2023

Manesis, A. C.; Slater, J. W.; Cantave, K.; Martin Bollinger, J.; Krebs, C.; Rosenzweig, A. C. Capturing a Bis-Fe(IV) State in Methylosinus Trichosporium OB3b MbnH. Biochemistry 2023, 62 (5), 1082–1092. https://doi.org/10.1021/acs.biochem.3c00021

2022

Manesis, A. C.; Yerbulekova, A.; Shearer, J.; Shafaat, H. S. Thioester Synthesis by a Designed Nickel Enzyme Models Prebiotic Energy Conversion. Proc. Natl. Acad. Sci. 2022, 119 (30), e2123022119. https://doi.org/10.1073/pnas.2123022119

2021

Manesis, A. C.; Jodts, R. J.; Hoffman, B. M.; Rosenzweig, A. C. Copper Binding by a Unique Family of Metalloproteins Is Dependent on Kynurenine Formation. Proc. Natl. Acad. Sci. 2021, 118 (23), e2100680118. https://doi.org/10.1073/pnas.2100680118.

Kisgeropoulos, E. C.; Manesis, A. C.; Shafaat, H. S. Ligand Field Inversion as a Mechanism to Gate Bioorganometallic Reactivity: Investigating a Biochemical Model of Acetyl coA Synthase Using Spectroscopy and Computation. J. Am. Chem. Soc.2021, 143 (2), 849–867. https://doi.org/10.1021/jacs.0c10135

2019

Kenney, G. E.; Dassama, L. M. K.; Manesis, A. C.; Chen, S.; Ross, M. O.; Hoffman, B. M.; Rosenzweig, A. C. MbnH Is a Diheme MauG-like Protein Associated with Microbial Copper Homeostasis. J. Biol. Chem. 2019,294 (44), 16141–16151. https://doi.org/10.1074/jbc.RA119.010202.

 Manesis, A. C.; Musselman, B. W.; Keegan, B. C.; Shearer, J.; Lehnert, N.; Shafaat, H. S. A Biochemical Nickel(I) State Supports Nucleophilic Alkyl Addition: A Roadmap for Methyl Reactivity in Acetyl Coenzyme A Synthase. Inorg. Chem.2019. https://doi.org/10.1021/acs.inorgchem.8b03546

2018

Behnke, S. L.; Manesis, A. C.; Shafaat, H. S. Spectroelectrochemical Investigations of Nickel Cyclam Indicate Different Reaction Mechanisms for Electrocatalytic CO2 and H+ Reduction. Dalton Trans. 2018, 47 (42), 15206–15216. https://doi.org/10.1039/C8DT02873G.

R. Schneider, C.; C. Manesis, A.; J. Stevenson, M.; S. Shafaat, H. A Photoactive Semisynthetic Metalloenzyme Exhibits Complete Selectivity for CO₂ Reduction in Water. Chem. Commun.2018, 54 (37), 4681–4684. https://doi.org/10.1039/C8CC01297K

2017

Manesis, A. C.; O’Connor, M. J.; Schneider, C. R.; Shafaat, H. S. Multielectron Chemistry within a Model Nickel Metalloprotein: Mechanistic Implications for Acetyl-Coa Synthase. J. Am. Chem. Soc. 2017, 139 (30), 10328–10338. https://doi.org/10.1021/jacs.7b03892

2015

Manesis, A. C.; Shafaat, H. S. Electrochemical, Spectroscopic, and Density Functional Theory Characterization of Redox Activity in Nickel-Substituted Azurin: A Model for Acetyl-Coa Synthase. Inorg. Chem. 2015, 54 (16), 7959–7967. https://doi.org/10.1021/acs.inorgchem.5b01103