Defenses Against Oxidative Stress
- Mancini, S. & Imlay, J. A. The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress. Mol. Microbiol. n/a–n/a (2015). doi:10.1111/mmi.12967
- Imlay, J. A. The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium. Nat. Rev. Microbiol. 11, 443–54 (2013).
- Mishra, S. & Imlay, J. A. An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide. Mol. Microbiol. 90, 1356–1371 (2013).
- Singh, A. K., Shin, J. H., Lee, K. L., Imlay, J. A. & Roe, J. H. Comparative study of SoxR activation by redox-active compounds. Mol. Microbiol. 90, 983–996 (2013).
- Mishra, S. & Imlay, J. A. Why do bacteria use so many enzymes to scavenge hydrogen peroxide? Arch. Biochem. Biophys. 525, 145–60 (2012).
- Arenas, F. a et al. The Escherichia coli BtuE protein functions as a resistance determinant against reactive oxygen species. PLoS One 6, e15979 (2011).
- Imlay, J. A. and Hassett, D. J. (2011) Oxidative and nitrosative stress defense systems in Escherichia coli and Pseudomonas aeruginosa: A model organism of study versus a human opportunistic pathogen. In S. Kidd (Ed. ), Stress Response in Pathogenic Bacteria (pp. 3-32). Cambridge, MA and Oxfordshire, UK: CABI
- Gu, M. & Imlay, J. A. The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide. Mol. Microbiol. 79, 1136–1150 (2011).
- Liu, Y., Bauer, S. C. & Imlay, J. A. The YaaA protein of the Escherichia coli OxyR regulon lessens hydrogen peroxide toxicity by diminishing the amount of intracellular unincorporated iron. J. Bacteriol. 193, 2186–2196 (2011).
- Martin, J. E. & Imlay, J. a. The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation. Mol. Microbiol. 80, 319–34 (2011).
- Arenas, F. A. et al. The Escherichia coli btuE gene encodes a glutathione peroxidase that is induced under oxidative stress conditions. Biochem. Biophys. Res. Commun. 398, 690–4 (2010).
- Jang, S. & Imlay, J. A. Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate. Mol. Microbiol. 78, 1448–1467 (2010).
- Anjem, A., Varghese, S. & Imlay, J. A. Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli. Mol. Microbiol. 72, 844–858 (2009).
- Imlay, J. A. Cellular defenses against superoxide and hydrogen peroxide. Annu. Rev. Biochem. 77,755–776 (2008).
- Munroe, W. et al. Only one of a wide assortment of manganese-containing SOD mimicking compounds rescues the slow aerobic growth phenotypes of both Escherichia coli and Saccharomyces cerevisiae strains lacking superoxide dismutase enzymes. J. Inorg. Biochem. 101,1875–1882 (2007).
- Gakh, O. et al. Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity. Hum. Mol. Genet. 15, 467–479 (2006).
- Djaman, O., Outten, F. W. & Imlay, J. A. Repair of oxidized iron-sulfur clusters in Escherichia coli. J. Biol. Chem. 279, 44590–44599 (2004).
- Pericone, C. D., Park, S., Imlay, J. A. & Weiser, J. N. Factors contributing to hydrogen peroxide resistance in Streptococcus pneumoniae include pyruvate oxidase (SpxB) and avoidance of the toxic effects of the Fenton reaction. J. Bacteriol. 185, 6815–6825 (2003).
- Smith, A. H., Imlay, J. a & Mackie, R. I. Increasing the oxidative stress response allows Escherichia coli to overcome inhibitory effects of condensed tannins. Appl. Environ. Microbiol. 69, 3406–3411 (2003).
- Korshunov, S. S. & Imlay, J. A. A potential role for periplasmic superoxide dismutase in blocking the penetration of external superoxide into the cytosol of Gram-negative bacteria. Mol. Microbiol. 43,95–106 (2002).
- Imlay, J. A. What biological purpose is served by superoxide reductase? JBIC J. Biol. Inorg. Chem.7, 659–663 (2002).
- Seaver, L. C. & Imlay, J. A. Alkyl Hydroperoxide reductase is the primary scavenger of endogenous Hydrogen peroxide in Escherichia coli. J. Bacteriol. 183, (2001).
- Schwartz, C. J., Djaman, O., Imlay, J. A. & Kiley, P. J. The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 97, 9009–9014 (2000).
- Gort, A. S., Ferber, D. M. & Imlay, J. A. The regulation and role of the periplasmic copper, zinc superoxide dismutase of Escherichia coli. Mol. Microbiol. 32, 179–191 (1999).
- Maringanti, S. & Imlay, J. A. An intracellular iron chelator pleiotropically suppresses enzymatic and growth defects of superoxide dismutase-deficient Escherichia coli. J. Bacteriol. 181, 3792–3802 (1999).
- Gort, A. S., Imlay, J. A. & Gort, A. M. Balance between endogenous superoxide stress and antioxidant defenses J. Bacteriol. 180, 1402–1410 (1998).
- Imlay, K. R. & Imlay, J. A. Cloning and analysis of sodC , encoding the copper-zinc superoxide dismutase of Escherichia coli . Microbiology 178, 2564–2571 (1996).
- Kargalioglu, Y. & Imlay, J. A. Importance of anaerobic superoxide dismutase synthesis in facilitating outgrowth of Escherichia coli upon entry into an aerobic habitat. J. Bacteriol. 176, 7653–7658 (1994).
- Imlay, J. A. & Fridovich, I. Isolation and genetic analysis of a mutation that suppresses the auxotrophies of superoxide dismutase-deficient Escherichia coli K12. Mol. Gen. Genet. 228, 410–416 (1991).
- Linn, S. & Imlay, J. A. Toxicity, mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide. J. Cell Sci. Suppl. 6, 289–301 (1987).