I am an Assistant Professor of Chemistry. My group invents and implements new technologies to obtain a comprehensive understanding of highly heterogeneous, dynamic biological systems. In particular, my group leverages expertise in drop-microfluidics, genomics, single-molecule imaging, and nanochemistry to study healthy and diseased tissues at unprecedented resolution. One of the major research areas in the Han lab is high throughput genome sequencing of singlevirions. Single virus sequencing reveals rare mutations, the reassortment/recombination state of each variant, and how mutations are grouped in each virion, thereby allows quantitative analysis on viral populations. Using our new single virus sequencing technology, we have been studying reassortment of influenza, by which the genomic materials of different influenza species are mixed upon coinfection, creating completely new influenza species. Other research directions pursued by our lab include image-based spatially resolved transcriptomics and the development of new quantum dot based imaging probes for single-molecule imaging in vivo. By extracting and integrating detailed molecular, structural and environmental information from healthy or diseased tissues, we aim to delineate molecular and cellular mechanisms underlying the function or dysfunction of tissues.
