Funding

We greatly appreciate the support from the School of Molecular Biology at UIUC, NIH/NIGMS, NIH/NIMH, National Science Foundation, Research Corporation for Science Advancement, and Cancer Center at Illinois (CCIL)

 

Ongoing Research Support
R01GM132438                                Zhang (PI)                                            2019-2023
Sponsor: NIH/NIGMS
Precise regulation of native transcription factor at the single-cell level
The goal of this study is to develop an optogenetic approach to control the transcriptional activity of the native transcription factor.

Award #27937 Levy (PI), Ross (PI), Zhang (PI)                                             2021-2023
Sponsor: Research Corporation for Science Advancement
Engineering Enteric Neuron Activity to Enhance Antimicrobial Immunity in the Gut
The goal of this grant is to determine how ENS activity promotes antimicrobial immunity in the gut.

R01 MH124827                Tsai (PI) Zhang (MPI)                                           2020-2025
Sponsor: NIH/NIMH
Mechanism of Gp1 mGluR-dependent translation and plasticity
The goal of this study is to determine the role of mGluR-dependent translation and neuronal plasticity.

NSF 2121003              Cao (PI) Zhang, Cheng, Schroeder (Co-PI)            10/01/2021-09/30/2026                                GCR: Synthetic Neurocomputers for Cognitive Information Processing                                                                       The goal of this study is to understand cognitive information processing through the experimental buildup of neuronal cell networks and machine learning modeling

R01 MH119149-01          Wang (PI) Zhang (CoI)                                          2019-2024
Sponsor: NIH/NIMH
Nonconventional role of ADCY in Gq-mediated neuronal signaling and neuroplasticity.
The goal of this study is to determine the role of adenylate cyclases (ADCY) in the development of neuroplasticity.

R01MH124992                  Wang (PI) Zhang (CoI)                                        2020-2024
Sponsor: NIH/NIMH
Mechanism underlying cognitive and synaptic flexibility
The goal of this study is to determine the role of adenylate cyclases 8-PI3K/Akt-GSK3β signaling in the regulation of synaptic depotentiation reversal/suppression of memory.

R01GM141298                 Pogorelov(PI) Zhang (CoI)                                   2021-2025
Sponsor: NIH/NIGMS
Capturing structure and dynamics of transmembrane signaling proteins
The goal of this project is to use computational prediction and in-cell signaling to quantitatively map out the structure-function relationship of single-transmembrane receptor tyrosine kinases.

Cancer Center at Illinois #9572  Zhang (PI)                                                   2022-2023
Sponsor: Cancer Center at Illinois 
Optogenetic Modulation of the Tumor Microenvironment to Improve Cancer Immunotherapy
The goal of this study is to use optogenetic stimulation to tune the immune landscape of the tumor microenvironment.

Completed Research Support
American Cancer Society PF-13-030-01-DDC         Zhang (PI)                     2013
Cell-fate determination by light-gated MAPK and AKT signaling pathways
The goal of this study is to compare the effects of light-activated MAPK and AKT pathways on cell proliferation and differentiation.

R56MH118908                         Wang (PI) Zhang (CoI)                                  2019-2020
Sponsor: NIH/NIMH
Mechanism underlying cognitive and synaptic flexibility
The goal of this study is to determine the role of adenylate cyclases 8-PI3K/Akt-GSK3β signaling in the regulation of synaptic depotentiation reversal/suppression of memory

R03NS120516                          Tsai (PI) Zhang (CoI)                                      2020-2021
Sponsor: NIH/NIMH
Study of PAK3 in epilepsy-associated defects in synaptic plasticity
The goal of this project is to determine how nuclear and cytoplasmic PAK3 contributes to epilepsy-associated defects in synaptic plasticity.