Steven’s multilineage supplementation paper accepted in Tissue Engineering

Congratulations to Steven Caliari for the acceptance of his new article, ‘Collagen-GAG scaffold biophysical properties bias MSC lineage choice in the presence of mixed soluble signals,’ in the journal Tissue Engineering. This paper describes pitfalls associated with the use of mixed media solutions to drive osteo vs. chondro differentiation of mesenchymal progenitor cells within 3D collagen biomaterials. Excellent work!

HarleyLab receives AO Foundation support

Dr. Harley has received a 2-year grant from the AO Foundation entitled ‘Multi-scale PCL-collagen composites for large bone defect repair.’ Working with Dr. Matt Wheeler (Illinois) and Dr. Scott Hollister (Michigan), the goal of this effort is to demonstrate a multi-scale collagen-PCL construct able to enhance mandibular bone repair while retaining mechanical integrity.

Steven’s multi-lineage differentiation article accepted in Adv Healthc Matls

Congratulations to Steven Caliari and Dr. Harley for the acceptance of a their new article, ‘Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation,’ in Advanced Healthcare Materials. This effort represents key foundational work in the design of a 3D biomaterial platform to regenerate the osteotendinous insertion.

Steven and Laura’s new article in JBMR Pt A

Congratulations to Steven Caliari, Laura Mozdzen and Dr. Harley for acceptance of their article, ‘Periodically-perforated core-shell collagen biomaterials balance cell infiltration, bioactivity, and mechanical properties,’ in J Biomed Mater Res Pt A. Working with Dr. Michelle Oyen and her graduate student Oli Armitage, this project demonstrated the integration of a periodically performated membrane shell within a collagen scaffold to enhance construct strength while maintaining high porosity and bioactivity.

Dr. Harley receives the 2014 Society for Biomaterials Young Investigator Award!

Brendan will be officially honored at the 2014 Soc. for Biomaterials meeting in Denver in April, but we are excited to announce it now! The award is given “to recognize an individual who has demonstrated outstanding achievements in the field of biomaterials research within ten years following his/her terminal degree or formal training.” This award recognizes all the work done by our lab, including development of biomaterials for regenerative repair of orthopedic insertional injuries (e.g., to repair tendon-bone junctions), as well as ex vivo platforms to examine the impact of the tissue microenvironment on stem cell and cancer cell fate decisions. Congrats to everyone!