Department of Statistics Weekly Seminar

Wei Sun (University of North Carolina): Statistical methods for RNA-seq data
Date            Oct 18, 2012
Time            4:00 pm – 5:00 pm
Location     156 Henry
Sponsor      Statistics Department
Event type   Seminar
RNA-seq is replacing gene expression microarrays as the most commonly used technique to assess genome-wide transcription abundance. RNA-seq delivers two novel features. First, it provides information on allele-specific expression (ASE), which is not available from gene expression microarrays. Second, it generates unprecedentedly rich data to study RNA-isoform expression. I will present statistical methods for joint study of allele-specific expression and total expression of a gene, transcriptome reconstruction, isoform abundance estimation, and Differential isOform usage Testing (DOT).