The Zhang lab studies how signal transduction regulates cell fate determination and how normal signaling processes are compromised in disease conditions. Using live-cell imaging and optogenetic control of signal transduction, we observe and perturb signaling modules to define cellular responses. Our major goal is to gain insight into signaling mechanisms that regulate critical cellular functions such as cell proliferation, differentiation, migration, and apoptosis and to apply the insight to understanding and treating neurological disorders. Homed in the Biochemistry Department at the School of Molecular and Cellular Biology, Dr. Zhang is also affiliated with the Beckman Institute, Neuroscience Program, the Center for Biophysics and Quantitative Biology, Chemistry-Biology Interface Training Program, and the Cancer Center at Illinois.
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