Dr. Hyang Yeon Lee

Hyang Yeon received her Ph.D. in chemical biology from the laboratory of professor Seung Bum Park at Seoul National University in Korea and joined the Hergenrother lab in February 2012 as a National Research Foundation of Korea Postdoctoral associate…

In the Hergenrother laboratory, Dr. Lee has been part of the team that developed and evaluated N-hydroxyindoles(NHI) as novel lactate dehydrogenase inhibitors and potent anticancer agents.


Synthesis of fusidic acid derivatives yields a potent antibiotic with an improved resistance profile Garcia Chavez, M.; Garcia, A.; Lee, H.Y.; Lau, G.W.; Parker, E.N.; Komnick, K.E.; Hergenrother, P.J. ACS Infect. Dis. 20217, 493-505

A gram-negative antibiotic active through inhibition of an essential riboswitch
Motika, S. E.; Ulrich, R. J.; Geddes, E. J.; Lee, H. Y.; Lau, G. W.; Hergenrother, P. J.
J. Am. Chem. Soc. 2020142, 10856-10862

Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens Parker, E. N.; Drown, B. S.; Geddes, E. J.; Lee, H.Y.; Ismail, N.; Lau, G. W. and Hergenrother, P. J. Nature Microbiology 2020, 5, 67-75

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis Llabani, E.; Hicklin, R. W.; Lee, H.Y.; Motika, S. E.; Crawford, L. A.; Weerapana, E., Hergenrother, P. J. Nature Chem. 201911, 521

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer
Granchi, C.; Fortunato, S.; Meni, S.; Rizzolio, F.; Caligiuri, I.; Tuccinardi, T.; Lee, H.Y.; Hergenrother, P. J.; Minutolo, F. J. Agric. Food Chem. 2017, 65, 5639-5649.

Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death
Lee, H.-Y.; Parkinson, E. I.; Granchi, C.; Paterni, I.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P. J.
ACS Chem. Biol. 201712, 1416-1424.

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy Luu, L. M.; Nguyen, L.; Peng, S.; Lee, J.; Lee, H. Y.; Wong, C. H.; Hergenrother, P. J.; Chan, H. Y.; Zimmerman, S. C. ChemMedChem 2016, 11, 1428-1435.

Salicylketoximes that target Glucose Transporter 1 restrict energy supply to lung cancer cells
Granchi, C.; Qian, Y.; Lee, H. Y.; Paterni, I.; Pasero, C.; Legre, J.; Carlson, K. E.; Tuccinardi, T.; Chen, X.; Katzenellebogen, J. A.; Hergenrother, P. J.; Minutolo, F.
ChemMedChem 201510, 1892-1900.

Deoxynybomycins inhibit mutant DNA Gyrase and rescue mice infected with fluoroquinolone-resistant bacteria
Parkinson, E. I.; Bair, J. S.; Nakamura, B.; Lee, H. Y.; Kuttab, H. I.; Southgate, E. H.; Lezmi, S.; Lau, G. W.; Hergenrother, P. J.
Nature Comm. 20156, 6947.

Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor
Calvaresi, E. C.; Granchi, C.; Tuccinardi, T.; Bussolo, V. D.; Huigens III, R. W.; Lee, H. Y.; Palchaudhuri, R.; Macchia, M.; Martinelli, A.; Minutolo, F.; Hergenrother, P. J. 
ChemBioChem 201314,  2263-2267.

Family-Selective detection of antibiotics using antibody-functionalized carbon nanotube sensors
Kim, B.; Lim, D.; Jin, H. J.; Lee, H. Y.; Namgung, S.; Ko, Y.; Park, S. B.; Hong, S.
Sensors & Actuators B: Chemical 2012, 166-167, 193-199.

Pharmacophore-based strategy for the development of general and specific scFv biosensors for abused antibiotics 
Cha, M. Y.; Lee, H. Y.; Ko, Y.; Shim, H.; Park, S. B. 
Bioconjugate Chem201122 , 88–94.

Development of fluorescent glucose bioprobes and their application on real-time and quantitative monitoring of glucose uptake in live cells.
Lee, H. Y.; Lee, J. J.; Park, J.; Park, S. B.
Chem. Eur. J. 201117, 143–150.

Surface modification for small molecule microarray and its application for the discovery of tyrosinase inhibitor
Lee, H. Y.; Park, S. B.
Mol. Biosyst. 20117, 304–310.

Anti-diabetic and anti-obesity effects of Ampkinone, a novel small molecule activator of AMP-activated protein kinase (AMPK)
Oh, S.; Kim, S. J.; Hwang, J. H.; Lee, H. Y.; Ryu, M. J.; Park, J.; Kim, S. J.; Jo, Y. S.; Kim, Y. K.; Lee, C. H.; Kweon, K. R.; Shong, M.; Park, S. B.
J. Med. Chem. 201053, 7405–7413.

Crystal structure of Tpa1 from saccharomyces cerevisiae, a component of the messenger ribonucleoprotein complex
Kim, H. S.; Kim, H. L.; Kim, K. H.; Kim, D. J.; Lee, S. J.; Yoon, J. Y.; Yoon, H. J.; Lee, H. Y.; Park, S. B.; Kim, S.-J.; Lee, J. Y.; Suh, S. W.
Nucleic Acids Research 201038, 2099–2110.

A Two-Photon tracer for glucose uptake
Tian, Y. S.; Lee. H. Y.; Lim, C. S.; Park, J.; Kim, H. M.; Shin, Y. N.; Kim, E. S.; Jeon, H. J.; Park, S. B.; Cho, B. R.
Angew. Chem. Int. Ed. 200948, 8027–8031.

Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study
Lee, H. Y.; Kwon, J.-T.; Koh, M.; Cho, M.-H.; Park, S. B.
Bioorg. Med. Chem. Lett. 200717, 6335–6339.

A practical procedure for producing silver nanocoated fabric and its antibacterial evaluation for biomedical applications
Lee, H. Y.; Park, H. K.; Lee, Y. M.; Kim, K.; Park, S. B.
Chem. Commun. 2007, 2959–2961.

Development of novel Cy3-labeled glucose bioprobe and its application in bioimaging and screening for anticancer agents 
Lee, H. Y.; Park, J.; Cho, M.-H.; Park, S. B.
Angew. Chem. Int. Ed. 200746, 2018-2022.

Quantitative evaluation of HiCore resin for the nonspecific binding of proteins by on-bead colorimetric assay
Kim, D.-H.; Lee, H. Y.; Kim, H.; Kim, H.; Lee, Y.-S.; Park, S. B.
J. Comb. Chem. 20068, 280–285.