Sunday, October 25, 2015

5:00p – 7:00p Reception for Attendees

Hampton Inn, 1200 W University Ave, Urbana, IL

Monday, October 26, 2015

All symposium sessions are in the NCSA Auditorium, 1205 W Clark Street, Urbana, IL

7:30a – 8:00a Check-in and Breakfast

8:00a – 8:20a Welcome and Introduction

Taher Saif, Mechanical Science and Engineering, University of Illinois at Urbana-Champaign (UIUC)

Tony Jacobi, Department Head, Mechanical Science and Engineering, UIUC

Peter Schiffer, Vice Chancellor for Research, UIUC


8:20a – 10:15a Relevant mechanical micro-environment in Biology

Quantifying cell and tissue mechanics (Abstract)
Paul Janmey, University of Pennsylvania (lecture video)

Aspects of cellular dynamics: hydraulics, motility and decision-making
L. Mahadevan, Harvard University (lecture video)

Mechanics of cancer cell invasion in vivo (Abstract)
Peter Friedl, Radboud University Nijmegen, Netherlands; MD Anderson Cancer Center (lecture video)

Dissecting the control circuit for cell migration (Abstract)
Yu-li Wang, Carnegie Mellon University (lecture video)

Discussion video

10:30a – 12:30p Cell mechanotransduction at the cell-ECM interface

Modeling of Cortical Bone Adaptation due to Mechanical Loading (Abstract)
Iwona Jasiuk, UIUC (lecture video)

Mechanical signaling in epithelial mesenchymal transition (Abstract)
Adam Engler,
University of California, San Diego (Lecture video)

Extracellular matrix mechanics and implications for cellular mechanosensing (Abstract)
Gijsje Koenderink, Universiteit Amsterdam, Netherlands (lecture video)

Mechanics of Adherent Cells (Abstract)
Margaret Gardel, University of Chicago (lecture video)

1:30p – 3:30p  Cell-matrix and cell-cell force interactions

Correlating Topology, Geometry, and Mechanics in Tissue Monolayers (Abstract)
Sascha Hilgenfeldt, UIUC (lecture video)

Modeling signaling and sensing in cancer: Implications for Global Health
Muhammad Zaman, Boston University (lecture video)

Think Globally, Act Locally (Abstract)(lecture video)
Deborah Leckband, UIUC (lecture video)

Single cell force generation in 3D biological gels (Abstract)
Mingming Wu, Cornell University (lecture video)


4:00p – 6:00p  Cell-matrix mechanotransduction at the nucleus-cytoplasm interface

Forcing the nucleus of a living cell to respond (Abstract)
Ning Wang, UIUC (lecture video)

Cells feel their microenvironment and and remodel their nucleus (Abstract)
Dennis Discher, University of Pennsylvania (lecture video)

Nuclear mechanics and genome regulation (Abstract)
GV Shivashankar, National University of Singapore, Singapore (lecture video)

Cell-material chemomechanics: Pulling it all together (Abstract)
Krystyn Van Vliet, MIT (lecture video)


6:30p – 9:00p Workshop dinner (by invitation)

Alice Campbell Alumni Center601 South Lincoln Avenue, Urbana, IL (Directions)

Perspectives from NSF and NIH: Dr David Fyhrie (NSF), Dr Nastaran Kuhn (NIH)

Moderator: Rashid Bashir

Tuesday, October 27, 2015

7:30a – 8:00a Breakfast

8:00a – 10:00a  Cell mechanotransduction within cell cytoskeleton

Mechanical regulation of the cytoskeleton
Daniel Fletcher, University of California at Berkeley (lecture video)

Cell Mechanics and Cell Volume
David Weitz, Harvard University (lecture video)

Substrate regulation of structural order and beating strain dynamics of single cardiomyocytes (Abstract)
Samuel Safran, Weizmann Institute of Science, Israel (lecture video)

Cell-Matrix interactions in fibrosis and cancer: multiscale mechano-chemical models (Abstract)
Vivek Shenoy, University of Pennsylvania (lecture video)


10:30a – 12:30p  Dynamic reciprocity between cells and microenvironment

Encoded biophysical information from actomyosin contractility can trigger discrete biochemical and cellular events (Abstract)
Vivian Tang, UIUC (lecture video)

T cell mechanoimmunology at the molecular level (Abstract)
Cheng Zhu, Georgia Institute of Technology (lecture video)

Nanostructure Modulation of Transepithelial Transport and Tight Junction Mechanics (Abstract)
Tejal Desai, University of California, San Francisco (lecture video)

Cancer cell migration in 3D (Abstract)
Denis Wirtz, John’s Hopkins University (lecture video)


1:30p – 3:30p Dynamic reciprocity between cells and microenvironment

Filopodia tip: chemical and mechanical sensors (Abstract)
Patricia Bassereau, Institut Curie, France (lecture video)

Transient interactions involving interstitial flow and cell migration or vascular sprouting (Abstract)
Roger Kamm, MIT (lecture video)

Mechanosensing of glial cells triggers immune response in the CNS (Abstract)
Jochen Guck, Technische Universität Dresden, Germany (lecture video)

Cells and viscoelasticity (Abstract)
David Mooney, Harvard University (lecture video)

4:00p – 6:00p Cell-matrix microenvironment during embryogenesis and early development

Emergent axonal tension during synaptogenesis – a potential force connection to memory and learning (Abstract)
Taher Saif, UIUC (lecture video)

       Cancer & Inflammation Pharmacology

Tim Mitchison, Harvard University (lecture video)

Combinatorial signals regulating liver differentiation (Abstract)
Gregory Underhill, UIUC (lecture video)

A mechanical role for extracellular matrix during early eye morphogenesis (Abstract)
Larry Taber, Washington University (lecture video)

6:30p – 9:00p Workshop banquet (by invitation)

Alice Campbell Alumni Center601 South Lincoln Avenue, Urbana, IL (Directions)

Keynote: Reengineering the tumor microenvironment to enhance cancer treatment: bench to bedside (Abstract)
Rakesh Jain, Harvard Medical School (Dean Cangellaris will introduce)

Wednesday, October 28, 2015

7:30a – 8:00a Breakfast

8:00a – 10:00a Cell-matrix microenvironment during disease progression

Decoupled control of extracellular matrix properties: cancer microenvironment
Hyunjoon Kong, UIUC (lecture video)

Cell-matrix interactions during tumor angiogenesis (Abstract)
Cindy Reinhart-King, Cornell University (lecture video)

Molecular-Level Rigidity Sensing in Metastasis (Abstract)
Mike Sheetz, Columbia University; National University of Singapore, Singapore (lecture video)

Shear-Mediated Platelet Activation – Mechanotransduction in the Free Flow: A Vital Mechanism in the Thrombosis of Therapeutic Cardiovascular Implant Systems
Marvin Slepian, University of Arizona (lecture video)

10:30a – 12:30p Group discussions on the challenges, opportunities and future research directions in cell-matrix mechanobiology

Beyond gel-to-gel combat: A high(er)-throughput platform for quantifying matrix biophysical control of cell behavior (Abstract)
Sanjay Kumar,
University of California at Berkeley (lecture video)

Nano- and micro-scale platforms for analyzing cell-ECM interactions: collective cell migration, chemoprotective adhesion, and tumor cell invasion (Abstract)
Andrew Holle, Max Planck Institute, Stuttgart, Germany (lecture video)

Discussion leads: Sanjay Kumar and Andrew Holly (video)

Concluding remarks: Taher Saif, UIUC