Sara’s new papers on the drug response and the GBM microenvironment

Congrats to Sara for the acceptance of two papers, both using biomaterial models to examine how the glioblastoma tumor microenvironment may alter how GBM cells respond to tyrosine kinase inhibitors. ‘Extracellular hyaluronic acid influences the efficacy of EGFR tyrosine kinase inhibitors in a biomaterial model of glioblastoma’ is out in Advanced Healthcare Materials, while ‘Spatially-graded hydrogels for preclinical testing of glioblastoma anticancer therapeutics’ has been accepted in MRS Communications. Both involve an exciting collaboration with Mayo Clinic and our use of patient-derived biospecimens (not cell lines)!

Welcome new grad students Tori and Samantha!

Tori Barnhouse graduated from The Ohio State University with a B.S. in Biomedical Engineering in 2017 where she worked as a research assistant under Dr. Jennifer Leight. She will be working on a project tracing the behavior of hematopoietic stem cells encapsulated within 3D hydrogels.

Samantha Zambuto received a B.S. in Biological Engineering from Cornell University in 2015 and a Sc.M. in Biomedical Engineering from Brown University in 2017. At Brown, she worked in Dr. Diane Hoffman-Kim’s lab and wrote a thesis titled “Advancing Tissue Engineered Neural Platforms to Explore Sex Differences in Ischemic Stroke and Traumatic Brain Injury.” Samantha will be expanding our efforts to generate models of the endometrium.

Brendan leads team awarded NSF MRI research award

Dr. Harley is the PI of a new research from the U.S. National Science Foundation entitled, ‘MRI: Acquisition of a 3D bioprinting system to generate composite biomaterials for regenerative medicine.’ This award will allow the Regenerative Biology and Tissue Engineering research theme at the IGB to acquire an Envison-TEC 3D Bioplotter. This 3D-printer will allow our theme new capabilities to fabricate large, geometrically complex, and cell-laden tissue biomaterials that mimic features of native tissues. Congrats to all involved, specifically all of the senior investigators and Co-PIs who helped make this application possible:  Rashid Bashir, Rohit Bhargava, Iwona Jasiuk, Kris Kilian, Hyun Joon Kong, Ceclia Leal, Larry Schook, Greg Underhill, Amy Wagoner Johnson, and Matt Wheeler!

Mai’s first paper accepted in Advanced Healthcare Materials

Congrats to Mai for the acceptance of her first paper, ‘The influence of hyaluronic acid and glioblastoma cell co-culture on the formation of endothelial cell networks in gelatin hydrogels,’ in Advanced Healthcare Materials. This study looks at the incorporating elements of the perivascular niche into gelatin hydrogels to explore the influence of glioblastoma-vascular interactions on GBM cell activity.

Brendan co-edits special journal issue: Gradient Biomaterials

Dr. Harley and Dr. Helen Lu (Columbia University) co-edited a Special Issue published in Acta Biomaterialia: Gradient in Biomaterials. This special issue highlighted some of the latest advances in developing biomaterials containing graded or non-uniform properties. The collection of scientific publications emphasized  existing challenges as well as opportunities in the fields of tissue engineering and regenerative engineering. Read it!

HarleyLab at #Biomaterials17

This week Brendan, Aidan, Mai, and Bill travel to the 2017 Society for Biomaterials annual meeting. Aidan Gilchrist has a podium presentation, ‘Tunable Biotransport Properties in Gelatin Hydrogels for Hematopoietic Stem Cell Culture,’ Wed 4:30p (#94, rm. 208CD). Mai Ngo has a podium presentation, ‘Impact of VEGF Presentation and Glioblastoma on Vascularization of GelMA,’ Thurs 11:00a (#133, rm 208CD). Bill Grier has a poster, ‘Combinatorial effects of cyclic tensile strain and local biomaterial cues on tendon-bone-junction engineering,’ Fri 2:15-3:45p (#867).

Brendan co-organizes NIDDK workshop on bone marrow remodeling

Brendan and Aidan travel to Washington this week to be part of a workshop Brendan helped organize with the NIDDK at the NIH. The goal of the Remodeling the Hematopoietic Bone Marrow Niche workshop is to bring together a multidisciplinary groups of researchers in a 1-day workshop format to learn more about the structure of the bone marrow, particularly the components of the niche that give rise to circulating blood cells and how the niche remodels to adequately respond to changes in environmental cues.