Metalloenzymes

  1. Martin, J. E., Waters, L. S., Storz, G. & Imlay, J. a. The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese. PLOS Genet. 11, e1004977 (2015).
  2. Imlay, J. A. The Mismetallation of Enzymes during Oxidative Stress. J. Biol. Chem. 289, 28121–28128 (2014).
  3. Gu, M. & Imlay, J. A. Superoxide poisons mononuclear iron enzymes by causing mismetallation. Mol. Microbiol. 89, 123–134 (2013).
  4. Xu, F. F. & Imlay, J. A. Silver(I), mercury(II), cadmium(II), and zinc(II) target exposed enzymic iron-sulfur clusters when they toxify Escherichia coli. Appl. Environ. Microbiol. 78, 3614–3621 (2012).
  5. Martin, J. E. & Imlay, J. a. The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation. Mol. Microbiol. 80, 319–34 (2011).
  6. Salvail, H. et al. A small RNA promotes siderophore production through transcriptional and metabolic remodeling. Proc. Natl. Acad. Sci. U. S. A. 107, 15223–15228 (2010).
  7. Wu, P., Imlay, J. A. & Shang, J. K. Mechanism of Escherichia coli inactivation on palladium-modified nitrogen-doped titanium dioxide. Biomaterials 31, 7526–7533 (2010).
  8. Yeom, J., Imlay, J. A. & Park, W. Iron homeostasis affects antibiotic-mediated cell death in Pseudomonas species. J. Biol. Chem. 285, 22689–22695 (2010).
  9. Anjem, A., Varghese, S. & Imlay, J. A. Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli. Mol. Microbiol. 72, 844–858 (2009).
  10. Macomber, L. & Imlay, J. a. The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity. Proc. Natl. Acad. Sci. U. S. A. 106, 8344–8349 (2009).
  11. Wu, P., Xie, R., Imlay, J. A. & Shang, J. K. Visible-light-induced photocatalytic inactivation of bacteria by composite photocatalysts of palladium oxide and nitrogen-doped titanium oxide. Appl. Catal. B Environ. 88, 576–581 (2008).
  12. Macomber, L., Rensing, C. & Imlay, J. A. Intracellular copper does not catalyze the formation of oxidative DNA damage in Escherichia coli. J. Bacteriol. 189, 1616–1626 (2007).
  13. Gakh, O. et al. Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity. Hum. Mol. Genet. 15, 467–479 (2006).
  14. Woodmansee, A. N. & Imlay, J. a. Quantitation of intracellular free iron by electron paramagnetic resonance spectroscopy. Methods Enzymol. 349, 3–9 (2002).
  15. Keyer, K. & Imlay, J. A. Superoxide accelerates DNA damage by elevating free-iron levels. Proc. Natl. Acad. Sci. U. S. A. 93, 13635–13640 (1996).