• Sinclair, W, Chang, HH, Dan, A, Kenis, PJ, Murphy, CJ, Leckband, DE (2021) Gold nanoparticles disrupt actin organization and pulmonary endothelial barriers, Sci Rep 10:13320
  • Thompson, CJ, Su, Z, Vu, V, Wu, Y, Leckband, DE, Schwartz, DK (2021) Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions, eLife, 9:e59035.
  • Vu, V, Light, T, Sullivan, B, Greiner, D., Hristova, K, Leckband, D. (2021) P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding, Curr Biol, 31(14):3017-3027
  • Mora-Sierra, Z, Gopan, G, Chang, R, Leckband, D., Gruebele, M. (2021) Stabilization and Kinetics of an Adsorbed Protein Depends on the Poly( N-isopropylacrylamide) Grafting Density, Biomacromolecules, 22:4470-4478
  • Ahmed, ST, Leckband, DE (2021) Forces between mica and end-grafted statistical copolymers of sulfobetaine and oligoethylene glycol in aqueous electrolyte solutions, J Colloid Interface Science, 608:1857-1867.
  • Thompson, CJ, Vu VH, Leckband DE, Schwartz, DK (2021) Cadherin cis and trans interactions are mutually cooperative, PNAS March 9, 2021 118 (10) e2019845118;


  • Thompson CJ, Su Z, Vu VH, Wu Y, Leckband DE, Schwartz DK (2020) Cadherin clusters stabilized by a combination of specific and nonspecific interactions, eLife, in press; doi: 10.7554/eLife.59035.
  • Sinclair WE, Chang HH, Dan A, Kenis PJA, Murphy CJ, Leckband DE (2020) Gold nanoparticles disrupt actin organization and endothelial barriers (2020) Scientific Reports. 10: 13320.
  • Ahmed, ST, Leckband DE (2020) Protein Adsorption on Grafted Zwitterionic Polymers Depends on Chain Density and Molecular Weight, Advanced Functional Materials. 30;.
  • Qin EC, Ahmed ST, Sehgal P, Vu VH, Kong H, Leckband DE (2020) Comparative Effects of N-cadherin Protein and Peptide Fragments on Mesenchymal Stem Cell Mechanotransduction and Paracrine Function, Biomaterials. 239:119846.


  • Thompson CJ, Vu VH, Leckband DE, Schwartz DK (2019) Cadherin Extracellular Domain Clustering in the Absence of Trans-Interactions,  J Phys Chem Lett. 10(16):4528-4534.
  • Ishiyama, N., Sarpal, R., Wood, M.N., Barrick, S.K., Nishikawa, T., Hayashi, H., Kobb, A., Flozak, A.A., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D.E., Gottardi, C.J., Tepass, U., Ikura, M. (2018) Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions, Nat Comm; 9: 5121.
  • Juettner, V., Kruse, K., Dan, A., Vu, V., Khan, Y., Le, J., Leckband, D., Malik, A., Komarova, Y. (2019) VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism, J Cell Biol, 218: 1725-1742.
  • Qin, E.C., Kandel, M.E., Lliamas, E., Shah, T.B., Kim, C., Kaufman, C.D., Zhang, Z.J., Popescu, G., Gillette, M.U., Leckband, D.E., Kong, H.-J. (2019) Enhanced Cell Adhesion on N-cadherin Modified Graphene Oxide Stimulates Neuronal Growth and Intracellular Transport, Acta Biomaterialia, 90: 412-423.
  • Kruse, K., Lee, Q., Sun, Y., Klomp, J., Yang, X., Huang, F., Vogel, S., Shin, J.W., Leckband, D., Tai, L., Malik, A., and Komarova, Y. (2019) N-cadherin Signals Assembly of VE-cadherin Junctions to Establish Vascular Barrier Set-Point, J Cell Biol, 218: 299-316.


  • Kisley, L., Serrano, K.A., Davis, C.M., Guin, D., Murphy, E.A., Gruebele, M., Leckband, D.E. (2018) Soluble Zwitterionic Poly(sulfobetaine) Destabilizes Proteins, Biomacromolecules, 19:3894-3901.



  • Vega L JCM, Lee MK, Qin EC, Rich M, Lee KY, Kim DH, Chung HJ, Leckband DE, Kong H. (2016)Three Dimensional Conjugation of Recombinant N-Cadherin to a Hydrogel for In Vitro Anisotropic Neural Growth, J Materials Chem B, 14: 6803-6811.
  • Cai, Y, Shashikanth, N, Leckband, DE, Schwartz DK (2016) Cadherin Diffusion in Supported Lipid Bilayers Exhibits Calcium-Dependent Dynamic Heterogeneity, Biophys J, 111:2658-2665.
  • Rahil, Z, Pedron, S, Wang, X., Ha, T, Harley, B., Leckband, D (2016) Nanoscale Mechanics Guides Cellular Decision Making, Integrative Biology, 8:929-35.
  • Dan, A, Huang, RB, Leckband, DE (2016) Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity, Ann Biomed Eng, doi:10.1007/s10439-016-1677-4
  • Shashikanth, N, Kisting, M, Park, S, Ha, T, Leckband, DE (2016) Enhanced protein-protein interactions at intercellular junctions, Sci Rep. 24;6:23623.
  • Muhamed, I, Wu, J, Sehgal, P, Kong, X, Tajik, A, Wang, N, Leckband, DE, E-Cadherin-mediated force transduction signals regulate global cell mechanics (2016) J Cell Sci, 29: 1843-54.
  • Leckband, D. (2016) Cadherins in Mechanotransduction in Molecular and Cellular Mechanobiology, Shu Chien, Adam J. Engler, Peter Yingxiao Wang, Eds, Springer, NY.


  • Choi, S., Camp, S., Dan, A., Garcia, J.G.N., Dudek, S.M., Leckband, D. (2015) A Genetic Variant of Cortactin Linked to Acute Lung Injury Impairs Lamellipodia Dynamics and Endothelial Wound Healing, J Physiol Lung Cell Mol Physiol, 309:L983-94
  • Shashikanth, N, Newhall, J, Petrova, Y, Park, S, Ha, TJ, Gumbiner, BM, Leckband, DE, Allosteric Regulation of E-Cadherin, J Biol Chem, 290: 21749-61.
  • Wang X, Rahil Z, Li IT, Chowdhury F, Leckband DE, Chemla YR, Ha T. (2015) Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors, Sci Rep, 6:21584.
  • Li, J., Newhall, J., Ishiyama, N., Gottardi, C., Ikura, M., Leckband, D.E., and Tajkhorshid, E. (2015) Structural Determinants of the Mechanical Stability of Alpha Catenin, J Biol Chem, 290:18890-903.
  • Kim, TJ, Zheng, S, Sun, J, Muhammed, I, Wu, J, Lei, L, Kong, X., Leckband, DE, Wang, Y. Dynamic Visualization of Alpha-Catenin Reveals Rapid, Reversible Conformation Switching between Tension States (2015) Current Biology, 25:218-24.
  • Escobar, DJ, Desai, R, Ishiyama, N, Folmsbee, SS, Novak, MN, Flozak, AS, Daugherty RL, Mo, R, Nanavati, D, Sarpal, R, Leckband, D, Ikura, M, Tepass U, Gottardi CJ. (2015) alpha-catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism, J Cell Sci. 128: 1150-1165.
  • Barry, A, Wang, N, Leckband, DE. Local VE-Cadherin Mechanotransduction Triggers Long-Ranged Remodeling of Endothelial Monolayers, 2015. J Cell Sci, 128: 134-51.


  • Leckband, D.E. and deRooij, J. Cadherin adhesion and mechanosensing, 2014, Ann Rev Cell Dev Biol, Epub 2014 Jul 9.
  • Vega L JC, Lee MK, Jeong JH, Smith CE, Lee KY, Chung HJ, Leckband DE, Kong H. Recapitulating cell-cell adhesion using N-cadherin biologically tethered to substrates, Biomacromolecules, 2014, 15:2172-9.
  • Barry, A, Tabdili, H, Muhamed, I, Wu, J, Shashikanth, N, deRooij J, Gottardi, C, Yap, A, Wang, N, Leckband, D α-Catenin cytomechanics: role in cadherin-dependent adhesion and mechanotransduction, J. Cell. Sci., 2014, 127:1779-91.
  • Parreira P, Magalhães A, Reis CA, Borén T, Leckband D, Martins MC. Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori. Acta Biomaterialia, 2014, 9: 8885-8893.


  • Choi, BC, Choi, S, Leckband, D Poly(N-isopropyl acrylamide) brush topography: dependence on grafting conditions and temperature Langmuir, 2013, 29:5841-50 (IF 4.3).
  • Leckband, D. Formin’ Cables Under Stress Nat Cell Biol, 2013, 15: 345-346 (IF 20.1).
  • Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y. N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways, Nat Commun, 2013, 4: 1589 (IF 7.4).
  • Choi, S., Choi, B-C, Xue, C. Protein Adsorption Mechanisms Determine the Efficiency of Thermally Controlled Cell Adhesion on Poly(N-isopropyl acrylamide) Brushes Biomacromolecules, 2013, 14: 92-100 (IF 5.65)


  • Twiss, F, le Duc, Q, van der Horst, S, Tabdili, H, van der Krogt, G, Wang, D, Rehmann, H, Huveneers, S, Leckband, D, De Rooij, J Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation Biology Open, 1: 1126-1140.
  • Leckband, D.E., Sivasankar, S. Cadherin recognition and adhesion, Curr Op Cell Biol, 2012, 24: 620-627.(IF 13.54)
  • Tabdili, H, Langer, M, Shi, Q, Poh, Y-C, Wang, N, Leckband, D Cadherin-dependent mechanotransduction depends on ligand identity but not affinity, J Cell Sci, 2012, 125: 4362-4371 (IF 6.73).
  • Tabdili, H., Barry, A., Langer, M, Shi, Chien, Y.H., Q, Lee, KJ, Leckband, D Cadherin point mutations alter cell sorting and GTPase signaling, J Cell Sci, 2012, 125: 3299-3309. (IF 6.73)
  • Leckband, D, Sivasankar, S Biophysics of Cadherin Adhesion, Subcellular Biochemistry, 2012, 60:63-88.
  • Xue, C., Choi B.C., Braun, P.V., Leckband, D.E. Protein Adsorption Modes Determine Reversible Cell Attachment on Poly(N-isopropyl acrylamide) Brushes, Adv Funct Mat, 2012, 22: 2394–2401. (IF 9.44)
  • Langer, M.D., Guo, H., Shashikanth N., Pierce, M., Leckband, D.E. (2011) N-Glycosylation Alters Cadherin-Mediated Intercellular Binding Kinetics, J Cell Sci, 2012, 125: 2478-2485.(IF 6.73)


  • Leckband, D., leDuc, Q, Wang, N., deRooij, J Mechanosensing at Cadherin Adhesions, Curr Op Cell Biol, 2011, 23: 523-530.(IF 13.54)
  • Parreira, P., Magalhaes, A., Goncalves,I.C., Gomes, J., Vidal, R., Reis, C.A., Leckband, D.E., Martins, C.L. Effect of surface chemistry on bacterial adhesion, viability, and morphology, Biomed. Mat. Res. J., 2011, 99: 344-353.(IF 3.62)
  • Andreasson-Ochsner, M., Romano, G., Hâkanson, M., Smith, M.L., Leckband, D.E., Textor, M., Reimhult, E. Single cell 3-D platform to study ligand mobility in cell–cell contact, Lab Chip, 2011, 11: 2876-2883 (IF 6.626)
  • Xue, C., Nisan-Tanyeri, N., Brouette, N., Sferrazza, M., Braun, P.V., Leckband, D.E. Protein resistant poly(N-isopropylacrylamide) brushes, Langmuir, 2011, 27: 8810-8818 (IF 4.26)
  • Leckband, D, Menon, S, Rosenberg, K, Graham, S, Ward, E, Taylor, M, Drickamer, K, Geometry of the extracellular domains of DC-SIGNR neck length variants analyzed by force-distance measurements, Biochemistry, 2011, 50: 6125-6132 (IF 3.226)
  • Leckband, D. Novel functions and binding mechanisms of carbohydrate-binding proteins identified from force measurements, Curr Protein Peptide Sci, 2011, in press (IF 3.83)
  • Yap, A, Leckband, D, Niessen, C. Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mchanisms of morphogenetic regulation, Physiol Rev, 2011, 91: 691-731.(IF 28.417)


  • Li, D., Zhou, J., Wang, L., Shin, M.-E., Su, P., Lei, X., Kuang, H., Guo, W., Yang, H., Tanaka, T., Leckband, D.E., Reynolds, A.B., Duan, E., and Wang, F. Integrated mechanical and biochemical input from non-muscle myosin IIA, E-cadherin and p120-catenin regulates intercellular adhesion, pluripotency and survival of human embryonic stem cells J Cell Bio, 2010, 191:631-44 (IF 9.92)
  • LeDuc, Q*, Shi, Q*, Blonk, I, Sonnenberg, A, Wang, N, Leckband, D, deRooij, J, Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosinII dependent manner, J Cell Biol, 2010, 189 (7): 1107-1115 pubmed (IF 9.92)
  • Shi, Q*, Maruthamuthu, V*, Li, F, Leckband, D., Allosteric cross-talk between cadherin domains, Biophys J, 2010, 99:95-104 (IF 4.28)
  • Leckband, D. Design rules for biomolecular adhesion: lessons from force measurements, Ann Rev Chem Biomol Eng 2010, 1, 365-389
  • Mann, C, Leckband, D. Traction force measurements in long term cell cultures, Cell And Mol Bioeng 2010, 3, 40-49.


  • Silvestre J, Kenis PJ, Leckband DE. Cadherin and Integrin Regulation of Epithelial Cell Migration, Langmuir 2009, 25, 10092-9 (IF 4.26)
  • Menon, S, Rosenberg, K, Graham, S, Ward, E, Taylor, M, Drickamer, K, Leckband, D. Surface force measurements demonstrate binding site geometry and flexibility in DC-SIGN, Proc Natl Acad Sci USA 2009, 106, 11524-9 (impact factor 9.771)
  • Maruthamuthu V, Schulten K, Leckband D. Elasticity and Rupture of a Multi-domain NCAM Complex. Biophys J. 2009, 96, 3005-3014 (IF 4.28)
  • Leckband D and Maruthamuthu V (2009) “Biophysical Methods for Investigating the Adhesive Function of Classical Cadherins” in Molecular and Molecular and Functional Diversities of Cadherin/Protocadherin (K Yoshida, editor).
  • Leckband, D (2009) “Nanoscale forces in protein recognition and adhesion” in Handbook of Nanophysics (K Sattler, editor).


  • Leckband, D. From single molecules to living cells: nanomechanical measurements of cell adhesion.Cell Mol Bioengineering, 2008, 1, 312-326.
  • Shi Q, Chien YH, Leckband D. Biophysical properties of cadherin bonds do not predict cell sorting. J Biol Chem. 2008 Vol. 283, 28454-28463 (IF 5.328)
  • Wuang, SC, Neoh, KG, Kang, ET, Pack, DW, Leckband, DE. HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization, Biomaterials, 2008, 29, 2270-2279 (IF 7.882)
  • Leckband D. Beyond structure: mechanism and dynamics of intercellular adhesion. Biochem Soc Trans. 2008, 36, 213-20 (IF 3.989)
  • Zarnitsyna VI, Huang J, Zhang F, Chien YH, Leckband D, Zhu C. Memory in receptor-ligand-mediated cell adhesion, Proc Natl Acad Sci USA, 2008, 104, 18037-18042 (IF 9.771)
  • Chien YH, Jiang N, Li F, Zhang F, Zhu C, Leckband D. Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region. J Biol Chem. 2008, 283, 1848-56. (IF 5.328)


  • Zhu, X., Yan, C., Winnik, F.M., Leckband, D.E. End-Grafted Low Molecular Weight PNIPAM Does Not Collapse above the LCST, Langmuir. 2007 23(1):162-9 (IF 4.26)
  • Dong R, Jensen TW, Engberg K, Nuzzo RG, Leckband DE. Variably elastic hydrogel patterned via capillary action in microchannels. Langmuir. 2007 Jan 30;23(3):1483-8 (IF 4.26)
  • Bayas, M.V., Kearney, A., van der Merwe, P.A., Leckband, D.E. Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58,J Biol Chem. 2007 282(8):5589-96. (IF 5.328)
  • Li, F., Leckband, D. (2006) Dynamic Strength of Molecularly Bonded Surfaces, J. Chem. Phys., 125, 194702.
  • Leckband, D., Prakasam, A. (2006) Mechanism and Dynamics of Cadherin Adhesion. Annu Rev Biomed Eng., 8, 259-287.
  • Prakasam, A., Maruthamuthu, V., Leckband, D.E. (2006) Similarities between Heterophilic and Homophilic Cadherin Adhesion, Proc Natl Acad Sci, 103, 15434-15439 (IF 9.771)
  • Wang, S.-C, Neoh, K.G., Kang, E.-T., Pack, D.W., Leckband, D.E. (2006) Heparinized Magnetic Nanoparticles: In-Vitro Assessment for Biomedical Applications, Adv. Functional Materials, 16, 1723-17 (IF 8.46)
  • Prakasam, A., Chien, Y.-H., Maruthamuthu, V., Leckband, D.E. (2006) Calcium site mutations in cadherin: impact on adhesion and evidence of cooperativity, Biochemistry, 49, 6930-6939.
  • Gunawan RC, Silvestre J, Gaskins HR, Kenis, P.J.A., Leckband, D.E. (2006) Cell migration and polarity on microfabricated gradients of extracellular matrix proteins, Langmuir, 22: 4250-4258 (IF 4.26)
  • Plunkett, KN, Zhu, X, Moore, JS, Leckband, D.E. (2006) PNIPAM chain collapse depends on the molecular weight and grafting density, Langmuir, 22: 4259-4266 (IF 4.26)
  • Bayas, M., Leung, A., Evans, E., Leckband, D. (2006) Lifetime Measurements Reveal Kinetic Differences between Homophilic Cadherin Bonds, Biophys. J., 90: 1385-1395.
  • Yan, C., Matsuda, W., Pepperberg, D.R., Zimmerman, S.C., Leckband, D.E. (2006) Synthesis and Characterization of an Electroactive Surface that Releases -Aminobutyric Acid (GABA), J. Coll. Int. Sci., 296: 165-177.


  • Hukkanen, E.J., Wieland, J.A., Gewirth, A.A., Braatz, R.D., Leckband, D.E. (2005) Multiple-bond Kinetics from Single-Molecules Pulling Experiments: Evidence for Multiple NCAM Bonds, Biophys. J., 89, 3434-3445.
  • Wieland, J.A., Gewirth, A., Leckband, D. (2005) Single Molecules Adhesion Measurements Reveal Two Homophilic NCAM Bonds with Mechanically Distinct Properties, J. Biol. Chem., 280: 41037-41046.
  • Wieland, J.A., Gewirth, A.A., Leckband, D.E., (2005) Single Molecule Measurements of the Impact of Lipid Phase Behavior on Anchor Strengths, J. Phys. Chem. B., 109, 5985-5993.
  • Gunawan, R.C., Choban, E.R., Conour, J.E., Schook, L.G., Gaskins, H.R., Kenis, P.J.A., Leckband, D.E. (2005) Regiospecific Control of Gene Expression in Cells Cultured on Two-component Counter Gradients of Extracellular Matrix Proteins, Langmuir, 21, 3061-3068.
  • Johnson, C.P., Fragnetto, G., Konovalov, O., Legrand, J.F., Leckband. D.E. (2005) Structural Studies of the Neural Cell Adhesion Molecule by X-Ray and Neutron Reflectivity, Biochemistry, 44, 546-554.
  • Johnson, C.P., Fujimoto, I., Rutishauser, U., Leckband, D.E. (2005) Direct Evidence that NCAM Polysialylation Increases Intermembrane Repulsion and Abrogates Adhesion, J. Biol. Chem., 280, 137-145.


  • Tan, W., Spendemir-Urkmez, Fahrner, L., Jamison, R., Leckband, D., Boppart, S.A. (2004) Structural and Functional Optical Imaging of Thee-Dimensional Engineered Tissue Development, Tissue Engineering, 10, 1747-1756.
  • Leckband, D. (2004) Adhesion Molecule NanoMechanics, Curr. Op. Struct. Biol., 14, 524-530.
  • Leckband, D. (2004) Novel Mechanisms of Cell Adhesion: new perspectives from force measurements, J. Adhesion, 80, 409-432.
  • Zhu, X., DeGraaf, J., Winnik, F.M., Leckband, D. (2004) pH Dependent Mucoadhesion of a Poly(N-isopropylacrylamide) Copolymer Reveals Design Rules for Drug Delivery, Langmuir, 20, 10648-10656.
  • Bayas, M., Schulten, K., Leckband, D. (2004) Forced Rupture of the Strand-dimer Interface between C-cadherin Ectodomains, Mechanics and Chemistry of Biosystems, 1:101-111.
  • Zhu, X., DeGraaf, J., Winnik, F., Leckband, D. (2004) pH-Responsive PNIPAM-N-Glycine Copolymer: Direct measurements of Interfacial Forces, Langmuir, 20, 1459-1465.
  • Johnson, C.P., Fujimoto, I., Perrin-Tricaud, C., Rutishauser, U., Leckband, D. (2004) Mechanism of Homophilic NCAM Adhesion: use of multiple domains and flexibility, Proc. Natl. Acad. Sci. USA, 101, 6963-6968.


  • Johnson, C., Prakasam, A., Jensen, I., Vijayendran, R., and Leckband, D. (2003) Engineered Protein A for the Orientational Control of Immobilized Proteins, Bioconjugate Chemistry, 14, 974-978.
  • Zhu, B., Chappuis-Flament, S., Wong, E., Jensen, I., Gumbiner, B.M., and Leckband, D.E. (2003) Functional Analysis of the Structural Basis of Homophilic Cadherin Adhesion, Biophys. J., 84, 4033-4042.
  • Bayas, M.V., Schulten, K.S., and Leckband, D. (2003) Forced dissociation of the CD2-CD58 Complex, ”Biophys. J.‘,84, 2223-2233.


  • Vijayendran, R, Motsegood, K.M., Beebe, D.J., Leckband, D.E. (2002) Evaluation of a Three-Dimensional Micromixer in a Surface-Based Biosensor, Langmuir, 19, 1824-1828.
  • Zhu, B., Davies, E.A., van der Merwe, A., Leckband, D. (2002) Direct Measurements of Heterotypic Adhesion Between the Cell Adhesion Proteins CD2 And CD48, Biochemistry, 42, 12163-12170.
  • Martel, L., Johnson, C., Boutet, S., Al- Kurdi, R., Konovalov, O., Robinson, I., Leckband, D., Legrand, J.F. (2002) X-Ray Reflectivity Investigation of the Structure of Cadherin Monolayers, J. Phys. IV France, 12, 365-377.
  • Efremova, NV, Huang, Y, Peppas, NA, and Leckband, D (2002) Direct Measurement of Interactions between Tethered PEG Chains and Adsorbed Mucin Layers, Langmuir, 18, 836-845


  • Efremova, NV, Sheth, S.R., and Leckband, D (2001) Protein-induced conformational changes in poly(ethylene glycol) brushes: molecular weight and temperature dependence, Langmuir, 17, 7628-7636.
  • Branch, DW, Wheeler, BC, Brewer, GJ, and Leckband, DE (2001) Long-Term Stability of Microstamped Substrates of Polylysine and Grafted Polyethylene Glycol in Cell Culture Conditions, “Biomaterials“, 22:1035-1047.
  • Zhu, B., Eurell, T., Gunawan, R., Leckband, D. (2001) Protein adsorption and cell adhesion on oligo(ethylene glycol)-terminated self-assembled monolayers on gold, “J. Biomat. Sci. Polym. Ed.“, 56, 406-416.
  • Sivasankar, S., Gumbiner, B., and Leckband, D. (2001) Molecular Mechanism of Cadherin Binding, “Biophys. J.“, 80, 1758-1768.
  • Leckband, D. and Israelachvili, J.N. (2001) Forces in Biology, Quarterly Reviews of Biophysics, 34, 105-267.
  • Leckband, D. (2001) Novel Recognition Mechanisms in Biological Adhesion, Curr. Op. Coll. Sci., 6, 498-505.
  • Leckband, D. (2001) Force as a Probe of Membrane Structure and Function, Current Op. Struct. Biol., 11, 433-439.


  • Vijayendran, R. and Leckband, D. (2000) Quantitative Assessment of the Heterogeneity of Immobilized Antibodies, Anal. Chem., 73, 471-480.
  • Eteshola, E. and Leckband, D. (2000) Development of a Microfluidic ELISA Assay, Sensors and Actuators B, 72, 129-133.
  • Sheth, S.R., Efremova, N., and D. Leckband (2000) Interactions of Polyethylene Oxide Brushes with Chemically Selective Surfaces, J. Phys. Chem. B, 104, 7652-7662.
  • Efremova, N., Bondurant, B., O’Brien, D., and Leckband, D. (2000) Interaction Forces and Protein Resistance of Neutral Membranes with End-Grafted Poly(ethylene glycol), Biochemistry, 39, 3441-3451.
  • A. Kloss, N. Lavrik, C. Yeung, and D. Leckband (2000) Effect of the Microenvironment on the Apparent Affinity of Immobilized Receptors, Langmuir, 16, 3414-3421.
  • D. Branch, B. Wheeler, G. Brewer, and D. Leckband, Long-Term Maintenance of Patterns of Hippocampal Pyramidal Cells on Substrates of Polyethylene Glycol and Microstamped Polylysine (2000) IEEE Transactions on Biomedical Engineering, 47, 290-300.
  • N. Lavrik and D. Leckband (2000) Optical and Direct Force Measurements of Interactions Between Monolayers of Aromatic Macrocycles on Surfactant Membranes, Langmuir, 16, 1842-1851.
  • Halperin, A. and Leckband, D. (2000) From Ship Hulls to Contact Lenses: Repression of Protein Adsorption and the Puzzle of PEO, C.R. Acad. Sci., Paris, Serie IV, 1171-1178.
  • Leckband, D. and Sivasankar, S. (2000) Mechanisms of Cadherin Binding, Current Opinions in Cell Biology, 12, 587-592.
  • Leckband, D. (2000) Measuring Forces that Control Protein Interactions, Ann. Rev. Biophys. Biomol. Structure, 29, 1-26.
  • Leckband, D., T.Kuhl, H.K. Wang, W. Müller, J. Herron, and H. Ringsdorf (2000) Direct Force Measurements of Antibody-Antigen Interactions, Methods, 20, 329-340.
  • Leckband, D. and Sivasankar, S., Forces in Protein Interactions: Theory and Experiment, Colloids and Surfaces, B, Special DLVO Edition (2000) 14, 83-97.


  • Vijayendran, R., Ligler, F.S., and Leckband, D. (1999) A Computational Transport-Kinetic Model for the Analysis of Transport-Limited Biosensor Data, “Anal. Chem.“, 71, 5455412.
  • S. Sivasankar, W. Brieher, N. Lavrik, B. Gumbiner, and D. Leckband, Direct Force Measurements of Multiple Adhesive Interactions Between Cadherin Ectodomains (1999) “Proc. Natl. Acad. Sci. USA“, 96, 11820-4.
  • C. Yeung, T. Purves, A. Kloss, T. Kuhl, S. Sligar, and D. Leckband (1999), Cytochrome c Recognition of Immobilized Orientational Variants of Cytochrome b5: Direct Force and Equilibrium Binding Measurements “Langmuir“, 15, 6829-6836.
  • Leckband, D., Sheth, S.R., and Halperin, A., (1999) Grafted Poly(ethylene oxide) Brushes as Nonfouling Surface Coatings, J. Biomat. Sci. Polym. Ed., 10, 1125-1147.


  • S. Sivasankar, S. Subramaniam, and D. Leckband (1998) Probing the Electrostatic Properties of Proteins at the Molecular Level, Proc. Natl. Acad. Sci., 95, 12961-12966.
  • T.L. Kuhl, J. Majewski, J.Y. Wong, S. Steinberg, D.E. Leckband, J.N. Israelachvili, and G.S. Smith (1998) The Structure of Polymer Decorated Biomembranes, Biophys. J., 75, 2352-2362.
  • D. E. Leckband, O.V. Borisov, and A. Halperin (1998) Cold and Hot Denaturation of Polysoaps, Macromolecules, 31, 2368-2374.
  • R. Vijayendran, D. Hammer, and D. Leckband (1998) Simulations of the adhesion between molecularly bonded surfaces in direct force measuremetns, J. Chem. Phys, 108, 7783-7794.
  • Z.-W. Yu, T. Calvert, and D. Leckband (1998) Forces Between Neutral Glycosphingolipids: Direct Evidence for Carbohydrate Attraction, “Biochemistry“, 37, 1540-1550.


  • C. Yeung and D. Leckband, (1997) Molecular Level Characterization of Microenvironmental Influences on the Properties of Immobilized Proteins (1997) Langmuir, 13, 6746-6754.
  • T. Calvert and D. Leckband (1997) Two-Dimensional Protein Crystallization on Solid Supports, Langmuir, 13, 6737-6745.
  • S. Sheth and D. Leckband (1997) Direct Measurements of Attractive Interactions Between Proteins and Grafted Poly(ethylene oxide) Chains, Proc. Natl. Acad. Sci., 94, 8399-8404.
  • S. Sheth and D. Leckband (1997) Direct Measurements of Polymerization-Dependent Changes in Diacetylene Films, Langmuir, 13, 5652-5662.


  • Kuhl, T., Guo, Y., Alderfer, J., Berman, A., Leckband, D., Israelachvili, J., and Hui, S. (1996) Direct Measurement of Polyethylene Glycol Induced Depletion Attraction Between Lipid Bilayers, Langmuir, 12, 3003-3014.

1995 and before

  • Sasisekharan, R., Leckband, D., Godavarthi, R., Vankataraman, G., Cooney, C. and Langer, R. (1995) Heparinase I from Flavobacterium heparanum. The role of cysteine residue in catalysis as probed by chemical modification and site-directed mutagenesis, Biochemistry, 34, 14441-14448.
  • Balgi, G., Leckband, D.E., and Nitsche, J.M. (1995) Transport Effects on the Kinetics of Protein-Surface Binding, Biophys. J, 68, 2251-2260.
  • D. Leckband, T. Kuhl, H.-K. Wang, W. Müller, J. Herron, and H. Ringsdorf (1995) 4-4-20 anti-fluorescyl IgG Fab’ Binding to Fluoresceinated Bilayers: The impact of protein and bilayer structure, Biochemistry, 34, 11467-11478.
  • D. Leckband, W. Müller, F.-J. Schmitt, and H. Ringsdorf (1995) Molecular Mechanisms Determining the Strength of Receptor-Mediated Intermembrane Adhesion, Biophys. J, 69, 1162-1169.
  • Leckband, D. (1995) Using the Soft Touch on Cell Surfaces, Biophys. J., 68, 2215-2216.
  • Leckband, D. (1995) The surface force apparatus-a tool for probing molecular protein interactions, Nature, 376, 617-618.
  • T.L. Kuhl, D.Leckband, and J.N. Israelachvili (1994) Modulation of interaction forces between lipid bilayers exposing short-chained ethylene oxide headgroups, Biophys. J, 66, 1479-1488.
  • D. Leckband, F.-J. Schmitt, W. Knoll, and J. Israelachvili (1994) Specific and Nonspecific Protein Interaction Forces: direct force measurements and observations of associated molecular rearrangements, Biochemistry, 33, 4611-4624.
  • Shivkumar, C., Israelachvili, J., Leckband, D., Schmitt, F.-J., Walker, S., and Zasadzinski, J. (1994) Higher order Self-Assembly of Vesicles via Site-Specific Binding, Science, 264, 1753-1756.
  • L. Evert, D. Leckband, and J. Israelachvili (1993) Structure and Dynamics of Ion Induced Domains in Free and Supported Monolayers and Bilayers, Langmuir, 10, 303-315.
  • Spinke, J., Liley, M., Schmitt, F-J., Guder, H.-J., Angermaier, L., Weisenhorn, A.L., Hansma, P.K., Helm, C.A., Leckband, D., Israelachvili, J., and Knoll, W. (1993) Supra-Biomolecular Architectures at Functionalized Surfaces, J. Chem. Phys., 99, 7012-7019.
  • D. Leckband, Y.-L. Chen, Israelachvili, J., H. Wickman, R. Zimmerman, and M. Fletcher (1993) Measurements of Conformational changes during Adhesion of Lipid and Protein (Polylysine and S-Layer) Surfaces, Biotech. Bioeng., 42, 167-177.
  • D. Leckband, C. Helm, J. Israelachvili (1993) The Role of Calcium in the Adhesion and Fusion of Mixed Lipid Bilayers, Biochemistry, 32, 1127-1140.
  • Leckband D. and Israelachvili, J. (1992) Determination of the Molecular Basis of Protein Function by Direct Force Measurements, Enzyme and Microbial Technology, Enzyme Microb. Technol, 15, 450-459.
  • D. Leckband, F.-J. Schmitt, W. Knoll, and J. Israelachvili (1992) Direct Measurement of a Long-Range Attraction and Molecular Rearrangements in Receptor-Ligand Interactions, Science, 255, 1419-142.
  • D. Leckband and R. Langer (1991) An Approach for the Stable Immobilization of Protein, Biotechnol. and Bioeng, 37, 227-237.
  • D. Leckband and G. Hammes (1988) Function of Tightly Bound Nucleotides on Membrane-Bound Chloroplast Coupling Factor, Biochemistry, 27, 3629-3633.
  • D. Leckband and G. Hammes (1987) Interactions Between Nucleotide Binding Sites on Chloroplast Coupling Factor One During ATP Hydrolysis, Biochemistry, 26, 2306-2312.