Dr. Ranoa received her M.Sc. in Molecular Biology and Biotechnology from the University of the Philippines–Diliman. In 2006, she moved to the United States to pursue her Ph.D. in Microbiology at the University of Illinois–Urbana-Champaign under the direction of Dr. Richard I. Tapping (Dept. of Microbiology). Her graduate studies focused on understanding the mechanisms of microbial sensing and the dynamics of interaction among members of the Toll-like receptor 2 subfamily of innate immune receptors. In 2014, she joined Dr. Ralph R. Weichselbaum’s lab at the University of Chicago Dept. of Radiation and Cellular Oncology to investigate the RNA- and DNA-mediated tumor cell intrinsic response to ionizing radiation, and to define the molecular mechanisms that promote tumor proliferation and metastasis. She joined Dr. Paul Hergenrother’s lab as a Cancer Center Illinois/IGB Fellow in November 2019.
Publications:
RIG-I-like receptor LGP2 is required for tumor control by radiation therapy
Zheng, W.; Ranoa, D.R.E.; Huang, X.; Hou, Y.; Yang, K.; Poli, E.C.; Beckett, M.A.; Fu, Y.X.; Weichselbaum, R.R.
Cancer Res. 2020 Oct 21:canres.2324.2020. doi: 10.1158/0008-5472.CAN-20-2324. Online ahead of print.PMID: 33087322
Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction
Ranoa, D.R.E.; Holland, R.L.; Alnaji, F.G.; Green, K.J.; Wang, L.; Brooke, C.B.; Burke, M.D.; Fan, T.M.; Hergenrother, P. J.
BioRxiv. June 18, 2020, doi.org/10.1101/2020.06.18.159434
Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity
Kim, S.M.; DeFazio, J.R.; Hyoju, S.K.; Sangani, K.; Keskey, R.; Krezalek, M.A.; Khodarev, N.N.; Sangwan, N.; Christley, S.; Harris, K.G.; Malik, A.; Zaborin, A.; Bouziat, R.; Ranoa, D.R.; Wiegerinck, M.; Ernest, J.D.; Shakhsheer, B.A.; Fleming, I.D.; Weichselbaum, R.R.; Antonopoulos, D.A.; Gilbert, J.A.; Barreiro, L.B.; Zaborina, O.; Jabri, B.; Alverdy, J.C.
Nat Commun. 2020;11(1):2354. doi: 10.1038/s41467-020-15545-w.
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy
Szymura, S.J.; Bernal, G.M.; Wu, L.; Zhang, Z.; Crawley, C.D.; Voce, D.J.; Campbell, P.A.; Ranoa, D.R.; Weichselbaum, R.R.; Yamini, B.
BMC Biol. 2020;18(1):32. doi: 10.1186/s12915-020-0764-z
Homeostatic roles of STING in cell growth and genomic instability
Ranoa, D.R.; Widau, R.C.; Mallon, S.; Parekh, A.D.; Huang, X.; Arina, A.; Parry, R.; Kron, S.; Khodarev, N.N.; Weichselbaum. R.R.
Cancer Res. 2019, 79, 1465-1479.
Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs
Ranoa, D.R.; Parekh, A.D.; Pitroda, S.P.; Huang, X.; Darga, T.; Wong, A.C.; Huang, L.; Andrade, J.; Staley, J.P.; Satoh, T.; Akira, S.; Weichselbaum, R.R.; Khodarev, N.N.
Oncotarget 2016, 7, 26494-26515.
Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses
Mattis, D.M.; Chervin, A.S.; Ranoa, D.R.; Kelley, S.L.; Tapping, R.I.; Kranz, D.M.
Mol. Immunol. 2015, 68, 203-212.
Human LBP and CD14 independently deliver triacylated lipoproteins to TLR1 and TLR2 and enhance formation of the ternary signaling complex
Ranoa, D.R.; Kelley, S.L.; Tapping, R.I.
J. Biol. Chem. 2013, 288, 9729-41.
Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling
Guan, Y.; Ranoa, D.R.; Jiang, S.; Mutha, S.K.; Li, X.; Baudry, J.; Tapping, R.I.
J. Immunol. 2010, 184, 5094-5103.
Sequence analysis of the Vibrio harveyi ornithine decarboxylase gene (odc) gene and detection of a gene homologue in Vibrio campbellii
Hedreyda, C.T.; Ranoa, D.R.
J. Gen. Appl. Microbiol. 2007, 53, 353-356.
Sequence Analysis of Partial toxR Gene from Philippine Vibrio Isolates and Design of toxR-targeted Primers for Detection
Ranoa, D.R.; Hedreyda, C.T.
J. Gen. Appl. Microbiol. 2005, 51, 343-351.