Dr. Harley is the PI of a new R01 research award from the National Institutes of Health entitled, ‘Mineralized collagen composite to accelerate craniofacial bone regeneration.’ Dr. Harley is leading a team, including Co-Investigators Dr. Justine Lee (UCLA) as well as Dr. Ramille Shah and Dr. Adam Jakus (Dimension Inx) to develop a composite biomaterial that blends surgical practicality and bioactivity so that it can be used off-the-shelf to improve implant integration and accelerate bone regeneration. Brendan, Justine and Ramille have been collaborators extended back almost two decades, and the #harleylab team is finally getting a chance to link the work of these great collaborators!
Congratulations to Samantha for winning the Society for Biomaterials 2021 Annual Meeting STAR award! The Student Travel Achievement Recognitions (STARs) recognize research excellence and develop future leaders within the Society for Biomaterials. Samantha won the STAR award with her amazing abstract and presentation titled “A Gelatin Hydrogel Model of the Endometrium and Trophoblast Invasion”.
Marley Dewey – she/her/hers (rapid fire, 3MT): “Antimicrobial drug delivery in infectious diseases” number 302
Vasiliki “Aliki” Kolliopoulos – she/her/hers (oral): “Modifying Mineralized Collagen Scaffolds to Modulate the Inflammatory Response in Craniomaxillofacial Defects and Enhance Bone Regeneration” session: Biomaterials-based strategies for endogenous tissue regeneration – 1
Samantha Zambuto – she/her/hers (oral): “A Gelatin Hydrogel Model of the Endometrium and Trophoblast Invasion” section: Biomaterials for Women’s and Fetal Health
Tori Barnhouse – she/her/hers (rapid fire): “Formation of a Primary Murine Perivascular Model to Study Hematopoietic Stem Cells In Vitro” number 519
Aleczandria Tiffany – she/her/hers (rapid fire): “Bioactive Alterations to Mineralized Collagen Scaffolds to Enhance Craniofacial Bone Repair” number 352
Sara Pedron – she/her/hers (oral): “Bioengineered Tissue Mimetic Hydrogels to Study Brain Tumor BiologyBioengineered Tissue Mimetic Hydrogels to Study Brain Tumor Biology” session: Engineered biomaterials for neural applications – 1
Congratulations to Aliki for passing her preliminary exams!
Congratulations to Marley for successfully defending her PhD thesis, ‘Modification of mineralized collagen scaffolds to overcome challenges of craniomaxillofacial bone repair.’ Marley transformed our efforts to create shape-fitting materials for bone repair. She constantly impressed us with her striking images connecting art with science. She will be moving on to a postdoc with Prof. Stephen Badylak at the University of Pittsburgh. We are so proud of her and will miss her very much! Congrats Dr. Dewey!
Congratulations to Mai for successfully defended her PhD thesis today, ‘Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression.’ Mai has led some exceptional programs in our group to reimagine how tissue engineering platforms can be generated and used to study progression and therapeutic resistance in glioblastoma, the most common and lethal form of primary brain cancer. Mai’s contributions fundamentally shifted our research program in GBM and we are so proud of all her work! She will be moving to a fantastic postdoc with Dr. Chris Chen in the Biological Design Center at Boston University and we will miss her very much! Congratulations Dr. Ngo!
Dr. Harley is the PI of a new R01 research award from the National Institutes of Health entitled, ‘Perivascular tissue models to overcome MGMT-mediated temozolomide resistance in glioblastoma.’ Dr. Harley is leading a team, including Co-Investigators Dr. Paul Hergenrother & Dr. Time Fan (Illinois), Dr. Rebecca Riggins (Georgetown), and Dr. Jann Sarkaria (Mayo) to develop a cancer tissue engineering program to investigate pathophysiological processes responsible for invasive spreading, therapeutic resistance, and poor survival in glioblastoma, the most common and lethal form of primary brain cancer. Congrats all!
This is exciting news as this award also provides the opportunity for the HarleyLAB to join the NCI Cancer Tissue Engineering Collaborative (CTEC) program, and initiative to help push the boundaries of how tissue engineering technologies can be exploited to accelerate diagnosis and treatment of cancer!
Dr. Sara Pedron has been selected as one of the NextGen Star speakers at the AACR Annual Meeting 2021. Her talk will be included in one of three dedicated NextGen Stars Spotlight Sessions. The AACR Annual Meeting 2021 will take place virtually Saturday, April 10. Annual Meeting website
Marley wins the Annual Innovation Award for Outstanding Ph.D. Thesis from Durgam and Subha Chakrapani Family Trust! This is awarded to a student demonstrating the potential for commercialization in the field of Materials Science and Engineering. Marley was awarded funds to support professional development and commercialization as well as a medallion.
Marley and Brendan published an article titled “Inclusion of a 3D-printed Hyperelastic Bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold” in Acta Biomaterialia. This describes their work towards regenerating craniomaxillofacial bone defects by combining mineralized collagen scaffolds with 3D-prints from chicago-based company Dimension Inx, LLC. Check it out here!