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Journal Articles


E.R. Neves, A. Anand, J. Mueller, R. Remy, H. Xu, K. Selting, J.N. Sarkaria, B.A.C. Harley, S. Pedron-Haba, ‘Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties,’ under review, 2024. bioRxiv online.

V. Kolliopoulos*, A. Tiffany*, M. Polanek, B.A.C. Harley, ‘Donor variability in human mesenchymal stem cell osteogenic response as a function of passage conditions and donor sex,’ under review, 2024. * co-first authors. bioRxiv online.

V. Kriuchkovskaia, E.K. Eames, R.B. Riggins, B.A.C. Harley, ‘Acquired temozolomide resistance instructs patterns of glioblastoma behavior in gelatin hydrogels,’ under review, 2024. bioRxiv online.

S.G. Zambuto, I. Jain, H.S. Theriault, G.H. Underhill, B.A.C. Harley, ‘Cell chirality of micropatterned endometrial microvascular endothelial cells,’ in revision, 2024. bioRxiv online.

S.G. Zambuto, H. Theriault, I. Jain, C. Crosby, I. Pintescu, N.Y. Chiou, J. Zoldan, G. Underhill, K.B.H. Clancy, B.A.C. Harley, ‘Endometrial decidualization status modulates endometrial perivascular complexity and trophoblast outgrowth in gelatin hydrogels,’ in revision, 2024. bioRxiv online.


Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Ashwin Bale, Brett L. Carlson, Kendra A. Porath, Katrina K. Bakken, Danielle M. Burgenske, Paul A. Decker, Rachael A. Vaubel, Jeanette E. Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan Harley, William F. Elmquist, Zachary D. Nagel, Shiv K. Gupta, Jann N. Sarkaria, ‘Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization’, Science translational medicine, 2024. [DOI]


M.J. Dewey*, K.B. Timmer*, A. Blystone, C. Lu, B.A.C. Harley, ‘Evaluating osteogenic effects associated with the incorporation of ascorbic acid in mineralized collagen scaffolds,’ J Biomed. Mater. Res. Pt. A, 2023. * co-first authors. [DOI]

M.J. Dewey, R. Sun Han Chang, A.V. Nosatov, K. Janssen, S.J. Crotts, S.J. Hollister, B.A.C. Harley, ‘Generative design approach to combine architected Voronoi foams with porous collagen scaffolds to create a tunable composite biomaterial,’ Acta Biomater., 172:249-59, 2023. [DOI].

E. Cosgriff-Hernandez, B.A. Aguado, B.S. Akpa, G. Coloyan Fleming, E. Moore, A.M. Porras, P.M. Boyle, D.D. Chan, N. Chesler, K.L. Christman, T.A. Desai, B.A.C. Harley, G.A. Hudalla, M.L. Killian, K. Maisel, K.C. Maitland, S.R. Peyton, B.L. Pruitt, S.E. Stabenfeldt, K.R. Stevens, A.K. Bowden, ‘Diversify your faculty: A roadmap for equitable hiring strategies,’ Nat. Biomed. Eng., 7:961–8, 2023. [DOI]

V. Kolliopoulos, M. Polanek, H. Xu, K. Spiller, B.A.C. Harley, ‘Inflammatory licensed hMSCs exhibit enhanced immunomodulatory capacity in a biomaterial mediated manner,’ ACS Biomater. Sci. Eng., 9(8):4916-28, 2023. [DOI]

J. Lumibao, P. Haak, V.L. Kolossov, J.-W. Chen, J. Stutchman, A. Ruiz, M. Sivaguru, J.N. Sarkaria, B.A.C. Harley, A.J. Steelman, H.R. Gaskins, ‘CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance,’ Int. J. Oncol., 63(5):117, 2023. [DOI]

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X. Ren, Q. Zhou, M. Bedar, D. Foulad, K.X. Huang, D. Dejam, N.J. Dahan, V. Kolliopoulos, B.A.C. Harley, J.C. Lee, ‘Modulating Temporospatial Phosphate Equilibrium by Nanoparticulate Mineralized Collagen Materials Induces Osteogenesis via PiT-1 and PiT-2,’ Adv. Healthc. Mater., 12(17):e2202750, 2023. [DOI]

M.J. Dewey, A.J. Collins, A. Tiffany, V.R. Barnhouse, C. Lu, V. Kolliopoulos, N.J. Hickok, B.A.C. Harley, ‘Evaluation of P. aeruginosa attachment on mineralized collagen scaffolds and addition of manuka honey to increase mesenchymal stem cell osteogenesis,’ Biomaterials, 294:122015, 2023. [DOI]

X. Ren, D. Dejam, M.K. Oberoi, N. Dahan, Q. Zhou, K.X. Huang, M. Bedar, C.H. Chan, V. Kolliopoulos, B.A.C. Harley, J.C. Lee, ‘Osteoprotegerin-eluting nanoparticulate mineralized collagen scaffolds improve skull regeneration,’ Biomater. Adv., 145:213262, 2023. [DOI]


V. Kolliopoulos, M.J. Dewey, M. Polanek, B.A.C. Harley, ‘Amnion and chorion matrix maintain hMSC osteogenic response and enhance immunomodulatory and angiogenic potential in a mineralized collagen scaffold,’ Front. Bioeng. Biotechnol., 10:1034701, 2022. [DOI] [Data repository].

M.T. Ngo, J.N Sarkaria, B.A.C. Harley, ‘Perivascular stromal cells instruct glioblastoma invasion, proliferation, and therapeutic response within an engineered brain perivascular niche model,’ Adv. Sci., 9(31):2201888, 2022. [DOI]

I. Pastrana-Otero*, S. Majumdar*, A.E. Gilchrist, B.A.C. Harley, M.L. Kraft, ‘Identification of the differentiation stages of living cells from six immature murine hematopoietic cell populations by multivariate analysis of single-cell Raman spectra,’  Anal. Chem., 94(35):11999-2007, 2022. * co-first authors. [DOI]

S.G. Zambuto, I. Jain, K.B.H. Clancy, G.H. Underhill, B.A.C. Harley, ‘The role of extracellular matrix biomolecules on endometrial epithelial cell attachment and cytokeratin 18 expression on gelatin hydrogels,’ ACS Biomater. Sci. Eng., 8(9):3819-30, 2022. [DOI].

A.S. Tiffany, B.A.C. Harley, ‘Growing pains: the need for engineered platforms to study growth plate biology,’ Adv. Healthc. Mater., 2200471, 2022. [DOI]

J.V.J. Cavalcanti, K.A. Selting, M.T. Ngo, C.K. Tran Hoang, D.J. Schaeffer, T.M. Fan, B.A.C. Harley, H. Phillips, ‘Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines,’ Amer. J. Vet. Res., 83(6):ajvr.21.10.0157, 2022. [DOI]

A.E. Gilchrist, B.A.C. Harley, ‘Engineered tissue models to replicate dynamic interactions within the hematopoietic stem cell niche,’ Adv. Healthc. Mater., 2102130, 2022. [DOI]

S.G. Zambuto, D. Dveksler, B.A.C. Harley, ‘Effects of pregnancy-specific glycoproteins on trophoblast motility in three-dimensional gelatin hydrogels,’ Cell. Mol. Bioeng., 15(2):175-91, 2022. [DOI]

J.-W.E. Chen, S. Leary, V. Barnhouse, J.N. Sarkaria, B.A.C. Harley, ‘Matrix hyaluronic acid and hypoxia influence a CD133+ subset of patient-derived glioblastoma cells,’ Tissue Eng. Part A, 28(7-8):330-40, 2022. [DOI]


M.J. Dewey*, D.J. Milner*, D. Weisgerber, C.L. Flanagan, M. Rubessa, S. Lotti, K.M. Polkoff, S. Crotts, S.J. Hollister, M.B. Wheeler, B.A.C. Harley, ‘Repair of critical-size porcine craniofacial bone defects using a collagen-polycaprolactone composite biomaterial,’ Biofabrication, 14(1):014102, 2021. [DOI] * co-first authors.

M.T. Ngo*, V.R. Barnhouse*, A.E. Gilchrist, B.P. Mahadik, C.J. Hunter, J.N. Hensold, B.A.C. Harley, ‘Hydrogels containing gradients in vascular density reveal dose-dependent role of angiocrine cues on stem cell behavior,’ Adv. Funct. Mater., 31(51):2101541, 2021. [DOI] * co-first authors.

A.E. Gilchrist, J. F. Serrano, M.T. Ngo, Z. Hrnjak, S. Kim, B.A.C. Harley, ‘Encapsulation of murine hematopoietic stem and progenitor cells in a thiol-crosslinked maleimide-functionalized gelatin hydrogel,’ Acta Biomater., 131:138-48, 2021. [DOI]

E. Neves, B.A.C. Harley, S. Pedron, ‘Microphysiological systems to study tumor-stroma interactions in brain cancer,’ Brain Res. Bull., 174:220-29, 2021. [DOI]

M.J. Dewey*, V. Kolliopoulos*, M.T. Ngo, B.A.C. Harley, ‘Glycosaminoglycan content of a mineralized collagen scaffold promotes mesenchymal stem cell secretion of factors to modulate angiogenesis and monocyte differentiation,’ Materialia, 18:101149, 2021. [DOI]

M.J. Dewey and B.A.C. Harley, ‘Biomaterial design strategies to address obstacles in craniomaxillofacial bone repair,’ RSC Adv., 11(29):17809-27, 2021. [DOI]

T.G. Molley, G.K. Jalandhra, S.R. Nemec, A.S. Tiffany, B.A.C. Harley, T.-T. Hung, K.A. Kilian, ‘Heterotypic tumor models through freeform printing into photostabilized granular microgels,’ Biomater. Sci., 9:4496-509, 2021. [DOI]

M.T. Ngo, B.A.C. Harley, ‘Progress in mimicking brain microenvironments to understand and treat neurological disorders,’ APL Bioeng., 5(2):020902, 2021. [DOI]

N. Richbourg, M. Wancura, A.E. Gilchrist, S. Toubbeh, B.A.C. Harley, E. Cosgriff-Hernandez, N.A. Peppas, ‘Hydrogel synthesis conditions control swelling and predict stiffness and solute diffusivity,’ Sci. Adv., 7(7):eabe3245, 2021. [DOI]

M.J. Dewey, A.V. Nosatov, K. Subedi, R. Shah, A. Jakus, B.A.C. Harley, ‘Inclusion of a 3D-printed Hyperelastic Bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold,’ Acta Biomater., 121:224-36, 2021. [DOI].

V. Barnhouse, N. Petrikas, C. Crosby, J. Zoldan, B.A.C. Harley, ‘Perivascular secretome influences hematopoietic stem cell maintenance in a gelatin hydrogel,’ Ann. Biomed. Eng., 49(2):780-792, 2021. [DOI]

Q. Zhou, S. Lyu, A.A. Bertrand, A.C. Hu, C.H. Chan, X. Ren, M.J. Dewey, A.S. Tiffany, B.A.C. Harley, J.C. Lee, ‘Stiffness of nanoparticulate mineralized collagen scaffolds triggers osteogenesis via mechanotransduction and canonical Wnt signaling,’ Macromol. Biosci., 21(3): e2000370, 2021. [DOI]

S.G Zambuto, K.B.H. Clancy, B.A.C. Harley, ‘Tuning trophoblast invasion in a gelatin hydrogel via soluble cues from the maternal-fetal interface,’ Tissue Eng. Part A, 27(15-16): 1064-73, 2021. [DOI]

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J.-W.E. Chen, J. Lumibao, S. Leary, J.N Sarkaria, A.J. Steelman, H.R. Gaskins, B.A.C. Harley, ‘Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model,’ J. Neuroinflammation, 17(1):346. [DOI]

I. Pastrana-Otero, S. Majumdar, A.E. Gilchrist, B.L. Gorman, B.A.C. Harley, M.L. Kraft, ‘Development of an inexpensive Raman-compatible substrate for the construction of a microarray screening platform,’ Analyst, 145(21):7030-9, 2020. [DOI]

A.S. Tiffany, M.J. Dewey, B.A.C. Harley, ‘Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds,’ RSC Adv., 10:26982-96, 2020. [DOI]

R.A. Sun Han Chang, J.F. Shanley, M.E. Kersh, B.A.C. Harley, ‘Tough and tunable scaffold-hydrogel composite biomaterial for soft-to-hard musculoskeletal tissue interfaces,’ Sci. Adv., 6(34):eabb6763, 2020. [DOI]

M.T. Ngo, B.A.C. Harley, ‘Angiogenic biomaterials to promote therapeutic regeneration and investigate disease progression,’ Biomaterials, 255:120207, 2020. [DOI]

A.E. Gilchrist, B.A.C. Harley, ‘Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche,’ Integr. Biol. (Camb.), 12(7):175-87, 2020. [DOI].

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M.T. Ngo, E. Karvelis, B.A.C. Harley, ‘Multidimensional hydrogel models reveal endothelial network angiocrine signals increase glioblastoma cell number, invasion, and temozolomide resistance,’ Integr. Biol. (Camb.), 12(6):139-49, 2020. [DOI]

M.J. Dewey, A.V. Nosatov, K. Subedi, B.A.C. Harley, ‘Anisotropic mineralized collagen scaffolds accelerate osteogenic response in a glycosaminoglycan-dependent fashion,’ RSC Adv., 10:15629-41, 2020. [DOI]

M.J. Dewey, E.M. Johnson, S.T. Slater, D.J. Milner, M.B. Wheeler, B.A.C. Harley, ‘Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions,’ Regen. Biomater., 7(3): 247-58, 2020. [DOI]

S.G. Zambuto*, J.F. Serrano*, A.C. Vilbert, Y. Lu, B.A.C. Harley§, S. Pedron§, ‘Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels,’ MRS Commun., 10(1):83-90, 2020. * co-first authors. § co-corresponding authors. [DOI]

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A.E. Gilchrist, S. Lee, Y. Hu, B.A.C. Harley, ‘Soluble signals and remodeling in a synthetic gelatin-based hematopoietic stem cell niche,’ Adv. Healthc. Mater., 8(20):1900751, 2019. [DOI]

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S. Pedron, G.L. Wolter, J.-W.E. Chen, S. Laken, J.N. Sarkaria, B.A.C. Harley, ‘Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens,’ Biomaterials, 219:119371, 2019. [DOI]

A.S. Tiffany, D.L. Gray, T.J. Woods, K. Subedi, B.A.C. Harley, ‘The inclusion of zinc into mineralized collagen scaffolds for craniofacial bone repair applications,’ Acta Biomater., 93:86-96, 2019. [DOI]

S. Zambuto, K.B.H. Clancy, B.A.C. Harley, ‘A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion,’ Interface Focus, 9(5):20190016, 2019. [DOI]

R. Sun Han Chang, J.C.-W. Lee, S. Pedron, B.A.C. Harley§, S.A. Rogers§, ‘Rheological analysis of the gelation kinetics of an enzyme-crosslinked PEG hydrogel,’ Biomacromolecules, 20(6): 2198-206, 2019. [DOI] § co-corresponding authors.

X. Ren, Q. Zhou, D. Foulad, A.S. Tiffany, M.J. Dewey, D. Bischoff, T.A. Miller, R. Reid, T.-C. He, D.T. Yamaguchi, B.A.C. Harley, J.C. Lee, ‘Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen glycosaminoglycan scaffolds,’ Sci. Adv., 5(6): eaaw4991, 2019. [DOI]

M.J. Dewey, E.M. Johnson, D.W. Weisgerber, M.B. Wheeler, B.A.C. Harley, ‘Shape-fitting collagen-PLA composite promotes osteogenic differentiation of porcine adipose stem cells,’ J. Mech. Behav. Biomed. Mater., 95:21-33, 2019. [DOI]

W.K. Grier, R. Sun Han Chang, M.D. Ramsey, B.A.C. Harley, ‘The influence of cyclic tensile strain on multi-compartment collagen-GAG scaffolds for tendon-bone junction repair,’ Connect Tissue Res, 60(6):530-43, 2019. [DOI]

B.P. Mahadik, B. Hannon, B.A.C. Harley, ‘A computational model of feedback-mediated hematopoietic stem cell differentiation in vitro,’ PLoS One, 14(3):e0212502, 2019. [DOI]

X. Ren, Q. Zhou, D. Foulad, M.J. Dewey, T.A. Miller, D.T. Yamaguchi, D. Bischoff, B.A.C. Harley, J.C. Lee, ‘Nanoparticulate mineralized collagen glycosaminoglycan materials directly and indirectly inhibit osteoclastogenesis and osteoclast activation,’ J. Tissue Eng. Regen. Med., 13(5):823-34, 2019. [DOI]

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M.T. Ngo, B.A.C. Harley, ‘Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel,’ Biomaterials, 198:122-34, 2019. [DOI]


R.A. Hortensius, J.H. Ebens, M.J. Dewey, B.A.C. Harley, ‘Incorporation of amniotic membrane as an immunomodulatory design element in collagen scaffolds for tendon repair,’ ACS Biomater. Sci. Eng., 4(12):4367–77, 2018. [DOI]

G. Offendu, B.A.C. Harley, M.L. Oyen, ‘Relationship between permeability and diffusivity in polyethylene glycol hydrogels,’ AIP Adv., 8(10):105006, 2018. [DOI]

J.-S. Choi*, Y. Ilin*, M.L. Kraft, B.A.C. Harley, ‘Tracing hematopoietic progenitor cell neutrophilic differentiation via Raman spectroscopy,’, Bioconjug. Chem., 29(9):3121-8, 2018. * co-first authors. [DOI]

W.K. Grier*, A.S. Tiffany*, M.D. Ramsey, B.A.C. Harley, ‘Incorporating β-cyclodextrin into collagen scaffolds to sequester growth factors and modulate MSC activity,’ Acta Biomater., 76:116-25, 2018. * co-first authors. [DOI]

S. Chen, T. Le, B.A.C. Harley, P.I. Imoukhuede, ‘Characterizing glioblastoma heterogeneity via single-cell receptor quantification,’ Front. Bioeng. Biotechnol., 6:92, 2018. [DOI]

A.M. Magarinos, S. Pedron, D.W. Pfaff§, B.A.C. Harley§, ‘The feasibility of encapsulated embryonic medullary reticular cells to grow and differentiate into neurons in functionalized gelatin-based hydrogels,’ Front. Mater., 5:40 2018. [DOI]

J.-W. Chen, S. Pedron, P. Shyu, Y. Hu, J.N. Sarkaria, B.A.C. Harley, ‘Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior,’ Front. Mater., 5:39, 2018. [DOI]

V. Mirshafiee, B.A.C. Harley, M.L. Kraft, ‘Visualizing intra-population hematopoietic cell heterogeneity with self-organizing maps of SIMS data,’ Tissue Eng. Part C Methods, 24(6):322-330, 2018. [DOI]

J.-W. Chen, J. Lumibao, A. Blazek, H.R. Gaskins, B.A.C. Harley, ‘Hypoxia activates enhanced invasive potential and endogenous hyaluronic acid production by glioblastoma cells,’ Biomater. Sci., 6:854-62, 2018. [DOI]

Y. Zhuo, J.S. Choi, T. Marin, H. Yu, B.A. Harley, B.T. Cunningham, ‘Quantitative analysis of focal adhesion dynamics using photonic resonator outcoupler microscopy (PROM),’ Light Sci. Appl., 7(1):9, 2018. [DOI]

D.W. Weisgerger, D.J. Milner, H. Lopez-Lake, M. Rubessa, S. Lotti, K. Polkoff, R.A. Hortensius, C.L. Flanagan, S.J. Hollister, M.B. Wheeler, B.A.C. Harley, ‘A mineralized collagen-polycaprolactone composite promotes healing of a porcine mandibular ramus defect,’ Tissue Eng Part A, 24(11-12): 943-54, 2018. [DOI]


S. Pedron, H. Polishetty, A.M. Pritchard, B.P. Mahadik, J.N. Sarkaria, B.A.C. Harley, ‘Spatially-graded hydrogels for preclinical testing of glioblastoma anticancer therapeutics,’ MRS Commun., 7(3):442-9, 2017. [DOI]

Q. Zhou, X. Ren, D. Bischoff, D.W. Weisgerber, D.T. Yamaguchi, T.A. Miller, B.A.C. Harley, J.C. Lee, ‘Nonmineralized and mineralized collagen scaffolds induce differential osteogenic signaling pathways in human mesenchymal stem cells,’ Adv. Healthc. Mater., 6(23):1700641, 2017. [DOI]

M.T. Ngo, B.A.C. Harley, ‘The influence of hyaluronic acid and glioblastoma cell co-culture on the formation of endothelial cell networks in gelatin hydrogels,’ Adv. Healthc. Mater., 6(22):1700687, 2017. [DOI]

S. Pedron, J.S. Hanselman, M. Schroeder, J.N. Sarkaria, B.A.C. Harley, ‘Extracellular hyaluronic acid influences the efficacy of EGFR tyrosine kinase inhibitors in a biomaterial model of glioblastoma,’ Adv. Healthc. Mater., 6(21):1700529, 2017. [DOI]

J.C. Pence, K.B.H. Clancy, B.A.C. Harley, ‘Pro-angiogenic activity of endometrial epithelial and stromal cells in response to estradiol in gelatin hydrogels,’ Adv. Biosys., 1(9):1700056, 2017. [DOI]

W.K. Grier, A.S. Moy, B.A.C. Harley, ‘Cyclic tensile strain enhances human mesenchymal stem cell Smad2/3 activation and tenogenic differentiation in anisotropic collagen-glycosaminoglycan scaffolds,’ Eur. Cell Mater., 33:227-39, 2017. [DOI]

J.-W. Chen, S. Pedron, B.A.C. Harley, ‘The combined influence of hydrogel stiffness and matrix-bound hyaluronic acid content on glioblastoma invasion,’ Macromol. Biosci., 17(8):1700018, 2017. [DOI]

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S. Pedron, A.M. Pritchard, G.A. Vincil, S.C. Zimmerman, B.A.C. Harley, ‘Patterning 3D hydrogel microenvironments using hyperbranched polyglycerols for independent control of mesh size and stiffness,’ Biomacromolecules, 18(4):1393-1400, 2017. [DOI]

B.P. Mahadik, N.A.K. Bharadwaj, R.H. Ewoldt, B.A.C. Harley, ‘Regulating dynamic signaling between hematopoietic stem cells and niche cells via a hydrogel matrix,’ Biomaterials, 125:54-64, 2017. [DOI]

J.-S. Choi, B.A.C. Harley, ‘Marrow-inspired matrix cues rapidly affect early fate decisions of hematopoietic stem and progenitor cells,’ Sci. Adv., 3(1):e1600455, 2017. [DOI]

L.C. Mozdzen, A. Vucetic, B.A.C. Harley, ‘Modifying the strength and strain concentration profile within collagen scaffolds using customizable arrays of poly-lactic acid fibers,’ J. Mech. Behav. Biomed. Mater., 66:28-36, 2017  [DOI]

W.K. Grier, E.M. Iyoha, B.A.C. Harley, ‘The influence of pore size and stiffness on tenocyte bioactivity and transcriptomic stability in collagen-GAG scaffolds,’ J. Mech. Behav. Biomed. Mater., 65:295-305, 2017. [DOI]


Y. Zhuo, J.-S. Choi, T. Marin, H. Yu, B.A. Harley, B.T. Cunningham, ‘Quantitative imaging of cell membrane-associated mass density using photonic crystal enhanced microscopy (PCEM),’ Prog. Quant. Electron., 50:1-18, 2016.  [DOI]

Z. Rahil*, S. Pedron*, X. Wang, T. Ha, B.A.C. Harley§, D.E. Leckband§, ‘Nanoscale mechanics guides cellular decision making,’ Integr. Biol. (Camb), 8(9):929-35, 2016. [DOI] * co-first authors. § co-corresponding authors.

X. Ren, D.W. Weisgerber, D. Bischoff, M.S. Lewis, R.R. Reid, T.-C. He, D.T. Yamaguchi, T.A. Miller, B.A.C. Harley, J.C. Lee, ‘Nanoparticulate mineralized collagen scaffolds and BMP-9 induce a long term bone cartilage construct in human mesenchymal stem cells,’ Adv. Healthc. Mater., 5(14):1821-30, 2016. [DOI]

L.C. Mozdzen, S. Thorpe, H.R.C. Screen, B.A.C. Harley, ‘The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials,’ Adv. Healthc. Mater., 5(14):1731-9, 2016. [DOI]

R.A. Hortensius§, B.A.C. Harley, ‘Naturally-derived biomaterials for addressing inflammation in tissue regeneration,’ Exp. Biol. Med., 241(10):1015-24, 2016. § corresponding author. [DOI]

D.W. Weisgerber, K. Erning, C. Flanagan, S.J. Hollister, B.A.C. Harley, ‘Evaluation of multi-scale mineralized collagen-polycaprolactone composites for bone tissue engineering,’ J. Mech. Behav. Biomed. Mater., 61:318-27, 2016. [DOI]

X. Ren, V. Tu, D. Bischoff, D.W. Weisgerber, M.S. Lewis, D.T. Yamaguchi, T.A. Miller, B.A.C. Harley, J.C. Lee, ‘Nanoparticulate mineralized collagen scaffolds induce in vivo bone regeneration independent of progenitor cell loading or exogenous growth factor stimulation,’ Biomaterials, 89:67-78, 2016. [DOI]

L.C. Mozdzen, R. Rodgers, J.M. Banks, R.C. Bailey, B.A.C. Harley, ‘Increasing the strength and bioactivity of collagen scaffolds using customizable arrays of 3D-printed polymer fibers,’ Acta Biomater., 15(33):25-33, 2016. [DOI]

R.A. Hortensius, J.H. Ebens, B.A.C. Harley, ‘Immunomodulatory effects of amniotic membrane matrix incorporated into collagen scaffolds,’ J. Biomed Mater. Res., 104(6):1332-42, 2016. [DOI]

J.-S. Choi, B.A.C. Harley, ‘Challenges and opportunities to harnessing the (hematopoietic) stem cell niche,’ Curr. Stem Cell Rep., 2(1):85-94, 2016. [DOI]


Y. Ilin, J.-S. Choi, B.A.C. Harley, M.L. Kraft, ‘Identifying states along the hematopoietic stem cell differentiation hierarchy with single cell specificity via Raman spectroscopy,’ Anal. Chem., 87(22):11317-24, 2015. [DOI]

T. Yokohama-Tamaki, K. Otsu, H. Harada, S. Shibata, N. Obara, K. Irie, A. Taniguchi, T. Nagasawa, K. Aoki, S.R. Caliari, D.W. Weisgerber, B.A.C. Harley, ‘CXCR4/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in the dental stem cell niche,’ Cell Tissue Res., 362(3):633-42, 2015. [DOI]

W. Chen, K.D. Long, J. Kurniawan, M. Hung, H. Yu, B.A. Harley, B.T. Cunningham, ‘Planar photonic crystal biosensor for quantitative label-free cell attachment microscopy,’ Adv. Optical Mater., 3(11):1623-32, 2015. [DOI]

B.P. Mahadik, S. Pedron Haba, L.J. Skertich, B.A.C. Harley, ‘The use of covalently immobilized stem cell factor to selectively affect hematopoietic stem cell activity within a gelatin hydrogel,’ Biomaterials, 67:297-307, 2015. [DOI]

J.M. Banks, B.A.C. Harley, R.C. Bailey, ‘Tunable, photoreactive hydrogel system to probe synergies between mechanical and biomolecular cues on adipose-derived mesenchymal stem cell differentiation,’ ACS Biomater. Sci. Eng., 1(8):718-25, 2015. [DOI]

cover J.S. Choi, B.P. Mahadik, B.A.C. Harley, ‘Engineering the hematopoietic stem cell niche: frontiers in biomaterial science,’ Biotechnol. J., 10(10):1529-45, 2015. [DOI].

News: This article was featured on the cover of the special issue on Stem Cell Engineering.

K.R.C. Kinneberg, A. Nelson, M. Stender, A.H. Aziz, L.C. Mozdzen, B.A.C. Harley, S.J. Bryant, V.L. Ferguson, ‘Reinforcement of mono- and bi-layer poly(ethylene glycol) hydrogels with a fibrous collagen scaffold,’ Ann. Biomed. Eng., 43(11):2618-29, 2015. [DOI]

J.C. Pence, K.B.H. Clancy, B.A.C. Harley, ‘The induction of pro-angiogenic processes within a collagen scaffold via exogenous estradiol and endometrial epithelial cells,’ Biotechnol. Bioeng., 112(10):2185-94, 2015. [DOI]News: A video highlight of this article was featured by Biotechnology and Bioengineering.

J.C. Lee, C. Pereira, X. Ren, W. Huang, D.W. Weisgerber, D.T. Yamaguchi, B.A. Harley, T.A. Miller, ‘Optimizing collagen scaffolds for bone engineering: effects of crosslinking and mineral content on structural contraction and osteogenesis,’ J. Craniofac. Surg., 26(6):1992-6, 2015. [DOI]

R.A. Hortensius, J.R. Becraft, D.W. Pack, B.A.C. Harley, ‘The effect of glycosaminoglycan content on polyethylenimine-based gene delivery within three-dimensional collagen-GAG scaffolds,’ Biomater. Sci., 3(4):645-54, 2015. [DOI]

X. Ren, D. Bischoff, D.W. Weisgerber, M.S. Lewis, V. Tu, D.T. Yamaguchi, T.A. Miller, B.A.C. Harley, J.C. Lee, ‘Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway,’ Biomaterials, 50:107-14, 2015. [DOI]

S.R. Caliari, W.K. Grier, D.W. Weisgerber, Z. Mahmassani, M.D. Boppart, B.A.C. Harley, ‘Collagen scaffolds incorporating coincident gradations of instructive structural and biochemical cues for osteotendinous junction engineering,’ Adv. Healthc. Mater., 4(6):831-7, 2015. [DOI]

D.W. Weisgerber, S.R. Caliari, B.A.C. Harley, ‘Mineralized collagen scaffolds induce hMSC osteogenesis and matrix remodeling,’ Biomater. Sci., 3(3):533-42, 2015. [DOI]

Pedron_Cover ArtS. Pedron, E. Becka, B.A.C. Harley, ‘Spatially-gradated hydrogel platform as a three-dimensional engineered tumor microenvironment,’ Adv. Mater., 27(9):1567-72, 2015. [DOI

News: This article was featured on the inside back cover of Advanced Materials.

S.R. Caliari, E.A. Gonnerman, W.K. Grier, D.W. Weisgerber, J.M. Banks, A.T. Alsop, J.-S. Lee, R.C. Bailey, B.A.C. Harley, ‘Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior,’ Adv. Healthc. Mater., 4(1):58-64, 2015. [DOI]


W. Chen, K.D. Long, H. Yu, Y. Tan, J.S. Choi, B.A.C. Harley, B.T. Cunningham, ‘Enhanced live cell imaging via photonic crystal enhanced fluorescence microscopy,’ Analyst, 139(22):5954-63, 2014. [DOI]

J.M. Banks, L.C. Mozdzen, B.A.C. Harley§, R.C. Bailey§, ‘The combined effects of matrix stiffness and growth factor immobilization on the bioactivity and differentiation capabilities of adipose-derived stem cells,’ Biomaterials, 35(32):8951-9, 2014. § co-corresponding authors. [DOI]

A.T. Alsop, J.C. Pence, D.W. Weisgerber, B.A.C. Harley, R.C. Bailey, ‘Photopatterning of VEGF within collagen-GAG scaffolds can induce a spatially confined response in human umbilical vein endothelial cells,’ Acta Biomater., 10(11):4715-22, 2014. [DOI]

J.C. Pence, E.A. Gonnerman, R.C. Bailey, B.A.C. Harley, ‘Strategies to balance covalent and non-covalent biomolecule attachment within collagen-GAG biomaterials,’ Biomater. Sci., 2(9):1296-1304, 2014. [DOI]

S.R. Caliari, B.A.C. Harley, ‘Collagen-GAG scaffold biophysical properties bias MSC lineage choice in the presence of mixed soluble signals,’ Tiss. Eng. A, 20(17-18):2463-72, 2014. [DOI]

S.R. Caliari, B.A.C. Harley, ‘Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation,’ Adv. Healthc. Mater., 3(7):1086-96, 2014. [DOI]

S.R. Caliari, L.C. Mozdzen, O.E. Armitage, M.L. Oyen, B.A.C. Harley, ‘Periodically-perforated core-shell collagen biomaterials balance cell infiltration, bioactivity, and mechanical properties,’ J. Biomed. Mater. Res. Pt. A, 102(4):917-27, 2014. [DOI]

ToC-Fig-300x300B.P. Mahadik, T.D. Wheeler, L.J. Skertich, P.J.A. Kenis, B.A.C. Harley, ‘Microfluidic generation of gradient hydrogels to modulate hematopoietic stem cell culture environment,’ Adv. Healthc. Mater., 3(3):449-458, 2014. [DOI]

News: This article was featured by Materials Views.


GAW. Chen, K.D. Long, M. Lu, V. Chaudhery, H. Yu, J.S. Choi, J. Polans, Y. Zhuo, B.A.C. Harley, B.T. Cunningham, ‘Photonic crystal enhanced microscopy for imaging of live cell adhesion,’ Analyst, 138(20):5886-94, 2013. [DOI]

News: This article was featured on the back cover of this issue of Analyst.

D.W. Weisgerber, D.O. Kelkhoff, S.R. Caliari, B.A.C. Harley, ‘The impact of discrete compartments of a multi-compartment collagen-GAG scaffold on overall construct biophysical properties,’ J. Mech. Behav. Biomed. Mater., 28:26-36, 2013. [DOI]

R.A. Hortensius, B.A.C. Harley, ‘The use of bioinspired alterations in the glycosaminoglycan content of collagen-GAG scaffolds to regulate cell activity,’ Biomaterials, 34(31):7645-52, 2013. [DOI]

76339Pedron, E. Becka, B.A.C. Harley, ‘Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid,’ Biomaterials, 34(30):7408–17, 2013. [DOI]

News: This article was featured by the Illinois News Bureau and AAAS EurekaAlert.

N.P. Gabrielson, A.V. Desai, B. Mahadik, M.-C. Hofmann, P.J.A. Kenis, B.A.C. Harley, ‘Cell-laden hydrogels in integrated microfluidic devices for long-term cell culture and tubulogenesis assays,’ Small, 9(18):3076-81, 2013. [DOI]

S. Pedron, B.A.C. Harley, ‘The impact of the biophysical features of a 3D gelatin microenvironment on glioblastoma malignancy,’ J. Biomed. Mater Res. Pt. A, 101(12):3404-15, 2013.  [DOI]

S.R. Caliari, B.A.C. Harley, ‘Composite growth factor supplementation strategies to enhance tenocyte bioactivity in aligned collagen-GAG scaffolds,’ Tiss. Eng. A, 19(9-10):1100-12, 2013.  [DOI]

C. Nombela-Arrieta, G. Pivarnik, B. Winkel, K.J. Canty, B.A.C. Harley, J.E. Mahoney, J. Lu, A. Protopopov, L.E. Silberstein, ‘Quantitative imaging of hematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment,’ Nat. Cell Biol., 15(5):533-543, 2013. [DOI]

S.-Y. Park, P. Wolfram, K. Canty, B.A. Harley, C. Nombela-Arrieta, G. Pivarnik, J. Manis, H.E. Beggs, L.E. Silberstein, ‘Focal adhesion kinase regulates the localization and retention of pro-B Cells in bone marrow microenvironments,’ J. Immunol., 190(3):1094-102, 2013.  [DOI]


E.A. Gonnerman, D.O. Kelkhoff, L.M. McGregor, B.A.C Harley, ‘The promotion of HL-1 cardiomyocyte beating using anisotropic collagen-GAG scaffolds,’ Biomaterials, 33(34):8812-21, 2012.  [DOI]

J.F. Frisz, J.S. Choi, R.L. Wilson, B.A.C. Harley, M.L. Kraft, ‘Identifying differentiation stage of individual primary hematopoietic cells from mouse bone marrow by multivariate analysis of TOF-secondary ion mass spectrometry data,’ Anal. Chem., 84(10):4307-13, 2012. [DOI]

J.S. Choi, B.A. Harley, ‘The combined influence of substrate elasticity and ligand density on the viability and biophysical properties of hematopoietic stem and progenitor cells,’ Biomaterials, 33(18):4460-4468, 2012.  [DOI]

S.R. Caliari, D.W. Weisgerber, M.A. Ramirez, D.O. Kelkhoff, B.A.C. Harley, ‘The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability,’ J. Mech. Behav. Biomed. Mater., 11:27-40, 2012.  [DOI]


S.R. Caliari, M. Ramirez, B.A.C. Harley, ‘The development of collagen-GAG scaffold-membrane composites for tendon tissue engineering,’ Biomaterials, 32(34):8990-8998, 2011.  [DOI]  News: This article was highlighted in MIT SCOPE magazine.

S.R. Caliari, B.A.C. Harley, ‘The effect of anisotropic collagen-GAG scaffolds and growth factor supplementation on tendon cell recruitment, alignment, and metabolic activity,’ Biomaterials, 32(23):5330-40, 2011. [DOI]

T. Martin, S.R. Caliari, P. Williford, B.A. Harley§, R.C. Bailey§, ‘The generation of biomolecular patterns in highly porous collagen-GAG scaffolds using direct photolithography,’ Biomaterials, 32(16):3949-57, 2011. § co-corresponding authors. [DOI]


A. Sannino, L. Silvestri, M. Madaghiele, B. Harley, I.V. Yannas, ‘Modeling the fabrication process of micropatterned macromolecular scaffolds for peripheral nerve regeneration,’ J. App. Polym. Sci., 116(4):1879-1888, 2010. [DOI]

I.V. Yannas, D.S. Tzeranis, B.A Harley, P.T.C. So, ‘Biologically active collagen-based scaffolds: Advances in processing and characterization,’ Philos. Transact. A Math Phys. Eng. Sci., 368(1917):2123-39, 2010. [DOI]

200908311113506342_0B.A. Harley, A.K. Lynn, Z. Wissner-Gross, W. Bonfield, I.V. Yannas, L.J. Gibson, ‘Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces,’ J. Biomed. Mater. Res. Part A, 92(3):1078-93, 2010. [DOI]  News: This article was featured by MIT News, Bionity, Forbes Magazine, & the New York Times.

B.A. Harley, A.K. Lynn, Z. Wissner-Gross, W. Bonfield, I.V. Yannas, L.J. Gibson, ‘Design of a multiphase osteochondral scaffold II: Fabrication of a mineralized collagen-GAG scaffold,’ J. Biomed. Mater. Res. Part A, 92(3):1066-77, 2010. [DOI]

A.K. Lynn, S.M. Best, R.E. Cameron, B.A. Harley, I.V. Yannas, L.J. Gibson, W. Bonfield, ‘Design of a multiphase osteochondral scaffold I: Control of chemical composition,’ J. Biomed. Mater. Res. Part A, 92(3):1057-65, 2010. [DOI]


B.A. Harley, H.-D. Kim, M.H. Zaman, I.V. Yannas, D.A. Lauffenburger, L.J. Gibson, ‘Micro-architecture of three-dimensional scaffolds influences cell migration behavior via junction interactions,’ Biophys. J., 95(8):4013-24, 2008. [DOI]

B.A.C. Harley and L.J. Gibson, ‘In vivo and in vitro applications of collagen-GAG scaffolds,’ Chem. Eng. J., 137:102-121, 2008. (Invited Review) [DOI]


K.H. Kim, T. Ragan, K. Bahlmann, M.J.R. Previte, B.A. Harley, D.M. Wiktor-Brown, C.A. Hendricks, B.P. Engelward, M.S. Stitt, K.H. Almeida, P.T.C. So, ‘Three-dimensional tissue cytometer based on high-speed multiphoton microscopy,’ Cytometry A, 71(12):991-1002, 2007. [DOI]

Y. Le, B. Zhu, B. Harley, S.-Y. Park, J.P. Manis, H.R. Luo, A. Yoshimura, L. Hennighausen, L.E. Silberstein, ‘SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis,’ Immunity, 27(5):811-823, 2007. [DOI]

B.A. Harley, T.M. Freyman, M.Q. Wong, L.J. Gibson, ‘A new technique for calculating individual dermal fibroblast contractile forces generated within collagen-GAG scaffolds,’ Biophys. J., 93(8):2911-2922, 2007. [DOI]

B.A. Harley, J.H. Leung, E. Silva, L.J. Gibson, ‘Mechanical characterization of collagen-glycosaminoglycan scaffolds,’ Acta Biomater., 3(4):463-474, 2007. [DOI]

F.J. O’Brien, B.A. Harley, M.A. Waller, I.V. Yannas, L.J. Gibson, P.J. Prendergast, ‘The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering,’ Technol. Health Care, 15(1):3-17, 2007. [DOI]


B. Harley and I.V. Yannas, ‘Induced peripheral nerve regeneration using scaffolds,’ Minerva Biotecnologica, 18(2):97-120, 2006. (Invited Review). Download

E. Farrell, F.J. O’Brien, E. Byrne, P. Doyle, J. Fischer, I.V. Yannas, B.A. Harley, B. O’Connell, P.J. Prendergast, V.A. Campbell, ‘A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along the osteogenic and chrondrogenic routes,’ Tiss. Eng., 12(3):459-468, 2006. [DOI]

B.A. Harley, A.Z Hastings, I.V. Yannas, A. Sannino, ‘Fabricating tubular scaffolds with a radial pore size gradient by a spinning technique,’ Biomaterials, 27(6):866-874, 2006. [DOI]


F.J. O’Brien, B.A. Harley, I.V. Yannas, L.J. Gibson, ‘The effect of pore size and structure on cell adhesion in collagen-GAG scaffolds,’ Biomaterials, 26(4):433-441, 2005.  [DOI]


B.A. Harley, M.H. Spilker, J.W. Wu, K.A. Asano, H.-P. Hsu, M. Spector, I.V. Yannas, ‘Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps,’ Cells Tissues Organs, 176(1-3):153-165, 2004. [DOI]

F.J. O’Brien, B.A. Harley, I.V. Yannas, L.J. Gibson, ‘Influence of freezing-rate on pore structure in freeze-dried collagen-GAG scaffolds,’ Biomaterials, 25(6):1077-1086, 2004.  [DOI]




imagesJ. Wagoner Johnson and B.A.C. Harley (eds.), ‘Mechanobiology of cell-cell and cell-matrix interactions,’ Springer, 2011. [DOI]


CellularSolidsBookCoverL.J. Gibson, M.F. Ashby, B.A. Harley, ‘Cellular materials in nature and medicine,’ Cambridge University Press, 2010. [DOI]



Book Chapters


R.A. Hortensius, L.C. Mozdzen, B.A.C. Harley, ‘Biomaterial scaffolds for tendon tissue engineering,’ in M.E Gomes, M.T. Rodrigues, and R.L. Reis (eds.) Tendon Regeneration, Elsevier, 2015. [Link]


A.J. Turgeon, B.A. Harley, R.C. Bailey, ‘Benzophenone-based photochemical micropatterning of biomolecules to create model substrates and instructive biomaterials,’ in M. Piel and M. Théry (eds.) Micropatterning in Cell Biology – Part C, Elsevier, 2014. [Link]


B.A.C. Harley and I.V Yannas, ‘In vivo synthesis of tissues and organs,’ in R. Lanza, R. Langer, and J.P. Vacanti (eds.) Principles of Tissue Engineering, 4rd Edition, New York: Elsevier, 2013.


D.W. Weisgerber, S.R. Caliari, B.A.C. Harley, ‘Synthesis of layered, graded bioscaffolds,’ in S. Thomopoulos, G. Genin, V. Birman (eds.) Structural interfaces and attachments in biology, Springer, 2012.


S.R. Caliari and B.A. Harley, ‘Collagen-GAG materials,’ in P. Ducheyne (ed.) Comprehensive Biomaterials, Kidlington (UK): Elsevier, 2011.


B.A. Harley and I.V Yannas, ‘In vivo synthesis of tissues and organs,’ in R. Lanza, R. Langer, and J.P. Vacanti (eds.) Principles of Tissue Engineering, 3rd Edition, New York: Elsevier, 2007.


B.A. Harley and I.V. Yannas, ‘Skin: Tissue engineering for regeneration,’ in J.G. Webster (ed.) The Encyclopedia of Medical Devices and Instrumentation, 2nd Edition, New York: Wiley, 2006.