Low-calorie sweeteners, taste perception and glucose metabolism
Until recently, the general belief was that Low-calorie sweeteners (LCS) could promote diet healthfulness, by delivering a pleasant sweet taste without calories or glycemic effects. However, recent data suggest that LCS are not inert but have metabolic effects. We have recently found that sucralose, the most commonly used LCS, affects the glycemic response to an oral glucose load and potentiates glucose-stimulated insulin secretion in people with obesity who are not regular consumers of LCS. We are currently working on a sucralose study that has two main goals. First, to assess the role of sweet taste signaling in the regulation of postprandial glucose metabolism. Second, to determine how acute and chronic consumption of LCS may affect such sweet taste signaling in people with obesity. This study is funded by the American Diabetes Association (ADA).
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