The DREAM (Developing Responses to Poverty through Education And Meaning) Project is a research and intervention program aimed at improving the daily lives of low-income Black mothers and daughters living in neighborhoods with high rates of poverty and crime. Our research will provide new evidence on how exposure to adverse social and environmental experiences become biologically embedded via epigenetic mechanisms to negatively affect African American women’s health and well-being. Equally important, our research will yield valuable information about the effectiveness of our program intervention, DREAM, including whether participation improves mental health and well-being and the extent to which these stress-related changes are linked with changes in epigenetic profiles.