Wei Sun (University of North Carolina): Statistical methods for RNA-seq data
Date Oct 18, 2012
Time 4:00 pm – 5:00 pm
Location 156 Henry
Sponsor Statistics Department
Event type Seminar
RNA-seq is replacing gene expression microarrays as the most commonly used technique to assess genome-wide transcription abundance. RNA-seq delivers two novel features. First, it provides information on allele-specific expression (ASE), which is not available from gene expression microarrays. Second, it generates unprecedentedly rich data to study RNA-isoform expression. I will present statistical methods for joint study of allele-specific expression and total expression of a gene, transcriptome reconstruction, isoform abundance estimation, and Differential isOform usage Testing (DOT).