Publications

2024
K.Y. Huang, G. Upadhyay, Y. Ahn, M. Sakakura, g.J. Pagan-Diaz, Y. Cho, A.C. Weiss, C. Huang, J.W. Mitchell, J. Li, Y. Tan, Y.H. Deng, A. Ellis-Mohr, Z. Dou, X. Zhang, S. Kang, Q. Chen, J.V. Sweedler, S.G Im, R. Bashir, H.J. Chung, G. Popescu, M.U. Gillette, M. Gazzola, H. Kong. Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle. Proc Natl Acad Sci U S A. 2024; 7:121(19): e2313590121. DOI: 10.1073/pnas.2313590121.

G. Wang, L. Li, X. Liao, S. Wang, J.W. Mitchell, C. Rabel, S. Luo, J. Shi, J.E. Sorrells, R.R. Iyer, E. Aksamitiene, C.A. Renteria, E.J. Chaney, D.J. Milner, M.B, Wheeler, M.U. Gillette, A. Schwing, J. Chen, H. Tu. Supercontinuum intrinsic fluorescence imaging heralds free view of living systems. bioRxiv [Preprint]. 2024 Feb 17:2024.01.26.577383. DOI: 10.1101/2024.01.26.577383

2023
L.J. Millet, A. Jain, M.U. Gillette. Less Is More: Oligomer Extraction and Hydrothermal Annealing Increase PDMS Adhesion Forces for Materials Studies and for Biology-Focused Microfluidic Applications. Micromachines (Basel). 2023; 14(1):214. DOI: 10.3390/mi14010214.

J.W. Mitchell, M.U. Gillette. Development of circadian neurovascular function and its implications. Front Neurosci. 2023; 17:1196606. DOI: 10.3389/fnins.2023.1196606

2022
G. Naseri Kouzehgarani, M.E. Kandel, M. Sakakura, J.S. Dupaty, G. Popescu, M.U. Gillette. Circadian Volume Changes in Hippocampal Glia Studied by Label-Free Interferometric Imaging. Cells. 2022; 11(13):2073. DOI: 10.3390/cells11132073

M.U. Gillette, J.W. Mitchell. Electrophysiology of the Suprachiasmatic Nucleus: Single-Unit Recording. Methods Mol Biol. 2022; 2482:181-189. DOI: 10.1007/978-1-0716-2249-0_12

2021
J.W. Mitchell, M.U. Gillette. 2021. Physiology of the Mammalian Circadian System. In: Principles and Practice of Sleep Medicine, 7th edition. Kryger, M.H., T. Roth, C.A. Goldstein, Eds. Elsevier. New York, NY (Chapter 36).

2020
G. Naseri Kouzehgarani, M.Y. Bothwell, M.U. Gillette. Circadian rhythm of redox state regulates membrane excitability in hippocampal CA1 neurons. Eur. J. Neurosci. Special Issue: Circadian Rhythms. 2020; 51(1): 34-46. DOI: 10.1111/ejn.14334.

C.D.Kaufman, S.C. Liu, C.S. Cvetkovic, C. Lee, G. Naseri Kouzehgarani, R. Gillette, R. Bashir, M.U. Gillette. Emergence of functional neuromuscular junctions in an engineered, multicellular spinal cord-muscle bioactuator. APL Bioeng. Special Topic Issue: Biohybrid Machines. 2020; 4(2):026104. DOI: 10.1063/1.5121440.

B.S. Kim, M.K. Kim, Y. Cho, E.E. Hamed, M.U. Gillette, H. Cha, N. Miljkovic, V.K. Aakalu, K. Kang, K.N. Son, K.M. Schachtschneider, L.B. Schook, C. Hu, G. Popescu, Y. Park, W.C. Ballance, S. Yu, S.G. Im, J. Lee, C.H. Lee, H. Kong. Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices. Sci Adv. 2020 6(42): eabc5630. DOI: 10.1126/sciadv.abc5630.

2019
P.T. Lindberg, J. W. Mitchell, P. W. Burgoon, C. Beaule, E. Weihe, M. K-H. Schaefer, L.E. Eiden, S. Z. Jiang, M.U. Gillette. Pituitary adenylate cyclase-activating peptide (PACAP)-glutamate co-transmission drives circadian phaseadvancing responses to intrinsically photosensitive retinal ganglion cell projections by suprachiasmatic nucleus. Front. Neurosci. 2019 Dec; 13: 1281. eCollection 2019. DOI: 10.3389/fnins.2019.01281.

M.E. Kandel, C. Hu, G. Naseri Kouzehgarani, E. Min, K.M. Sullivan, H. Kong, J.M. Li, D.N. Robson, M.U. Gillette, C. Best-Popescu, G. Popescu. Epi-illumination gradient light interference microscopy for imaging opaque structures. Nat. Comm. 2019 Oct 16; 10(1): 4691. DOI: 10.1038/s41467-019-12634-3.
W.C. Ballance, E.C. Qin, H.J. Chung, M.U. Gillette, H. Kong. Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases. Biomat. 2019 Oct; 217: 119292. DOI: 10.1016/j.biomaterials.2019.119292.

E.C. Qin, M.E. Kandel, E. Liamas, T.B. Shah, C. Kim, C.D. Kaufman, Z.J. Zhang, G. Popescu, M.U. Gillette, D.E. Leckband, H. Kong. Graphene oxide substrates with N-cadherin stimulates neuronal growth and intracellular transport. Acta Biomater. 2019 May; 90:412-423. DOI: 10.1016/j.actbio.2019.04.005.
C. Hu, R. Sam, M. Shan, V. Nastasa, M. Wang, T. Kim, M.U. Gillette, P. Sengupta, G. Popescu. Optical excitation and detection of neuronal activity. J. Biophotonics 2019 Mar; 12(3): e201800269. 10.1002/jbio.201800269

2018
R.D. Kamm, R. Bashir, N. Arora, R.D. Dar, M.U. Gillette, L.G. Griffith, M.L. Kemp, K. Kinlaw, M. Levin, A.C. Martin, T.C. McDevitt, R.M. Nerem, M.J. Powers, T.A. Saif, J. Sharpe, S. Takayama, S. Takeuchi, R. Weiss, K. Ye, H.G. Yevick, M.H. Zaman. Perspective: The promise of multi-cellular engineered living systems. APL Bioeng. 2018 Dec; 2(4): 040901. DOI: 10.1063/1.5038337

O.V. Cangellaris, E.A. Corbin, P. Froeter, J.A. Michaels, X. Li, M.U. Gillette. Aligning synthetic hippocampal neural circuits via self-rolled-up silicon nitride microtube arrays. ACS Appl. Mater. Interfaces 2018, 10 (42): 35705-35714. Online 9 October 2018. DOI: 10.1021/acsami.8b10233

E.K. Neumann, T.J. Comi, N.Spegazzini, J.W. Mitchell, S.S. Rubakhin, M.U. Gillette, R. Bhargava, J.V. Sweedler. Multimodal chemical analysis of the brain by high mass resolution mass spectrometry and infrared spectroscopic imaging. Anal. Chem. 2018, 90 (19): 11572-11580. Online 19 September 2018. DOI: 10.1021/acs.analchem.8b02913

N. Atkins, Jr., S. Ren, N. Hatcher, P.W. Burgoon, J.W. Mitchell, J.V. Sweedler, M.U. Gillette. Functional peptidomics: Stimulus- and time-of-day-specific peptide release in the mammalian circadian clock. ACS Chem. Neurosci. 2018, 9 (8): 2001-2008. Online 20 June 2018. DOI: 10.1021/acschemneuro.8b00089

O.V. Cangellaris & M.U. Gillette. Biomaterials for enhancing neuronal repair. Frontiers in Materials Special Issue: Biomaterials (Invited Review), 2018. 10 April 2018. DOI: doi.org/10.3389/fmats.2018.00021

M.Y. Bothwell & M.U. Gillette. Circadian redox rhythms in the regulation of neuronal excitability. Free Radical Biol. Med. Special Issue: Circadian Regulation of Metabolism, Redox Signaling and Function in Health and Disease (Invited Review), 2018, 119:45-55. On-line 2018 Feb 2. DOI: 10.1016/j.freeradbiomed.2018.01.025.

2017
Seo, Y., J. Leong, J.Y.Teo , J.W. Mitchell, M.U. Gillette, B. Han, J. Lee, H. Kong. Active antioxidizing particles for on-demand pressure-driven molecular release. ACS Appl Mater Interfaces 2017 Oct 18;9(41):35642-35650. DOI: 10.1021/acsami.7b12297. Epub 2017 Oct 9.

Wu, Q., J.L. Chu, S.S. Rubakhin, M.U. Gillette, J.V. Sweedler. Dopamine-modified TiO2 monolith-assisted LDI MS imaging: Development and application to simultaneous localization of small metabolites and large lipids in mouse brain tissue with high detection selectivity and sensitivity. Chem. Sci. 2017, 8 (5): 3926-3938. DOI: 10.1039/C7SC00937B. PMID:28553535; PMCID: PMC5433501

Zhang, D., J. Lee, M. B. Sun, Y. Pei, J. Chu, M. U. Gillette, T. M. Fan, K. A. Kilian. Combinatorial discovery of defined substrates that promote a stem cell state in malignant melanoma. ACS Cent. Sci. 2017 May 24; 3(5): 381 – 393. DOI: 10.1021/acscentsci.6b00329 PMCID: PMC5445527

Kandel, M.E., G. Naseri Kouzehgarani , T. H. Nguyen , M.U. Gillette, G. Popescu. Label-free tomographic reconstruction of optically thick structures using GLIM (Conference Proceedings). Proc. SPIE 10074, Quantitative Phase Imaging III, 1007403 (April 24, 2017) DOI:10.1117/12.2257046

2016
Ma, L., G. Rajshekhar, R. Wan, B. Bhadur, S. Sridhara, M. Mir, A. Chakraborty, R. Iyer, S. Prasanth, L. Millet, M. U. Gillette & G. Popescu. Phase correlation imaging of unlabeled cell dynamics.Sci. Rep. 2016,6:32702. DOI: 10.1038/srep32702. PMID: 27615512; PMCID: MPC5018886

Kandalepas, P.C., J.W. Mitchell, M.U. Gillette. 2016. Melatonin signal transduction pathways require E-Box mediated transcription of Per1 and Per2 to reset the SCN clock at dusk. PLoS One 2016 Jun 30; 11(6): e0157824. DOI: 10.1371/journal.pone.0157824. PMID: 27362940; PMCID: PMC4928778

2015
Lee, M.K., M.H. Rich, A. Shkumatov, J.H. Jeong, M.D. Boppart, R. Bashir, M.U. Gillette, J. Lee, H. Kong. Glacier moraine formation-mimicking colloidal particle assembly in microchanneled, bioactive hydrogel for guided vascular network construction. Adv. Healthc. Mater. 2015 Jan 28. doi: 10.1002/adhm.201400153. [Epub 2014 Jun 4.] PMID: 24898521

Jain, A., M.U. Gillette. Development of microfluidic devices for the manipulation of neuronal synapses. In, ‘Microfluidic and Compartmentalized Platforms for Neurobiological Research,’ edited by E. Biffi. Springer Protocols: Neuromethods 103 E. Biffi (ed.), New York: Springer Science + Business Media, Inc (2015); 127-137.

2014
Froeter, P., Y. Huang, O.V. Cangellaris, E.W. Dent, M.U. Gillette, J.C. Williams, X. Li. Toward intelligent synthetic neural circuits: Directing and accelerating neuron cell growth by self-rolled-up silicon nitride microtube array. ACS Nano 2014 Nov 25; 8 (11): 11108-11117. doi:10.1021/nn504876y [Epub 2104 Nov 3] PMID: 25329686 [PubMed – in process] PMCID: PMC4246008 [Available on 2015-10-20]

Gillette, M.U., T.A. Wang. Brain oscillators and redox mechanisms in mammals. Antioxidants & Redox Signaling (ARS) Forum Issue on ‘Circadian clocks and redox signaling’ A. Reddy, Ed. 2014 Feb 10; 20(17): 2955-2965.

Iyer, R., T.A. Wang, M.U. Gillette. Circadian gating of neuronal functionality: a basis for iterative metaplasticity. In, ‘Sleep and Circadian Rhythms in Plasticity and Memory,’ edited by J. Gerstner, H.C. Heller, S. Aton. Front. Syst. Neurosci. 2014 Sept 19; 8:164. 32 pgs. doi:10.3389/fnsys.2014.00164. [Epub ahead of print]

Mir, M., T. Kim, A. Majumder, M. Xiang, R. Wang, S.C. Liu, M.U. Gillette, S. Stice, and G. Popescu. Label-free characterization of self-organizing human neuronal networks. Sci. Rep. 2014; 4: 4434 (8 pg). PMCID: PMC3963031

Southey, B.R., J.E. Lee, L. Zamdborg, N. Atkins, Jr., J,W. Mitchell, M. Li, M.U. Gillette, N.L. Kelleher, J.V. Sweedler. Comparing label-free quantitative peptidomics approaches to characterize diurnal variation of peptides in the rat suprachiasmatic nucleus. Anal. Chem. 2014; 86(1): 443-452. PMCID: PMC3886391

Yang, N., S.J. Irving, E.V. Romanova, J.W. Mitchell, M.U. Gillette, J.V. Sweedler. Neuropeptidomics: the characterization of neuropeptides and hormones in the nervous and neuroendocrine systems. International Neuroendocrine Federation (INF) Masterclass Series: ‘Molecular Neuroendocrinology’ In Press.

2013
Abbott, S.M., J.M. Arnold, Q. Chang, H. Miao, N. Ota, C. Cecala, P.E. Gold, J.V. Sweedler, M.U. Gillette. Signals from the brainstem sleep/wake centers regulate behavioral timing via the circadian clock. PLoS One. 2013 Aug 12; 8(8): e70481.

Lee, J.E., L. Zamdborg, B.R. Southey, N. Atkins, Jr., J.W. Mitchell, M. Li, M.U. Gillette, N.L. Kelleher, J.V. Sweedler. Quantitative peptidomics for discovery of circadian-related peptides from the rat suprachiasmatic nucleus. J. Proteome Research. 2013. 12, 585-593.

2012
Cecala, C., S.S. Rubakhin, J.W. Mitchell, M.U. Gillette, J.V. Sweedler. A hyphenated optical trap capillary electrophoresis laser-induced native fluoresence system for single-cell chemical analysis. Analyst. (2012 April 30) epub ahead of print.

Gillette, M.U., S.M. Abbott, J.M. Arnold. Biological Timekeeping, Sleep Medical Clinics, Biology of Sleep. Guest Edited by T. Lee-Chiong. (2012 September) 7(3), 427-442.
Govindaiah, G., T. Wang, M.U. Gillette, C.L. Cox. Activity-dependent regulation of retinogeniculate signaling by metabotropic glutamate receptors. J. Neuroscience. 2012 Sep 12; 32(37): 12820-31.

Millet, L.J.and M.U. Gillette. New perspectives on neuronal development via microfluidic environments. Trends in Neuroscience. 2012 Dec; 35(12): 752-761.

Millet, L.J.and M.U. Gillette. Over a century of neuron culture: from the hanging drop to microfluidic devices. Yale Journal of Biology and Medicine. 2012 Dec; 85: 501-521.

Murphy, D., A. Konopacka, C. Hindmarch, J.F.R. Paton, J.V. Sweedler, M.U. Gillette, U. Ueta, V. Grinevich, M. Lozic, N. Japundzic-Zigon. The hypothalamic-neurohypophyseal system: from genome to physiology. J. Neuroendocrinol. (2012 April) Vol. 24, 539-553.

Wang, T.A., Y.V. Yu, G. Govindaiah, X. Ye, L. Artinian, T.P. Coleman, J.V. Sweedler, C.L. Cox, M.U. Gillette. Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons. Science. (2012 August 17) Vol. 337, 839-842. Science Express link.

Yin, P., A. Knolhoff, H.J. Rosenberg, L.J. Millet, M.U. Gillette, J.V. Sweedler. Peptidomic analyses of mouse astrocytic celllines and rat primary cultures astrocytes. J. Proteome Research. 2012, 11, 3965-3973.

2011
Mitchell J., N. Atkins, Jr., J.V. Sweedler, M.U. Gillette. Direct cellular peptidomics of hypothalamic neurons. Front. in Neuroendocrinol. (epub 2011 Feb 18); (Oct. 2011); 32(4), 377-386. doi:10.1016/j.yfrne.2011.02.005.

Shepherd, J.N. Hanson, S.T. Parker, R.F. Shepherd, M.U. Gillette, J.A. Lewis, R.G. Nuzzo.3D microperiodic hydrogel scaffolds for robust neuronal cultures. Advanced Functional Materials (2011 Jan 7); 21(9):47-54.

Wang, Z., L. Millet, V. Chan, H. Ding, M.U. Gillette, R. Bashir, G. Popescu. Label-free intracellular transport measured by spatial light interference microscopy. J. Biomed. Opt. (2011 Feb. 28); Vol. 16, 026019.

Wang, Z., D. L. Marks, P. C. Carney, L. J. Millet, M.U. Gillette, A. Mihi, P. V. Braun, Z. Shen, S. G. Prasanth, G. Popescu. Spatial light interference tomography (SLIT). Optics Express (2011 Oct. 10); Vol. 19, #21; 19907-19918.

Wang, Z., L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M.U. Gillette, G. Popescu. Spatial light interference microscopy (SLIM). Optics Express (2011 Jan 17); 19(2):1016-1026.

Wang, R., Z. Wang, J. Leigh, N. Sobh, L. Millet, M.U. Gillette, A.J. Levine, G. Popescu. One-dimensional deterministic transport in neurons measured by dispersion-relation phase spectroscopy. J. Phys.: Condens. Matter (2011 Aug 23); 374107.

Wang, R., Z. Wang, L. Millet, M.U. Gillette, A.J. Levine, G. Popescu. Dispersion-relation phase spectroscopy of intracellular transport. Optics Express (2011 Oct. 3); 19 (21):20571-20579.

2010
Atkins, N., Jr., J.W. Mitchell, E.V. Romanova, D.J. Morgan, T.P. Cominski, J.L. Ecker, J.E. Pintar, J.V. Sweedler,M.U. Gillette. Circadian integration of glutamergic signals by little SAAS in novel suprachiasmatic circuits. PLoS One (2010 Sep 7); 5(9): e12612.

Ding, H., E. Berl, Z. Wang, L.J. Millet, M.U. Gillette, J. Liu, M. Boppart, G. Popescu. Fourier transform light scattering of biological structures and dynamics. IEEE Journal of Selected Topics in Quantum Electronics (2010 July-August); 16(4): 909-918.

Ding, H., L.J. Millet, M.U. Gillette, G. Popescu. Actin-driven cell dynamics probed by Fourier transform light scattering. Biomedical Optics Express (2010 July 22); Vol. 1, Issue 1, 260-267.

Ding, H., Z. Wang, F. Nguyen, S.A. Boppart, L.J. Millet, M.U. Gillette, J. Liu, M. Boppart, G. Popescu. Fourier transform light scattering (FTLS) of cells and tissues. Journal of Computational and Theoretical Nanoscience (2010 Dec); 7: 1-11.

Govindaiah, G., T. Wang, M.U. Gillette, S.R. Crandall, C.L. Cox. Regulation of inhibitory synapses by presynaptic D4 dopamine receptors. J. Neurophysiology (2010 Nov; Epub 2010 Sep 8); 104(5):2757-65

Lee, J.E., N. Atkins, Jr., N.G. Hatcher, L. Zamdborg, M.U. Gillette, J.V. Sweedler, N.L. Kelleher. Endogenous peptide discovery of the rat circadian clock: a focused study of the suprachiasmatic nucleus by ultrahigh performance tandem mass spectrometry. Mol Cell Proteomics (2010 Feb; Epub 2009 Nov 10); 9(2):285-97.

Millet, L.J., A. Bora, J.V. Sweedler, M.U. Gillette. Direct cellular peptidomics of supraoptic magnocellular and hippocampal neurons in low-density co-cultures. ACS Chem Neuroscience (2010 Jan 20); 1(1): 36-48.

Millet, L.J., M.E. Stewart, R.G. Nuzzo, M.U. Gillette. Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices. Lab on a Chip (2010 Jun 21; Epub 2010 Apr 1); 10(12):1525-35.

Wang, Z., I.S. Chun, X Li, Z.Y. Ong, E. Pop, L.J. Millet, M.U. Gillette, G. Popescu. Topography and refractometry of nanostructures using spatial light interference microscopy. Optics Letters (2010 Jan 15; doi: 10.1364/OL.35.000208); 35(2): 208-210.

2009
Beaulé C, J.W. Mitchell , P.T. Lindberg , R. Damadzic, L.E. Eiden, M.U. Gillette. Temporally restricted role of retinal PACAP: integration of the phase-advancing light signal to the SCN. J Biol Rhythms (2009 Apr); 24(2):126-34.

Gillette, M.U., S.M. Abbott. Biological Timekeeping. Sleep Med. Clin. (2009 June 1); 4(2):99-110.

Gillette, M.U., S-H Tyan. Circadian Gene Expression in the Suprachiasmatic Nucleus. Encyclopedia of Neuroscience (2009) 2:901-908.

Hanson, J.N., M.J. Motola, M.L. Heien, J.W. Mitchell, M.U. Gillette, J.V. Sweedler, R.G. Nuzzo. Textural guidance cues for controlling process outgrowth of mammalian neurons. Lab on a Chip (2009 Jan 7; Epub 2008 Oct 21);9(1):122-31.

2008
Bora, A., S. Annangudi, L. Millet, S Rubakhin, A. Forbes, N. Kelleher, M. Gillette, J. Sweedler. Neuropeptidomics of the rat supraoptic nucleus. Journal of Proteome Research. (2008 Nov; Epub 2008 Sep 25);7(11):4992-5003.

Gillette, M.U. Biological Rhythms and Sleep in Encyclopedia of Neuroscience. M.D. Binder, N. Hirokawa, U. Windhorst (eds), Springer-Verlag GmbH Berlin Heidelberg. (2008); DOI 10. 1007/978-3-540-29678-2_642.

Hatcher, N.G., N. Atkins Jr., S.P. Annangudi, A.J. Forbes, N.L. Kelleher, M.U. Gillette, J.V. Sweedler. Mass spectrometry-based discovery of circadian peptides. Proc. Natl. Acad. Sci. U.S.A. (2008 Aug 26; Epub 2008 Aug 21); 105(34):12527-12532.

Wang Z., L.J. Millet, M.U. Gillette, G. Popescu. Jones phase microscopy of transparent and anisotropic samples. Opt. Lett. (2008 June 1); 33(1):1270-1272. (Selected for the August 1, 2008 issue of ‘Virtual Journal of Biological Physics Research’, an edited compilation of links to articles covering a focused area of frontier research published by the American Physical Society and the American Institute of Physics.)

2007
Millet, L.J., M.E. Stewart, J.V. Sweedler, R.G. Nuzzo, M.U. Gillette. Microfluidic devices for culturing primary mammalian neurons at low densities. Lab on a Chip (2007 Aug); 7(8):987-994.

2005
Buchanan, G.F. and M.U. Gillette. New light on an old paradox: site-dependent effects of carbachol on circadian rhythms, Experimental Neurology (2005 June); 193:489-96.

Gillette, M.U. and S.M. Abbott. Fundamentals of the circadian system in: Basics of Sleep Guide, M. Opp (ed.), Sleep Research Society (2005); 131-138.

Gillette, M.U. and S.M. Abbott. Basic mechanisms of circadian rhythms and their relation to the sleep/wake cycle in: Neuroendocrine Correlates of Sleep/Wakefulness, S. R. Pandi-Perumal and D. P. Cardinali (eds.), Springer Science+Business Media, Inc. (2005); 19-40.

Gillette, M.U. and T. Sejnowski. Biological clocks coordinately keep life on time, Science (2005 Aug 19); 309:1196-1198.

Tischkau, S.A. and M.U. Gillette. Oligodeoxynucleotide methods for analyzing the circadian clock in the suprachiasmatic nucleus, in: Methods in Enzymology: Circadian Rhythms, M.W. Young (ed.), Elsevier, Inc. (2005); 393:593-610.

2004
Burgoon, P.W., P.T. Lindberg, and M.U. Gillette. Different patterns of circadian oscillation in the suprachiasmatic nucleus of hamster, mouse, and rat, J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2004 Feb; Epub 2004 Jan 9); 190:167-171.

Gerdin, M.J., M.I. Masana, M.A. Rivera-Bermudez, R.L. Hudson, D.J. Earnest, M.U. Gillette, and M.L. Dubocovich. Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: Relevance for defining periods of sensitivity of the mammalian circadian clock to melatonin, FASEB Journal (2004 Nov); 18:1646-1656.
Gillette, M.U. Does the SCN regulate more than sleep timing?, Sleep (2004 Nov 1); 27:1240-1241.

Tischkau S.A., J.W. Mitchell, L.A. Pace, J.W. Barnes, J.A. Barnes, and M.U. Gillette. Protein kinase G type II is required for night-to-day progression of the mammalian circadian clock, Neuron (2004 Aug 19); 43:539-549.

Turek, F.W. and M.U. Gillette. Melatonin, sleep, and circadian rhythms: Rationale for development of specific melatonin agonists, Sleep Medicine (2004 Nov); 5:523-532.

2003
Barnes, J.W., S.A. Tischkau, J.A. Barnes, J.W. Mitchell, P.W. Burgoon, J. Hickok, and M.U. Gillette. Requirement of mammalian Timeless for circadian rhythmicity, Science (2003 Oct 17); 302:439-442. [supplement]

Tischkau, S.A., J.W. Mitchell, S.H. Tyan, G.F. Buchanan, and M.U. Gillette. Ca2+ / cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock, Journal of Biological Chemistry (2003 Jan 10; Epub 2002 Oct 29); 278:718-723

Tischkau, S.A., E.T. Weber, S.M. Abbott, J.W. Mitchell, and M.U. Gillette. Circadian clock-controlled regulation of cGMP-Protein kinase G in the nocturnal domain, Journal of Neuroscience (2003 Aug 20); 20:7543-7550.

2002
Gillette, M.U. and J.W. Mitchell. Signaling in the suprachiasmatic nucleus: selectively responsive and integrative, Cell and Tissue Research (2002 July); 309:99-107.

Hurst, W.J., D. Earnest, and M.U. Gillette. Immortalized suprachiasmatic nucleus cells express components of multiple circadian regulatory pathways, Biochemical and Biophysical Research Communications (2002 Oct 18); 292:20-30.

Hurst, W.J., J.W. Mitchell, and M.U. Gillette. Synchronization and phase-resetting by glutamate of an immortalized SCN cell line, Biochemical and Biophysical Research Communications (2002 Mar 22); 298:133-143.

2001
Artinian, L.R, Ding, J.M., and Gillette, M.U. Carbon monoxide and nitric oxide: Interacting messengers in muscarinic signaling to the brain’s circadian clock, Experimental Neurology (2001 Oct); 171:293-300.

Gillette, M.U., G.F. Buchanan, L. Artinian, S.E. Hamilton, N.M. Nathanson, and C. Liu. Role of the M1 receptor in regulating circadian rhythms, Life Sciences (2001 April 27); 68:2467-2472.

Hunt, A.E., W.M. Al-Ghoul, M.U. Gillette, and M.L. Dubocovich. Activation of MT2 melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock, Am J Physiol Cell Physiol (2001 Jan); 280:C110-C118.

2000
Gillette, M.U. Cellular regulators of circadian timing in: The Regulation of Sleep, A.A. Borbely, O. Hayaishi, T. Sejnowski, J. Altman (eds.), Human Frontier Science Program 10th Anniversary Workshop (VIII), (2000 April); 203-212.

Tischkau, S.A., E.A. Gallman, G.F. Buchanan, and M.U. Gillette. Differential cAMP gating of glutamatergic signaling regulates long-term state changes in the suprachiasmatic circadian clock, Journal of Neuroscience (2000 Oct 15); 20:7830-7837.

1999
Chen, D., G.F. Buchanan, J.M. Ding, J. Hannibal, and M.U. Gillette. Pituitary adenylyl cyclase-activating peptide: a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock, Proceedings of the National Academy of Sciences of the United States of America (1999 Nov 9); 96:13468-13473.

Gillette, M.U., T. Roth, and J.P. Kiley. NIH funding of sleep research: a prospective and retrospective view, Sleep (1999 Nov 1); 22:956-958.

Gillette, M.U. and S.A. Tischkau. Suprachiasmatic nucleus: the brain�s circadian clock in: Recent Progress in Hormone Research (1999); 54:33-59.

Hurst, W.J., L.L. Moroz, M.U. Gillette, and R. Gillette. Nitric oxide synthase immunolabeling in the molluscan CNS and peripheral tissues, Biochemical and Biophysical Research Communications (1999 Aug 27); 262:545-548.

Tischkau, S.A., J.A. Barnes, F.-J. Lin, E. M. Myers, J.W. Barnes, E.L. Meyer-Bernstein, W.J. Hurst, P.W. Burgoon, D. Chen, A. Sehgal, and M.U. Gillette. Oscillation and light induction of timeless mRNA in the mammalian circadian clock, Journal of Neuroscience (1999 June 15); 19:RC15, 1-6.

1998
Ding, J.M., G.F. Buchanan, S.A. Tischkau, D. Chen, L. Kuriaskina, L.E. Faiman, J.M. Alster, P.S. McPherson, K.P. Campbell, and M.U. Gillette. A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock, Nature (1998 July 23); 394:381-384.

Gillette, M.U. The Neuroethology of time: regulation of the brain�s circadian clock, in: New Neuroethology on the Move, Proceedings of the 26th Göttingen Neurobiology Conference, R. Wehner and N. Elsner (eds.), G.R. Verlag, Stuttgart (1998); 105-125.

Hannibal, J., J.M. Ding, D. Chen, J. Fahrenkrug, P.J. Larsen, M.U. Gillette, and J.D. Mikkelsen. Pituitary adenylate cyclase activating peptide (PACAP) in the retinohypothalamic tract: a daytime regulator of the biological clock, Annals New York Academy of Sciences (1998 Dec 11); 865:197-206.

Mikkelsen, J.D., J. Hannibal, J. Fahrenkrug, P.J. Larsen, D. Chen, J.M. Ding, and M.U. Gillette. Pituitary adenylate cyclase activating peptide (PACAP) in the retinohypothalamic tract phase shifts the circadian clock in: Biological clocks: mechanisms and applications, Y. Touitou (ed.), Elsevier Science, Amsterdam, (1998) 93-95.

1997
Chen, D., W.J. Hurst, J.M. Ding, L.E. Faiman, B. Mayer, and M.U. Gillette. Localization and characterization of nitric oxide synthase in the rat suprachiasmatic nucleus: evidence for a nitrergic plexus in the biological clock, Journal of Neurochemistry (1997 Feb); 68:855-861.

Ding, J.M., L.E. Faiman, W.J. Hurst, L.R. Kuriashkina, and M.U. Gillette. Resetting the biological clock: mediation of nocturnal CREB phosphorylation via light, glutamate, and nitric oxide, Journal of Neuroscience (1997 Jan 15); 17:667-675.

Gillette, M.U. Cellular and biochemical mechanisms underlying circadian rhythms in vertebrates, Current Opinion in Neurobiology (1997 Dec); 7:797-804.

Hannibal, J., J.M. Ding, D. Chen, J. Fahrenkrug, P.J. Larsen, M.U. Gillette, and J.D. Mikkelsen. Pituitary adenylate cyclase-activating peptide (PACAP) in the retinohypothalamic tract: a potential daytime regulator of the biological clock, Journal of Neuroscience (1997 April 1); 17:2637-2644.

Liu, C., J.M. Ding, L.E. Faiman, and M.U. Gillette. Coupling of muscarinic cholinergic receptors and cGMP in nocturnal regulation of the suprachiasmatic circadian clock, Journal of Neuroscience (1997 Jan 15); 17:659-666.

McArthur, A. J., A.E. Hunt, and M.U. Gillette. Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn, Endocrinology (1997 Feb); 138:627-634.

1996
Gillette, M.U. Regulation of entrainment pathways by the suprachiasmatic circadian clock: sensitivities to second messengers, Progress in Brain Research (1996); 111:121-132.

Gillette, M.U. and A.J. McArthur. Circadian actions of melatonin at the suprachiasmatic nucleus, Behavioural Brain Research (1996); 73:135-139.

Liu, C. and M.U. Gillette. Cholinergic regulation of the suprachiasmatic nucleus circadian rhythm via a muscarinic mechanism at night, Journal of Neuroscience (1996 Jan 15);16:744-751.

Moroz, L.L., D. Chen, M.U. Gillette, and R. Gillette. Nitric oxide synthase activity in the molluscan CNS, Journal of Neurochemistry (1996 Feb); 66:873-876.

Tcheng, T.K. and M.U. Gillette. A novel carbon fiber bundle microelectrode and modified brain slice chamber for recording long-term multiunit activity from brain slices, Journal of Neuroscience Methods(1996 Nov); 69:163-169.

1995
Gillette, M.U., M. Medanic, A.J. McArthur, C. Liu, J.M. Ding, L.E. Faiman, E.T. Weber, T.K. Tcheng, and E.A. Gallman. Intrinsic neuronal rhythms in the suprachiasmatic nuclei and their adjustment, Ciba Foundation Symposium (1995); 183:134-153.

Weber, E. T., R.L. Gannon, A.M. Michel, M.U. Gillette, and M.A. Rea. Nitric oxide synthase inhibitor blocks light-induced phase shifts of the circadian activity rhythm, but not c-fos expression in the suprachiasmatic nucleus of the Syrian hamster, Brain Research (1995 Sep 18); 692:137-142.

1994
Ding, J. M., D. Chen, E.T. Weber, L.E. Faiman, M.A. Rea, and M.U. Gillette. Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO, Science (1994 Dec 9); 266:1713-1717.

1993
Gillette, M.U., S.J. DeMarco, J.M. Ding, E.A. Gallman, L.E. Faiman, C. Liu, A.J. McArthur, M. Medanic, D. Richard, T.K. Tcheng, and E.T. Weber. The organization of the suprachiasmatic circadian pacemaker of the rat and its regulation by neurotransmitters and modulators, Journal of Biological Rhythms (1993); 8:S53-S58.

Medanic, M. and M.U. Gillette. Suprachiasmatic circadian pacemaker of rat shows two windows of sensitivity to neuropeptide Y in vitro, Brain Research (1993 Aug 27); 620:281-286.

Satinoff, E., H. Li, T.K. Tcheng, C. Liu, A.J. McArthur, M. Medanic, and M.U. Gillette. Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones? American Journal of Physiology (1993 Nov); 265:R1216-R1222.

1992
Medanic, M. and M.U. Gillette. Serotonin regulates the phase of the rat suprachiasmatic circadian pacemaker in vitro only during the subjective day, Journal of Physiology(1992 May); 450:629-642.

1991
Gillette, M.U. Intrinsic SCN rhythms, in: Suprachiasmatic Nucleus: The Mind’s Clock, D.C. Klein, R.Y. Moore, and S.M. Reppert (eds.), Oxford University Press, New York (1991); 121-123.

Gillette, M.U. SCN electrophysiology in vitro: Rhythmic activity and endogenous clock properties, in: Suprachiasmatic Nucleus: The Mind’s Clock, D.C. Klein, R.Y. Moore, and S.M. Reppert (eds.), Oxford University Press, New York (1991); 125-143.

McArthur, A.J., M.U. Gillette, and R.A. Prosser. Melatonin directly resets the rat suprachiasmatic circadian clock in vitro, Brain Research (1991 Nov 22); 565:158-161.

Prosser, R.A. and M.U. Gillette. Cyclic changes in cAMP concentration and phosphodiesterase activity in a mammalian circadian clock studied in vitro, Brain Research(1991 Dec 24); 568:185-192.

1990
Gillette, R., M. U. Gillette, L. E. Lipeski, and J. M. Connor. pH-sensitive, Ca2+/calmodulin-dependent phosphorylation of unique protein in molluscan nervous system, Biochimica et Biophysica Acta (1990 Dec 6); 1036:207-212.

1989
Gillette, R., M.U. Gillette, D.J. Green, and R.-C. Huang. The neuromodulatory response: Integrating second messenger pathways, American Zoologist (1989); 29:1275-1286.

Prosser, R.A. and M.U. Gillette. The mammalian circadian clock in the suprachiasmatic nuclei is reset in vitro by cAMP, Journal of Neuroscience (1989 March); 9:1073-1081.

Prosser, R.A., A.J. McArthur, and M.U. Gillette. cGMP induces phase shifts of a mammalian circadian pacemaker at night, in antiphase to cAMP effects, Proceedings of the National Academy of Sciences of the United States of America(1989 Sep); 86:6812-6815.

1988
Gillette, M.U. and R.A. Prosser. Circadian rhythm of the rat suprachiasmatic brain slice is rapidly reset by daytime application of cAMP analogs, Brain Research (1988 Dec 6); 474:348-352.

1987
Gillette, M.U. and S.M. Reppert. The hypothalamic suprachiasmatic nuclei: circadian patterns of vasopressin secretion and neuronal activity in vitro, Brain Research Bulletin (1987 July); 19:135-139.

1986
Gillette, M.U. The suprachiasmatic nuclei: circadian phase-shifts induced at the time of hypothalamic slice preparation are preserved in vitro, Brain Research(1986 July 30); 379:176-181.

1985
Gillette, M.U. Preparation of brain slices from the suprachiasmatic nuclei of rat can reset the circadian clock, J Physiol (1985 July 11); 369 (Suppl):55P.

1984
Gillette, M.L. Stimulation of chemosensory pathways and intracellular alkalinization mimic cAMP activation of endogenous bursting in feeding command neurones, Journal of Experimental Biology (1984 July); 111:239-245.

1983
Gillette, M.U. and R. Gillette. Bursting neurons command consummatory feeding behavior and coordinated visceral receptivity in the predatory mollusk Pleurobranchaea, Journal of Neuroscience (1983 Sep); 3:1791-1806.

1982
Gillette, R., M.U. Gillette and W.J. Davis. Substrates of command ability in a buccal neuron of Pleurobranchaea. II. Potential role of cyclic AMP, Journal of Comparative Physiology (1982); 146:461-470.

Gillette, R., M.U. Gillette and W.J. Davis. Substrates of command ability in a buccal neuron of Pleurobranchaea. I. Mechanisms of action potential broadening, Journal of Comparative Physiology (1982); 146:449-459.

1980
Gillette, R., M.U. Gillette, and W.J. Davis. Action-potential broadening and endogenously sustained bursting are substrates of command ability in a feeding neuron of Pleurobranchaea, Journal of Neurophysiology (1980 March); 43:669-685.

1976
Gillette, M.L.U. The role of the cell surface in aggregation of the cellular slime molds Dictyostelium discoideum and D. mucoroides: Morphological and biochemical studies using Concanavalin A, Ph.D Thesis, University of Toronto. (This file is over 8MB in size.) (1976 June 4).

1975
Filosa, M.F., S.G. Kent, and M.U. Gillette. The developmental capacity of various stages of a macrocyst-forming strain of the cellular slime mold, Dictyostelium mucoroides, Developmental Biology (1975 Sep); 46:49-55.

1974
Gillette, M.U., R.E. Dengler, and M.F. Filosa. Localization and fate of Concanavalin A in amoebae of the cellular slime mold, Dictyostelium discoideum, Journal of Experimental Zoology (1974 Nov); 190:243-248.

1973
Gillette, M.U. and M.F. Filosa. Effect of Concanavalin A on cellular slime mold development: Premature appearance of membrane-bound cyclic AMP phosphodiesterase, Biochemical and Biophysical Research Communications (1973 Aug 21); 53:1159-1166.

1972
Hadfield, M.G., E.A. Kay, M.U. Gillette, and M.C. Lloyd. The Vermetidae (Mollusca: Gastropoda) of the Hawaiian Islands, Marine Biology (1972); 12:81-98.

1969
Gillette, M.U. Studies on Crucibulum spinosum (Sowerby), Proc. Malacol. Soc. (London) (1969); 38:431-438.