Complete Publication List

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Obesity, Cholesterol and Breast Cancer

Ma L., Wang L., Nelson A.T., Han C., He S., Henn M., Menon K., Chen J.J., Baek A.E., Vardanyan A., Shahoei S.H., Park SH., Shapiro D.J., Nanjappa S.G., and Nelson E.R. (2020). 27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression. Cancer Letters, available online: Cancer Letters Article

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Baek A.E., Yu Y.R., He S., Wardell S.E., Chang C.Y., Kwon S., Pillai R.V., Thompson W., Dubois L.G., Sullivan P.M., Kemper J.K., Gunn M.D., McDonnell D.P., and Nelson E.R. (2017). The cholesterol metabolite 27-hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nature Communications, 8(1):864. Featured By: Science Daily, Illinois News Bureau, Medical Xpress, Youth Health Magzine, Cardiovascular Business, Gears Of Biz, EurekAlert! etc. PMCID: PMC5636879

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Baek A.E. and Nelson E.R. (2016). The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer. Hormones and Cancer. 7(4):219-28. PMCID: PMC4930376. Invited Review, Cover Story.

Nelson E.R., Chang, C.Y., and McDonnell, D.P. (2014). Cholesterol and Breast Cancer Pathophysiology. Trends in Endocrinology and Metabolism. 25(12):649-655. PMCID: PMC4268141. Invited Review, Chosen as one of the top ten editorial board favorite articles of 2014.

Nelson E.R., Wardell S.E., Jasper J.S., Park S., Suchindran S., Howe M.K.,Carver N.J., Pillai R.V., Sullivan P.M., Sondhi V., Umetani M., Geradts J., and McDonnell D.P. (2013). 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology. Science. 342(6162):1094-8. PMCID: PMC3899689. Featured by: New England Journal of Medicine, Science News and Analyses, Nature Reviews Endocrinology, The ASCO Post, The Endocrine Daily Briefing, Ivanhoe Broadcast News, BBC News, The Washington Post, Fox News, Irish Independent, and several other media outlets. Also featured by Faculty 1000 Medicine.

Cholesterol Metabolism and Ovarian Cancer

He S., Ma L., Baek A.E., Vardanyan A., Vembar V., Chen J.J., Nelson A.T., Burdette J.E., and Nelson E.R. (2019). Host CYP27A1 expression is essential for ovarian cancer progression. Endocrine-Related Cancer 2019 Vol. 26, issue 7

Cholesterol Metabolism and the Immune System

Shahoei, S.H., Kim, Y.C., Cler, S., Ma, L., Anakk, S., Kemper J.K. and Nelson E.R. (2019). Small Heterodimer Partner regulates dichotomous T cell expansion by macrophages. Endocrinology 160(7):1573-1589.

Shahoei S.H., and Nelson E.R. (2019). Nuclear Receptors, Cholesterol Homeostasis and the Immune System. Journal of Steroid Biochemistry and Molecular Biology. 191:105364-105364

Cholesterol and Oxysterols in Health and Disease

Ma, L., and Nelson E.R. (2019). Oxysterols and Nuclear Receptors. Molecular and Cellular Endocrinology.15; 484:42-51

Nelson E.R. (2017). Cholesterol, 27-Hydroxychoelsterol and their significance in breast cancer. Molecular and Cellular Endocrinology. S0303-7207(17)30506-3. PMID: 28919300.

He, S. and Nelson E.R. (2017). 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. Maturitas. 104: 29-35. PMID: 28923174

Development of Novel Cancer Therapeutics

Yu L., Wang L., Maoa C., Duraki D., Kim J.E., Huang R., Helferich W.G. Nelson, E.R., Park B.H., Shapiro D.J. (2019) Estrogen-Independent Myc Overexpression Confers Endocrine Therapy Resistance on Breast Cancer Cells Expressing ERαY537S and ERαD538G Mutations. Cancer Letters. 9: 442:373-382.

Zheng X., Andruska N.D., Lambrecht M.J., He S., Parissenti A., Hergenrother P.J., Nelson E.R., and Shapiro D.J. (2016). Targeting Multidrug-resistant Ovarian Cancer Through Estrogen Receptor α Dependent Hyperactivation of the UPR. Oncotarget. July 24, 2016 issue. PMID: 27463013

Ma, L., Liu, T-W., Wallig, M.A., Dobrucka, I.T. Dobrucki, L.W., Nelson E.R., Swanson, K.S., and Smith A.M. (2016). Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nano-Carriers. ACS Nano. 10(7):6952-62. PMID: 27281538

Wardell S.E., Nelson E.R., Chao C.A., Alley H.M., and McDonnell D.P. (2015). Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. Endocrine Related Cancer. 22(5):713-24. PMCID: PMC4545300.

Wright T.M., Wardell S.E., Jasper J.S, Stice J.P., Safi R., Nelson E.R., and McDonnell D.P. (2014). Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine resistant breast cancer. Molecular Cancer Research. 12(12); 1829–39. PMCID: PMC4272635. Featured in Editor’s Highlights. Selected for Cover Story.

Safi R., Nelson E.R., Chitneni S.K., Franz K.J., George D.J., Zalutsky M.R., and McDonnell D.P. (2014). The Copper-Signaling Axis as a Target for Prostate Cancer Therapeutics. Cancer Research. 15;74(20):5819-31. PMCID: PMC4203427.

Wardell S.E., Nelson E.R., and McDonnell D.P. (2014). From empirical to mechanism based discovery of clinically useful ER ligands. Steroids. 90:30-8. PMCID: PMC4192009. Invited Review.

Wardell S.E., Nelson E.R., Chao C.A., and McDonnell D.P. (2013). Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen resistant breast cancer; implications for treatment of advanced disease. Clinical Cancer Research 1;19(9):2420-31. PMCID: PMC3643989. Featured by: Endocrine Society News Room,, Fox News, Express News, About Breast, Toronto Sun and Ivanhoe Broadcast News.

Cholesterol, Nuclear Receptors and Bone Physiology

Nelson E.R., Wardell S.E., and McDonnell D.P. (2013). The Molecular Mechanisms Underlying the Pharmacological Actions of Estrogens, SERMs and Oxysterols: Implications for the Treatment and Prevention of Osteoporosis. Bone, 53:42-52. PMCID: PMC3552054. Invited Review.

Nelson E.R., DuSell C.D., Wang X., Howe M.K., Evans G., Michalek R.D., Rathmell J.C., Khosla S., Gesty-Palmer D., and McDonnell D.P. (2011). The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology, 152(12): 4691-705. PMCID: PMC3230052. Featured by:, Duke Chronicle, Consumer’s Digest, Daily Rx, US Corporate Wellness, UWire, and Stone Hearth News. Received The Endocrine Society Award for Outstanding Paper.

DuSell C.D., Nelson E.R., Wang X., Abdo J., Mödder U.L., Umetani M., Gesty-Palmer D., Javitt N.B., Khosla S., McDonnell D.P. (2010). The Endogenous Selective Estrogen Receptor Modulator 27-hydroxycholesterol is a Negative Regulator of Bone Homeostasis. Endocrinology, 151(8): 3675-85. PMCID: PMC2940523. Featured by Nature Reviews Endocrinology and MDLinx

DuSell C.D., Nelson E.R., Wittmann B.M., Fretz J.A., Kazmin D., Thomas R.S., J. Pike W., and McDonnell D.P. (2010). Regulation of aryl hydrocarbon receptor function by Selective Estrogen Receptor Modulators. Molecular Endocrinology, 24(1): 33-46. PMCID: PMC2802893. Selected for Cover Story. Featured in Jan. 2010 Endocrine News.