13698-705. [Highlighted in Chemical & Engineering News].
  1. Agarwal, V., Metlytskaya, A., Severinov, K., and Nair, S. K. (2011) “Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase J. Biol. Chem. 286, 21295-303.
  1. Yoshida, S., Park, D. S., Bae, B., Mackie, R., Cann, I. K., Nair, S. K. (2011) “Structural and Functional Analyses of a Glycoside Hydrolase Family 5 Enzyme with an Unexpected β-Fucosidase Activity.” Biochemistry, 50, 3369-75.
  1. Li, Z., Rupasinghe, S. G., Schuler, M. A., Nair, S. K. (2011) “Crystal structure of a phenol-coupling P450 monooxygenase involved in teicoplanin biosynthesis.” Proteins 79, 1728-38.
  1. McIntosh, J. A., Robertson, C. R., Agarwal, V., Nair, S. K., Bulaj, G. W., Schmidt, E. W. (2010) “Circular logic: Nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.” J. Am. Chem. Soc. 132, 15499-501.
  1. Lee, J.H. Bae, B., Kuemin, M., Circello, B.T., Metcalf, W.W., Nair, S.K.* and van der Donk, W.A.* (2010) “Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis.” Proc. Nat’l Acad. Sci. USA. 107, 17557-62. (*Corresponding author)
  1. Nair, S. K.*, van der Donk, W.A.* (2010) “Structure and Mechanism of Enzymes Involved in the Biosynthesis and Breakdown of the Phosphonates Fosfomycin, Dehydrophos and Phosphinothricin.” Arch. Biochem. Biophys. 505, 13-21. (*Corresponding author)
  1. Su, X., Agarwal, V., Dodd, D., Bae, B., Mackie, R. I., Nair, S. K.*, Cann, I. K.* (2010) “Mutational insights into the roles of amino acid residues in ligand binding for two closely related family 16 carbohydrate binding modules.” J. Biol. Chem. 285, 34665-76. (*Corresponding author)
  1. Bae, B., Sullivan, R. P. Zhao, H., and Nair, S. K. (2010) Structure and Engineering of L-Arbinitol-4-Dehydrogenase from Neurospora crassa. J. Mol. Bio. 402, 230-40.
  1. Lin, L. J, Yoshinaga, A., Lin, Y., Guzman, C., Chen, Y. H., Mei, S., Lagunas, A. M., Koike, S., Iwai, S., Spies, M. A., Nair, S. K., Mackie, R. I., Ishino, Y., Cann, I. K. (2010) “Molecular Analyses of an Unusual Translesion DNA Polymerase from Methanosarcina acetivorans C2A.” J. Mol. Bio. 397, 13-30
  1. Lhee, S., Kolling, D. R., Nair, S. K., Dikanov, S. A., and Crofts, A. R., (2010) “Modifications of Protein Environment of the [2Fe-2S] Cluster of the bc1 Complex: Effects on the Biophysical Properties of the Rieske Iron-Sulfur Protein and on the Kinetics of the Complex.” J. Biol. Chem. 285, 9233-45.
  1. Zou, Y., and Nair, S.K. (2009) “Molecular Basis for the Recognition of Structurally Distinct Autoinducer Mimics by the Pseudomonas aeruginosa LasR Quorum Sensing Signaling Receptor.” Chemistry & Biology, 16, 961-970. [Highlighted with Editors Preview].
  1. Cicchillo, R. M., Zhang, H., Blodgett, J.A.V., Whitteck, J.T., Li, H., Nair, S.K.*, van der Donk, W.A.*, and Metcalf, W.W.* (2009) An Unusual Carbon-Carbon Bond Cleavage Reaction in the Biosynthesis of the Herbicide Phosphinothricin. Nature, 459, 871-74. (*Corresponding author) [Highlighted in Chemical & Engineering News, etc.].
  1. Bae, B., Chen, Y-H., Costa, A., Onesti, S., Brunzelle, J.S., Lin, Y., Cann, I.K.O. and Nair, S.K. (2009) Crystal structure of an archaeal MCM homolog provides insights into the architecture of the replicative helicase. Structure, 17, 211-22.
  1. Rubin-Pitel, S., Zhang, H., Vu, T., Brunzelle, J.S., Zhao, H.*, and Nair, S.K.* (2008) Unique Structural Elements Dictate the Specificity of the Type III Polyketide Synthase from Neurospora crassa. Chem. Biol., 15, 1079-1090. (*Corresponding author)
  1. Zou, Y., Brunzelle, J.S., and Nair, S.K. (2008) “Crystal structures of lipoglycopeptide antibiotic deacetylases: Implication for the biosynthesis of A40926 and Teicoplanin” Chem. Biol., 15, 533-45.
  1. Choi, Y.S., Zhang, H., Brunzelle, J.S., Nair, S.K.*, and Zhao, H.* (2008) “In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.” Proc. Nat’l Acad. Sci. USA 105, 6858-63. (*Corresponding author)
  1. Bae, B., Ohene-Adjei, S., Kocherginskaya, Mackie, R. I., Spies, M.A., Cann, I. K. O.*, and Nair, S. K.* (2007) “Molecular Bases for the Specificity of Ligand Recognition by the Carbohydrate Binding Modules from Thermoanaerobacterium polysaccharolyticum manA.” J. Biol. Chem. 283, 12415-25. (*Corresponding author)
  1. Kolling, D., Brunzelle, J. S., Lee S., Crofts, A., and Nair, S K. (2007) “Atomic Resolution Structures of Rieske Iron-Sulfur Protein: Role of Hydrogen Bonds in Tuning Redox Potential of Iron-Sulfur Clusters”. Structure, 15, 29-38.
  1. Zou, Y., Li, C., Brunzelle, J.S., and Nair, S.K. (2006) “Crystallographic tracking of conformational changes during the catalytic reaction of an LPS biosynthetic enzyme”. Biochemistry 46, 4294-4304
  1. Kemp, M., Bae, B., Yu, J.P., Ghosh, M., Leffak, M., and Nair, S.K. (2006) “Structure and function of the DNA unwinding element binding protein: A regulator of DNA replication factor assembly” J. Biol. Chem. 282, 10441-10448.
  1. Dikanov, S.A., Kolling, D.R.J., Endeward, B., Samoilova, R.I., Prisner, T.F., Nair, S.K., and Crofts, A.R. (2006) “Identification of hydrogen bonds to the Rieske cluster through the weakly coupled nitrogens detected by ESEEM spectroscopy” J. Biol. Chem. 281, 27416-25.
  1. Lin, Y., Guzman, C.E., McKinney, M.C., Nair, S.K., Ha, T., Cann, I.K.O. (2006) “Methanosarcina acetivorans flap endonuclease 1 activity is inhibited by a cognate single-stranded DNA-binding protein”. J. Bacteriology, 188, 6153-6167.
  1. Lasker, M. V., and Nair, S. K. (2006) “Molecular Aspects of Signaling in the Innate Immune Response J. Immunology, 177, 11-16.
  1. Lasker, M.V., Kuruvilla, S., Kapoor, A., Gajjar, M., and Nair, S.K. (2006) “Metal Ion Mediated Reduction in Surface Entropy Improves Diffraction Quality of Crystals of the IRAK-4 Death Domain” J. Biomol. Techniques, 17, 114-121.
  1. Nair, S.K.*, and Burley, S.K. (2006) “Structural Aspects of Interactions Within the Myc/Max/Mad Network” The Myc/Max/Mad Transcription Factor Network. Eisenman, R.N., ed. Current Topics in Molecular Immunology 302, 123-144. (*Corresponding author)
  1. Li, B., Yu, J.P., Brunzelle, J.S., Moll, G.N., van der Donk, W.A.*, and Nair, S.K.* (2006) “Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis” Science, 311, 1464-67. [Highlighted in Chemical & Engineering News, etc.]. (*Corresponding author)
  1. Lasker, M.V., Gajjar, M,M., and Nair, S.K. (2005) “Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling.” J. Immunology 175, 4175-9.

Recent Publications

Before 2005