Other Anticancer Compounds

Through our own synthesis and screening, and through work with collaborators, we have identified a multitude of other anticancer compounds. These compounds are advancing through mode-of-action studies, and through evaluation of efficacy in animal models of cancer.

Diagram showing four other anticancer compounds that we have identified.

Related Publications:

  1. Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma
    Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. M.; Riggins, G. J.; Hergenrother, P. J.
    ACS Chem. Biol. 2018,13, 3206-3216.

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  1. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
    Palchaudhuri, R.; Lambrecht, M. J.; Botham, R. C.; Partlow, K. C.; Van Ham, T. J.; Putt, K. S.; Nguyen, L. T.; Kim, S.-H.; Peterson, R. T.; Fan, T. M.; Hergenrother, P. J. 
    Cell Reports 201513, 2027-2036.

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  1. Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines
    Han, S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.
    J. Org. Chem. 201479, 473-486.

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  1. Synthesis and Anticancer Activity of all known (–)-Agelastatin Alkaloids
    Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M.
    J. Org. Chem. 201378, 11970-11984.

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  1. Synthesis of (+/-)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis
    Granger, B. A.; Jewett, I, T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E. I.; Hergenrother, P. J.; Martin, S. F.
    J. Am. Chem. Soc. 2013135, 12984-12986.

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  1. Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids
    Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M.
    Chem. Sci. 20134, 1646-1657.

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    MIT News Highlight

  1. Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins
    Risberg, K.; Guldvik, I. J.; Palchaudhuri, R.; Xi, Y.; Ju, J., Fodstad, O.; Hergenrother, P. J.; Andersson, Y. 
    J. Immunother. 201134, 438-447.

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  1. Cribostatin 6 Induces Death in Cancer Cells Through a Reactive Oxygen Species (ROS)-Mediated Mechanism
    Hoyt, M.T.; Palchaudhuri, R.; Hergenrother, P. J.
    Invest. New Drugs 201129, 562-573.

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    MDLinx Highlight

  1. A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth that Enhances Proteasome-dependent Degradation of Estrogen Receptor α
    Cherian, M. T.; Mao, C.; Aninye, I. O.; Reynolds, P. D.; Schiff, R.; Hergenrother, P. J.; Nordeen, S. K.; Wilson, E. M.; Shapiro, D. J.
    J. Biol. Chem. 2010285, 41863-41873.

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  1. Phenylcinnamides as Novel Antimitotic Agents
    Leslie, B. J.; Holaday, C. R.; Nguyen, T.; Hergenrother, P. J.
    J. Med. Chem. 201053, 3964-3972.

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  1. N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines
    Stefely, J. A.; Palchaudhuri, R.; Miller, P. A.; Peterson, R. J.; Moraski, G. C.; Hergenrother, P. J.; Miller, M. J.
    J. Med. Chem. 201053, 3389-3395.

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  1. Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Having Also Selective and Powerful Anticancer Activity
    Rosenthal, A. S.; Chen, X.; Liu, J.; West, D. C.; Hergenrother, P. J.; Shapiro, T. A; Posner, G. H.
    J. Med. Chem. 200952, 1198-1203.

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  1. Structure-Activity-Relationship of Triphenylmethylamides, Compounds that Potently Induce Apoptosis in Melanoma Cell Lines
    Palchaudhuri, R.; Hergenrother, P. J.
    Bioorg. Med. Chem. Lett. 200818, 5888-5891.

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  1. The Complex Role of the Triphenylmethyl Motif in Anti-Cancer Compounds
    Palchaudhuri, R.; Nesterenko, V.; Hergenrother, P. J.
    J. Am. Chem. Soc. 2008130, 10274-10274.

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  1. A Small Molecule, Identified as an Inhibitor of the Binding of Estrogen Receptor a to Estrogen Response Elements Blocks the Estrogen-dependent Growth of Cancer Cells
    Mao, C.; Patterson, N.; Cherian, M.; Aninye, I.; Zhang, C.; Patterson, N.; Cheng, J.; Putt; K. S.; Hergenrother, P. J.; Wilson, E.; Nordeen, S. K.; Shapiro, D. J.
    J. Biol. Chem. 2008283, 12819-12830.

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  1. Chelated Iron Sources are Inhibitors of Psudomonas aeruginosa Biofilms and Distribute Efficiently in an in vitro Model of Drug Delivery to the Human Lung
    Musk, D. J.; Hergenrother, P. J.
    J. Appl. Microbiol2008105, 380-388.

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  1. A Novel Synthetic Analogue of a Constituent of Isodon excisus Inhibits Transcription of CYP1A1, -1A2, and -1B1 by Preventing Activation of the Aryl Hydrocarbon Receptor
    Sienkiewicz, P.; Ciolino, H.; Leslie, B. J.; Hergenrother, P. J.; Singletary, K.; Yeh, G. C.
    Carcinogenesis 200728, 1052-1057.

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  1. The Compound 13-D Selectively Induces Apoptosis in White Blood Cancers Versus Other Cancer Cell Types
    Putt, K. S.; Nesterenko, V.; Dothager, R. S.; Hergenrother, P. J. 
    ChemBioChem 20067, 1916-1922.

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  1. Obtaining and screening compound collections: A user’s guide and a call to chemists
    Hergenrother, P. J.
    Curr. Opin. Chem. Biol. 200610, 213-218.

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  1. Synthesis and Identification of Small Molecules that Potently Induce Apoptosis in Melanoma Cell Through G1 Cell Cycle Arrest
    Dothager, R. S.; Putt, K. S.; Allen, B. J.; Leslie, B. J.; Nesterenko, V.; Hergenrother, P. J.
    J. Am. Chem. Soc. 2005127, 8686-8696.

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    Chemical & Engineering News Highlight

  1. Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells
    Nesterenko, V.; Putt, K. S.; Hergenrother, P. J.
    J. Am. Chem. Soc. 2003125, 14672-14673.

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    Chemical & Engineering News Highlight