Latest News
12/19/2017: Congratulations to Imoukhuede Lab alum: Dr. Weddell, doctoral candidate: Si Chen, and PI: Dr. Princess Imoukhuede on the publication of the manuscript VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways in npj Systems Biology and Applications!
In this article, we study the key proteins that direct blood vessel formation: vascular endothelial growth factor receptors (VEGFRs). Researchers often seek to block VEGFR signaling for cancer therapy and conversely, researchers seek to enhance VEGFR signaling for cardiovascular disease treatment. So, understanding VEGFR signaling would offer new approaches for treating these and several other diseases.
Here we demonstrate that two important cell functions: cell growth (proliferation) and cell movement (migration) can be predicted based on the proteins that interact with VEGFRs. We also developed a mechanism for accurately predicting how drugs would manipulate these cell functions.
Some describe cell function as a “black box,” where the signal goes in and cells respond. By developing mechanisms for predicting how cells respond to signals—we show that the fundamental principles of engineering with mathematics and computation can provide never-before seen insight into biology.
Moreover, by specifically showing that we can predict signaling through the VEGFRs, we are advancing new tools that can be used in designing drugs to treat these diseases. Our future goal is to extend this approach we have established to determine how cancer cells respond to VEGFR signals.
12/07/17: Dr. Princess Imoukhuede gives a talk titled, Growth Factor Receptor Signaling and Cancer: New Mechanisms and Insights, at the Cancer Center Faculty Seminar, University of Illinois (Urbana, IL).
11/27/17: Congratulations to Imoukhuede Lab doctoral student: Spencer Mamer; doctoral candidate: Si Chen; alums: Dr. Jared Weddell, Alexandra Palsz, Ashley Wittenkeller, and Manu Kumar; and PI: Dr. Princess Imoukhuede the publication of the article: Discovery of High Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics in Nature’s Scientific Reports!
The discovery of new, strong interactions across the VEGF and PDGF families (cross-talk), represents a significant advance to the angiogenesis field. Indeed, nearly all studies of angiogenesis have focused on uni-axis ligand-receptor binding: VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. However, my research team recently measured extracellular cross-talk between the VEGF—PDGFR families, by identifying that VEGF-A165, acts independently of VEGFRs to modulate PDGFR concentrations on fibroblasts [Chen et al (2014) Cell Mol Bioeng].
To date there are very few publications exploring VEGF-PDGF cross-talk: the kinetics of the VEGF-PDGFR binding are unknown, and no studies explored the possibility of PDGF–VEGFR binding. So today’s publication addresses this unmet need. We report for the first-time, PDGF—VEGFR binding. We measured high-affinity binding between VEGF—PDGFR and PDGF—VEGFR. We also established a rigorous standard for identifying true binding interactions, which we and others can apply to identify and measure other possible interactions. The discovery and measurement of these interactions presents an expanded role of growth factor signaling with significance across cell signaling and angiogenesis-dependent disease (e.g., cancer, cardiovascular, diabetes, obesity, and others).
11/14/17: Congratulations to Imoukhuede Lab doctoral student: Spencer Mamer; doctoral candidate: Si Chen; alums: Dr. Jared Weddell, Alexandra Palsz, Ashley Wittenkeller, and Manu Kumar; and PI: Dr. Princess Imoukhuede on the acceptance of the article: Discovery of High Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics in Nature’s Scientific Reports!!
11/07/17: Congratulations to Imoukhuede Lab alum: Dr. Weddell, doctoral candidate: Si Chen, and PI: Dr. Princess Imoukhuede on the acceptance of the manuscript VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways to npj Systems Biology and Applications.
10/17/17: Dr. Princess Imoukhuede gives a talk titled, Design of BIOE201: Conservation Principles in Bioengineering, at the Teaching Computation in the Sciences Using MATLAB Workshop at Carleton College (Northfield, MN).
10/14/17: Imoukhuede Lab REU student Amanda Craine presents a poster titled, Quantification of Angiogenic Receptors on Circulating Endothelial Cells at the Biomedical Engineering Society Annual Meeting (Phoenix, AZ).
10/14/17: Dr. Princess Imoukhuede co-chairs a session on Analysis of Cell Signaling, which is part of the Bioinformatics, Computational, and Systems Biology Track at the Biomedical Engineering Society Annual Meeting (Phoenix, AZ).
10/13/17: Imoukhuede Lab doctoral candidate, Si Chen gives a talk titled, Multiplexed Quantification of Angiogenic Receptors via qFlow Cytometry and Qdot-nanosensors, at the Biomedical Engineering Society Annual Meeting (Phoenix, AZ).
08/16/17: Dr. Princess Imoukhuede’s research is featured in a People Behind the Science Podcast, titled: Making Sense of the Signaling Networks that Stimulate Blood Vessel Formation.
07/31/17: Dr. Princess Imoukhuede gives a talk titled, Predicting new targets for inducing sprouting angiogenesis via systems biology, at an American Heart Association (AHA)–Davie Foundation Progress Meeting (Chicago, IL).
07/27/17: Dr. Princess Imoukhuede gives a talk titled, Quantitative + Computational Biology of Angiogenesis, at the North American Vascular Biology Organization (NAVBO) VASCULATA, University of Illinois at Chicago (Chicago, IL).
07/25/17: Dr. Princess Imoukhuede gives a talk titled, …but PDGFs are Supposed to Bind to PDGFRs, at the Gordon Research Conference (GRC): Biomaterials & Tissue Engineering (Holderness, NH).
08/07/17: Imoukhuede Lab REU student Amanda Craine and her research mentor, doctoral student, Yingye Fang and are featured in an Illinois story on undergraduate research.
04/29/17: Imoukhuede Lab doctoral student, Yingye “Cheri” Fang, presents a poster titled, Quantification of VEGF Receptors on Circulating Endothelial Cells at the 1st Annual Bioengineering Graduate Student Symposium (Urbana, IL).
04/25/17: Dr. Princess Imoukhuede gives a talk titled, Understanding growth factors and receptors in tumor angiogenesis through systems biology at the 3rd Annual Midwest Tumor Microenvironment Meeting at Washington University School of Medicine (St. Louis, MO).
04/25/17: Congratulations to Imoukhuede Lab doctoral student: Spencer Mamer; our collaborators:Jamila Hedhli et al; and Dr. Princess Imoukhuede on the acceptance of the manuscript, Synthesis, Chemical Characterization and Biological Evaluation of Novel Dimeric-cRGD Peptide for Targeted Imaging of Integrin Activity in Nature’s Scientific Reports!!
04/24/17: Congratulations to Dr. Princess Imoukhuede on receiving the Rose Award for Teaching Excellence, presented by the University of Illinois at Urbana Champaign College of Engineering (Urbana, IL).
04/24/17: Imoukhuede Lab doctoral student, Si Chen presents a poster titled, “Multiplexed quantification of angiogenic receptors on endothelial cells and glioblastoma xenografts via qFlow cytometry and Qdot-nanosensors” at the 3rd Annual Midwest Tumor Microenvironment Meeting at Washington University School of Medicine (St. Louis, MO).
04/12/17: Congratulations to Imoukhuede Lab graduate, Dr. Weddell on the publication of his first-author manuscript, titled, Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling in Integrative Biology.
This work progresses our larger goals of understanding blood vessel development. Here, we identify a hierarchy in the signaling of several commonly studied proteins. We also identify the main locations that these proteins “hang-out/reside” on cells when they are signaling. This new understanding of protein signaling and protein residence will help us and others better target these proteins to control blood vessel development.
03/28/17: Congratulations to Imoukhuede Lab doctoral student, Ali Ansari on receiving a Travel Award from the University of Illinois at Urbana Champaign Graduate College to attend the Gordon Research Conference on Biomaterials.
02/21/17: Dr. Princess Imoukhuede gives a qB3 seminar, titled, “Peering into the ‘black-box’ of protein signaling: quantifying protein-protein interaction kinetics and protein concentrations to computationally predict cell response” at the University of California at Berkeley (Berkeley, CA).
02/21/17: Congratulations to Dr. Princess Imoukhuede on receiving an NSF CAREER Award. “The Faculty Early Career Development (CAREER) Program is the National Science Foundation’s most prestigious awards in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization.”
02/06/17: Dr. Princess Imoukhuede serves as a discussion leader and presents a poster, titled, “What’s in a name? Would a growth factor by any other name bind VEGFRs just as strongly?” at the Gordon Research Conference Physical Sciences of Cancer (Galveston, TX).
01/24/17: Dr. Princess Imoukhuede gives a Clinical Pharmacology Grand Rounds seminar, titled, “Predicting VEGFR-mediated cell response via protein-protein interaction kinetics and concentrations” in at Vanderbilt University (Nashville, TX).
2016
12/15/16: Imoukhuede Lab Doctoral Student, Ali Ansari presents a poster, titled, “Enabling gentle and rapid spiral microfluidic-based cell isolation via flow rate, antibody, and buffer optimization” at the IEEE Engineering in Medicine and Biology Society (EMBS) Micro and Nanotechnology in Medicine Conference (Waikoloa, HI).
12/10/16: Today Dr. Jared Weddell will receive his doctoral hood. Dr. Weddell is the first person to earn a PhD from the Imoukhuede Lab
12/09/16: Dr. Princess Imoukhuede gives a talk at Columbia University, titled, “Predicting Angiogenic Cell Response by Merging Quantitative Experimental Biology and Computational Biology,” (New York, NY).
11/16/16: Imoukhuede Lab Doctoral Student, Ali Ansari, gives a talk, titled, “Gentle Cell Capture and Release: PLL Stabilization of the Secondary Anchor Targeted Cell Release System” at the American Institute of Chemical Engineers (AIChE) Annual Meeting (San Francisco, CA).
11/15/16: Imoukhuede Lab Doctoral Candidate, Jared Weddell, gives a talk, titled, “VEGFR1 Mediates Cell Migration through Activation of PI3K and PLCɣ” at the American Institute of Chemical Engineers (AIChE) Annual Meeting (San Francisco, CA).
11/14/16: Imoukhuede Lab Doctoral Candidate, Jared Weddell, presents a poster, titled, “Integrative Meta-Modeling Ranks RTK Signaling and Identifies Connection Between Nuclear Translocation and Extracellular Ligand Concentrations” at the American Institute of Chemical Engineers (AIChE) Annual Meeting (San Francisco, CA).
11/10/16: Congratulations to Dr. Jared Weddell on successfully defending his thesis (Urbana, IL).
11/07/16: Dr. Princess Imoukhuede gives a talk at the NIH-NIDDK: Network of Minority Health Research Investigators Midwest Regional Meeting, Case Western Reserve University, titled, “Merging Quantitative Experimental Biology and Computational Biology to Control Angiogenesis“ (Cleveland, OH).
11/04/16: Dr. Princess Imoukhuede serves on the Tenure Track Panel at the BMES Midwest Regional Conference (Champaign, IL).
11/04/16: Imoukhuede Lab Doctoral Student, Yingye Fang, presents a poster, titled, “Identifying Patient Responsiveness to Anti-Angiogenic Drug Through Angiogenic Biomarker Quantification” at the BMES Midwest Regional Conference (Champaign, IL).
11/01/16: Dr. Princess Imoukhuede presents a poster, titled, “Enabling multiplexed single-cell mapping of receptors via quantum dot (QD) nanosensors” at the International Vascular Biology Meeting (Boston, MA).
10/31/16: Dr. Princess Imoukhuede presents a poster, titled, “VEGF-A splice variants bind VEGFR1 and VEGFR2 with differential affinities” at the International Vascular Biology Meeting (Boston, MA).
10/24/16: Dr. Princess Imoukhuede serves as a Working Group Leader at the Teaching Computation in the Sciences Using MATLAB Workshop.
10/22/16: Imoukhuede Lab Doctoral Student, Si Chen, presents a lightning talk, titled, “Quantum dot-enabled Quantitative Single-cell Proteomics” at the 4th Midwest Quantitative Biology Symposium (Indianapolis, IN).
10/07/16: Dr. Princess Imoukhuede gives a talk at the Biomedical Engineering Society Annual Meeting, Computational Modeling in Cardiovascular Systems Session (Minneapolis, MN).
Title: Quantitative + Computational Biology: Towards Directed Control of Neovascularization
Time: 8:00-9:00 AM
Location: Room 101B
10/06/16: Imoukhuede Lab undergraduate researchers, Jacob Erstling and Dipen Kumar present posters at the Biomedical Engineering Society Annual Meeting (Minneapolis, MN)
10/07/16: Imoukhuede Lab Doctoral Candidate, Jared Weddell gives a talk at the Biomedical Engineering Society Annual Meeting (Minneapolis, MN).
Title: PI3K and PLClgamma Pathways Regulate VEGF-A–VEGFR1-Mediated Cell Migration
Time: 8:45-9:00 AM
Location: Room 200J
10/06/16: Imoukhuede Lab Doctoral Candidate, Jared Weddell presents a poster at the Biomedical Engineering Society Annual Meeting (Minneapolis, MN)
Title: Meta-Modeling Reveals that Tyrosine Kinase Receptor Signaling is Primarily Directed by Endocytic Vesicles, Late Endosome, and the Nucleus
Time: 9:30-5:00 pm
Location: Exhibit Hall BC
Poster #: P-Fri-93
10/05/16: Imoukhuede Lab Doctoral Student, Ali Ansari presents a poster at the Biomedical Engineering Society Annual Meeting (Minneapolis, MN)
Title: Towards fast & gentle cell isolation: integrating microfluidics & Secondary Anchor Targeted Cell Release (Minneapolis, MN)
Time: 9:30-5:00 pm
Location: Exhibit Hall BC
Poster Number: P-Th-464
10/05/16: Imoukhuede Lab Doctoral Student, Spencer Mamer presents a poster at the Biomedical Engineering Society Annual Meeting (Minneapolis, MN)
Title: Pro- and Anti-angiogenic VEGF-A Splice Variants Bind VEGFRs with Differential Affinities
Time: 9:30-5:00 pm
Location: Exhibit Hall BC
Poster Number: P-Th-310
10/05/16: Imoukhuede Lab Doctoral Student, Si Chen gives a talk at the Biomedical Engineering Society Annual Meeting (Minneapolis, MN)
Title: Enabling Multiplexed Single-cell Measurement of Angiogenic Receptors via Quantum dot (QD) Nanosensors: A High-throughput Quantification Approach
Time: 9:00-9:15 AM
Location: Room 101B
09/20/16: Congratulations to Imoukhuede Lab doctoral student: Ali Ansari; undergraduate researchers: Reema Patel, Kinsey Schultheis, and Vesna Naumovski; and PI: Dr. Princess Imoukhuede on the publication of the article, “A Method of Targeted Cell Isolation via Glass Surface Functionalization” in the Journal of Visualized Experiments (JoVE). This is an inaugural article in JoVE’s new “Cancer Research” specialty.
08/31/16: Congratulations to Dr. Princess Imoukhuede (Co-PI) and collaborators, Drs Jenny Amos (PI), Kelly Cross (Co-PI), Kathryn Clancy (Co-PI), and Ruby Mendenhall (Co-PI) on the awarding of our NSF grant, “The Double Bind of Race and Gender: A Look into the Experiences of Women of Color in Engineering.”
07/05/16: Congratulations to Dr. Princess Imoukhuede and collaborator, Dr. David Rosch on having their article, Improving Bioengineering Student Leadership Identity Via Training and Practice within the Core-Course, published in the Biomedical Engineering Society (BMES) journal, Annals of Biomedical Engineering.
06/29/16: Dr. Princess Imoukhuede gives a talk, “Computational Analysis of Growth Factor Regulation of Angiogenesis” at the Gordon Conference: Signal Transduction by Engineered Extracellular Matrices (Biddeford, ME).
04/28/16: The research of Imoukhuede Lab doctoral candidate, Si Chen, will be presented at tonight’s Art of Science gallery opening. Showcasing imagery from the Core Facilities at the IGB, the Art of Science traveling art exhibit highlights cutting-edge research that is addressing significant problems in the environment, medicine, energy use and production, and fundamental research (Champaign, IL).
04/15/16: Dr. Princess Imoukhuede gives a talk, Systems Biology: Towards Predictive Models of Cell Activation for the Research Initiative for Scientific Enhancement (Bayamón, PR).
04/09/16: Dr. Princess Imoukhuede gives a talk, titled: qBio + cBio = sBio: Advancing Knowledge on Biomarkers, Drugs, & Disease for the 3rd Semi-Annual Midwestern Quantitative Biology (MidQBio) Seminar (Urbana, IL).
03/09/16: Congratulations to Imoukhuede Lab doctoral student: Ali Ansari and undergraduate researchers: Reema Patel, Kinsey Schultheis, and Vesna Naumovski; and PI: Dr. Princess Imoukhuede on having the article, A method of targeted cell isolation via glass surface functionalization, accepted for publication in the Journal of Visualized Experiments (JoVE).
01/15/16: See Dr. Imoukhuede discuss the “Importance of Federal Funding for Biomedical Research: National Funding Needs of Junior Faculty” at this University of Illinois event with Illinois’ Senior U.S. Senator, Dick Durbin.
2015
11/09/15: Congratulations to Imoukhuede Lab alum, Dr. Felipe Lee-Montiel on his first-author manuscript, titled, Quantum dot multiplexing for the profiling of cellular receptors being featured as a 2015 HOT Paper in Nanoscale.
10/08-10/15: Imoukhuede Lab presents its work @ BMES. Visit our Facebook page for BMES updates and pictures.
10/01/15: Congratulations to Imoukhuede Lab doctoral student: Ali Ansari; undergraduate researchers: Reema Patel, Kinsey Schultheis, Aradhana Sridaran; postdoc alum: Dr. Felipe Lee-Montiel; and PI: Dr. Princess Imoukhuede on our work being featured on this month’s cover of Biotechnology and Bioengineering.
09/21/15: Congratulations to Imoukhuede Lab alum: Dr. Felipe Lee-Montiel and PI: Dr. Princess Imoukhuede on the publication of the manuscript, titled, Quantum dot multiplexing for the profiling of cellular receptors in Nanoscale.
09/11/15: Dr. Princess Imoukhuede presents a talk, titled, Systems Biology & Bioengineering: Predicting Angiogenic Activation via Integrative Receptor Quantification & Computational Modeling at the HAL Symposium (Pasadena, CA).
08/13/15: Congratulations to Imoukhuede Lab doctoral candidate: Si Chen; and PI:Dr. Princess Imoukhuede on the publication of the manuscript, Quantification of VEGFRs, NRP1, and PDGFRs on Endothelial Cells and Fibroblasts Reveals Serum, Intra-Family Ligand, and Cross-Family Ligand Regulation in Cellular and Molecular Bioengineering.
07/07/15: Congratulations to Imoukhuede Lab doctoral candidate, Spencer Mamer, on being selected for a Biomedical Engineering Society (BMES) Travel Award!
07/03/15: Imoukhuede Lab doctoral candidate, Jared Weddell, presents a talk, titled, Developing Mechanistic Models Of Adapter-receptor Interactions To Predict Cell Response in the Nonlinear Dynamics in Cardiac Electrophysiology at the Society for Mathematical Biology Annual Meeting (Atlanta, GA).
06/30/15: Dr. Princess Imoukhuede presents a talk, titled, Predicting tumor response by integrating quantitative VEGFR1 profiling with kinetic modeling in the Biomedical Applications of Mathematical Biology Session at the Society for Mathematical Biology Annual Meeting (Atlanta, GA).
06/21/15: The Imoukhuede Lab receives a National Science Foundation (NSF) grant towards Advancing Cell-Preserving Separation via Detachable Cell Anchoring & Spiral Micro-Mixing.
06/02/15: Congratulations to Imoukhuede Lab doctoral candidate: Ali Ansari; postdoc alum: Dr. Felipe Lee-Montiel; and PI: Dr. Princess Imoukhuede on the publication of Secondary Anchor Targeted Cell Release in Biotechnology and Bioengineering.
05/08/15: Spencer Mamer presents a talk, titled, Quantitative and Computational Analysis of Novel VEGF-PDGF Cross-Family Interactions in Angiogenesis at the Center for Nanoscale Science and Technology 13th Annual Workshop (Urbana, IL).
05/06/15: Congratulations to Imoukhuede Lab undergraduate researcher, Osazomon Imarenezor, on her induction to the Ronald E. McNair Scholars Program.
04/23/15: Osazomon Imazenezor & Xinyi Guo present their poster, titled, Levels of Cell Confluence Infleunce PDGFRalpha & PDGFRbeta Angiogenic Receptors Cell Surface Localization at the University of Illinois Undergraduate Research Symposium (Urbana, IL).
04/22/15: Congratulations to Imoukhuede Lab doctoral candidate: Jared Weddell and PI: Dr. Princess Imoukhuede on the publication of Hemodynamic Analysis in an Idealized Artery Tree: Differences in Wall Shear Stress between Newtonian and Non-Newtonian Blood Models in PLoS ONE.
03/23/15: Dr. Imoukhuede, Dr. Jenny Amos, and Dr. Troy Vogel’s study on cross-disciplinary team projects, titled, Assessing teaming skills and major identity through collaborative sophomore design projects across disciplines is accepted for publication and presentation to the American Society for Engineering Education Conference Proceedings.
03/08/15: Congratulations to Ali Ansari, Jared Weddell, and Dr. Imoukhuede for being listed as EXCELLENT instructors for the Fall 2014 semester by the UIUC Center for Teaching Excellence.
02/18/15: Dr. Imoukhuede gives a seminar: “Quantitative fluorescent profiling of angiogenic receptors” at the University of Illinois at Urbana Champaign iOptics seminar. Sponsored by OSA Student Chapter & SPIE Student Chapter (Urbana, IL).
2014
12/16/14: Congratulations to Si Chen, Ali Ansari, Jared Weddell and other students from Spring 2014 BIOE 498/598 on the publication of the review article: “Current State-of-the-Art and Future Directions in Systems Biology,” which was recently published in Progress and Communication in Sciences!
12/04/14: Dr. Imoukhuede gives a seminar: “Understanding Angiogenic Signaling Through Systems Biology” at the University of Illinois at Chicago, Department of Chemical Engineering (Chicago, IL).
10/25/14: Audra Storm presents a poster, “Examining The Partitioning Of Angiogenic Receptors In Vitro ” (9:30 AM – 10:30 AM, Exhibit Hall A, P-Sat-4) at the Biomedical Engineering Society (BMES) National Meeting (San Antonio, TX).
10/25/14: Xinyi (Cathy) Guo presents a poster, “PDGFRα And PDGFRβ Cell Surface Levels Are Positively Correlated With Cell Confluency In Vitro ” (9:30 AM – 10:30 AM, Exhibit Hall A, P-Sat-2) at the Biomedical Engineering Society (BMES) National Meeting (San Antonio, TX).
10/24/14: Si Chen presents a poster, “Quantitative Profiling of Angiogenic Receptors on Human Dermal Fibroblasts,” (9:30 AM – 10:30 AM, Exhibit Hall A, P-Fri-277) at the Biomedical Engineering Society (BMES) National Meeting (San Antonio, TX).
10/24/14: Ali Ansari presents a poster, “Novel Tunable Functionalized Surface for the Isolation of Tumor Associated Cells,” (9:30 AM – 10:30 AM, Exhibit Hall A, P-Fri-190) at the Biomedical Engineering Society (BMES) National Meeting (San Antonio, TX).
10/23/14: Jared Weddell presents a poster, “Quantitative Analysis of Hemodynamics in a Novel Standardized Geometry Reveals Inconsistencies between Newtonian and Non-Newtonian Constitutive Models” (9:30 AM – 10:30 AM, Exhibit Hall A, P-Th-574) at the Biomedical Engineering Society (BMES) National Meeting (San Antonio, TX).
10/23/14: Dr. Imoukhuede co-chairs the platform session, “Cell Regulatory Circuits,” (4:30 PM to 6:00 PM, Room 202A) at the Biomedical Engineering Society (BMES) National Meeting (San Antonio, TX).
10/22/14: Congratulations to Imoukhuede Lab undergraduate researcher, Audra Storm, on being awarded a Conference Travel Grant to attend the Biomedical Engineering Society (BMES) National Meeting by the University of Illinois Office of Undergraduate Research.
09/19/14: Dr. Imoukhuede gives a talk: “Introduction to VEGFRs in Breast Cancer and Peripheral Artery Disease” at the University of Illinois Angiogenesis Symposium (Chicago, IL).
09/09/14: Dr. Imoukhuede gives a talk: “Systems Biology: merging experiment with computation” at the Frontiers in Bioengineering Symposium (Urbana, IL).
09/01/14: Congratulations to Imoukhuede Lab doctoral students Si Chen, Ali Ansari, and Jared Weddell on having their review article, Current State-of-the-Art and Future Directions in Systems Biology accepted for publication in Progress and Communication in Sciences!
08/29/14: Institute for Genomic Biology press release on our recent findings.
08/25/14: Congratulations to Imoukhuede Lab undergraduate researcher, Xinyi (Cathy) Guo on being awarded a Biomedical Engineering Society (BMES) Student Travel Award.
07/01/14: Congratulations to Imoukhuede Lab doctoral students, Ali Ansari, Si “Stacie” Chen, Spencer Mamer, and Jared Weddell for being selected as travel award recipients to NAVBO Vasculata.
05/14/14: Congratulations to Imoukhuede Lab doctoral student, Jared Weddell, on having his paper, Quantitative characterization of cellular membrane-receptor heterogeneity through statistical and computational modeling published in PLoS ONE!
05/09/14: Congratulations to Imoukhuede Lab undergraduate researcher, Osazomon (Erica) Imarenezor on being awarded an American Heart Association Midwestern Affiliate Undergraduate Student Research Fellowship. This fellowship will enable Osazomon to continue her research on Analysis of Angiogenesis via ligand-receptor signaling.
05/09/14: Congratulations to Imoukhuede Lab undergraduate researcher, Xinyi (Cathy) Guo on being awarded a School of Molecular and Cellular Biology Summer Undergraduate Research Fellowship. This fellowship will enable Xinyi to continue her research on Quantitative Angiogenic Receptor Profiling.
05/09/14: Congratulations to Imoukhuede Lab undergraduate researcher, Brendan Mathias on being awarded an American Heart Association Midwestern Affiliate Undergraduate Student Research Fellowship.
04/18/14: Congratulations to Imoukhuede Lab doctoral student, Jared Weddell, on having his paper, Quantitative characterization of cellular membrane-receptor heterogeneity through statistical and computational modeling accepted for publication in PLoS ONE!
04/17/14: Dipen Kumar presents a talk, “Quantification of Gene Expression in Angiogenic Receptors and Ligands Using qPCR” at the Undergraduate Research Symposium (Urbana, IL).
04/17/14: Brendan Mathias, Osazomon Imarenzor, and Xinyi (Cathy) Guo present their poster, “Quantitative Flow Cytometry of Angiogenic Growth Factor Receptors in the EA.hy926 Cell Line” at the Undergraduate Research Symposium (Urbana, IL).
04/17/14: Audra Storm presents her poster, “Methods of Investigating the Subcellular Localization of VEGFR-3 in HUVECs” at the Undergraduate Research Symposium (Urbana, IL).
04/17/14: Manu Kumar and Tyler Cowman present their poster, “Quantitative Analysis and Computational Modeling of PDGFR-VEGFR Crosstalk” at the Undergraduate Research Symposium (Urbana, IL).
04/17/14: Grace Conard and Pavan Gupta present their poster, “Quantitative Flow Cytometry Analysis of Angiogenic Growth Factor Receptors” at the Undergraduate Research Symposium (Urbana, IL).
04/16/14: Dr. Imoukhuede co-chairs a session at the Illinois-Tsinghua Nanotechnology Symposium/Center for Nanoscale Science and Technology 12th Annual Nanotechnology Workshop (Urbana, IL).
04/14/14: Dr. Imoukhuede presents a poster on “Systems Biology and Angiogenesis: Engineerign Nanosensors and Calibration Standards for Angiogenic Receptor Mapping” at the National Institutes of Health Network of Minority Health Research Investigators 12th Annual Workshop (Bethesda, MD).
04/07/14: Plasmonic Optical Trapping in Biologically Relevant Media has been published in PLoS ONE.
03/28/14: Dr. Imoukhuede presents her research on “Systems Biology: interdisciplinary research advancing personalized medicine” and serves as a panelist on Interdisciplinary research at the Annual Faculty Women of Color in the Academy Conference (Urbana, IL).
03/11/14: Congratulations to collaborator and first author Brian Roxworthy, former Imoukhuede Lab postdoc: Dr. Lee Montiel, and collaborators: Michael Johnston, Randy Ewolt, & Kimani Toussaint on having our paper, Plasmonic Optical Trapping in Biologically Relevant Media, accepted for publication in PLoS ONE.
02/04/14: Dr. Imoukhuede is featured on the front page of The News Gazette in an article on campus safety.
01/23/14: Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts has been published in the journal of Cancer Medicine.
01/18/14: Dr. Imoukhuede gives a seminar talk titled “Systems Biology: modeling pathways and networks, data integration into models.” @ Mayo Clinic Biomarker Discovery Retreat (Rochester, MN).
2013
12/11/13: Dr. Imoukhuede gives a seminar titled “Bimodal Systems Biology: Integrating Biological Assays with Computational Modeling .” @ the Institute for Genomic Biology at the University of Illinois (Urbana, IL).
11/20/13: Dr. Imoukhuede gives the Distinguished Lecture titled “Systems Biology and Bioengineering: Integrating biological assays with computation.” @ Purdue University (West Lafayette, IN).
11/13/13: Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts has been accepted for publication in the journal of Cancer Medicine.
10/04/13: Engineering quantum dot calibration standards for quantitative fluorescent profiling has been accepted for publication in the Journal of Materials Chemistry B. This represents the first paper to be published from the Imoukhuede Lab. Congratulations to first author, Dr. Lee Montiel on his achievement.
09/29/13: Pavan Gupta and Dr. Imoukhuede are pictured in the Oct. 7, 3013 edition of Time Magazine under the Special Section: US Research Universities: The Nation’s Edge in Innovation.
09/28/13: Dr. Imoukhuede co-chairs the Targeted Delivery III Session at the Biomedical Engineering Society (BMES) National Meeting. Track: Drug Delivery. Room 619. 3:15-4:45 pm.
09/28/13: Grace Conard and Pavan Gupta present a poster on “Quantitative Flow Cytometry Analysis of Angiogenic Growth Factor” at the Biomedical Engineering Society (BMES) National Meeting. Track: Undergraduate Research, Bioinformatics, Compuational and Systems Biology. Washington State Convention Center (Seattle, WA). 9:30-10:30 am.
09/27/13: Jared Weddell presents a poster on “Interpreting the Effect of Heterogeneity and Hemodynamics on Tumor Angiogenesis Using a Multi-scale Model of Anti-angiogenic Therapy” at the Biomedical Engineering Society (BMES) National Meeting. Track: Bioinformatics, Computational and Systems Biology, Multiscale Modeling – Cells to the Whole Body. Washington State Convention Center (Seattle, WA). 3:45-4:45 pm.
09/26/13: Dr. Lee Montiel presents a poster on “Advancing Quantum Dot Nanosensors and Calibration Beads for Quantitative Cellular Profiling” at the Biomedical Engineering Society (BMES) National Meeting. Track: Cancer Technologies, Biomedical Engineering Modalities for Personalized Cancer Therapy. Washington State Convention Center (Seattle, WA). 3-4 pm.
08/23/13: The Imoukhuede Lab welcomes our new Graduate Student Researchers: Si Chen and Spencer Mamer!
08/13/13: Congratulations to Dr. Lee Montiel on being awarded a 2013 BMES Innovation and Career Development Travel Award!
05/28/13: Dr. Imoukhuede is awarded a grant from the American Cancer Society (ACS), Illinois Division on “Sensing and Predictive Tuning of Tumor Angiogenesis through Systems Biology”
03/22/13: Dr. Imoukhuede gives a talk on “Advancing computational modeling and quantitative receptor profiling of vascular pathologies” at Frontiers in Systems and Synthetic Biology ’13 (FSSB’13); Georgia Tech (Atlanta, GA).
03/20/13: Dr. Lee Montiel presents a poster on “Engineering Quantum Dot Calibration Beads for the Profiling of Cellular Heterogeneity” at Frontiers in Systems and Synthetic Biology ’13 (FSSB’13); Georgia Tech (Atlanta, GA).
03/20/13: Jared Weddell presents a poster on “Multiscale Modeling: Computational Simulation of the Tumor Microenvironment” at Frontiers in Systems and Synthetic Biology ’13 (FSSB’13); Georgia Tech (Atlanta, GA).
03/19/13: Dr. Imoukhuede gives a talk on “Progress of Women In Science, Technology, Engineering and Mathematics” Administrative Offices of the U.S. Courts; (Washington, DC).
02/18/13: Dr. Imoukhuede serves as a panelist for “Black Women in Geek Culture” during Black Geek Week; University of Illinois (Urbana, IL).
01/25/13: Dr. Lee Montiel presents a poster at the 3rd Annual Beckman Institute Postdoctoral Symposium; University of Illinois (Urbana, IL).
2012
11/29/12: Dr. Imoukhuede gives a talk at in the Department of Biomedical Engineering at the University of Michigan; 12:00 pm-1:00pm; (Ann Arbor, MI).
11/07/12: Dr. Imoukhuede gives a Regenerative Biology and Tissue Engineering theme seminar on “Interpreting angiogenesis through systems biology” at the Institute for Genomic Biology; 4:00pm; (Urbana, IL).
11/02/12: Dr. Imoukhuede gives a talk at Caltech; 2:00 pm; (Pasadena, CA).
10/27/12: Dr. Imoukhuede co-chairs the session, “Biomaterial Topics in Drug Delivery” at the Biomedical Engineering Society Annual Meeting ; 3:15pm-4:45pm; Room A311; (Atlanta, GA).
10/26/12: Dr. Imoukhuede gives the New Faculty talk on “Profiling the Vascular Microenvironment: Quantitative Fluorescent Biosensors & Computational Modeling” at the 25th Molecular Biophysics Training Grant (MBTG) Annual Symposium (Urbana, IL).
10/25/12: Shaneen Braswell, M.Eng. serves as a panelist at the Society of Women Engineers, University of Illinois Chapter, Graduate School Application Seminar.