Congratulations Dr. Mai Ngo!!

Congratulations to Mai for successfully defended her PhD thesis today, ‘Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression.’ Mai has led some exceptional programs in our group to reimagine how tissue engineering platforms can be generated and used to study progression and therapeutic resistance in glioblastoma, the most common and lethal form of primary brain cancer. Mai’s contributions fundamentally shifted our research program in GBM and we are so proud of all her work! She will be moving to a fantastic postdoc with Dr. Chris Chen in the Biological Design Center at Boston University and we will miss her very much! Congratulations Dr. Ngo!

HarleyLAB receives new NIH funding and joins the NCI Cancer Tissue Engineering Collaborative!

Dr. Harley is the PI of a new R01 research award from the National Institutes of Health entitled, ‘Perivascular tissue models to overcome MGMT-mediated temozolomide resistance in glioblastoma.’ Dr. Harley is leading a team, including Co-Investigators Dr. Paul Hergenrother & Dr. Time Fan (Illinois), Dr. Rebecca Riggins (Georgetown), and Dr. Jann Sarkaria (Mayo) to develop a cancer tissue engineering program to investigate pathophysiological processes responsible for invasive spreading, therapeutic resistance, and poor survival in glioblastoma, the most common and lethal form of primary brain cancer. Congrats all!

This is exciting news as this award also provides the opportunity for the HarleyLAB to join the NCI Cancer Tissue Engineering Collaborative (CTEC) program, and initiative to help push the boundaries of how tissue engineering technologies can be exploited to accelerate diagnosis and treatment of cancer!

Marley publishes in Acta Biomaterialia

Marley and Brendan published an article titled “Inclusion of a 3D-printed Hyperelastic Bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold” in Acta Biomaterialia. This describes their work towards regenerating craniomaxillofacial bone defects by combining mineralized collagen scaffolds with 3D-prints from chicago-based company Dimension Inx, LLC. Check it out here!

Congratulations Dr. Aidan Gilchrist!!!

Congratulations to Aidan for successfully defended his PhD thesis today, ‘Soluble factors and remodeling in a synthetic stem cell niche.’ Aidan transformed our efforts to create artificial platforms to culture hematopoietic stem cells in the laboratory. While we are excited that he will be moving on to a fantastic postdoc with Dr. Sarah Heilshorn at Stanford University,  we will miss him very much! Congratulations again Dr. Gilchrist!