Our long-term goal is to develop and use mechanics-based technology that can non-invasively detect soft tissue microdamage, disease, and dysfunction. Our research program has two tool-building pillars that work toward this larger goal: (1) optimization of full-field inverse methods for tissue characterization and (2) identification of constitutive models with appropriate mechano-biomarkers. The tools we develop will facilitate (3) novel, hypothesis-driven research on the interplay between tissue-scale mechanics and microscale structural alterations.