Dr. Harley is the PI of a new R01 research award from the National Institutes of Health entitled, ‘Mineralized collagen composite to accelerate craniofacial bone regeneration.’ Dr. Harley is leading a team, including Co-Investigators Dr. Justine Lee (UCLA) as well as Dr. Ramille Shah and Dr. Adam Jakus (Dimension Inx) to develop a composite biomaterial that blends surgical practicality and bioactivity so that it can be used off-the-shelf to improve implant integration and accelerate bone regeneration. Brendan, Justine and Ramille have been collaborators extended back almost two decades, and the #harleylab team is finally getting a chance to link the work of these great collaborators!
Congratulations to Mai for successfully defended her PhD thesis today, ‘Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression.’ Mai has led some exceptional programs in our group to reimagine how tissue engineering platforms can be generated and used to study progression and therapeutic resistance in glioblastoma, the most common and lethal form of primary brain cancer. Mai’s contributions fundamentally shifted our research program in GBM and we are so proud of all her work! She will be moving to a fantastic postdoc with Dr. Chris Chen in the Biological Design Center at Boston University and we will miss her very much! Congratulations Dr. Ngo!
Dr. Harley is the PI of a new R01 research award from the National Institutes of Health entitled, ‘Perivascular tissue models to overcome MGMT-mediated temozolomide resistance in glioblastoma.’ Dr. Harley is leading a team, including Co-Investigators Dr. Paul Hergenrother & Dr. Time Fan (Illinois), Dr. Rebecca Riggins (Georgetown), and Dr. Jann Sarkaria (Mayo) to develop a cancer tissue engineering program to investigate pathophysiological processes responsible for invasive spreading, therapeutic resistance, and poor survival in glioblastoma, the most common and lethal form of primary brain cancer. Congrats all!
This is exciting news as this award also provides the opportunity for the HarleyLAB to join the NCI Cancer Tissue Engineering Collaborative (CTEC) program, and initiative to help push the boundaries of how tissue engineering technologies can be exploited to accelerate diagnosis and treatment of cancer!
Dr. Harley is the Co-Investigator of a new R01 research award from the National Institutes of Health entitled, ‘Osteoclast modulatory biomaterials for skull regeneration.’ Working with our long-time collaborators (and PI of this grant), Dr. Justine Lee (UCLA), the Harley LAB is developing a new class of mineralized collagen biomaterial to improve craniofacial bone regeneration!
Dr. Harley is the PI of a new R56 research award from the National Institutes of Health entitled, ‘Stratified and mechanically-tough biomaterial implant to improve tendon-to-bone enthesis regeneration.’ Working with Co-Investigators Dr. Simon Rogers (Illinois) as wellas Dr. Meg Killian and Dr. Jim Carpenter (U. Michigan) our lab will lead efforts to develop processing conditions to stably integrate a hydrogel enthesis into a stratified biomaterial implant to improve repair of the structure, composition, and mechanical performance of the injured tendon-to-bone interface!
Samantha received the 2019 Constance Campbell Research Award for best oral presentation at the 2019 Illinois Symposium on Reproductive Science at Northwestern University for a presentation, “Gelatin-based biomaterials for modeling the endometrium and trophoblast invasion.” Congrats Samantha!
Congrats to Samantha Zambuto and Tori Barnhouse, who both received Graduate College Conference Travel Awards this fall!
Congrats to Brendan and Bryan Bryson (MIT BE) for receiving a collaborative science supplement to Brendan’s NIH R21 to study macrophage heterogeneity in biomaterials under development for craniofacial bone regeneration. A fantastic chance for our groups to work collaboratively to integrate bioinformatics and biomaterials!
Congrats to Brendan and Sara Pedron for receiving a Alzheimer’s-focused administrative supplement to our NIH R01 in the space of biomaterial models of brain cancer. With support from NCI they will be adapting these cultures to create neurodegenerative conditions!
Congrats to Brendan for being named the Robert W. Schaefer Professor in the Dept. of Chemical and Biomolecular Engineering at the University of Illinois.